Affiliation: Ruhr-University Bochum
- Effects of acute oral Delta9-tetrahydrocannabinol and standardized cannabis extract on the auditory P300 event-related potential in healthy volunteersPatrik Roser
Department of Psychiatry, Ruhr University Bochum, Bochum, Germany
Eur Neuropsychopharmacol 18:569-77. 2008..It can be speculated whether the lack of effect of CBD may be due to an insufficient dose used or to an involvement of neurotransmitter systems in P300 generation which are not influenced by CBD...
- Auditory mismatch negativity deficits in long-term heavy cannabis usersPatrik Roser
Department of Psychiatry, Ruhr University Bochum, Alexandrinenstr 1, 44791, Bochum, Germany
Eur Arch Psychiatry Clin Neurosci 260:491-8. 2010..The results indicate that chronic cannabis use may cause a specific impairment of auditory information processing. In particular, duration and quantity of cannabis use could be identified as important factors of deficient MMN generation...
- Acute effects of Delta9-tetrahydrocannabinol and standardized cannabis extract on the auditory evoked mismatch negativityGeorg Juckel
Department of Psychiatry, University Hospital Charite, Berlin, Germany
Schizophr Res 97:109-17. 2007..This effect may be relevant for auditory cortex activity in particular because only MMN amplitudes at the central, but not at the frontal electrodes were enhanced under cannabis...
- Psychomotor performance in relation to acute oral administration of Delta9-tetrahydrocannabinol and standardized cannabis extract in healthy human subjectsPatrik Roser
Department of Psychiatry, Ruhr University Bochum, Bochum, Germany
Eur Arch Psychiatry Clin Neurosci 259:284-92. 2009..This result may be due to functional changes involving GABAergic and glutamatergic neurotransmission within the corpus callosum...
- Alterations of theory of mind network activation in chronic cannabis usersPatrik Roser
Department of Psychiatry, LWL University Hospital, Ruhr University Bochum, Germany
Schizophr Res 139:19-26. 2012..These activation patterns resemble those found in at-risk populations, suggesting that cannabis use can affect the processing of social information similar to other risk factor constellations for psychosis...
- Impaired facial emotion recognition in a ketamine model of psychosisAndreas Ebert
Department of Psychiatry, LWL University Hospital, Ruhr University Bochum, Bochum, Germany
Psychiatry Res 200:724-7. 2012..Given the role of glutamatergic neurotransmission in schizophrenia-related cognitive impairments, we investigated the effects of the glutamatergic NMDA receptor antagonist ketamine on facial emotion recognition...
- Alterations of monetary reward and punishment processing in chronic cannabis users: an FMRI studyBjörn Enzi
Department of Psychiatry, Psychotherapy and Preventive Medicine, LWL University Hospital, Ruhr University Bochum, Bochum, Germany
PLoS ONE 10:e0119150. 2015..In addition, the enhanced lateral prefrontal activation in cannabis users that is related to non-punishing feedback may reflect a deficit in emotion regulation or cognitive reappraisal in these subjects. ..
- Antipsychotic-like effects of cannabidiol and rimonabant: systematic review of animal and human studiesPatrik Roser
Department of Psychiatry, LWL University Hospital, Ruhr University Bochum, Alexandrinenstr 1 3, 44791 Bochum, Germany
Curr Pharm Des 18:5141-55. 2012..The results predominantly confirm the hypothesis of an antipsychotic activity of both cannabinoids. In comparison, cannabidiol appears to be superior to rimonabant with a pharmacological profile similar to atypical antipsychotic drugs...
- Nonverbal communication of patients with borderline personality disorder during clinical interviews: a double-blind placebo-controlled study using intranasal oxytocinMartin Brune
LWL University Hospital, Department of Psychiatry, Psychotherapy and Preventive Medicine, University of Bochum, Division of Cognitive Neuropsychiatry and Psychiatric Preventive Medicine, Bochum, Germany
J Nerv Ment Dis 203:107-11. 2015..OT responses were unrelated to the patients' history of childhood trauma. The present findings are informative with respect to patients' nonverbal prosocial behavior in clinical settings. ..
- Mental state decoding and mental state reasoning in recently detoxified alcohol-dependent individualsPatrizia Thoma
Department of Neuropsychology, Institute of Cognitive Neuroscience, Ruhr University Bochum, Universitatsstrase 150, D 44780 Bochum, Germany
Psychiatry Res 205:232-40. 2013..Findings ought to be incorporated into current treatment strategies...
- Neurophysiological effects of cannabinoids: implications for psychosis researchJurgen Gallinat
Department of Psychiatry, Charite University Medicine Berlin, Campus Charite Mitte, Berlin, Germany
Curr Pharm Des 18:4938-49. 2012....
- No association between chronic cannabis use and loudness dependence of auditory evoked potentials as indicator of central serotonergic neurotransmissionPatrik Roser
Department of Psychiatry, Ruhr University, Alexandrinenstr 1, 44791 Bochum, Germany
Neurosci Lett 465:113-7. 2009..It can be suggested that significant alterations in serotonergic systems may rather be related to acute activation of the endogenous cannabinoid system or to cannabis dependence accompanied by manifest depressive symptoms...
- Social cognition and social problem solving abilities in individuals with alcohol use disorderTobias Schmidt
a Department of Neuropsychology, Institute of Cognitive Neuroscience, Ruhr University Bochum, Bochum, Germany
J Clin Exp Neuropsychol 38:974-90. 2016..However, impairments in these domains lead to an increased probability for relapse and are thus highly relevant in treatment contexts...
- Serotonergic modulation of orbitofrontal activity and its relevance for decision making and impulsivityParaskevi Mavrogiorgou
Department of Psychiatry, Ruhr University Bochum, LWL University Hospital, Alexandrinenstr 1, Bochum, 44791, Germany
Hum Brain Mapp . 2016....
- Modulation of interpersonal trust in borderline personality disorder by intranasal oxytocin and childhood traumaAndreas Ebert
Department of Psychiatry, Psychotherapy and Preventive Medicine, Division of Cognitive Neuropsychiatry and Psychiatric Preventive Medicine, Ruhr University Bochum, LWL University Hospital, Bochum, Germany
Soc Neurosci 8:305-13. 2013....
- Nonverbal behavior during clinical interviews: similarities and dissimilarities among schizophrenia, mania, and depressionSigrid Annen
Research Department of Cognitive Neuropsychiatry and Psychiatric Preventive Medicine, Department of Psychiatry, Psychotherapy and Preventive Medicine, Ruhr University of Bochum, LWL University Hospital Bochum, Alexandrinenstrasse 1, Bochum, Germany
J Nerv Ment Dis 200:26-32. 2012..Patients with schizophrenia, depression, and mania differ in nonverbal behavior. Nonverbal communication seems to be a significant contributor to clinicians' intuitive ratings...
- Inhibition of cerebral type 1 cannabinoid receptors is associated with impaired auditory mismatch negativity generation in the ketamine model of schizophreniaPatrik Roser
Department of Psychiatry, LWL University Hospital, Ruhr University Bochum, Alexandrinenstr 1, 44791 Bochum, Germany
Psychopharmacology (Berl) 218:611-20. 2011..Experimental studies implicate deficient N-methyl-D: -aspartate (NMDA) receptor functioning in such abnormalities...
- Simultaneous and sensitive analysis of THC, 11-OH-THC, THC-COOH, CBD, and CBN by GC-MS in plasma after oral application of small doses of THC and cannabis extractThomas Nadulski
Institute of Legal Medicine, University Hospital Charite, Hannoversche Strabe 6, D 10115 Berlin, Germany
J Anal Toxicol 29:782-9. 2005..Therefore, the concentration ratio 11-OH-THC/THC was discussed as a criterion for distinguishing oral from inhalative cannabis consumption...
- Randomized, double-blind, placebo-controlled study about the effects of cannabidiol (CBD) on the pharmacokinetics of Delta9-tetrahydrocannabinol (THC) after oral application of THC verses standardized cannabis extractThomas Nadulski
Institute of Legal Medicine and Department of Psychiatry, University Hospital Charite, Berlin, Germany
Ther Drug Monit 27:799-810. 2005..Significantly higher AUC and Cmax and shorter tmax were found for females as compared with males...