Terry Roemer

Summary

Publications

  1. ncbi Novel strategies in antifungal lead discovery
    Bo Jiang
    Elitra Canada, 225 President Kennedy West, Suite 2550, Montreal, Quebec, H2X 3Y8, Canada
    Curr Opin Microbiol 5:466-71. 2002
  2. ncbi Large-scale essential gene identification in Candida albicans and applications to antifungal drug discovery
    Terry Roemer
    Elitra Canada, Montreal, Quebec, Canada, H2X 3Y8
    Mol Microbiol 50:167-81. 2003
  3. pmc Essential gene identification and drug target prioritization in Aspergillus fumigatus
    Wenqi Hu
    Merck Frosst Center of Fungal Genetics, Montreal, Quebec, Canada
    PLoS Pathog 3:e24. 2007
  4. ncbi Mechanism-of-action determination of GMP synthase inhibitors and target validation in Candida albicans and Aspergillus fumigatus
    Roberto Rodriguez-Suarez
    Center of Fungal Genetics, Merck Frosst Canada, Montreal, Quebec H2X 3Y8, Canada
    Chem Biol 14:1163-75. 2007
  5. pmc Genome-wide fitness test and mechanism-of-action studies of inhibitory compounds in Candida albicans
    Deming Xu
    Center of Fungal Genetics, Merck Frosst Canada Ltd, Montreal, Quebec, Canada
    PLoS Pathog 3:e92. 2007
  6. doi PAP inhibitor with in vivo efficacy identified by Candida albicans genetic profiling of natural products
    Bo Jiang
    Center of Fungal Genetics, Merck Frosst Canada and Co, 225 President Kennedy West, Suite 2550, Montreal, Quebec H2X 3Y8, Canada
    Chem Biol 15:363-74. 2008
  7. pmc Chemical genetic profiling and characterization of small-molecule compounds that affect the biosynthesis of unsaturated fatty acids in Candida albicans
    Deming Xu
    Center of Fungal Genetics, Merck Frosst Canada Ltd, Montreal, Quebec H9H 3L1, Canada
    J Biol Chem 284:19754-64. 2009
  8. pmc Depletion of the cullin Cdc53p induces morphogenetic changes in Candida albicans
    Katharina Trunk
    Institute for Research in Immunology and Cancer, Universite de Montreal, Montreal, Quebec, Canada
    Eukaryot Cell 8:756-67. 2009
  9. pmc Transcription factor substitution during the evolution of fungal ribosome regulation
    Herve Hogues
    Biotechnology Research Institute, National Research Council, Montreal, QC H4P 2R2, Canada
    Mol Cell 29:552-62. 2008
  10. doi Confronting the challenges of natural product-based antifungal discovery
    Terry Roemer
    Department of Infectious Disease, Merck Frosst Canada Ltd, Montreal, QC, Canada
    Chem Biol 18:148-64. 2011

Collaborators

Detail Information

Publications13

  1. ncbi Novel strategies in antifungal lead discovery
    Bo Jiang
    Elitra Canada, 225 President Kennedy West, Suite 2550, Montreal, Quebec, H2X 3Y8, Canada
    Curr Opin Microbiol 5:466-71. 2002
    ..Emerging experimental analysis tools, such as fitness profiling and protein microarrays, have greatly enhanced our ability to conduct genome-wide functional studies...
  2. ncbi Large-scale essential gene identification in Candida albicans and applications to antifungal drug discovery
    Terry Roemer
    Elitra Canada, Montreal, Quebec, Canada, H2X 3Y8
    Mol Microbiol 50:167-81. 2003
    ..albicans essential gene set, and their respective conditional mutant strains may be directly used as sensitive whole-cell assays for drug screening...
  3. pmc Essential gene identification and drug target prioritization in Aspergillus fumigatus
    Wenqi Hu
    Merck Frosst Center of Fungal Genetics, Montreal, Quebec, Canada
    PLoS Pathog 3:e24. 2007
    ..fumigatus essential genes for cognate antifungal inhibitors...
  4. ncbi Mechanism-of-action determination of GMP synthase inhibitors and target validation in Candida albicans and Aspergillus fumigatus
    Roberto Rodriguez-Suarez
    Center of Fungal Genetics, Merck Frosst Canada, Montreal, Quebec H2X 3Y8, Canada
    Chem Biol 14:1163-75. 2007
    ..Importantly, GMP synthase activity is conditionally essential in C. albicans and Aspergillus fumigatus and is required for virulence of both pathogens, thus constituting an unexpected antifungal target...
  5. pmc Genome-wide fitness test and mechanism-of-action studies of inhibitory compounds in Candida albicans
    Deming Xu
    Center of Fungal Genetics, Merck Frosst Canada Ltd, Montreal, Quebec, Canada
    PLoS Pathog 3:e92. 2007
    ..We also demonstrate how chemically induced haploinsufficiency profiles can be used to identify the mechanism of action of novel antifungal agents, thereby illustrating the potential utility of this approach to antifungal drug discovery...
  6. doi PAP inhibitor with in vivo efficacy identified by Candida albicans genetic profiling of natural products
    Bo Jiang
    Center of Fungal Genetics, Merck Frosst Canada and Co, 225 President Kennedy West, Suite 2550, Montreal, Quebec H2X 3Y8, Canada
    Chem Biol 15:363-74. 2008
    ..Thus, mechanism-of-action determination of crude fermentation extracts by chemical-genetic profiling brings a powerful strategy to natural-product-based drug discovery...
  7. pmc Chemical genetic profiling and characterization of small-molecule compounds that affect the biosynthesis of unsaturated fatty acids in Candida albicans
    Deming Xu
    Center of Fungal Genetics, Merck Frosst Canada Ltd, Montreal, Quebec H9H 3L1, Canada
    J Biol Chem 284:19754-64. 2009
    ....
  8. pmc Depletion of the cullin Cdc53p induces morphogenetic changes in Candida albicans
    Katharina Trunk
    Institute for Research in Immunology and Cancer, Universite de Montreal, Montreal, Quebec, Canada
    Eukaryot Cell 8:756-67. 2009
    ..These results indicate that Cdc53p enables C. albicans to adequately respond to environmental signals...
  9. pmc Transcription factor substitution during the evolution of fungal ribosome regulation
    Herve Hogues
    Biotechnology Research Institute, National Research Council, Montreal, QC H4P 2R2, Canada
    Mol Cell 29:552-62. 2008
    ..cerevisiae lineage, this substitution also occurred independently at RP genes, illustrating the extreme adaptability and flexibility of transcriptional regulatory networks...
  10. doi Confronting the challenges of natural product-based antifungal discovery
    Terry Roemer
    Department of Infectious Disease, Merck Frosst Canada Ltd, Montreal, QC, Canada
    Chem Biol 18:148-64. 2011
    ....
  11. doi High-frequency transposition for determining antibacterial mode of action
    Hao Wang
    Infectious Diseases Division, Merck Frosst Center for Therapeutic Research, Kirkland, Quebec, Canada
    Nat Chem Biol 7:720-9. 2011
    ..Using a panel of antibiotics, we demonstrate the ability to unveil not only an inhibitor's molecular target but also its route of cellular entry, efflux susceptibility and other off-target resistance mechanisms...
  12. doi Isolation and structure elucidation of parnafungins, antifungal natural products that inhibit mRNA polyadenylation
    Craig A Parish
    Natural Products Chemistry, Infectious Diseases, and Process Research, Merck Research Laboratories, Merck and Company, P O Box 2000, Rahway, New Jersey 07065, USA
    J Am Chem Soc 130:7060-6. 2008
    ..The intact isoxazolidinone ring was required for antifungal activity. In addition, the natural products were efficacious in a mouse model of disseminated candidiasis...
  13. pmc Genomic islands in the pathogenic filamentous fungus Aspergillus fumigatus
    Natalie D Fedorova
    The J Craig Venter Institute, Rockville, Maryland, United States of America
    PLoS Genet 4:e1000046. 2008
    ..The role of duplication in the origin of lineage-specific genes is further underlined by the discovery of genomic islands that seem to function as designated "gene dumps" and, perhaps, simultaneously, as "gene factories"...