Bernardo Rodriguez-Iturbe

Summary

Publications

  1. pmc The immunological basis of hypertension
    Bernardo Rodriguez-Iturbe
    Hospital Universitario y Universidad del Zulia, Maracaibo, Venezuela Instituto Venezolano de Investigaciones Científicas Zulia, Maracaibo, Venezuela
    Am J Hypertens 27:1327-37. 2014
  2. doi request reprint Impaired pressure natriuresis is associated with interstitial inflammation in salt-sensitive hypertension
    Bernardo Rodriguez-Iturbe
    The Renal Service, Hospital Universitario, Universidad del Zulia, Maracaibo, Venezuela
    Curr Opin Nephrol Hypertens 22:37-44. 2013
  3. pmc Renal inflammation, autoimmunity and salt-sensitive hypertension
    Bernardo Rodriguez-Iturbe
    Renal Service, University Hospital, University of Zulia and Venezuelan Institute of Scientific Research Zulia, Maracaibo, Estado Zulia, Venezuela
    Clin Exp Pharmacol Physiol 39:96-103. 2012
  4. ncbi request reprint Reduction of renal immune cell infiltration results in blood pressure control in genetically hypertensive rats
    Bernardo Rodriguez-Iturbe
    Renal Service and Laboratory, Hospital Universitario, Instituto de Investigaciones Biomedicas, Universidad del Zulia, Maracaibo, Zulia 4001 A, Venezuela
    Am J Physiol Renal Physiol 282:F191-201. 2002
  5. ncbi request reprint Mycophenolate mofetil administration reduces renal inflammation, oxidative stress, and arterial pressure in rats with lead-induced hypertension
    Yanauri Bravo
    Instituto Venezolano de Investigaciones Científicas Zulia, Maracaibo, Venezuela
    Am J Physiol Renal Physiol 293:F616-23. 2007
  6. ncbi request reprint Overload proteinuria is followed by salt-sensitive hypertension caused by renal infiltration of immune cells
    Violeta Alvarez
    Renal Service and Laboratory and Instituto de Investigaciones Biomédicas, Fundacite Zulia, Hospital Universitario, Universidad del Zulia, Maracaibo 4001 A, Venezuela
    Am J Physiol Renal Physiol 283:F1132-41. 2002
  7. ncbi request reprint Antioxidant-rich diet relieves hypertension and reduces renal immune infiltration in spontaneously hypertensive rats
    Bernardo Rodriguez-Iturbe
    Renal Service and Laboratory, Hospital Universitario, Instituto de Investigaciones Biomédicas Fundacite Zulia, Universidad del Zulia, Maracaibo, Venezuela
    Hypertension 41:341-6. 2003
  8. ncbi request reprint Melatonin ameliorates oxidative stress, inflammation, proteinuria, and progression of renal damage in rats with renal mass reduction
    Yasmir Quiroz
    Centro de Investigaciones Biomedicas, Instituto Venezolano de Investigaciones Científicas Zulia, Maracaibo, Venezuela
    Am J Physiol Renal Physiol 294:F336-44. 2008
  9. ncbi request reprint Chronic exposure to low doses of lead results in renal infiltration of immune cells, NF-kappaB activation, and overexpression of tubulointerstitial angiotensin II
    Bernardo Rodriguez-Iturbe
    Servicio de Nefrologia, Hospital Universitario, Universidad del Zulia, Maracaibo, Venezuela
    Antioxid Redox Signal 7:1269-74. 2005
  10. ncbi request reprint Hypertension in Page (cellophane-wrapped) kidney is due to interstitial nephritis
    Valentina Vanegas
    Renal Service, Hospital Universitario, Instituto de Investigaciones Biomedicas INBIOMED, Universidad del Zulia, Maracaibo, Venezuela
    Kidney Int 68:1161-70. 2005

Collaborators

Detail Information

Publications36

  1. pmc The immunological basis of hypertension
    Bernardo Rodriguez-Iturbe
    Hospital Universitario y Universidad del Zulia, Maracaibo, Venezuela Instituto Venezolano de Investigaciones Científicas Zulia, Maracaibo, Venezuela
    Am J Hypertens 27:1327-37. 2014
    ....
  2. doi request reprint Impaired pressure natriuresis is associated with interstitial inflammation in salt-sensitive hypertension
    Bernardo Rodriguez-Iturbe
    The Renal Service, Hospital Universitario, Universidad del Zulia, Maracaibo, Venezuela
    Curr Opin Nephrol Hypertens 22:37-44. 2013
    ..Renal tubulointerstitial inflammation results in salt-sensitive hypertension and, until recently, the changes in pressure natriuresis induced by renal inflammation received little attention...
  3. pmc Renal inflammation, autoimmunity and salt-sensitive hypertension
    Bernardo Rodriguez-Iturbe
    Renal Service, University Hospital, University of Zulia and Venezuelan Institute of Scientific Research Zulia, Maracaibo, Estado Zulia, Venezuela
    Clin Exp Pharmacol Physiol 39:96-103. 2012
    ..3. The potential role of T-cell-driven reactivity in sustaining the renal inflammation is examined in the light of accumulating evidence of autoimmune mechanisms in experimental and clinical hypertension...
  4. ncbi request reprint Reduction of renal immune cell infiltration results in blood pressure control in genetically hypertensive rats
    Bernardo Rodriguez-Iturbe
    Renal Service and Laboratory, Hospital Universitario, Instituto de Investigaciones Biomedicas, Universidad del Zulia, Maracaibo, Zulia 4001 A, Venezuela
    Am J Physiol Renal Physiol 282:F191-201. 2002
    ..We conclude that the renal immune infiltrate plays a major role in the hypertension in SHR...
  5. ncbi request reprint Mycophenolate mofetil administration reduces renal inflammation, oxidative stress, and arterial pressure in rats with lead-induced hypertension
    Yanauri Bravo
    Instituto Venezolano de Investigaciones Científicas Zulia, Maracaibo, Venezuela
    Am J Physiol Renal Physiol 293:F616-23. 2007
    ..We conclude that interstitial inflammation plays an important role in lead-induced hypertension...
  6. ncbi request reprint Overload proteinuria is followed by salt-sensitive hypertension caused by renal infiltration of immune cells
    Violeta Alvarez
    Renal Service and Laboratory and Instituto de Investigaciones Biomédicas, Fundacite Zulia, Hospital Universitario, Universidad del Zulia, Maracaibo 4001 A, Venezuela
    Am J Physiol Renal Physiol 283:F1132-41. 2002
    ....
  7. ncbi request reprint Antioxidant-rich diet relieves hypertension and reduces renal immune infiltration in spontaneously hypertensive rats
    Bernardo Rodriguez-Iturbe
    Renal Service and Laboratory, Hospital Universitario, Instituto de Investigaciones Biomédicas Fundacite Zulia, Universidad del Zulia, Maracaibo, Venezuela
    Hypertension 41:341-6. 2003
    ..These findings point to interrelation between oxidative stress and inflammatory reactivity in the pathogenesis of hypertension...
  8. ncbi request reprint Melatonin ameliorates oxidative stress, inflammation, proteinuria, and progression of renal damage in rats with renal mass reduction
    Yasmir Quiroz
    Centro de Investigaciones Biomedicas, Instituto Venezolano de Investigaciones Científicas Zulia, Maracaibo, Venezuela
    Am J Physiol Renal Physiol 294:F336-44. 2008
    ..Further studies are necessary to define the potential usefulness of this treatment in other animal models and in patients with chronic renal disease...
  9. ncbi request reprint Chronic exposure to low doses of lead results in renal infiltration of immune cells, NF-kappaB activation, and overexpression of tubulointerstitial angiotensin II
    Bernardo Rodriguez-Iturbe
    Servicio de Nefrologia, Hospital Universitario, Universidad del Zulia, Maracaibo, Venezuela
    Antioxid Redox Signal 7:1269-74. 2005
    ..Tubulointerstitial inflammation, cells expressing angiotensin II, and NF-kappaB activation are consequences of a 3-month low-dose exposure to lead and likely play a role in the development of hypertension and chronic lead nephropathy...
  10. ncbi request reprint Hypertension in Page (cellophane-wrapped) kidney is due to interstitial nephritis
    Valentina Vanegas
    Renal Service, Hospital Universitario, Instituto de Investigaciones Biomedicas INBIOMED, Universidad del Zulia, Maracaibo, Venezuela
    Kidney Int 68:1161-70. 2005
    ..We investigated if interstitial nephritis, rather than plasma angiotensin activity, played a role in the development of hypertension in the Page kidney model...
  11. ncbi request reprint Evolution of renal interstitial inflammation and NF-kappaB activation in spontaneously hypertensive rats
    Bernardo Rodriguez-Iturbe
    Renal Service, Hospital Universitario de Maracaibo, Instituto de Investigaciones Biomedicas, Fundacite Zulia, Universidad del Zulia, Maracaibo, Venezuela
    Am J Nephrol 24:587-94. 2004
    ..These findings are consistent with the possibility that activation of NF-kappaB and renal interstitial infiltration of immune cells may be part of the pathophysiologic process that drives hypertension in the SHR...
  12. ncbi request reprint Early and sustained inhibition of nuclear factor-kappaB prevents hypertension in spontaneously hypertensive rats
    Bernardo Rodriguez-Iturbe
    Renal Service, Hospital Universitario, Universidad del Zulia, Instituto de Investigaciones Biomedicas, Maracaibo, Venezuela
    J Pharmacol Exp Ther 315:51-7. 2005
    ..Results suggest that NF-kappaB-driven intrarenal inflammatory reactivity play a major role in the pathogenesis of hypertension in the SHR...
  13. pmc Immune reactivity to heat shock protein 70 expressed in the kidney is cause of salt-sensitive hypertension
    Hector Pons
    Hospital Universitario y Universidad del Zulia, Maracaibo, Venezuela
    Am J Physiol Renal Physiol 304:F289-99. 2013
    ..These findings raise the possibility of novel approaches to the treatment of this condition...
  14. ncbi request reprint Association of mitochondrial SOD deficiency with salt-sensitive hypertension and accelerated renal senescence
    Bernardo Rodriguez-Iturbe
    Renal Service and Laboratory, Instituto de Investigaciones Biomédicas Fundacite Zulia, Hospital Universitario, Universidad del Zulia, Maracaibo, Venezuela
    J Appl Physiol (1985) 102:255-60. 2007
    ..These findings are consistent with the pattern described in numerous other models of salt-sensitive hypertension and resemble that commonly seen in elderly humans...
  15. ncbi request reprint Hypertension induced by aortic coarctation above the renal arteries is associated with immune cell infiltration of the kidneys
    Bernardo Rodriguez-Iturbe
    Renal Service, Hospital Universitario, Universidad del Zulia, Instituto de Investigaciones Biomédicas INBIOMED Maracaibo, Venezuela
    Am J Hypertens 18:1449-56. 2005
    ..Also unclear is whether the cellular infiltration is caused by the local activation of immune cells in the kidney or a consequence of leukocyte activation in the systemic circulation...
  16. ncbi request reprint Experimental induction of salt-sensitive hypertension is associated with lymphocyte proliferative response to HSP70
    Gustavo Parra
    Renal Service and Laboratory, Hospital Universitario and Universidad del Zulia, Maracaibo, Estado Zulia, Venezuela
    Kidney Int Suppl . 2008
    ..These studies suggest that autoimmunity to stress proteins is involved in the sustained low-grade inflammatory infiltration that occurs in the tubulointerstitial areas of the hypertensive kidney...
  17. doi request reprint Renal infiltration of immunocompetent cells: cause and effect of sodium-sensitive hypertension
    Bernardo Rodriguez-Iturbe
    Renal Service, Instituto Venezolano de Investigaciones Científicas IVIC Zulia, Hospital Universitario, Universidad del Zulia, Maracaibo, Venezuela
    Clin Exp Nephrol 14:105-11. 2010
    ..It is suggested that autoimmune reactivity may play a role in the development and maintenance of renal inflammation in hypertensive states...
  18. ncbi request reprint Oxidative stress, renal infiltration of immune cells, and salt-sensitive hypertension: all for one and one for all
    Bernardo Rodriguez-Iturbe
    Servicio de Nefrologia, Hospital Universitario, Universidad del Zulia, Instituto de Inmunobiología Fundacite Zulia Maracaibo 400 A, Venezuela
    Am J Physiol Renal Physiol 286:F606-16. 2004
    ..Finally, we present some clinical considerations derived from the recognition of this interrelationship...
  19. ncbi request reprint Mycophenolate mofetil ameliorates nephropathy in the obese Zucker rat
    Bernardo Rodriguez-Iturbe
    Renal Service, Hospital Universitario, Universidad del Zulia, Instituto de Investigaciones Biomédicas INBIOMED Maracaibo, Venezuela
    Kidney Int 68:1041-7. 2005
    ....
  20. ncbi request reprint The role of immune cells infiltrating the kidney in the pathogenesis of salt-sensitive hypertension
    Bernardo Rodriguez-Iturbe
    Renal Service and Laboratory, Hospital Universitario, Instituto de Investigaciones Biomedicas INBIOMED, Fundacite Zulia, Maracaibo, Venezuela
    J Hypertens Suppl 20:S9-14. 2002
    ....
  21. ncbi request reprint Early treatment with cGMP phosphodiesterase inhibitor ameliorates progression of renal damage
    Bernardo Rodriguez-Iturbe
    Renal Service, Hospital Universitario, Universidad del Zulia, Instituto de Investigaciones Biomédicas INBIOMED Maracaibo, Venezuela
    Kidney Int 68:2131-42. 2005
    ..Therefore, we investigated if inhibition of PDE-5 would retard the progression of chronic renal failure...
  22. ncbi request reprint Integrin expression and H2O2 production in circulating and splenic leukocytes of obese rats
    Choong H Kim
    Renal Service, Hospital Universitario, Avenida Goajira s n, Maracaibo, Venezuela
    Obesity (Silver Spring) 15:2209-16. 2007
    ..We hypothesized that the pro-inflammatory state in obesity may result in spontaneous activation and, hence, increased generation of reactive oxygen species (ROS) and integrin expression in the circulating leukocytes...
  23. ncbi request reprint AT-1 receptor blockade prevents proteinuria, renal failure, hyperlipidemia, and glomerulosclerosis in the Imai rat
    Bernardo Rodriguez-Iturbe
    Hospital Universitario, Universidad del Zulia and Instituto de Investigaciones Biomédicas, Maracaibo, Venezuela
    Kidney Int 66:668-75. 2004
    ..All treatments were started at 10 weeks of age when the rats were already proteinuric and continued for 6 months when rats were sacrificed...
  24. doi request reprint Effect of chronic antioxidant therapy with superoxide dismutase-mimetic drug, tempol, on progression of renal disease in rats with renal mass reduction
    Yasmir Quiroz
    Centro de Investigaciones Biomedicas, Instituto Venezolano de Investigaciones Científicas Zulia, Maracaibo, Venezuela
    Nephron Exp Nephrol 112:e31-42. 2009
    ....
  25. doi request reprint The role of tubulointerstitial inflammation in the progression of chronic renal failure
    Bernardo Rodriguez-Iturbe
    Servicio de Nefrologia, Hospital Universitario de Maracaibo, Universidad del Zulia and Centro de Investigaciones Biomédicas, Instituto Venezolano de Investigaciones Científicas IVIC Zulia, Maracaibo, Venezuela
    Nephron Clin Pract 116:c81-8. 2010
    ....
  26. doi request reprint The role of renal microvascular disease and interstitial inflammation in salt-sensitive hypertension
    Bernardo Rodriguez-Iturbe
    Hospital Universitario and Universidad del Zulia, IVIC Zulia, Maracaibo, Venezuela
    Hypertens Res 33:975-80. 2010
    ....
  27. ncbi request reprint Impaired creatinine secretion after an intravenous creatinine load is an early characteristic of the nephropathy of sickle cell anaemia
    Jose Herrera
    Renal Service, Hospital Universitario, Universidad del Zulia, Medical School, Maracaibo, Venezuela
    Nephrol Dial Transplant 17:602-7. 2002
    ..We decided to investigate if this response was impaired in sickle cell anaemia (SCA) patients before there was evidence of deterioration of renal function...
  28. doi request reprint Autoimmunity in the pathogenesis of hypertension
    Bernardo Rodriguez-Iturbe
    Renal Service, Hospital Universitario and Laboratorio de Inmunobiología, Instituto Venezolano de Investigaciones Científicas IVIC Zulia, Hospital Universitario de Maracaibo, Ave Goajira s n, Maracaibo, Estado Zulia 4001 A, Venezuela
    Nat Rev Nephrol 10:56-62. 2014
    ..Finally, we highlight the clinical evidence that supports the participation of autoimmunity in essential hypertension. ..
  29. ncbi request reprint Temporary discontinuation of immunosuppressive treatment and renal graft rejection. Experience of a center in Venezuela
    Jose Herrera
    Renal Service, Hospital Universitario de Maracaibo, Maracaibo, Estado Zulia, Venezuela
    Rev Panam Salud Publica 20:338-40. 2006
    ..3% (10/30) of the episodes of institutional noncompliance. Institutional noncompliance represents a preventable cause of graft loss in some transplantation programs in developing countries...
  30. pmc The role of T cells in the pathogenesis of primary hypertension
    Yasmir Quiroz
    Instituto Venezolano de Investigaciones Científicas IVIC Zulia, Maracaibo, Venezuela
    Nephrol Dial Transplant 27:iv2-5. 2012
    ..The potential participation of autoimmune mechanisms in the renal infiltration of immune competent cells is discussed...
  31. ncbi request reprint Melatonin reduces renal interstitial inflammation and improves hypertension in spontaneously hypertensive rats
    Mayerly Nava
    Renal Service and Laboratory, Hospital Universitario, Instituto de Investigaciones Biomédicas Fundacite Zulia, Universidad del Zulia, Maracaibo 4001 A, Venezuela
    Am J Physiol Renal Physiol 284:F447-54. 2003
    ..Decreased activation of NF-kappaB, likely resulting from a reduction in local oxidative stress, may play a role in the suppression of renal immune infiltration and, thereby, in the antihypertensive effects of melatonin...
  32. ncbi request reprint Mycophenolate mofetil treatment improves hypertension in patients with psoriasis and rheumatoid arthritis
    Jose Herrera
    Renal Service, Hospital Universitario, Universidad del Zulia, Maracaibo, Estado Zulia, Venezuela
    J Am Soc Nephrol 17:S218-25. 2006
    ..These data are consistent with the hypothesis that renal immune cell infiltration and oxidative stress play a role in human hypertension...
  33. ncbi request reprint Pathophysiological mechanisms of salt-dependent hypertension
    Bernardo Rodriguez-Iturbe
    Hospital Universitario, Universidad del Zulia, Maracaibo, Venezuela
    Am J Kidney Dis 50:655-72. 2007
    ..In addition, we discuss systemic and renal conditions that result in decreased urinary sodium excretion and were implicated in the development of salt-sensitive hypertension...
  34. ncbi request reprint Effect of hereditary obesity on renal expressions of NO synthase, caveolin-1, AKt, guanylate cyclase, and calmodulin
    Zhen Li
    Renal Service, Hospital Universitario, Universidad del Zulia, Instituto de Investigaciones Biomedicas, Maracaibo, Venezuela
    Kidney Int 68:2766-72. 2005
    ..The study further sought to explore expressions of caveolin-1, phospho AKt, and calmodulin, which regulate activities of constituitive NOS isoforms, as well as soluble guanylate cyclase (sGC), which is involved in NO signaling...
  35. doi request reprint Cardiovascular risk factors and prevention of cardiovascular disease in patients with chronic renal disease
    Bernardo Rodriguez-Iturbe
    Hospital Universitario, Nephrology, Avenida Goajira, Maracaibo, 4001 A, Venezuela
    Expert Opin Pharmacother 11:2687-98. 2010
    ..In predialysis stages as well as in end-stage renal disease (ESRD), mortality in patients with chronic renal failure is most frequently due to cardiovascular disease...