Helge H Rasmussen

Summary

Publications

  1. doi Reversible oxidative modification: implications for cardiovascular physiology and pathophysiology
    Helge H Rasmussen
    North Shore Heart Research Group, Kolling Institute, University of Sydney, NSW 2006, Australia
    Trends Cardiovasc Med 20:85-90. 2010
  2. pmc Activation of cAMP-dependent signaling induces oxidative modification of the cardiac Na+-K+ pump and inhibits its activity
    Caroline N White
    North Shore Heart Research Group, Kolling Institute, University of Sydney, Sydney 2065, Australia
    J Biol Chem 285:13712-20. 2010
  3. doi Redox-dependent regulation of the Na⁺-K⁺ pump: new twists to an old target for treatment of heart failure
    Chia Chi Liu
    North Shore Heart Research Group, Kolling Medical Research Institute, University of Sydney, Australia
    J Mol Cell Cardiol 61:94-101. 2013
  4. pmc Protein kinase-dependent oxidative regulation of the cardiac Na+-K+ pump: evidence from in vivo and in vitro modulation of cell signalling
    Keyvan Karimi Galougahi
    North Shore Heart Research Group, Kolling Institute, University of Sydney, Australia
    J Physiol 591:2999-3015. 2013
  5. pmc Susceptibility of β1 Na+-K+ pump subunit to glutathionylation and oxidative inhibition depends on conformational state of pump
    Chia Chi Liu
    North Shore Heart Research Group, Kolling Institute, St Leonards, New South Wales 2065, Australia
    J Biol Chem 287:12353-64. 2012
  6. doi Angiotensin II inhibits the Na+-K+ pump via PKC-dependent activation of NADPH oxidase
    Caroline N White
    North Shore Cardiac Research Group, Kolling Institute, University of Sydney, Sydney, Australia
    Am J Physiol Cell Physiol 296:C693-700. 2009
  7. pmc Extracellular allosteric Na(+) binding to the Na(+),K(+)-ATPase in cardiac myocytes
    Alvaro Garcia
    Department of Cardiology, Royal North Shore Hospital, Sydney, Australia Kolling Institute, University of Sydney, Sydney, Australia
    Biophys J 105:2695-705. 2013
  8. doi β(3) adrenergic stimulation of the cardiac Na+-K+ pump by reversal of an inhibitory oxidative modification
    Henning Bundgaard
    North Shore Heart Research Group, Kolling Institute of Medical Research, University of Sydney, Australia
    Circulation 122:2699-708. 2010
  9. pmc β3-Adrenoceptor activation relieves oxidative inhibition of the cardiac Na+-K+ pump in hyperglycemia induced by insulin receptor blockade
    Keyvan Karimi Galougahi
    North Shore Heart Research Group, Kolling Institute, University of Sydney, Sydney, Australia and Department of Cardiology, Royal North Shore Hospital, Sydney, Australia
    Am J Physiol Cell Physiol 309:C286-95. 2015
  10. doi Oxidative regulation of the Na(+)-K(+) pump in the cardiovascular system
    Gemma A Figtree
    North Shore Heart Research Group, Kolling Institute of Medical Research, University of Sydney, St Leonards, NSW 2065, Australia Department of Cardiology, Royal North Shore Hospital, Sydney, NSW, Australia Electronic address
    Free Radic Biol Med 53:2263-8. 2012

Collaborators

Detail Information

Publications20

  1. doi Reversible oxidative modification: implications for cardiovascular physiology and pathophysiology
    Helge H Rasmussen
    North Shore Heart Research Group, Kolling Institute, University of Sydney, NSW 2006, Australia
    Trends Cardiovasc Med 20:85-90. 2010
    ....
  2. pmc Activation of cAMP-dependent signaling induces oxidative modification of the cardiac Na+-K+ pump and inhibits its activity
    Caroline N White
    North Shore Heart Research Group, Kolling Institute, University of Sydney, Sydney 2065, Australia
    J Biol Chem 285:13712-20. 2010
    ..We conclude that cAMP- and PKC-dependent inhibition of the cardiac Na(+)-K(+) pump occurs via a shared downstream oxidative signaling pathway involving NADPH oxidase activation and glutathionylation of the pump beta(1) subunit...
  3. doi Redox-dependent regulation of the Na⁺-K⁺ pump: new twists to an old target for treatment of heart failure
    Chia Chi Liu
    North Shore Heart Research Group, Kolling Medical Research Institute, University of Sydney, Australia
    J Mol Cell Cardiol 61:94-101. 2013
    ..We propose that targeting oxidative inhibition of the pump is useful for the exploration of future treatment strategies. This article is part of a Special Issue entitled "Na(+)Regulation in Cardiac Myocytes"...
  4. pmc Protein kinase-dependent oxidative regulation of the cardiac Na+-K+ pump: evidence from in vivo and in vitro modulation of cell signalling
    Keyvan Karimi Galougahi
    North Shore Heart Research Group, Kolling Institute, University of Sydney, Australia
    J Physiol 591:2999-3015. 2013
    ..This scheme is consistent with the efficacy of β1 AR blockade in the treatment of heart failure...
  5. pmc Susceptibility of β1 Na+-K+ pump subunit to glutathionylation and oxidative inhibition depends on conformational state of pump
    Chia Chi Liu
    North Shore Heart Research Group, Kolling Institute, St Leonards, New South Wales 2065, Australia
    J Biol Chem 287:12353-64. 2012
    ..We conclude that susceptibility of the β1 subunit to glutathionylation depends on the conformational poise of the Na(+)-K(+) pump...
  6. doi Angiotensin II inhibits the Na+-K+ pump via PKC-dependent activation of NADPH oxidase
    Caroline N White
    North Shore Cardiac Research Group, Kolling Institute, University of Sydney, Sydney, Australia
    Am J Physiol Cell Physiol 296:C693-700. 2009
    ..ANG II had no effect on alpha(1)/caveolin 3 or alpha(1)/p22(phox) interaction, but it increased alpha(1)/p47(phox) coimmunoprecipitation. We conclude that ANG II inhibits the Na(+)-K(+) pump via PKC-dependent NADPH oxidase activation...
  7. pmc Extracellular allosteric Na(+) binding to the Na(+),K(+)-ATPase in cardiac myocytes
    Alvaro Garcia
    Department of Cardiology, Royal North Shore Hospital, Sydney, Australia Kolling Institute, University of Sydney, Sydney, Australia
    Biophys J 105:2695-705. 2013
    ..Based on published crystal structures, a possible location of the allosteric site is within a cleft between the α- and β-subunits of the enzyme. ..
  8. doi β(3) adrenergic stimulation of the cardiac Na+-K+ pump by reversal of an inhibitory oxidative modification
    Henning Bundgaard
    North Shore Heart Research Group, Kolling Institute of Medical Research, University of Sydney, Australia
    Circulation 122:2699-708. 2010
    ..Of these, the Na(+)-K(+) pump is of particular interest because of adverse effects attributed to high cardiac myocyte Na(+) levels and upregulation of the β(3) AR in heart failure...
  9. pmc β3-Adrenoceptor activation relieves oxidative inhibition of the cardiac Na+-K+ pump in hyperglycemia induced by insulin receptor blockade
    Keyvan Karimi Galougahi
    North Shore Heart Research Group, Kolling Institute, University of Sydney, Sydney, Australia and Department of Cardiology, Royal North Shore Hospital, Sydney, Australia
    Am J Physiol Cell Physiol 309:C286-95. 2015
    ..In vivo β3-AR activation relieves oxidative inhibition of key cardiac myocyte proteins in hyperglycemia and may be effective in targeting the deleterious cardiac effects of diabetes. ..
  10. doi Oxidative regulation of the Na(+)-K(+) pump in the cardiovascular system
    Gemma A Figtree
    North Shore Heart Research Group, Kolling Institute of Medical Research, University of Sydney, St Leonards, NSW 2065, Australia Department of Cardiology, Royal North Shore Hospital, Sydney, NSW, Australia Electronic address
    Free Radic Biol Med 53:2263-8. 2012
    ..Treatment strategies that are able to reverse this oxidative inhibition of the Na(+)-K(+) pump have the potential for cardiovascular-protective effects. ..
  11. pmc Stimulation of the cardiac myocyte Na+-K+ pump due to reversal of its constitutive oxidative inhibition
    Karin K M Chia
    North Shore Heart Research Group, Kolling Medical Research Institute, University of Sydney, Sydney, Australia Royal Brisbane and Women s Hospital, The University of Queensland, Queensland, Australia and
    Am J Physiol Cell Physiol 309:C239-50. 2015
    ..This could account for pump stimulation with neurohormonal oxidative stress expected in vivo. ..
  12. doi Quantitative calculation of the role of the Na(+),K(+)-ATPase in thermogenesis
    Ronald J Clarke
    School of Chemistry, University of Sydney, Sydney, NSW 2006, Australia
    Biochim Biophys Acta 1827:1205-12. 2013
    ..A simultaneous increase in both Na(+),K(+)-ATPase activity and the membrane's passive Na(+) permeability could promote a higher body temperature. ..
  13. pmc Glutathionylation-Dependence of Na(+)-K(+)-Pump Currents Can Mimic Reduced Subsarcolemmal Na(+) Diffusion
    Alvaro Garcia
    North Shore Heart Research Group, Kolling Institute, University of Sydney, Sydney, Australia School of Chemistry, University of Sydney, Sydney, Australia
    Biophys J 110:1099-109. 2016
    ..We conclude that transient K(+)-induced peak Na(+)-K(+) pump current reflects the effect of conformation-dependent β1 pump subunit glutathionylation, not restricted subsarcolemmal diffusion of Na(+). ..
  14. pmc Identification of electric-field-dependent steps in the Na(+),K(+)-pump cycle
    Laura J Mares
    School of Chemistry, University of Sydney, Sydney, Australia
    Biophys J 107:1352-63. 2014
    ..The most likely origin of the RH421 fluorescence response is a change in membrane dipole potential caused by membrane deformation. ..
  15. pmc Glutathionylation mediates angiotensin II-induced eNOS uncoupling, amplifying NADPH oxidase-dependent endothelial dysfunction
    Keyvan Karimi Galougahi
    North Shore Heart Research Group, Kolling Institute, University of Sydney, Australia
    J Am Heart Assoc 3:e000731. 2014
    ..We examined whether this reversible redox modification plays a role in angiotensin II (Ang II)-induced endothelial dysfunction...
  16. doi β-Adrenergic regulation of the cardiac Na+-K+ ATPase mediated by oxidative signaling
    Keyvan Karimi Galougahi
    North Shore Heart Research Group, Kolling Institute, University of Sydney, St Leonards, NSW 2065, Australia
    Trends Cardiovasc Med 22:83-7. 2012
    ....
  17. pmc Kinetic comparisons of heart and kidney Na+,K(+)-ATPases
    Alvaro Garcia
    Department of Cardiology, Royal North Shore Hospital, and Kolling Institute, University of Sydney, Sydney, Australia
    Biophys J 103:677-88. 2012
    ..Around a membrane potential of zero, negligible voltage dependence is observed because the voltage-independent E2(K(+))(2) → E1 + 2K(+) transition is the major rate-determining step...
  18. doi Membrane accessibility of glutathione
    Alvaro Garcia
    School of Chemistry, University of Sydney, Sydney, New South Wales 2006, Australia
    Biochim Biophys Acta 1848:2430-6. 2015
    ..The results obtained, therefore, suggest a possible structural mechanism of how the Na+,K+-ATPase could be regulated by glutathione...
  19. doi Reversible oxidative modification: a key mechanism of Na+-K+ pump regulation
    Gemma A Figtree
    Department of Cardiology, Royal North Shore Hospital, University of Sydney, St Leonards NSW 2065, Australia
    Circ Res 105:185-93. 2009
    ..These findings have implications for pathophysiological conditions characterized by neurohormonal dysregulation, myocardial oxidative stress and raised myocyte Na(+) levels...
  20. doi Silencing overexpression of FXYD3 protein in breast cancer cells amplifies effects of doxorubicin and γ-radiation on Na(+)/K(+)-ATPase and cell survival
    Chia Chi Liu
    North Shore Heart Research Group, Kolling Institute of Medical Research, University of Sydney, Sydney, Australia
    Breast Cancer Res Treat 155:203-13. 2016
    ..Overexpression of FXYD3 may be a marker of resistance to cancer treatments and a potentially important therapeutic target. ..