Natacha Rochel

Summary

Publications

  1. doi request reprint Crystal structure of hereditary vitamin D-resistant rickets--associated mutant H305Q of vitamin D nuclear receptor bound to its natural ligand
    Natacha Rochel
    IGBMC Institut de Génétique et de Biologie Moléculaire et Cellulaire, Departement de Biologie et de Genomique Structurales, Centre National de la Recherche Scientifique, Institut National de la Sante de la Recherche Medicale, Universite de Strasbourg, 1 rue Laurent Fries, Illkirch, France
    J Steroid Biochem Mol Biol 121:84-7. 2010
  2. pmc The "Phantom Effect" of the Rexinoid LG100754: structural and functional insights
    Yoshiteru Sato
    Departement de Biologie et de Genomique Structurales, Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, Institut National de Santé et de Recherche Médicale INSERM U964 Centre National de Recherche Scientifique CNRS UMR 1704 Université de Strasbourg, Illkirch, France
    PLoS ONE 5:e15119. 2010
  3. ncbi request reprint Modulators of vitamin D nuclear receptor: recent advances from structural studies
    Anna Y Belorusova
    Department of Integrative Structural Biology, Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, Institut National de Santé et de Recherche Médicale INSERM U964 Centre National de Recherche Scientifique CNRS UMR 7104 Université de Strasbourg, 67404 Illkirch, France
    Curr Top Med Chem 14:2368-77. 2014
  4. doi request reprint Architecture of DNA Bound RAR heterodimers
    Natacha Rochel
    Department of Integrative Structural Biology, Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, Institut National de Sante et de Recherche Medicale INSERM, U964, Centre National de Recherche Scientifique CNRS, UMR7104, Universite de Strasbourg, 67404, Illkirch, France
    Subcell Biochem 70:21-36. 2014
  5. pmc Solution Structures of PPARγ2/RXRα Complexes
    Judit Osz
    Department of Integrative Structural Biology, Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, Centre National de Recherche Scientifique CNRS UMR 7104, Institut National de Santé et de Recherche Médicale INSERM U964, Universite de Strasbourg, 67404 Illkirch, France
    PPAR Res 2012:701412. 2012
  6. ncbi request reprint Crystal structure of a vitamin D3 analog, ZK203278, showing dissociated profile
    Natacha Rochel
    Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, Institut National de Santé et de Recherche Médicale INSERM U964 Centre National de Recherche Scientifique CNRS UMR 7104 Université de Strasbourg, 67404 Illkirch, France
    Anticancer Res 32:335-9. 2012
  7. doi request reprint Common architecture of nuclear receptor heterodimers on DNA direct repeat elements with different spacings
    Natacha Rochel
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch, France
    Nat Struct Mol Biol 18:564-70. 2011
  8. doi request reprint Structure-function relationships and crystal structures of the vitamin D receptor bound 2 alpha-methyl-(20S,23S)- and 2 alpha-methyl-(20S,23R)-epoxymethano-1 alpha,25-dihydroxyvitamin D3
    Pierre Antony
    Departement de Biologie et de Genomique Structurales, Centre National de la Recherche Scientifique, Institut National de la Sante de la Recherche Medicale, Universite de Strasbourg, 1 rue Laurent Fries, 67404 Illkirch, France
    J Med Chem 53:1159-71. 2010
  9. ncbi request reprint Probing a water channel near the A-ring of receptor-bound 1 alpha,25-dihydroxyvitamin D3 with selected 2 alpha-substituted analogues
    Shinji Hourai
    Laboratoire de Biologie et Genomique Structurales, UMR 7104, Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 1, rue Laurent Fries, BP 10142, 67404 Illkirch Cedex, France
    J Med Chem 49:5199-205. 2006
  10. pmc Structure of the full human RXR/VDR nuclear receptor heterodimer complex with its DR3 target DNA
    Igor Orlov
    Department of Integrated Structural Biology, IGBMC Institute of Genetics and of Molecular and Cellular Biology, 1 rue Laurent Fries, Illkirch, France
    EMBO J 31:291-300. 2012

Collaborators

Detail Information

Publications38

  1. doi request reprint Crystal structure of hereditary vitamin D-resistant rickets--associated mutant H305Q of vitamin D nuclear receptor bound to its natural ligand
    Natacha Rochel
    IGBMC Institut de Génétique et de Biologie Moléculaire et Cellulaire, Departement de Biologie et de Genomique Structurales, Centre National de la Recherche Scientifique, Institut National de la Sante de la Recherche Medicale, Universite de Strasbourg, 1 rue Laurent Fries, Illkirch, France
    J Steroid Biochem Mol Biol 121:84-7. 2010
    ..The structure provides the basis for a rational approach to the design of more potent ligands for the treatment of HVDRR...
  2. pmc The "Phantom Effect" of the Rexinoid LG100754: structural and functional insights
    Yoshiteru Sato
    Departement de Biologie et de Genomique Structurales, Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, Institut National de Santé et de Recherche Médicale INSERM U964 Centre National de Recherche Scientifique CNRS UMR 1704 Université de Strasbourg, Illkirch, France
    PLoS ONE 5:e15119. 2010
    ..Finally we show that the 'phantom ligand effect' of the LG100754 is due to a direct binding of the ligand to RAR that stabilizes coactivator interactions thus accounting for the observed transcriptional activation of RAR/RXR...
  3. ncbi request reprint Modulators of vitamin D nuclear receptor: recent advances from structural studies
    Anna Y Belorusova
    Department of Integrative Structural Biology, Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, Institut National de Santé et de Recherche Médicale INSERM U964 Centre National de Recherche Scientifique CNRS UMR 7104 Université de Strasbourg, 67404 Illkirch, France
    Curr Top Med Chem 14:2368-77. 2014
    ....
  4. doi request reprint Architecture of DNA Bound RAR heterodimers
    Natacha Rochel
    Department of Integrative Structural Biology, Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, Institut National de Sante et de Recherche Medicale INSERM, U964, Centre National de Recherche Scientifique CNRS, UMR7104, Universite de Strasbourg, 67404, Illkirch, France
    Subcell Biochem 70:21-36. 2014
    ..The structural data highlight the importance of DNA sequences for binding selectivity and the role of promoter response elements in the spatial organization of the protein domains into functional complexes. ..
  5. pmc Solution Structures of PPARγ2/RXRα Complexes
    Judit Osz
    Department of Integrative Structural Biology, Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, Centre National de Recherche Scientifique CNRS UMR 7104, Institut National de Santé et de Recherche Médicale INSERM U964, Universite de Strasbourg, 67404 Illkirch, France
    PPAR Res 2012:701412. 2012
    ..The solution structures reveal an asymmetry of the overall structure due to the crucial role of the DNA in positioning the heterodimer and indicate asymmetrical binding of TIF2 to the heterodimer...
  6. ncbi request reprint Crystal structure of a vitamin D3 analog, ZK203278, showing dissociated profile
    Natacha Rochel
    Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, Institut National de Santé et de Recherche Médicale INSERM U964 Centre National de Recherche Scientifique CNRS UMR 7104 Université de Strasbourg, 67404 Illkirch, France
    Anticancer Res 32:335-9. 2012
    ..These specific interactions may lead to altered selective interactions with co-regulators and consequently to the dissociated biologic profile of this novel ligand...
  7. doi request reprint Common architecture of nuclear receptor heterodimers on DNA direct repeat elements with different spacings
    Natacha Rochel
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch, France
    Nat Struct Mol Biol 18:564-70. 2011
    ..The results reveal two additional features: the conserved position of the ligand-binding domains at the 5' ends of the target DNAs and the binding of only one coactivator molecule per heterodimer, to RXR's partner...
  8. doi request reprint Structure-function relationships and crystal structures of the vitamin D receptor bound 2 alpha-methyl-(20S,23S)- and 2 alpha-methyl-(20S,23R)-epoxymethano-1 alpha,25-dihydroxyvitamin D3
    Pierre Antony
    Departement de Biologie et de Genomique Structurales, Centre National de la Recherche Scientifique, Institut National de la Sante de la Recherche Medicale, Universite de Strasbourg, 1 rue Laurent Fries, 67404 Illkirch, France
    J Med Chem 53:1159-71. 2010
    ..Here, we solved the crystal structures of the hVDR LBD in complex with the 4a (C23S) and its epimer 4b (C23R) and determined their correlation with specific biological outcomes...
  9. ncbi request reprint Probing a water channel near the A-ring of receptor-bound 1 alpha,25-dihydroxyvitamin D3 with selected 2 alpha-substituted analogues
    Shinji Hourai
    Laboratoire de Biologie et Genomique Structurales, UMR 7104, Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM ULP, 1, rue Laurent Fries, BP 10142, 67404 Illkirch Cedex, France
    J Med Chem 49:5199-205. 2006
    ..Our overall findings highlight a rational approach to the design of more potent ligands by building in features revealed in the crystal structures...
  10. pmc Structure of the full human RXR/VDR nuclear receptor heterodimer complex with its DR3 target DNA
    Igor Orlov
    Department of Integrated Structural Biology, IGBMC Institute of Genetics and of Molecular and Cellular Biology, 1 rue Laurent Fries, Illkirch, France
    EMBO J 31:291-300. 2012
    ....
  11. doi request reprint Structure-based design of a superagonist ligand for the vitamin D nuclear receptor
    Shinji Hourai
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Departement de Biologie et de Genomique Structurales, Universite Louis Pasteur, Strasbourg F 67000, France
    Chem Biol 15:383-92. 2008
    ..The crystal structures of the complexes between the ligand binding domain of hVDR and these ligands provide a rational approach to the design of more potent superagonist ligands for potential clinical application...
  12. ncbi request reprint Adaptability of the Vitamin D nuclear receptor to the synthetic ligand Gemini: remodelling the LBP with one side chain rotation
    Fabrice Ciesielski
    Departement de Biologie et de Genomique Structurales, IGBMC, CNRS INSERM Universite Louis Pasteur, Parc d innovation BP10142, 67404 Illkirch Cedex, France
    J Steroid Biochem Mol Biol 103:235-42. 2007
    ..The possibility to adapt the LBP to novel ligands with different chemistry and/or structure opens new perspectives in the design of more specifically targeted ligands...
  13. pmc Phosphorylation of the retinoic acid receptor alpha induces a mechanical allosteric regulation and changes in internal dynamics
    Yassmine Chebaro
    Institute of Genetics and Molecular and Cellular Biology, Integrated Structural Biology Department, Illkirch, France
    PLoS Comput Biol 9:e1003012. 2013
    ..This results in changes in conformation and flexibility of the latter. The high conservation of the residues implicated in this signal transduction suggests a mechanism that could be applied to other nuclear receptor proteins...
  14. ncbi request reprint Crystal structure of the vitamin D nuclear receptor ligand binding domain in complex with a locked side chain analog of calcitriol
    Natacha Rochel
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Departement de Biologie et de Genomique Structurales, Illkirch F 67400, France
    Arch Biochem Biophys 460:172-6. 2007
    ..The crystal structure of VDR LBD bound to this locked side chain analogue while confirming the docking provides a structural basis for the activity of this compound...
  15. doi request reprint Expression of functional full-length hSRC-1 in eukaryotic cells using modified vaccinia virus Ankara and baculovirus
    Judit Osz
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Institut National de Santé et de Recherche Médicale U964 Centre National de Recherche Scientifique UMR 7104 Université de Strasbourg, 67404 Illkirch, France
    Anal Biochem 426:106-8. 2012
    ..The results indicate that we can produce biologically active human SRC-1 in mammalian and insect cells in large scale...
  16. pmc Structural basis for a molecular allosteric control mechanism of cofactor binding to nuclear receptors
    Judit Osz
    Institut National de Santé et de Recherche Médicale U964 Centre National de Recherche Scientifique, Unité Mixte de Recherche 7104 Université de Strasbourg, 67404 Illkirch, France
    Proc Natl Acad Sci U S A 109:E588-94. 2012
    ..Correlation with published data on other NRs confirms the general character of this regulatory pathway...
  17. ncbi request reprint RARbeta ligand-binding domain bound to an SRC-1 co-activator peptide: purification, crystallization and preliminary X-ray diffraction analysis
    Sabrina Kammerer
    Department of Structural Biology and Genomics, Institut de Genetique et de Biologie Moleculaire et Cellulaire, France
    Acta Crystallogr D Biol Crystallogr 60:2048-50. 2004
    ..The unit-cell parameters are a = 47.81, b = 58.52, c = 92.83 A for the TTNPB-hRARbeta LBD crystal and a = 58.14, b = 84.07, c = 102.37 A when the SRC-1 peptide is also bound...
  18. doi request reprint Communication between the ERRalpha homodimer interface and the PGC-1alpha binding surface via the helix 8-9 loop
    Holger Greschik
    Département de Biologie et Génomique Structurales, Institut de Genetique et de Biologie Moleculaire et Cellulaire, Illkirch, France
    J Biol Chem 283:20220-30. 2008
    ....
  19. pmc 1α,25(OH)2-3-epi-vitamin D3, a natural physiological metabolite of vitamin D3: its synthesis, biological activity and crystal structure with its receptor
    Ferdinand Molnár
    Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, U964 Centre National de Recherche Scientifique CNRS UMR 7104 Université de Strasbourg, Illkirch, France
    PLoS ONE 6:e18124. 2011
    ....
  20. doi request reprint Structural and functional insights into the ligand-binding domain of a nonduplicated retinoid X nuclear receptor from the invertebrate chordate amphioxus
    Giuseppe D Tocchini-Valentini
    Département de Biologie et de Génomique Structurales and Département Biologie du Cancer, Institut de Genetique et de Biologie Moleculaire et Cellulaire, UMR7104 CNRS, U596 INSERM, Universite Louis Pasteur, 67400 Illkirch, France
    J Biol Chem 284:1938-48. 2009
    ..Our data suggest that amphioxus RXR is, functionally, an intermediate between arthropods RXR/USPs and vertebrate RXRs...
  21. ncbi request reprint Structural investigation of the ligand binding domain of the zebrafish VDR in complexes with 1alpha,25(OH)2D3 and Gemini: purification, crystallization and preliminary X-ray diffraction analysis
    Fabrice Ciesielski
    Departement de Biologie et de Genomique Structurales, IGBMC, CNRS INSERM Universite Louis Pasteur, Parc d innovation BP10142, 67404 Illkirch Cedex, France
    J Steroid Biochem Mol Biol 89:55-9. 2004
    ..We now have extended our database, using a wild-type LBD from zebrafish that confirms the previously reported results and allows to investigate the binding of ligands that induce significant conformational changes at the protein level...
  22. pmc Allosteric Regulation in the Ligand Binding Domain of Retinoic Acid Receptorγ
    Yassmine Chebaro
    Department of Integrative Structural Biology, Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, Institut National de la Santé et de la Recherche Médicale INSERM U964, Centre National de la Recherche Scientifique CNRS UMR 7104, Universite de Strasbourg, Illkirch, France
    PLoS ONE 12:e0171043. 2017
    ....
  23. doi request reprint A vitamin D receptor selectively activated by gemini analogs reveals ligand dependent and independent effects
    Tiphaine Huet
    Department of Integrative Structural Biology, Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, Institut National de la Santé et de la Recherche Médicale INSERM U964, Centre National de la Recherche Scientifique CNRS UMR 7104, Universite de Strasbourg, 67404 Illkirch, France
    Cell Rep 10:516-26. 2015
    ..As gemini ligands induce VDR(gem) transcriptional activity in mice and normalize their serum calcium levels, VDR(gem) is a powerful tool to further unravel both liganded and unliganded VDR signaling...
  24. ncbi request reprint Ligand binding domain of vitamin D receptors
    Natacha Rochel
    Departement de Biologie et de Genomique Structurales, IGBMC, CNRS INSERM Universite Louis Pasteur, Parc d innovation BP10142, 67404 Illkirch Cedex, France
    Curr Top Med Chem 6:1229-41. 2006
    ..Tissue selectivity may also be achieved by developing ligands that specifically activate the non-genomic pathway...
  25. doi request reprint Structural Studies of Vitamin D Nuclear Receptor Ligand-Binding Properties
    Anna Y Belorusova
    Department of Integrative Structural Biology, Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, Institut National de Santé et de Recherche Médicale INSERM U964, Centre National de Recherche Scientifique CNRS UMR 7104, Universite de Strasbourg, Illkirch, France
    Vitam Horm 100:83-116. 2016
    ..Additionally, we describe the crystal structures of VDR mutants associated with hereditary vitamin D-resistant rickets that display impaired ligand-binding function. ..
  26. doi request reprint Structural insights into the molecular mechanism of vitamin D receptor activation by lithocholic acid involving a new mode of ligand recognition
    Anna Y Belorusova
    Department of Integrative Structural Biology, Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, Institut National de Santé et de Recherche Médicale INSERM U964, Centre National de Recherche Scientifique CNRS UMR 7104, Universite de Strasbourg, 67404 Illkirch, France
    J Med Chem 57:4710-9. 2014
    ..The unique binding mode of LCA provides clues for the development of new chemical compounds that target alternative binding sites for therapeutic applications. ..
  27. ncbi request reprint Crystal structures of the vitamin D nuclear receptor liganded with the vitamin D side chain analogues calcipotriol and seocalcitol, receptor agonists of clinical importance. Insights into a structural basis for the switching of calcipotriol to a receptor
    Giuseppe Tocchini-Valentini
    Departement de Biologie et de Genomique Structurales, IGBMC, CNRS INSERM Universite Louis Pasteur, Parc d innovation BP10142, 67404 Illkirch Cedex, France
    J Med Chem 47:1956-61. 2004
    ..The VDR-seocalcitol structure, in comparison with the structure of VDR-KH1060, a superagonist ligand closely related to seocalcitol, shows adaptation of the D ring and position of C-21 in order to adapt its more rigid side chain...
  28. doi request reprint Structural basis for the accommodation of bis- and tris-aromatic derivatives in vitamin D nuclear receptor
    Fabrice Ciesielski
    Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, Institut National de Santé et de Recherche Médicale INSERM U964, Centre National de Recherche Scientifique CNRS UMR 7104, Universite de Strasbourg, 67404 Illkirch, France
    J Med Chem 55:8440-9. 2012
    ..The structures with the tris-aromatic ligands exhibit a rearrangement of a novel region of the VDR ligand binding pocket, helix H6...
  29. pmc Retinoic acid receptors recognize the mouse genome through binding elements with diverse spacing and topology
    Emmanuel Moutier
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, CNRS INSERM UdS, 1 rue Laurent Fries, 67404 Illkirch Cedex, France
    J Biol Chem 287:26328-41. 2012
    ..The differential ability of RAR-RXR bound to DR0 compared to DR2, DR5, and DR8 to mediate RA-dependent transcriptional activation indicates that half-site spacing allosterically regulates RAR function...
  30. doi request reprint Structural analysis of nuclear receptors: from isolated domains to integral proteins
    Yann Brelivet
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, Institut National de la Santé et de la Recherche Médicale U964 Centre National de Recherche Scientifique UMR7104 Université de Strasbourg, 1 rue Laurent Fries, 67404 Illkirch, France
    Mol Cell Endocrinol 348:466-73. 2012
    ..The results shed light on the dynamics of the molecular recognition process...
  31. pmc Structural analysis and biological activities of BXL0124, a gemini analog of vitamin D
    Anna Y Belorusova
    Department of Integrated Structural Biology, IGBMC Institute of Genetics and of Molecular and Cellular Biology, 1 rue Laurent Fries, Illkirch, France Centre National de la Recherche Scientifique CNRS UMR 7104, Illkirch, France Institut National de la Santé et de la Recherche Médicale INSERM U964, Illkirch, France Université de Strasbourg, Strasbourg, France
    J Steroid Biochem Mol Biol . 2016
    ..Structural comparisons of BXL0097 and BXL0124, as their VDR complexes, explain the elevated activity of the latter...
  32. pmc Solution Behavior of the Intrinsically Disordered N-Terminal Domain of Retinoid X Receptor α in the Context of the Full-Length Protein
    Anna Y Belorusova
    Department of Integrative Structural Biology, Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, Institut National de la Santé et de la Recherche Médicale INSERM U964 Centre National de la Recherche Scientifique CNRS UMR 7104, Universite de Strasbourg, 67404 Illkirch, France
    Biochemistry 55:1741-8. 2016
    ..We report the solution structure of the full-length homodimeric RXRα on DNA and show that the NTD remains highly flexible within this complex. ..
  33. pmc Structural basis of natural promoter recognition by the retinoid X nuclear receptor
    Judit Osz
    Department of Integrative Structural Biology, Institut de Genetique et de Biologie Moleculaire et Cellulaire IGBMC, Institut National de la Santé et de la Recherche Médicale INSERM U964 Centre National de la Recherche Scientifique CNRS UMR 7104 Université de Strasbourg, 67404 Illkirch, France
    Sci Rep 5:8216. 2015
    ....
  34. ncbi request reprint Structural adaptability in the ligand-binding pocket of the ecdysone hormone receptor
    Isabelle M L Billas
    Departement de Biologie et de Genomique Structurales, IGBMC, CNRS INSERM Universite Louis Pasteur, Parc d innovation BP10142, 67404 Illkirch Cedex, France
    Nature 426:91-6. 2003
    ..The concept of a ligand-dependent binding pocket in EcR provides an insight into the moulding of nuclear receptors to their ligand, and has potential applications for human nuclear receptors...
  35. pmc Signature of the oligomeric behaviour of nuclear receptors at the sequence and structural level
    Yann Brelivet
    Département de Biologie et Génomique Structurales, IGBMC, 1 rue Laurent Fries, 67404 Illkirch, France
    EMBO Rep 5:423-9. 2004
    ..RXR/USP and all Caenorhabditis elegans NRs belong to class I, supporting the hypothesis of an earlier emergence of this class...
  36. pmc Structure-function study of gemini derivatives with two different side chains at C-20, Gemini-0072 and Gemini-0097
    Tiphaine Huet
    Departement de Biologie et de Genomique Structurales, IGBMC Institut de Génétique et de Biologie Moléculaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Santé de la Recherche Méedicale, Universite de Strasbourg, 1 rue Laurent Fries, 67404 Illkirch, France
    Medchemcomm 2:424-429. 2011
    ....
  37. doi request reprint A set of baculovirus transfer vectors for screening of affinity tags and parallel expression strategies
    Wassim Abdulrahman
    Institut de Genetique et de Biologie Moleculaire et Cellulaire, UMR 7104, Illkirch Cedex, France
    Anal Biochem 385:383-5. 2009
    ..We found that expression in fusion with GST and protein A provided an efficient compromise of excellent purification with acceptable yields and costs...
  38. ncbi request reprint Co-expression of protein complexes in prokaryotic and eukaryotic hosts: experimental procedures, database tracking and case studies
    Christophe Romier
    Institut de Génétique et Biologie Moléculaire et Cellulaire, 1 rue Laurent Fries, BP 163, Illkirch Cedex, France
    Acta Crystallogr D Biol Crystallogr 62:1232-42. 2006
    ..coli and a database system dedicated to handle co-expression data are described. Results are also reported from various case studies investigating different methods for performing co-expression in E. coli and insect cells...