D Rades

Summary

Publications

  1. ncbi request reprint Number of extraspinal organs with metastases: a prognostic factor of survival in patients with metastatic spinal cord compression (MSCC) from non-small cell lung cancer (NSCLC)
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Anticancer Res 34:2503-7. 2014
  2. ncbi request reprint A Total Radiation Dose of 70 Gy Is Required After Macroscopically Incomplete Resection of Squamous Cell Carcinoma of the Head and Neck
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Anticancer Res 36:2989-92. 2016
  3. ncbi request reprint Personalized Radiotherapeutic Approaches for Elderly Patients with Epidural Cord Compression from Gastric Cancer
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    In Vivo 30:69-72. 2016
  4. doi request reprint A New Score for Estimating Survival After Definitive Radiochemotherapy of Limited Disease Small Cell Lung Cancers
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Lung 194:625-9. 2016
  5. doi request reprint Comparing two lower-dose cisplatin programs for radio-chemotherapy of locally advanced head-and-neck cancers
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Eur Arch Otorhinolaryngol 274:1021-1027. 2017
  6. pmc A matched-pair study comparing whole-brain irradiation alone to radiosurgery or fractionated stereotactic radiotherapy alone in patients irradiated for up to three brain metastases
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, D 23538, Lubeck, Germany
    BMC Cancer 17:30. 2017
  7. pmc Comparison of weekly administration of cisplatin versus three courses of cisplatin 100 mg/m(2) for definitive radiochemotherapy of locally advanced head-and-neck cancers
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, D 23538, Lubeck, Germany
    BMC Cancer 16:437. 2016
  8. ncbi request reprint Radiochemotherapy with Paclitaxel for Recurrent Previously Irradiated Squamous Cell Carcinoma of the Head and Neck
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Anticancer Res 36:5463-5468. 2016
  9. pmc A predictive tool particularly designed for elderly myeloma patients presenting with spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, D 23538, Lubeck, Germany
    BMC Cancer 16:292. 2016
  10. ncbi request reprint Potential Impact of the Overall Treatment Time on Outcomes after Whole-brain Irradiation with 10×3 Gy for Brain Metastases
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Anticancer Res 36:3071-4. 2016

Detail Information

Publications207 found, 100 shown here

  1. ncbi request reprint Number of extraspinal organs with metastases: a prognostic factor of survival in patients with metastatic spinal cord compression (MSCC) from non-small cell lung cancer (NSCLC)
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Anticancer Res 34:2503-7. 2014
    ..In patients irradiated for MSCC from NSCLC, the number of extraspinal organs involved by metastases was investigated for associations with survival...
  2. ncbi request reprint A Total Radiation Dose of 70 Gy Is Required After Macroscopically Incomplete Resection of Squamous Cell Carcinoma of the Head and Neck
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Anticancer Res 36:2989-92. 2016
    ..To contribute to the definition of the optimal total radiation dose and to determine the role of concurrent chemotherapy after macroscopically incomplete resection of squamous cell carcinoma of the head and neck (SCCHN)...
  3. ncbi request reprint Personalized Radiotherapeutic Approaches for Elderly Patients with Epidural Cord Compression from Gastric Cancer
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    In Vivo 30:69-72. 2016
    ..To facilitate personalization of radiotherapy (RT) for elderly patients with epidural cord compression (ECC) from gastric cancer...
  4. doi request reprint A New Score for Estimating Survival After Definitive Radiochemotherapy of Limited Disease Small Cell Lung Cancers
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Lung 194:625-9. 2016
    ..For patients with favorable prognoses, cure while avoiding late toxicity is important. Personalized treatment programs are required. An instrument to estimate the survival after radiochemotherapy of LD-SCLC was created...
  5. doi request reprint Comparing two lower-dose cisplatin programs for radio-chemotherapy of locally advanced head-and-neck cancers
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Eur Arch Otorhinolaryngol 274:1021-1027. 2017
    ..Confirmation of these results in a randomized trial is warranted...
  6. pmc A matched-pair study comparing whole-brain irradiation alone to radiosurgery or fractionated stereotactic radiotherapy alone in patients irradiated for up to three brain metastases
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, D 23538, Lubeck, Germany
    BMC Cancer 17:30. 2017
    ..This matched-pair study was initiated to validate the results of a retrospective study of 186 patients published in 2007 that compared whole-brain irradiation (WBI) alone and radiosurgery (RS) alone for up to three brain metastases...
  7. pmc Comparison of weekly administration of cisplatin versus three courses of cisplatin 100 mg/m(2) for definitive radiochemotherapy of locally advanced head-and-neck cancers
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, D 23538, Lubeck, Germany
    BMC Cancer 16:437. 2016
    ..To compare definitive radiochemotherapy with weekly administration of 30-40 mg/m(2) of cisplatin to 100 mg/m(2) of cisplatin on days 1, 22 and 43 for outcomes and toxicity in patients with squamous cell carcinoma of the head-and-neck...
  8. ncbi request reprint Radiochemotherapy with Paclitaxel for Recurrent Previously Irradiated Squamous Cell Carcinoma of the Head and Neck
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Anticancer Res 36:5463-5468. 2016
    ..If radiotherapy was included in the primary treatment, another curative course of radiotherapy incurs substantial risk of complications. Results of re-irradiation can be improved by concurrent chemotherapy...
  9. pmc A predictive tool particularly designed for elderly myeloma patients presenting with spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, D 23538, Lubeck, Germany
    BMC Cancer 16:292. 2016
    ..This study was performed to design a predictive tool that allows the estimation of overall survival (OS) of elderly myeloma patients (aged ≥ 65 years) presenting with myeloma-induced spinal cord compression (SCC)...
  10. ncbi request reprint Potential Impact of the Overall Treatment Time on Outcomes after Whole-brain Irradiation with 10×3 Gy for Brain Metastases
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Anticancer Res 36:3071-4. 2016
    ..To investigate the impact of the overall treatment time (OTT) of whole-brain irradiation (WBI) with 10×3 Gy on outcomes in patients with brain metastases...
  11. ncbi request reprint Radiation Therapy Alone Provides Excellent Outcomes for Spinal Cord Compression from Vertebral Lymphoma
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Anticancer Res 36:3081-3. 2016
    ..Although lymphomas were excluded from that trial, neurosurgery is also increasingly being performed in these patients. This study investigated whether neurosurgery is actually required for this group...
  12. doi request reprint Radiochemotherapy for locally advanced squamous cell carcinoma of the head and neck: Higher-dose cisplatin every 3 weeks versus cisplatin/5-fluorouracil every 4 weeks
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany Electronic address
    J Craniomaxillofac Surg 44:1436-40. 2016
    ..Otherwise, adverse events were not significantly different. Thus, both radiochemotherapy regimens appeared similarly effective for LASCCHN. Patients receiving 100 mg/m(2) of cisplatin require close monitoring of their renal function. ..
  13. ncbi request reprint Overall Survival After Whole-Brain Radiation Therapy for Intracerebral Metastases from Testicular Cancer
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Anticancer Res 36:4817-9. 2016
    ..To identify predictors and develop a score for overall survival of patients with intracerebral metastasis from testicular cancer...
  14. doi request reprint Role of the overall treatment time of radiotherapy with 10 × 3 Gy for outcomes in patients with metastatic spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    J Med Imaging Radiat Oncol . 2016
    ..has been asked whether an overall treatment time (OTT) of 14-15 days including two weekends without irradiation leads to worse outcomes than OTT of 12 days (beginning of radiotherapy on a Monday resulting in only one weekend break)?..
  15. ncbi request reprint Survival Following Palliative External-beam Radiotherapy of Locally Advanced and Metastatic Liver Cancer
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Anticancer Res 37:203-206. 2017
    ..The goal of this study was to identify prognostic factors of survival in patients receiving palliative external-beam radiotherapy (EBRT) for advanced liver cancer...
  16. doi request reprint A Prognostic Instrument to Estimate the Survival of Elderly Patients Irradiated for Metastatic Epidural Spinal Cord Compression From Lung Cancer
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany Electronic address
    Clin Lung Cancer 17:279-84. 2016
    ..Therefore, a prognostic instrument enabling physicians to estimate a patient's survival time is required. We created such an instrument in the present study...
  17. ncbi request reprint Forecasting Survival Probabilities After Radiotherapy of Metastatic Epidural Spinal Cord Compression from Colorectal Cancer in the Elderly
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Anticancer Res 36:1829-33. 2016
    ..To develop a tool forecasting survival of elderly patients with metastatic epidural spinal cord compression (MESCC) from colorectal cancer (CRC)...
  18. doi request reprint A Survival Score for Patients Receiving Palliative Irradiation for Locally Advanced Lung Cancer
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany Electronic address
    Clin Lung Cancer 17:558-562. 2016
    ..Treatment should be tailored to each patient's situation and remaining lifespan. The present study aimed to create a survival score for patients requiring palliative irradiation for locally advanced lung cancer...
  19. ncbi request reprint Outcomes After Whole-brain Radiotherapy for Brain Metastases with 5×4 Gy: Importance of Overall Treatment Time
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Anticancer Res 36:4941-5. 2016
    ..To investigate the impact of overall treatment time (OTT) of whole-brain radiotherapy (WBRT) with 5×4 Gy on outcomes...
  20. doi request reprint The effect of low hemoglobin levels on outcomes of radiotherapy following microscopically complete resection of locally advanced SCCHN: Implications for the future
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany Electronic address
    J Craniomaxillofac Surg 44:1441-4. 2016
    ..Levels <12 g/dl were associated with worse outcomes than ≥12 g/dl. Tumor cell oxygenation and correction of anemia appear important also after R0-resection. ..
  21. ncbi request reprint Comparison of 20×2 Gy and 12×3 Gy for Whole-brain Irradiation of Multiple Brain Metastases from Malignant Melanoma
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    In Vivo 30:917-919. 2016
    ..However, the optimal dose-fractionation regimen has not yet been defined. This study compared 20×2 Gy over four weeks, which was used in the previous study, to 12×3 Gy over two-and-a-half weeks...
  22. ncbi request reprint Prognostic Factors After Whole-brain Radiotherapy Alone for Brain Metastases from Malignant Melanoma
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Anticancer Res 36:6637-6640. 2016
    ..Many patients with brain metastases from melanoma receive whole-brain radiotherapy (WBRT). WBRT-regimens must consider the patient's prognosis in order to deliver the best therapy...
  23. ncbi request reprint Outcomes After Irradiation of Epidural Spinal Cord Compression Due to Metastatic Thyroid Cancer
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Anticancer Res 36:2035-9. 2016
    ..Epidural spinal cord compression (ESCC) from thyroid cancer is uncommon. This study aimed to contribute to the identification of the most appropriate treatment for these patients...
  24. doi request reprint Do we need 5-FU in addition to cisplatin for chemoradiation of locally advanced head-and-neck cancer?
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany Electronic address
    Oral Oncol 57:40-5. 2016
    ..To compare chemoradiation with cisplatin alone or cisplatin plus 5-FU for locally advanced squamous cell carcinoma of the head-and-neck (SCCHN)...
  25. doi request reprint Chemoradiation of locally advanced squamous cell carcinoma of the head-and-neck (LASCCHN): Is 20mg/m(2) cisplatin on five days every four weeks an alternative to 100mg/m(2) cisplatin every three weeks?
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany Electronic address
    Oral Oncol 59:67-72. 2016
    ..To compare chemoradiation with 100mg/m(2) cisplatin every three weeks to 20mg/m(2) on five days every four weeks for locally advanced squamous cell carcinoma of the head-and-neck (LASCCHN)...
  26. ncbi request reprint A Survival Score for Patients Receiving Stereotactic Radiosurgery Alone for Brain Metastases from Breast Cancer
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Anticancer Res 36:1073-6. 2016
    ..To generate a survival score for patients with breast cancer treated with stereotactic radiosurgery (SRS) alone for brain metastases...
  27. ncbi request reprint Radiation Therapy for Metastatic Spinal Cord Compression in Patients with Hepatocellular Carcinoma
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    In Vivo 29:749-52. 2015
    ..This is the first study to investigate patients with metastatic spinal cord compression (MSCC) from hepatocellular carcinoma (HCC)...
  28. doi request reprint Radiotherapy With 4 Gy × 5 Versus 3 Gy × 10 for Metastatic Epidural Spinal Cord Compression: Final Results of the SCORE-2 Trial (ARO 2009/01)
    Dirk Rades
    Dirk Rades, University of Lubeck, Lübeck Michaela Metz, University of Wurzburg, Würzburg Harun Badakhshi, Charite Berlin, Berlin Andreas Schreiber, Radiotherapy Practice Dresden Friedrichstadt, Dresden Mirko Nitsche, Center of Radiotherapy, Bremen Peter Hipp, University of Regensburg, Regensburg, and Oberschwabenklinik, Ravensburg Wolfgang Schulze, Klinikum Bayreuth, Bayreuth Irenaeus A Adamietz, Ruhr University Bochum, Bochum, Germany Barbara Šegedin and Ana Perpar, Institute of Oncology Ljubljana, Ljubljana, Slovenia Antonio J Conde Moreno and Raquel Garcia, Consorcio Hospital Provincial de Castellón, Castellón Jon Cacicedo, Cruces University Hospital, Barakaldo, Vizcaya, Spain Darius Norkus, University of Vilnius, Vilnius, Lithuania Volker Rudat, Saad Specialist Hospital, Al Khobar, Saudi Arabia and Steven E Schild, Mayo Clinic, India
    J Clin Oncol 34:597-602. 2016
    ..To compare short-course radiotherapy (RT) (4 Gy × 5) to longer-course RT (3 Gy × 10) for metastatic epidural spinal cord compression (MESCC)...
  29. ncbi request reprint Defining the Optimal Dose of Stereotactic Radiosurgery for Treating Cerebral Metastases in Elderly Patients
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Anticancer Res 35:5701-4. 2015
    ..This applies to the treatment of cerebral metastases as well. The present study focused on elderly patients receiving stereotactic radiosurgery (SRS) for few cerebral lesions...
  30. ncbi request reprint A Tool to Estimate Survival of Elderly Patients Presenting with Metastatic Epidural Spinal Cord Compression (MESCC) from Cancer of Unknown Primary
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Anticancer Res 35:6219-22. 2015
    ..Immediate treatment is indicated. Personalizing treatment for MESCC requires for clear understanding of the patients' survival prognosis. In this case, a tool for estimating survival would be valuable...
  31. ncbi request reprint Predicting Survival After Irradiation for Brain Metastases from Head and Neck Cancer
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    In Vivo 29:525-8. 2015
    ..Patients with cerebral metastases from head and neck cancer are not common. This study aimed to create an instrument for estimating survival in this particular group of patients...
  32. ncbi request reprint Metastatic Spinal Cord Compression: A Survival Score Particularly Developed for Elderly Prostate Cancer Patients
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Anticancer Res 35:6189-92. 2015
    ..The goal of the present study was to develop a survival score for elderly prostate cancer patients with MSCC...
  33. ncbi request reprint Immunoglobulin G (IgG) Subtype Is Associated with a Favorable Survival Prognosis in Patients Irradiated for Spinal Cord Compression from Myeloma
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Anticancer Res 36:375-8. 2016
    ..This study was performed to investigate the prognostic impact of the myeloma subtype on the survival prognosis of patients with spinal cord compression (SCC) from myeloma...
  34. ncbi request reprint Estimating the Survival of Elderly Patients with Renal Cell Carcinoma Presenting with Malignant Spinal Cord Compression
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Anticancer Res 36:409-13. 2016
    ..To develop a tool for predicting survival of elderly patients with malignant spinal cord compression (MSCC) from renal cell carcinoma...
  35. doi request reprint Single-Fraction Versus 5-Fraction Radiation Therapy for Metastatic Epidural Spinal Cord Compression in Patients With Limited Survival Prognoses: Results of a Matched-Pair Analysis
    Dirk Rades
    Department of Radiation Oncology, University Hospital Lubeck, Lubeck, Germany Electronic address
    Int J Radiat Oncol Biol Phys 93:368-72. 2015
    ..This study compared single-fraction to multi-fraction short-course radiation therapy (RT) for symptomatic metastatic epidural spinal cord compression (MESCC) in patients with limited survival prognosis...
  36. ncbi request reprint A New Predictive Tool for Optimization of the Treatment of Brain Metastases from Colorectal Cancer After Stereotactic Radiosurgery
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Anticancer Res 35:5515-8. 2015
    ..To develop a predictive tool for survival after stereotactic radiosurgery of brain metastases from colorectal cancer...
  37. pmc A new instrument for estimation of survival in elderly patients irradiated for metastatic spinal cord compression from breast cancer
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Radiat Oncol 10:173. 2015
    ..In this study, an instrument was generated to estimate the survival of elderly patients developing metastatic spinal cord compression (MSCC) from breast cancer...
  38. doi request reprint Predicting the survival probability of gastric cancer patients developing metastatic epidural spinal cord compression (MESCC)
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Gastric Cancer 18:881-4. 2015
    ..Six-month survival rates were 0, 20 and 100 % (p < 0.001). This tool for patients with MESCC from gastric cancer estimates survival probabilities, which is important for tailoring treatment to patients' needs...
  39. ncbi request reprint Impact of stereotactic radiosurgery dose on control of cerebral metastases from renal cell carcinoma
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Anticancer Res 35:3571-4. 2015
    ..Renal cell carcinoma (RCC) is a relatively radioresistant tumor and may require for higher radiation doses than other tumor types...
  40. pmc Do patients with very few brain metastases from breast cancer benefit from whole-brain radiotherapy in addition to radiosurgery?
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, Lubeck, 23538, Germany
    Radiat Oncol 9:267. 2014
    ..This study investigated the role of whole-brain radiotherapy added to radiosurgery in breast cancer patients...
  41. pmc A matched-pair analysis comparing 5x4 Gy and 10x3 Gy for metastatic spinal cord compression (MSCC) in patients with favorable survival prognoses
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Radiat Oncol 10:90. 2015
    ..Therefore, this matched-pair study following strict matching criteria was perfomed instead...
  42. ncbi request reprint A new tool to predict survival after radiosurgery alone for newly diagnosed cerebral metastases
    Dirk Rades
    Department of Radiation Oncology, Faculty of Medicine, University of Lubeck, Schleswig Holstein, Germany e mail
    Asian Pac J Cancer Prev 16:2967-70. 2015
    ..As cause of death in group B was mostly new cerebral metastases, additional WBI appears even more important for this group. ..
  43. doi request reprint A new tool predicting survival after radiosurgery alone for one or two cerebral metastases from lung cancer
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Lung 193:299-302. 2015
    ..001). This new tool enables physicians to estimate the survival of lung cancer patients with few cerebral metastases which should impact individualized treatment choices...
  44. ncbi request reprint Metastatic spinal cord compression from pancreatic cancer
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Anticancer Res 34:3727-30. 2014
    ..Pancreatic cancer is an extremely rare entity in patients with metastatic epidural spinal cord compression (MESCC). This study aimed to identify prognostic factors for functional outcome and survival following irradiation...
  45. pmc Radiosurgery alone versus radiosurgery plus whole-brain irradiation for very few cerebral metastases from lung cancer
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    BMC Cancer 14:931. 2014
    ..Since primary tumors disseminating to the brain show different behavior, this question should be answered separately for each tumor type. This study compared both treatments in patients with 1-3 cerebral metastases from lung cancer...
  46. ncbi request reprint Comparison of two dose levels of stereotactic radiosurgery for 1-3 brain metastases from non-small cell lung cancer
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Anticancer Res 34:7309-13. 2014
    ..Two dose groups of patients treated with stereotactic radiosurgery (SRS) alone for 1-3 brain metastases from non-small cell lung cancer (NSCLC) were compared for outcomes...
  47. ncbi request reprint Evaluation of five radiation schedules and prognostic factors for metastatic spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg, Martinistr 52, D 20246 Hamburg, Germany
    J Clin Oncol 23:3366-75. 2005
    ..To study five radiotherapy (RT) schedules and potential prognostic factors for functional outcome in metastatic spinal cord compression (MSCC)...
  48. doi request reprint Impact of the HPV-positivity definition on the prognostic value of HPV status in patients with locally advanced squamous cell carcinoma of the head and neck
    D Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Strahlenther Onkol 189:856-60. 2013
    ..A modified definition of HPV positivity was used in the current study compared to the authors' previous study...
  49. doi request reprint Stereotactic radiosurgery for newly diagnosed brain metastases: comparison of three dose levels
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Strahlenther Onkol 190:786-91. 2014
    ..Three doses were compared for local control of irradiated metastases, freedom from new brain metastases, and survival in patients receiving stereotactic radiosurgery (SRS) alone for one to three newly diagnosed brain metastases...
  50. doi request reprint Evaluation of prognostic factors and two radiation techniques in patients treated with surgery followed by radio(chemo)therapy or definitive radio(chemo)therapy for locally advanced head-and-neck cancer
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Luebeck, Germany
    Strahlenther Onkol 184:198-205. 2008
    ..Comparative studies regarding outcome and toxicity are lacking. This study compared both techniques for overall survival (OS), metastases-free survival (MFS), loco-regional control (LC), and toxicity in stage III/IV head-and-neck cancer...
  51. ncbi request reprint Impact of VEGF and VEGF receptor 1 (FLT1) expression on the prognosis of stage III esophageal cancer patients after radiochemotherapy
    Dirk Rades
    Department of Radiation Oncology, University Medical Center Hamburg Eppendorf, Germany
    Strahlenther Onkol 184:416-20. 2008
    ..The prognostic value of VEGF receptor 1 (FLT1) is unclear. This retrospective study investigated the impact of tumor expression of VEGF and FLT1 on outcome in 68 stage III esophageal cancer patients...
  52. doi request reprint Dose escalation of whole-brain radiotherapy for brain metastases from melanoma
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Lubeck, Germany
    Int J Radiat Oncol Biol Phys 77:537-41. 2010
    ..Hypofractionation regimens failed to improve the outcome of these patients. This study investigates a potential benefit from escalation of the WBRT dose beyond the "standard" regimen 30 Gy in 10 fractions (10x3 Gy)...
  53. doi request reprint Do patients with a limited number of brain metastases need whole-brain radiotherapy in addition to radiosurgery?
    D Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538, Luebeck, Germany
    Strahlenther Onkol 188:702-6. 2012
    ..In patients with a good performance status, radiosurgery also resulted in better survival. However, the question is whether the results of radiosurgery alone can be further improved with additional WBRT...
  54. doi request reprint Prognostic role of the number of involved extraspinal organs in patients with metastatic spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany Electronic address
    Clin Neurol Neurosurg 118:12-5. 2014
    ..This study was investigated the prognostic role of the number of involved extraspinal organs in the survival of patients with metastatic spinal cord compression (MSCC)...
  55. doi request reprint Metastatic spinal cord compression: a validated survival score for elderly patients
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Strahlenther Onkol 190:919-24. 2014
    ..This study aimed to develop a validated survival score for elderly patients with metastatic spinal cord compression (MSCC)...
  56. ncbi request reprint Radiosurgery alone for 1-3 newly-diagnosed brain metastases from melanoma: impact of dose on treatment outcomes
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Anticancer Res 34:5079-82. 2014
    ..To compare different doses of stereotactic radiosurgery (SRS) for 1-3 newly-diagnosed cerebral metastases from melanoma...
  57. ncbi request reprint Predicting overall survival in patients with brain metastases from esophageal cancer
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Anticancer Res 34:6763-5. 2014
    ..To identify survival predictors and develop a survival score for patients with brain metastases from esophageal cancer...
  58. ncbi request reprint Radiosurgery with 20 Gy provides better local contol of 1-3 brain metastases from breast cancer than with lower doses
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Anticancer Res 35:333-6. 2015
    ..To determine the optimal dose of radiosurgery-alone for patients with 1-3 cerebral metastases from breast cancer...
  59. ncbi request reprint Predicting survival of patients with metastatic epidural spinal cord compression from cancer of the head-and-neck
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Anticancer Res 35:385-8. 2015
    ..To develop an instrument for estimating survival after irradiation for metastatic epidural spinal cord compression (MESCC) from head and neck cancer...
  60. pmc A new prognostic instrument to predict the probability of developing new cerebral metastases after radiosurgery alone
    Stefan Huttenlocher
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, Lubeck 23538, Germany
    Radiat Oncol 9:215. 2014
    ..This study aimed to create an instrument that estimates the probability of developing new cerebral metastases after radiosurgery to facilitate the decision regarding additional WBI...
  61. pmc A validated score estimating ambulatory status following radiotherapy of elderly patients for metastatic spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    BMC Cancer 14:589. 2014
    ..This study was performed to develop a validated score predicting ambulatory status after radiotherapy (RT) alone for metastatic spinal cord compression (MSCC) in elderly patients...
  62. ncbi request reprint Value of postoperative stereotactic radiosurgery and conventional radiotherapy for incompletely resected typical neurocytomas
    Dirk Rades
    Department of Radiation Oncology, University Medical Center Hamburg Eppendorf, Hamburg, Germany
    Cancer 106:1140-3. 2006
    ..The current study investigated whether the outcome after incomplete resection can be improved by postoperative stereotactic radiosurgery (SRS) or by conventional radiotherapy...
  63. ncbi request reprint Two radiation regimens and prognostic factors for brain metastases in nonsmall cell lung cancer patients
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Luebeck, Germany
    Cancer 110:1077-82. 2007
    ..A short course of WBRT would be preferable to longer regimens if it could provide similar survival. This retrospective study of NSCLC patients compared longer treatment programs with short-course WBRT with 5 x 4 Gy given during 5 days...
  64. doi request reprint Comparison of short-course versus long-course whole-brain radiotherapy in the treatment of brain metastases
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Luebeck, Germany
    Strahlenther Onkol 184:30-5. 2008
    ..This study compares 20 Gy in five fractions (treatment time: 1 week) to longer programs, with higher doses including 30 Gy in ten fractions (2 weeks) and 40 Gy in 20 fractions (4 weeks)...
  65. doi request reprint Hypofractionated whole-brain radiotherapy for multiple brain metastases from transitional cell carcinoma of the bladder
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Germany
    Int J Radiat Oncol Biol Phys 78:404-8. 2010
    ..Because its radiosensitivity is relatively low, metastases from bladder cancer may be treated better with hypofractionated radiotherapy. This study compared short-course hypofractionated WBRT (5 × 4 Gy/1 week) to longer-course WBRT...
  66. ncbi request reprint A survival score for patients with metastatic spinal cord compression from prostate cancer
    D Rades
    Department of Radiation Oncology, University of Lubeck, Germany
    Strahlenther Onkol 188:802-6. 2012
    ..This study aimed to develop and validate a survival scoring system for patients with metastatic spinal cord compression (MSCC) from prostate cancer...
  67. doi request reprint A new prognostic factor for the survival of patients with renal cell carcinoma developing metastatic spinal cord compression
    D Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Campus Lubeck, University of Lubeck, 23538, Ratzeburger Allee 160, Lubeck, Germany
    Strahlenther Onkol 190:667-70. 2014
    ..This study aimed to identify a potential association of the number of involved extraspinal organs with the survival of patients with metastatic spinal cord compression (MSCC) from renal cell carcinoma...
  68. ncbi request reprint [The value of radiotherapy in treatment of meningeal melanocytoma]
    Dirk Rades
    Abteilung für Strahlentherapie und spezielle Onkologie, Medizinische Hochschule Hannover
    Strahlenther Onkol 178:336-42. 2002
    ..Meningeal melanocytoma is described as rare benign lesion with a high risk of recurrence. There are no well-substantiated treatment recommendations in the literature. Only case reports have been published by now...
  69. ncbi request reprint Escalation of radiation dose beyond 30 Gy in 10 fractions for metastatic spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Luebeck, Germany
    Int J Radiat Oncol Biol Phys 67:525-31. 2007
    ..In many centers worldwide, radiotherapy for metastatic spinal cord compression (MSCC) is performed with 30 Gy in 10 fractions. This study investigated the potential benefit of dose escalation...
  70. doi request reprint Scoring systems to estimate intracerebral control and survival rates of patients irradiated for brain metastases
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Int J Radiat Oncol Biol Phys 80:1122-7. 2011
    ..To create and validate scoring systems for intracerebral control (IC) and overall survival (OS) of patients irradiated for brain metastases...
  71. doi request reprint Surgery followed by radiotherapy versus radiotherapy alone for metastatic spinal cord compression from unfavorable tumors
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Int J Radiat Oncol Biol Phys 81:e861-8. 2011
    ..It is thought that patients with MSCC from relatively radioresistant tumors or tumors associated with poor functional outcome after radiotherapy alone may benefit from surgery. This study focuses on these tumors...
  72. doi request reprint Resection plus whole-brain irradiation versus resection plus whole-brain irradiation plus boost for the treatment of single brain metastasis
    D Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, Lubeck, Germany
    Strahlenther Onkol 188:143-7. 2012
    ..The optimal treatment for patients with a single brain metastasis is controversial. This study investigated the value of a radiation boost given in addition to neurosurgerical resection and whole-brain irradiation (WBI)...
  73. doi request reprint Prognostic factors for local control and survival in patients with spinal cord compression from myeloma
    D Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Strahlenther Onkol 188:628-31. 2012
    ..This retrospective study aimed to identify prognostic factors for local control and survival in 214 patients irradiated for spinal cord compression (SCC) from myeloma...
  74. ncbi request reprint Impact of zoledronic acid on control of metastatic spinal cord compression
    D Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538 Lubeck, Germany
    Strahlenther Onkol 188:910-6. 2012
    ..In contrast to other studies, this matched-pair analysis focused solely on the impact of zoledronic acid on metastatic spinal cord compression (MSCC)...
  75. doi request reprint A simple survival score for patients with brain metastases from breast cancer
    D Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538, Luebeck, Germany
    Strahlenther Onkol 189:664-7. 2013
    ..This study aimed to create and validate a survival score for patients with brain metastasis from breast cancer, which is the second most common primary tumor in these patients...
  76. ncbi request reprint Number of involved extracranial organs predicts survival in patients with brain metastasis from small cell lung cancer
    Lavinia Gerdan
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Anticancer Res 33:3887-9. 2013
    ..To investigate the prognostic role of the number of involved extracranial organs in patients with brain metastasis from small-cell lung cancer (SCLC)...
  77. doi request reprint Brain metastasis. Prognostic value of the number of involved extracranial organs
    D Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Strahlenther Onkol 189:996-1000. 2013
    ..This study was performed to evaluate the prognostic role for survival of the number and the type of involved extracranial organs in patients with brain metastasis...
  78. doi request reprint Predicting the presence of extracranial metastases in patients with brain metastases upon first diagnosis of cancer
    D Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Strahlenther Onkol 190:405-7. 2014
    ..This study aimed to determine factors allowing the prediction of extracranial metastases in patients presenting with brain metastases at the first diagnosis of cancer...
  79. ncbi request reprint Re-irradiation of spinal cord compression due to metastasis in elderly patients
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Anticancer Res 34:2555-8. 2014
    ..The present study investigated efficacy and toxicity of re-irradiation for an in-field recurrence of spinal cord compression due to metastasis (SCCM) in elderly patients...
  80. ncbi request reprint Prognostic significance of the time of developing motor deficits before radiation therapy in metastatic spinal cord compression: one-year results of a prospective trial
    D Rades
    Department of Radiation Oncology, Hannover Medical University, Hannover, Germany
    Int J Radiat Oncol Biol Phys 48:1403-8. 2000
    ..To investigate prospectively the prognostic value of the time of developing motor deficits before radiation therapy (RT) for post-treatment functional outcome in metastatic spinal cord compression...
  81. ncbi request reprint Therapeutic options for meningeal melanocytoma. Case report
    D Rades
    Department of Radiation Oncology, Hannover Medical College, Germany
    J Neurosurg 95:225-31. 2001
    ..050) and for incomplete resection combined with radiotherapy after 2 years (p = 0.034). Complete tumor resection should be considered the best therapeutic option, followed by incomplete resection combined with postoperative radiotherapy...
  82. ncbi request reprint Localised disease in cancer of unknown primary (CUP): the value of positron emission tomography (PET) for individual therapeutic management
    D Rades
    Department of Radiation Oncology, Hannover Medical College, Germany
    Ann Oncol 12:1605-9. 2001
    ..After conservative diagnostic procedures including MRI, the primary is detected in less than 25%. The diagnostic value of PET and its influence on therapeutic strategies was evaluated...
  83. ncbi request reprint Radiotherapy of metastatic spinal cord compression in very elderly patients
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Luebeck, Germany
    Int J Radiat Oncol Biol Phys 67:256-63. 2007
    ..This study investigated the results of radiotherapy (RT) for metastatic spinal cord compression (MSCC) in the very elderly, because few data are available for these patients...
  84. ncbi request reprint Dose escalation beyond 30 grays in 10 fractions for patients with multiple brain metastases
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Luebeck, Germany
    Cancer 110:1345-50. 2007
    ..The current study investigated the potential benefit of dose escalation beyond 30 Gy...
  85. ncbi request reprint Biologic factors associated with tumor oxygenation are prognostic in patients with stage III esophageal cancer: long-term results
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany
    Anticancer Res 34:4351-5. 2014
    ..Long-term results of a study investigating potential prognostic factors for treatment outcomes in patients with stage III esophageal cancer are presented...
  86. ncbi request reprint A new score predicting survival prognosis after whole-brain radiotherapy alone for brain metastases in elderly patients
    Jasmin N Evers
    Department of Radiation Oncology, University of Lubeck, Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Anticancer Res 34:2455-8. 2014
    ..Elderly patients represent an important subgroup of patients with brain metastases. A survival score has been developed specifically for these patients...
  87. doi request reprint Fibroblast growth factor 2 is of prognostic value for patients with locally advanced squamous cell carcinoma of the head and neck
    D Rades
    Department of Radiation Oncology, University of Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Strahlenther Onkol 190:68-74. 2014
    ..Patients with locally advanced SCCHN have a poor prognosis. This study investigated the prognostic value of the tumor cell expression of the fibroblast growth factor 2 (FGF-2) in patients treated with surgery followed by radiotherapy...
  88. doi request reprint A new survival score for patients with brain metastases from non-small cell lung cancer
    D Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, 23538, Luebeck, Germany
    Strahlenther Onkol 189:777-81. 2013
    ..Non-small cell lung cancer (NSCLC) is the most common primary tumor in patients developing brain metastasis. This study was performed to develop and validate a survival score particularly for this group of patients...
  89. doi request reprint The first survival score for patients with brain metastases from small cell lung cancer (SCLC)
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Lubeck, Germany Electronic address
    Clin Neurol Neurosurg 115:2029-32. 2013
    ..Primary tumors have different biological behavior justifying separate scoring systems for different tumors. In this study, a survival score was developed for patients with brain metastasis from SCLC...
  90. ncbi request reprint Survival in patients with metastatic spinal cord compression from prostate cancer is associated with the number of extra-spinal organs involved
    Axel Weber
    Department of Radiation Oncology, University of Lubeck, Lubeck, Ratzeburger Allee 160, D 23538 Lubeck, Germany
    Anticancer Res 33:4505-7. 2013
    ..To investigate the predictive value of the number of extra-spinal organs involved by metastases for survival in metastatic spinal cord compression (MSCC) from prostate cancer...
  91. ncbi request reprint [The value of positron emission tomography (PET) in the treatment of patients with cancer of unknown primary (CUP)]
    D Rades
    Abteilung für Strahlentherapie und spezielle Onkologie, Medizinische Hochschule Hannover
    Strahlenther Onkol 177:525-9. 2001
    ..In the study presented here the value of PET for detection of the primary tumor and a possible dissemination has been investigated and related to therapeutic regimens...
  92. ncbi request reprint Prognostic value of haemoglobin levels during concurrent radio-chemotherapy in the treatment of oesophageal cancer
    D Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Germany
    Clin Oncol (R Coll Radiol) 18:139-44. 2006
    ..To evaluate the prognostic value of haemoglobin levels during radio-chemotherapy for overall survival, metastases-free survival (MFS) and locoregional control in patients with locally advanced oesophageal cancer...
  93. ncbi request reprint Do bladder cancer patients with metastatic spinal cord compression benefit from radiotherapy alone?
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Luebeck, Germany
    Urology 69:1081-5. 2007
    ..To investigate the role of radiotherapy (RT) alone in metastatic spinal cord compression (MSCC) patients with bladder cancer...
  94. doi request reprint Comparison of different treatment approaches for one to two brain metastases in elderly patients
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Campus Lubeck, Lubeck, Germany
    Strahlenther Onkol 184:565-71. 2008
    ..It compares whole-brain radiotherapy (WBRT), stereotactic radiosurgery (SRS), resection plus WBRT (OP + WBRT), and resection plus WBRT plus boost (OP + WBRT + boost) in elderly patients...
  95. doi request reprint Whole brain radiotherapy plus stereotactic radiosurgery (WBRT+SRS) versus surgery plus whole brain radiotherapy (OP+WBRT) for 1-3 brain metastases: results of a matched pair analysis
    Dirk Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Campus Luebeck, Ratzeburger Allee 160, D 23538 Luebeck, Germany
    Eur J Cancer 45:400-4. 2009
    ..002) and longer interval (p=0.004); WBRT+SRS achieved borderline significance (p=0.052). Improved LC was associated with longer interval (p=0.017); WBRT+SRS showed a trend (p=0.09). WBRT+SRS appears at least as effective as OP+WBRT...
  96. doi request reprint Prognostic factors for survival and intracerebral control after irradiation for brain metastases from gynecological cancer
    Dirk Rades
    Department of Radiation Oncology, University of Lubeck, Germany
    Gynecol Oncol 114:506-8. 2009
    ..Most of these patients receive whole-brain radiotherapy (WBRT) alone. Prognostic factors predicting the outcomes of these patients may guide the physician to select the appropriate treatment regimen for the individual patient...
  97. doi request reprint A validated survival score for breast cancer patients with metastatic spinal cord compression
    D Rades
    Department of Radiation Oncology, University Hospital Schleswig Holstein, Lubeck, Ratzeburger Allee 160, 23538, Lubeck, Germany
    Strahlenther Onkol 189:41-6. 2013
    ..To create a validated scoring system predicting survival of breast cancer patients with metastatic spinal cord compression (MSCC)...
  98. ncbi request reprint Role of radiotherapy in the treatment of motor dysfunction due to metastatic spinal cord compression: comparison of three different fractionation schedules
    Dirk Rades
    Department of Radiation Oncology, Hannover Medical School, Hannover, Germany
    Int J Radiat Oncol Biol Phys 54:1160-4. 2002
    ..Several reports have compared different fractionation schedules for pain relief. To our knowledge, this retrospective analysis is the first to compare three different schedules for functional outcome...
  99. ncbi request reprint Prognostic factors in the nonsurgical treatment of esophageal carcinoma with radiotherapy or radiochemotherapy: the importance of pretreatment hemoglobin levels
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, Hamburg, Germany
    Cancer 103:1740-6. 2005
    ..The current study was performed to evaluate prognostic factors for overall survival (OS), distant metastasis (DM), and local failure (LF) in patients with Stage II/III esophageal carcinoma...
  100. ncbi request reprint Effectiveness and toxicity of single-fraction radiotherapy with 1 x 8 Gy for metastatic spinal cord compression
    Dirk Rades
    Department of Radiation Oncology, University Hospital Hamburg Eppendorf, D 20246 Hamburg, Germany
    Radiother Oncol 75:70-3. 2005
    ..Acute toxicity was mild, late toxicity not observed. A randomised trial comparing single-fraction RT to multi-fraction RT is mandatory...