Jacob H Rand

Summary

Publications

  1. ncbi request reprint The antiphospholipid syndrome
    Jacob H Rand
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Annu Rev Med 54:409-24. 2003
  2. ncbi request reprint Molecular pathogenesis of the antiphospholipid syndrome
    Jacob H Rand
    Thrombosis and Hemostasis Section, Hematology Division, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Circ Res 90:29-37. 2002
  3. ncbi request reprint Antibody-mediated interference with annexins in the antiphospholipid syndrome
    Jacob H Rand
    Hematology Laboratory Montefiore Medical Center Core Laboratory Office, North 8, 111 East 210th Street, Bronx, NY 10467, USA
    Thromb Res 114:383-9. 2004
  4. ncbi request reprint Controversies in differentiating thrombotic thrombocytopenic purpura and hemolytic uremic syndrome
    Neelam T Shah
    Albert Einstein College of Medicine, Montefiore Medical Center, Core Laboratory Office North Pavilion 8, 111 East 210th Street, Bronx, NY 10467, USA
    Mt Sinai J Med 70:344-51. 2003
  5. ncbi request reprint Detection of antibody-mediated reduction of annexin A5 anticoagulant activity in plasmas of patients with the antiphospholipid syndrome
    Jacob H Rand
    Department of Pathology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA
    Blood 104:2783-90. 2004
  6. pmc Human monoclonal antiphospholipid antibodies disrupt the annexin A5 anticoagulant crystal shield on phospholipid bilayers: evidence from atomic force microscopy and functional assay
    Jacob H Rand
    Department of Pathology, Montefiore Medical Center, Albert Einstein College of Medicine, Moses Division Campus, Core Laboratory Office, North 8, 110 East 210th Street, Bronx, NY 10467, USA
    Am J Pathol 163:1193-200. 2003
  7. ncbi request reprint Reduction of circulating annexin A5 levels and resistance to annexin A5 anticoagulant activity in women with recurrent spontaneous pregnancy losses
    Jacob H Rand
    Division of Clinical Pathology, Department of Pathology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA
    Am J Obstet Gynecol 194:182-8. 2006
  8. ncbi request reprint Analysis of circulating annexin A5 parameters during pregnancy: absence of differences between women with recurrent spontaneous pregnancy losses and controls
    Xiao Xuan Wu
    Department of Pathology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA
    Am J Obstet Gynecol 195:971-8. 2006
  9. ncbi request reprint Correlation between antiphospholipid antibodies that recognize domain I of beta2-glycoprotein I and a reduction in the anticoagulant activity of annexin A5
    Bas de Laat
    Department of Haematology, University Medical Center Utrecht, The Netherlands
    Blood 109:1490-4. 2007
  10. pmc Hydroxychloroquine directly reduces the binding of antiphospholipid antibody-beta2-glycoprotein I complexes to phospholipid bilayers
    Jacob H Rand
    Department of Pathology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA
    Blood 112:1687-95. 2008

Collaborators

  • Thomas L Ortel
  • Xiao Xuan Wu
  • Bas de Laat
  • Neelam T Shah
  • Menno van Lummel
  • Philip G de Groot
  • Ronald H W M Derksen
  • Chris P Reutelingsperger
  • Alan A Arslan
  • Charles J Lockwood
  • Rosemary Wein
  • Edward Kuczynski

Detail Information

Publications10

  1. ncbi request reprint The antiphospholipid syndrome
    Jacob H Rand
    Department of Medicine, Mount Sinai School of Medicine, New York, New York 10029, USA
    Annu Rev Med 54:409-24. 2003
    ..Current treatment relies primarily on anticoagulant therapy. Research advances are expected to bring mechanistically based diagnostic tests and improved therapy that target the roots of the disease process...
  2. ncbi request reprint Molecular pathogenesis of the antiphospholipid syndrome
    Jacob H Rand
    Thrombosis and Hemostasis Section, Hematology Division, Department of Medicine, Mount Sinai School of Medicine, New York, NY 10029, USA
    Circ Res 90:29-37. 2002
    ..This review focuses on some of the major mechanisms that have been proposed to explain this disorder...
  3. ncbi request reprint Antibody-mediated interference with annexins in the antiphospholipid syndrome
    Jacob H Rand
    Hematology Laboratory Montefiore Medical Center Core Laboratory Office, North 8, 111 East 210th Street, Bronx, NY 10467, USA
    Thromb Res 114:383-9. 2004
    ..It is anticipated that further research will elucidate the biologic functions of these proteins and their roles in the aPL disease processes...
  4. ncbi request reprint Controversies in differentiating thrombotic thrombocytopenic purpura and hemolytic uremic syndrome
    Neelam T Shah
    Albert Einstein College of Medicine, Montefiore Medical Center, Core Laboratory Office North Pavilion 8, 111 East 210th Street, Bronx, NY 10467, USA
    Mt Sinai J Med 70:344-51. 2003
    ..However, several questions are still not definitively answered. In this article, we will review background on both entities, and then describe the controversy in differentiating between them...
  5. ncbi request reprint Detection of antibody-mediated reduction of annexin A5 anticoagulant activity in plasmas of patients with the antiphospholipid syndrome
    Jacob H Rand
    Department of Pathology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA
    Blood 104:2783-90. 2004
    ..This "annexin A5 resistance" identifies a novel mechanism for thrombosis in the aPL syndrome...
  6. pmc Human monoclonal antiphospholipid antibodies disrupt the annexin A5 anticoagulant crystal shield on phospholipid bilayers: evidence from atomic force microscopy and functional assay
    Jacob H Rand
    Department of Pathology, Montefiore Medical Center, Albert Einstein College of Medicine, Moses Division Campus, Core Laboratory Office, North 8, 110 East 210th Street, Bronx, NY 10467, USA
    Am J Pathol 163:1193-200. 2003
    ..The aPL antibody-mediated disruption of the annexin A5 anticoagulant shield may be an important prothrombotic mechanism in the aPL syndrome...
  7. ncbi request reprint Reduction of circulating annexin A5 levels and resistance to annexin A5 anticoagulant activity in women with recurrent spontaneous pregnancy losses
    Jacob H Rand
    Division of Clinical Pathology, Department of Pathology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA
    Am J Obstet Gynecol 194:182-8. 2006
    ..We investigated whether levels of annexin A5, evidence for resistance to annexin A5 activity, and levels anti-annexin A5 antibodies might be altered in women with a history of recurrent spontaneous pregnancy losses...
  8. ncbi request reprint Analysis of circulating annexin A5 parameters during pregnancy: absence of differences between women with recurrent spontaneous pregnancy losses and controls
    Xiao Xuan Wu
    Department of Pathology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA
    Am J Obstet Gynecol 195:971-8. 2006
    ....
  9. ncbi request reprint Correlation between antiphospholipid antibodies that recognize domain I of beta2-glycoprotein I and a reduction in the anticoagulant activity of annexin A5
    Bas de Laat
    Department of Haematology, University Medical Center Utrecht, The Netherlands
    Blood 109:1490-4. 2007
    ..These results are consistent with a model in which aPL antibodies may promote thrombosis by interfering with the anticoagulant activity of AnxA5...
  10. pmc Hydroxychloroquine directly reduces the binding of antiphospholipid antibody-beta2-glycoprotein I complexes to phospholipid bilayers
    Jacob H Rand
    Department of Pathology, Montefiore Medical Center, Albert Einstein College of Medicine, Bronx, NY, USA
    Blood 112:1687-95. 2008
    ..These results support the possibility that HCQ, or analogous molecules, may offer novel nonanticoagulant therapeutic strategies for treating APS...