Rayner Rodriguez-Diaz

Summary

Publications

  1. doi request reprint Neural control of the endocrine pancreas
    Rayner Rodriguez-Diaz
    Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Stockholm, SE 17177, Sweden Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA Electronic address
    Best Pract Res Clin Endocrinol Metab 28:745-56. 2014
  2. pmc Novel approaches to studying the role of innervation in the biology of pancreatic islets
    Rayner Rodriguez-Diaz
    Diabetes Research Institute, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Endocrinol Metab Clin North Am 42:39-56. 2013
  3. pmc Noninvasive in vivo model demonstrating the effects of autonomic innervation on pancreatic islet function
    Rayner Rodriguez-Diaz
    Diabetes Research Institute, Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Proc Natl Acad Sci U S A 109:21456-61. 2012
  4. pmc Donor islet endothelial cells in pancreatic islet revascularization
    Daniel Nyqvist
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Stockholm, Sweden
    Diabetes 60:2571-7. 2011
  5. pmc Real-time detection of acetylcholine release from the human endocrine pancreas
    Rayner Rodriguez-Diaz
    Diabetes Research Institute, Miller School of Medicine, University of Miami, Miami, Florida, USA
    Nat Protoc 7:1015-23. 2012
  6. pmc Liraglutide Compromises Pancreatic β Cell Function in a Humanized Mouse Model
    Midhat H Abdulreda
    Diabetes Research Institute, University of Miami Miller School of Medicine, 1450 NW 10th Avenue, Miami, FL 33136, USA Electronic address
    Cell Metab 23:541-6. 2016
  7. pmc Control of insulin secretion by cholinergic signaling in the human pancreatic islet
    Judith Molina
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL
    Diabetes 63:2714-26. 2014
  8. doi request reprint The Different Faces of the Pancreatic Islet
    Midhat H Abdulreda
    Diabetes Research Institute Department of Surgery, University of Miami Leonard M Miller School of Medicine, Miami, FL, USA
    Adv Exp Med Biol 938:11-24. 2016
  9. pmc Alpha cells secrete acetylcholine as a non-neuronal paracrine signal priming beta cell function in humans
    Rayner Rodriguez-Diaz
    Diabetes Research Institute, Miller School of Medicine, University of Miami, Miami, Florida, USA
    Nat Med 17:888-92. 2011
  10. pmc High-resolution, noninvasive longitudinal live imaging of immune responses
    Midhat H Abdulreda
    Diabetes Research Institute, Department of Biomedical Engineering, University of Miami, Miami, FL 33136, USA
    Proc Natl Acad Sci U S A 108:12863-8. 2011

Collaborators

Detail Information

Publications12

  1. doi request reprint Neural control of the endocrine pancreas
    Rayner Rodriguez-Diaz
    Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Stockholm, SE 17177, Sweden Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA Electronic address
    Best Pract Res Clin Endocrinol Metab 28:745-56. 2014
    ..We discuss recent findings on islet innervation, the connections of the islet with the brain, and the role islet innervation plays during the progression of diabetes. ..
  2. pmc Novel approaches to studying the role of innervation in the biology of pancreatic islets
    Rayner Rodriguez-Diaz
    Diabetes Research Institute, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Endocrinol Metab Clin North Am 42:39-56. 2013
    ..It describes recent advances in microscopy and novel approaches to studying the effects of nervous input that may help clarify how autonomic axons regulate islet biology...
  3. pmc Noninvasive in vivo model demonstrating the effects of autonomic innervation on pancreatic islet function
    Rayner Rodriguez-Diaz
    Diabetes Research Institute, Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL 33136, USA
    Proc Natl Acad Sci U S A 109:21456-61. 2012
    ..This study directly demonstrates that autonomic axons innervating the islet modulate glucose homeostasis...
  4. pmc Donor islet endothelial cells in pancreatic islet revascularization
    Daniel Nyqvist
    The Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institutet, Stockholm, Sweden
    Diabetes 60:2571-7. 2011
    ..We have characterized how donor islet endothelial cells (DIECs) may contribute to the revascularization rate, vascular density, and endocrine graft function after transplantation of freshly isolated and cultured islets...
  5. pmc Real-time detection of acetylcholine release from the human endocrine pancreas
    Rayner Rodriguez-Diaz
    Diabetes Research Institute, Miller School of Medicine, University of Miami, Miami, Florida, USA
    Nat Protoc 7:1015-23. 2012
    ..The technique is versatile because biosensor cells expressing a variety of receptors can be used in many applications. The protocol takes ∼3 h...
  6. pmc Liraglutide Compromises Pancreatic β Cell Function in a Humanized Mouse Model
    Midhat H Abdulreda
    Diabetes Research Institute, University of Miami Miller School of Medicine, 1450 NW 10th Avenue, Miami, FL 33136, USA Electronic address
    Cell Metab 23:541-6. 2016
    ..These findings raise concern about the chronic potentiation of β cell function through incretin mimetic therapy in diabetes...
  7. pmc Control of insulin secretion by cholinergic signaling in the human pancreatic islet
    Judith Molina
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL
    Diabetes 63:2714-26. 2014
    ..Endogenous cholinergic signaling therefore provides direct stimulatory and indirect inhibitory input to β-cells to regulate insulin secretion from the human islet. ..
  8. doi request reprint The Different Faces of the Pancreatic Islet
    Midhat H Abdulreda
    Diabetes Research Institute Department of Surgery, University of Miami Leonard M Miller School of Medicine, Miami, FL, USA
    Adv Exp Med Biol 938:11-24. 2016
    ..In this chapter, we explore the structural and functional features of pancreatic islets from mice, pigs, nonhuman primates, and humans because of their prevalent use in nonclinical, preclinical, and clinical applications. ..
  9. pmc Alpha cells secrete acetylcholine as a non-neuronal paracrine signal priming beta cell function in humans
    Rayner Rodriguez-Diaz
    Diabetes Research Institute, Miller School of Medicine, University of Miami, Miami, Florida, USA
    Nat Med 17:888-92. 2011
    ..Cholinergic signaling within islets represents a potential therapeutic target in diabetes, highlighting the relevance of this advance to future drug development...
  10. pmc High-resolution, noninvasive longitudinal live imaging of immune responses
    Midhat H Abdulreda
    Diabetes Research Institute, Department of Biomedical Engineering, University of Miami, Miami, FL 33136, USA
    Proc Natl Acad Sci U S A 108:12863-8. 2011
    ....
  11. pmc Innervation patterns of autonomic axons in the human endocrine pancreas
    Rayner Rodriguez-Diaz
    Diabetes Research Institute, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
    Cell Metab 14:45-54. 2011
    ..Thus, rather than modulating endocrine cell function directly, sympathetic nerves may regulate hormone secretion in human islets by controlling local blood flow or by acting on islet regions located downstream...
  12. pmc Neurotransmitters act as paracrine signals to regulate insulin secretion from the human pancreatic islet
    Rayner Rodriguez-Diaz
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, University of Miami Miller School of Medicine, Miami, FL, 33136, USA Rolf Luft Research Center for Diabetes and Endocrinology, Karolinska Institute, Stockholm, SE 17177, Sweden
    J Physiol 592:3413-7. 2014
    ..Here we propose that the role of neurotransmitters may extend beyond controlling endocrine cell function to work as signals modulating vascular flow and immune responses within the islet. ..