Gabriel A Rabinovich

Summary

Publications

  1. doi request reprint Shaping the Immune Landscape in Cancer by Galectin-Driven Regulatory Pathways
    Gabriel A Rabinovich
    Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental IBYME, Consejo Nacional de Investigaciones Cientificas y Tecnicas CONICET, Vuelta de Obligado 2490, Buenos Aires C1428, Argentina Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Buenos Aires C1428, Argentina Electronic address
    J Mol Biol 428:3266-81. 2016
  2. pmc Mast cells rescue implantation defects caused by c-kit deficiency
    K Woidacki
    Experimental Obstetrics and Gynecology, Medical Faculty, Otto von Guericke University, Magdeburg, Germany
    Cell Death Dis 4:e462. 2013
  3. pmc Glycobiology of immune responses
    Gabriel A Rabinovich
    Laboratorio de Inmunopatología, Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Ciudad de Buenos Aires, Argentina
    Ann N Y Acad Sci 1253:1-15. 2012
  4. doi request reprint Regulatory circuits mediated by lectin-glycan interactions in autoimmunity and cancer
    Gabriel A Rabinovich
    Laboratorio de Inmunopatología, Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas, C1428 Buenos Aires, Argentina
    Immunity 36:322-35. 2012
  5. pmc "Time sweet time": circadian characterization of galectin-1 null mice
    Leandro P Casiraghi
    Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes CONICET, Argentina
    J Circadian Rhythms 8:4. 2010
  6. doi request reprint Glycosylation-dependent lectin-receptor interactions preserve angiogenesis in anti-VEGF refractory tumors
    Diego O Croci
    Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental IBYME, Consejo Nacional de Investigaciones Cientificas y Tecnicas CONICET, 1428 Buenos Aires, Argentina
    Cell 156:744-58. 2014
  7. pmc Disrupting galectin-1 interactions with N-glycans suppresses hypoxia-driven angiogenesis and tumorigenesis in Kaposi's sarcoma
    Diego O Croci
    Laboratorio de Inmunopatología, Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas, 1428 Buenos Aires, Argentina
    J Exp Med 209:1985-2000. 2012
  8. pmc Nuclear factor (NF)-kappaB-dependent thyroid hormone receptor beta1 expression controls dendritic cell function via Akt signaling
    Ivan D Mascanfroni
    Centro de Investigaciones en Bioquimica Clinica e Inmunologia, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Departamento de Bioquimica Clinica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, 5000 Cordoba, Argentina
    J Biol Chem 285:9569-82. 2010
  9. pmc Tumour-experienced T cells promote NK cell activity through trogocytosis of NKG2D and NKp46 ligands
    Carolina I Domaica
    Institute of Biology and Experimental Medicine IBYME, National Research Council CONICET, Ciudad de Buenos Aires, Argentina
    EMBO Rep 10:908-15. 2009
  10. doi request reprint Nuclear factor (NF)-κB controls expression of the immunoregulatory glycan-binding protein galectin-1
    Marta A Toscano
    Laboratorio de Inmunopatología, Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Tecnológicas CONICET, Buenos Aires, Argentina
    Mol Immunol 48:1940-9. 2011

Collaborators

Detail Information

Publications59

  1. doi request reprint Shaping the Immune Landscape in Cancer by Galectin-Driven Regulatory Pathways
    Gabriel A Rabinovich
    Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental IBYME, Consejo Nacional de Investigaciones Cientificas y Tecnicas CONICET, Vuelta de Obligado 2490, Buenos Aires C1428, Argentina Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad Universitaria, Buenos Aires C1428, Argentina Electronic address
    J Mol Biol 428:3266-81. 2016
    ....
  2. pmc Mast cells rescue implantation defects caused by c-kit deficiency
    K Woidacki
    Experimental Obstetrics and Gynecology, Medical Faculty, Otto von Guericke University, Magdeburg, Germany
    Cell Death Dis 4:e462. 2013
    ..Our data unveil unrecognized roles for MCs at the fetomaternal interface with critical implications in reproductive medicine...
  3. pmc Glycobiology of immune responses
    Gabriel A Rabinovich
    Laboratorio de Inmunopatología, Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Ciudad de Buenos Aires, Argentina
    Ann N Y Acad Sci 1253:1-15. 2012
    ..Here, we attempt to summarize general concepts on glycans and glycan-binding proteins (mainly C-type lectins, siglecs, and galectins) and their contributions to the biology of immune responses in physiologic and pathologic settings...
  4. doi request reprint Regulatory circuits mediated by lectin-glycan interactions in autoimmunity and cancer
    Gabriel A Rabinovich
    Laboratorio de Inmunopatología, Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas, C1428 Buenos Aires, Argentina
    Immunity 36:322-35. 2012
    ..We also discuss the mechanisms by which glycan-dependent regulatory programs integrate into canonical circuits that amplify or silence immune responses related to autoimmunity and neoplastic disease...
  5. pmc "Time sweet time": circadian characterization of galectin-1 null mice
    Leandro P Casiraghi
    Departamento de Ciencia y Tecnologia, Universidad Nacional de Quilmes CONICET, Argentina
    J Circadian Rhythms 8:4. 2010
    ..To further analyze the role of endogenous galectin-1 in vivo, we aimed to characterize the circadian behavior of galectin-1 null (Lgals1-/-) mice...
  6. doi request reprint Glycosylation-dependent lectin-receptor interactions preserve angiogenesis in anti-VEGF refractory tumors
    Diego O Croci
    Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental IBYME, Consejo Nacional de Investigaciones Cientificas y Tecnicas CONICET, 1428 Buenos Aires, Argentina
    Cell 156:744-58. 2014
    ..Disruption of the Gal1-N-glycan axis promoted vascular remodeling, immune cell influx and tumor growth inhibition. Thus, targeting glycosylation-dependent lectin-receptor interactions may increase the efficacy of anti-VEGF treatment...
  7. pmc Disrupting galectin-1 interactions with N-glycans suppresses hypoxia-driven angiogenesis and tumorigenesis in Kaposi's sarcoma
    Diego O Croci
    Laboratorio de Inmunopatología, Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas, 1428 Buenos Aires, Argentina
    J Exp Med 209:1985-2000. 2012
    ....
  8. pmc Nuclear factor (NF)-kappaB-dependent thyroid hormone receptor beta1 expression controls dendritic cell function via Akt signaling
    Ivan D Mascanfroni
    Centro de Investigaciones en Bioquimica Clinica e Inmunologia, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Departamento de Bioquimica Clinica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, 5000 Cordoba, Argentina
    J Biol Chem 285:9569-82. 2010
    ..These results underscore a novel unrecognized target that regulates DC maturation and function with critical implications in immunopathology at the cross-roads of the immune-endocrine circuits...
  9. pmc Tumour-experienced T cells promote NK cell activity through trogocytosis of NKG2D and NKp46 ligands
    Carolina I Domaica
    Institute of Biology and Experimental Medicine IBYME, National Research Council CONICET, Ciudad de Buenos Aires, Argentina
    EMBO Rep 10:908-15. 2009
    ..Our findings identify a new, so far, unrecognized mechanism by which effector T cells support NK cell function through the capture of specific tumour ligands with profound implications at the crossroad of innate and adaptive immunity...
  10. doi request reprint Nuclear factor (NF)-κB controls expression of the immunoregulatory glycan-binding protein galectin-1
    Marta A Toscano
    Laboratorio de Inmunopatología, Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Tecnológicas CONICET, Buenos Aires, Argentina
    Mol Immunol 48:1940-9. 2011
    ..The present study suggest a novel regulatory loop by which NF-κB induces expression of Gal-1, which in turn may lead to negative control of NF-κB signaling...
  11. doi request reprint Endogenous lectins shape the function of dendritic cells and tailor adaptive immunity: mechanisms and biomedical applications
    Ivan D Mascanfroni
    Laboratorio de Inmunopatología, Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas, C1428 Ciudad de Buenos Aires, Argentina
    Int Immunopharmacol 11:833-41. 2011
    ....
  12. doi request reprint Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10
    Juan M Ilarregui
    Laboratorio de Inmunopatología, Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires, Argentina
    Nat Immunol 10:981-91. 2009
    ..Our findings identify a tolerogenic circuit linking galectin-1 signaling, IL-27-producing DCs and IL-10-secreting T cells, which has broad therapeutic implications in immunopathology...
  13. doi request reprint An integrated computational analysis of the structure, dynamics, and ligand binding interactions of the human galectin network
    Carlos M A Guardia
    Departamento de Química Inorgánica, Analítica y Química Física, INQUIMAE CONICET, Universidad de Buenos Aires, Ciudad Universitaria, Pabellón II, C1428EHA Ciudad de Buenos Aires, Argentina
    J Chem Inf Model 51:1918-30. 2011
    ..Taken together, our results may contribute to the understanding, at a molecular level, of the structural and dynamical determinants that distinguish individual human galectins...
  14. ncbi request reprint Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death
    Marta A Toscano
    División de Immunogenética Hospital de Clínicas José de San Martín, Facultad de Medicina, Universidad de Buenos Aires, C1120AAF Buenos Aires, Argentina
    Nat Immunol 8:825-34. 2007
    ..Our findings identify a molecular link among differential glycosylation of T helper cells, susceptibility to cell death and termination of the inflammatory response...
  15. doi request reprint Regulation of galectins by hypoxia and their relevance in angiogenesis: strategies and methods
    Mariana Salatino
    Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental IBYME, Consejo Nacional de Investigaciones Cientificas y Tecnicas CONICET, Vuelta de Obligado 2490, C1428, Buenos Aires, Argentina
    Methods Mol Biol 1207:293-304. 2015
    ..Here we describe selected strategies and methods used to study the galectin-1 regulation by hypoxia and its role in blood vessel formation. ..
  16. doi request reprint Conveying glycan information into T-cell homeostatic programs: a challenging role for galectin-1 in inflammatory and tumor microenvironments
    Gabriel A Rabinovich
    Laboratorio de Inmunopatología, Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Ciudad de Buenos Aires, Argentina
    Immunol Rev 230:144-59. 2009
    ....
  17. doi request reprint Histone deacetylase inhibitors impair NK cell viability and effector functions through inhibition of activation and receptor expression
    Lucas E Rossi
    Instituto de Biología y Medicina Experimental IBYME, Consejo Nacional de Investigaciones Científicas y Técicas CONICET, Buenos Aires, Argentina
    J Leukoc Biol 91:321-31. 2012
    ..Thus, our preclinical results indicate that HDACi exert deleterious effects on NK cell function, which may weaken immune surveillance and facilitate relapse of the malignant disease in HDACi-treated patients...
  18. doi request reprint Regulatory Dendritic Cells Restrain NK Cell IFN-γ Production through Mechanisms Involving NKp46, IL-10, and MHC Class I-Specific Inhibitory Receptors
    Raúl G Spallanzani
    Laboratorio de Fisiopatología de la Inmunidad Innata, Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas, C1428ADN Buenos Aires, Argentina
    J Immunol 195:2141-8. 2015
    ..In addition, our findings contribute to identify a novel inhibitory role for NKp46 in the control of NK cell function, and have broad implications in the resolution of inflammatory responses and evasion of antitumor responses...
  19. ncbi request reprint Galectin-1 as a potential therapeutic target in autoimmune disorders and cancer
    Mariana Salatino
    Instituto de Biología y Medicina Experimental IBYME, Laboratorio de Inmunopatología, Consejo Nacional de Investigaciones Cientificas y Tecnicas CONICET, Argentina
    Expert Opin Biol Ther 8:45-57. 2008
    ..Here the authors review the dual role of galectin-1 as a selective immunosuppressive agent in T helper (T(H))1 and T(H)17-mediated inflammatory/autoimmune disorders and a potential therapeutic target in cancer and metastasis...
  20. ncbi request reprint [How do protein-glycan interactions regulate T-cell physiology?]
    Marta A Toscano
    División Inmunogenética, Hospital de Clinicas Jose de San Martin, Facultad de Medicina, Universidad de Buenos Aires, Argentina
    Medicina (B Aires) 66:357-62. 2006
    ..This article briefly reviews the mechanisms by which protein-carbohydrate interactions modulate immunological processes such as T-cell activation, migration and apoptosis...
  21. doi request reprint Study of galectins in tumor immunity: strategies and methods
    Juan P Cerliani
    Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental IBYME, Consejo Nacional de Investigaciones Cientificas y Tecnicas CONICET, C1428, Buenos Aires, Argentina
    Methods Mol Biol 1207:249-68. 2015
    ..Here we describe a selection of methods used to investigate the role of galectin-1 in tumor-immune escape. ..
  22. doi request reprint Modulation of endothelial cell migration and angiogenesis: a novel function for the "tandem-repeat" lectin galectin-8
    Víctor M Cárdenas Delgado
    Instituto de Química y Fisicoquímica Biológicas UBA CONICET, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Junín 956 C1113, Buenos Aires, Argentina
    FASEB J 25:242-54. 2011
    ..Collectively, these data provide the first evidence demonstrating an essential role for Gal-8 in the regulation of angiogenesis with critical implications in tumor biology...
  23. pmc When galectins recognize glycans: from biochemistry to physiology and back again
    Santiago Di Lella
    Laboratorio de Inmunopatologı́a, Instituto de Biologı́a y Medicina Experimental, CONICET, Ciudad de Buenos Aires, Argentina
    Biochemistry 50:7842-57. 2011
    ..In this review, we aim to integrate structural, biochemical, and functional aspects of this bewildering and ancient family of glycan-binding proteins and discuss their implications in physiologic and pathologic settings...
  24. doi request reprint Targeting galectin-1 overcomes breast cancer-associated immunosuppression and prevents metastatic disease
    Tomás Dalotto-Moreno
    Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental IBYME, Consejo Nacional de Investigaciones Cientificas y Tecnicas CONICET, Buenos Aires, Argentina
    Cancer Res 73:1107-17. 2013
    ..Taken together, our results offer a preclinical proof of concept that therapeutic targeting of Gal1 can overcome breast cancer-associated immunosuppression and can prevent metastatic disease...
  25. doi request reprint Neuroblastoma triggers an immunoevasive program involving galectin-1-dependent modulation of T cell and dendritic cell compartments
    Rocío Soldati
    Laboratory of Pediatric Immunotherapy, Department of Pediatrics, Medical Faculty, Otto von Guericke University of Magdeburg, Germany
    Int J Cancer 131:1131-41. 2012
    ..These results demonstrate a novel immunoinhibitory role of the Gal-1-glycan axis in NB, highlighting an alternative target for novel immunotherapeutic modalities...
  26. doi request reprint Fine-tuning antitumor responses through the control of galectin-glycan interactions: an overview
    Mariana Salatino
    Laboratorio de Inmunopatología, Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires, Argentina
    Methods Mol Biol 677:355-74. 2011
    ..In this review, we will highlight recent findings on how galectin-glycan lattices control the dialogue between tumor and immune cells and how these interactions could be exploited for therapeutic purposes...
  27. doi request reprint 'Sweetening' pregnancy: galectins at the fetomaternal interface
    Ada G Blidner
    Instituto de Oncologia Angel H Roffo, Universidad de Buenos Aires, Buenos Aires, Argentina
    Am J Reprod Immunol 69:369-82. 2013
    ..Here we outline the regulated expression and function of individual members of the galectin family within the fetoplacental unit and their biological implications for the development and preservation of successful pregnancies...
  28. doi request reprint Dissecting the signal transduction pathways triggered by galectin-glycan interactions in physiological and pathological settings
    Diego J Laderach
    Facultad de Ciencias Exactas y Naturales, Departamento de Quimica Biologica, Universidad de Buenos Aires, Buenos Aires C1428, Argentina
    IUBMB Life 62:1-13. 2010
    ..Understanding the "galectin signalosome" will be essential to delineate rational therapeutic strategies based on the specific control of galectin expression and function...
  29. doi request reprint Turning 'sweet' on immunity: galectin-glycan interactions in immune tolerance and inflammation
    Gabriel A Rabinovich
    Laboratorio de Inmunopatología, Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas, C1428, Ciudad de Buenos Aires, Argentina
    Nat Rev Immunol 9:338-52. 2009
    ....
  30. doi request reprint Tolerogenic dendritic cells in the control of autoimmune neuroinflammation: an emerging role of protein-glycan interactions
    Juan M Ilarregui
    Laboratorio de Inmunopatología, Instituto de Biologia, Buenos Aires, Argentina
    Neuroimmunomodulation 17:157-60. 2010
    ..In addition, we will underscore recent findings on the emerging role of galectin-glycan interactions in the establishment of immunosuppressive networks during the resolution of chronic inflammation...
  31. doi request reprint Novel roles of galectin-1 in hepatocellular carcinoma cell adhesion, polarization, and in vivo tumor growth
    Maria V Espelt
    Instituto de Quimica y Fisicoquimica Biologicas, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Departamento de Quimica Biologica, Facultad de Farmacia y Bioquimica, Universidad de Buenos Aires, Argentina
    Hepatology 53:2097-106. 2011
    ..Finally, expression levels of this endogenous lectin correlated with HCC cell adhesion and polarization and up-regulation of Gal-1-favored growth of hepatocarcinoma in vivo...
  32. pmc Functions of cell surface galectin-glycoprotein lattices
    Gabriel A Rabinovich
    Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental IBYME, CONICET, Buenos Aires, Argentina
    Curr Opin Struct Biol 17:513-20. 2007
    ....
  33. doi request reprint A unique galectin signature in human prostate cancer progression suggests galectin-1 as a key target for treatment of advanced disease
    Diego J Laderach
    Laboratorio de Glicómica Estructural y Funcional, IQUIBICEN CONICET, Departamento de Quimica Biologica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
    Cancer Res 73:86-96. 2013
    ....
  34. ncbi request reprint Overcoming the hurdles of tumor immunity by targeting regulatory pathways in innate and adaptive immune cells
    Norberto W Zwirner
    Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental IBYME, Consejo Nacional de Investigaciones Cientificas y Tecnicas CONICET, Buenos Aires, Argentina
    Curr Pharm Des 16:255-67. 2010
    ....
  35. ncbi request reprint Control of dendritic cell maturation and function by triiodothyronine
    Ivan Mascanfroni
    CIBICI CONICET, Departamento de Bioquimica Clinica, Facultad de Ciencias Quimicas, Universidad Nacional de Cordoba, Haya de la Torre esq Medina Allende, Ciudad Universitaria, 5000 Cordoba, Argentina
    FASEB J 22:1032-42. 2008
    ..These results have profound implications in immunopathology, including cancer and autoimmune manifestations of the thyroid gland at the crossroads of the immune and endocrine systems...
  36. doi request reprint Targeting galectin-1-induced angiogenesis mitigates the severity of endometriosis
    Juan I Bastón
    Laboratorio de Fisiopatología Endometrial, Instituto de Biología y Medicina Experimental Consejo Nacional de Investigaciones Científicas y Técnicas IBYME CONICET, Vuelta de Obligado 2490, Buenos Aires, C1428ADN, Argentina
    J Pathol 234:329-37. 2014
    ..These results underline the essential role of Gal-1 during endometriosis and validate this lectin as a possible target for the treatment of disease...
  37. ncbi request reprint Intracellular retention of the NKG2D ligand MHC class I chain-related gene A in human melanomas confers immune privilege and prevents NK cell-mediated cytotoxicity
    Mercedes B Fuertes
    Laboratorio de Inmunogenética, Hospital de Clínicas and Departamento de Microbiología, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
    J Immunol 180:4606-14. 2008
    ..Furthermore, this tumor immune escape strategy can be overcome by gene therapy approaches aimed at overexpressing MICA on tumor cells...
  38. ncbi request reprint A novel function for galectin-1 at the crossroad of innate and adaptive immunity: galectin-1 regulates monocyte/macrophage physiology through a nonapoptotic ERK-dependent pathway
    Paula Barrionuevo
    División Inmunogenética Hospital de Clínicas José de San Martín, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
    J Immunol 178:436-45. 2007
    ..Our results provide evidence of a novel unrecognized role for galectin-1 in the control of monocyte/macrophage physiology with potential implications at the crossroad of innate and adaptive immunity...
  39. doi request reprint Translating the 'Sugar Code' into Immune and Vascular Signaling Programs
    Juan P Cerliani
    Laboratorio de Inmunopatología, Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas CONICET, C1428 Buenos Aires, Argentina
    Trends Biochem Sci . 2016
    ..Implementation of novel glycoanalytical approaches, as well as the use of genetically engineered cell and organism models, have allowed glycans and galectins to be explored across a range of cellular processes...
  40. doi request reprint Expanding the universe of cytokines and pattern recognition receptors: galectins and glycans in innate immunity
    Juan P Cerliani
    Laboratorio de Inmunopatología, Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas, 1428 Buenos Aires, Argentina
    J Clin Immunol 31:10-21. 2011
    ..Challenges for the future will embrace the rational manipulation of galectin-glycan interactions to instruct and shape innate immunity during microbial infections, inflammation, and cancer...
  41. doi request reprint The galectin-1-glycan axis controls sperm fertilizing capacity by regulating sperm motility and membrane hyperpolarization
    Gustavo Vasen
    Instituto de Biologia y Medicina Experimental IByME CONICET, Buenos Aires, Argentina and Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Buenos Aires, Argentina
    FASEB J 29:4189-200. 2015
    ..Our study highlights the relevance of the Gal-1-glycan axis in sperm function with critical implications in mammalian reproductive biology...
  42. doi request reprint Differential response of myeloid-derived suppressor cells to the nonsteroidal anti-inflammatory agent indomethacin in tumor-associated and tumor-free microenvironments
    Ada G Blidner
    Area Investigacion, Instituto de Oncologia Angel H Roffo, Universidad de Buenos Aires, C1427 Buenos Aires, Argentina Laboratorio de Inmunopatología, Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas, C1428 Buenos Aires, Argentina and
    J Immunol 194:3452-62. 2015
    ..These results have broad clinical implication in cancer, chronic inflammation and autoimmunity. ..
  43. doi request reprint Galectins and microenvironmental niches during hematopoiesis
    Gabriel A Rabinovich
    Instituto de Biología y Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
    Curr Opin Hematol 18:443-51. 2011
    ..g. chronic inflammation, autoimmunity, cancer, infection). We discuss here how galectins contribute to the development of specialized microenvironmental niches during hematopoiesis...
  44. pmc Fucans, but not fucomannoglucuronans, determine the biological activities of sulfated polysaccharides from Laminaria saccharina brown seaweed
    Diego O Croci
    Laboratorio de Inmunopatología, Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas y Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, Ciudad de Buenos Aires, Argentina
    PLoS ONE 6:e17283. 2011
    ..Thus, sulfated fucans are mainly responsible for the anti-inflammatory, anticoagulant, antiangiogenic, and antitumor activities of sulfated polysaccharides from L. saccharina brown seaweed...
  45. doi request reprint Trypanosoma cruzi Infection Imparts a Regulatory Program in Dendritic Cells and T Cells via Galectin-1-Dependent Mechanisms
    Carolina V Poncini
    Instituto de Investigaciones en Microbiología y Parasitología Médicas, Facultad de Medicina, Universidad de Buenos Aires, Consejo Nacional de Investigaciones Cientificas y Tecnicas, C1121 Buenos Aires, Argentina
    J Immunol 195:3311-24. 2015
    ..Thus, endogenous Gal-1 may influence T. cruzi infection by fueling tolerogenic circuits that hinder anti-parasite immunity. ..
  46. doi request reprint Driving CARs into Sweet Roads: Targeting Glycosylated Antigens in Cancer
    Ada G Blidner
    Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental IBYME, Consejo Nacional de Investigaciones Cientificas y Tecnicas CONICET, Vuelta de Obligado 2490, C1428ADN Buenos Aires, Argentina
    Immunity 44:1248-50. 2016
    ..In this issue of Immunity, June and colleagues demonstrate the broad antitumor efficacy of a newly-designed CAR targeting the O-linked hypoglycosylated epitopes Tn and sialyl-Tn on cancer-associated MUC-1. ..
  47. ncbi request reprint Role of galectins in inflammatory and immunomodulatory processes
    Gabriel A Rabinovich
    División de Immunogenética, Hospital de Clinicas Jose de San Martin, Facultad de Medicina, Universidad de Buenos Aires, Cordoba 2351, 3er Piso, CP 1120, Buenos Aires, Argentina
    Biochim Biophys Acta 1572:274-84. 2002
    ....
  48. doi request reprint Galectins: emerging regulatory checkpoints linking tumor immunity and angiogenesis
    Santiago P Méndez-Huergo
    Laboratorio de Inmunopatología, Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas CONICET, C1428 Buenos Aires, Argentina
    Curr Opin Immunol 45:8-15. 2017
    ..Thus, targeting galectin-glycan interactions may halt tumor progression by simultaneously augmenting antitumor immunity and suppressing aberrant angiogenesis...
  49. doi request reprint Integration of lectin-glycan recognition systems and immune cell networks in CNS inflammation
    Santiago P Méndez-Huergo
    Laboratorio de Inmunopatología, Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Científicas y Técnicas IBYME CONICET, C1428 Buenos Aires, Argentina
    Cytokine Growth Factor Rev 25:247-55. 2014
    ..Understanding the regulatory circuits governed by lectin-glycan interactions and their association with disease-associated cytokine networks will contribute to develop novel therapeutic strategies in MS. ..
  50. doi request reprint Silencing survivin gene expression promotes apoptosis of human breast cancer cells through a caspase-independent pathway
    Diego O Croci
    Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental IBYME, Consejo Nacional de Investigaciones Cientificas y Tecnicas CONICET, Buenos Aires, Argentina
    J Cell Biochem 105:381-90. 2008
    ..Thus, silencing survivin expression using siRNA strategies represents a suitable therapeutic approach to selectively modulate the survival and growth of human breast cancer cells...
  51. ncbi request reprint Up-regulated expression of MICA on activated T lymphocytes involves Lck and Fyn kinases and signaling through MEK1/ERK, p38 MAP kinase, and calcineurin
    Luciana L Molinero
    Laboratorio de Inmunogenética, Hospital de Clinicas Jose de San Martin, Facultad de Medicina, Universidad de Buenos Aires, Argentina
    J Leukoc Biol 73:815-22. 2003
    ..This is the first demonstration of the intracellular pathways involved in activation-induced expression of MICA, which may reveal potential targets for immune intervention to modulate MICA expression in pathological disorders...
  52. doi request reprint Re-wiring regulatory cell networks in immunity by galectin-glycan interactions
    Ada G Blidner
    Laboratory of Immunopathology and Functional Glycomics, Institute of Biology and Experimental Medicine IBYME, CONICET, C1428 Buenos Aires, Argentina
    FEBS Lett 589:3407-18. 2015
    ....
  53. doi request reprint Regulatory role of glycans in the control of hypoxia-driven angiogenesis and sensitivity to anti-angiogenic treatment
    Diego O Croci
    Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental IBYME, Consejo Nacional de Investigaciones Cientificas y Tecnicas CONICET, 1428 Buenos Aires, Argentina
    Glycobiology 24:1283-90. 2014
    ..These glycosylation-dependent lectin-receptor interactions can link tumor hypoxia to EC signaling and control tumor sensitivity to anti-angiogenic treatment. ..
  54. doi request reprint Linking the structure and thermal stability of beta-galactoside-binding protein galectin-1 to ligand binding and dimerization equilibria
    Santiago Di Lella
    Departamento de Quimica Inorganica, Analitica y Quimica Fisica INQUIMAE CONICET, Universidad de Buenos Aires, Ciudad de Buenos Aires, Argentina
    Biochemistry 49:7652-8. 2010
    ....
  55. doi request reprint Glyco-nano-oncology: Novel therapeutic opportunities by combining small and sweet
    Pablo F Hockl
    Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental IBYME, Consejo Nacional de Investigaciones Cientificas y Tecnicas CONICET, Vuelta de Obligado 2490, C1428ADN Buenos Aires, Argentina
    Pharmacol Res 109:45-54. 2016
    ....
  56. doi request reprint Immunology south of the equator in the Americas
    Gabriel A Rabinovich
    Laboratorio de Inmunopatología, Instituto de Biologia y Medicina Experimental, Consejo Nacional de Investigaciones Cientificas y Tecnicas, Buenos Aires, Argentina
    Nat Immunol 9:1087-90. 2008
    ..Despite a troubled economic and political past, a tradition of fundamental research in immunology and infectious diseases has been fostered in Argentina, Brazil and Chile, as well as in other South American countries...
  57. pmc Turning-Off Signaling by Siglecs, Selectins, and Galectins: Chemical Inhibition of Glycan-Dependent Interactions in Cancer
    Alejandro J Cagnoni
    Laboratorio de Glicómica Funcional y Molecular, Instituto de Biología y Medicina Experimental IBYME, Consejo Nacional de Investigaciones Cientificas y Tecnicas CONICET, Buenos Aires, Argentina Laboratorio de Inmunopatología, Instituto de Biología y Medicina Experimental IBYME, Consejo Nacional de Investigaciones Cientificas y Tecnicas CONICET, Buenos Aires, Argentina
    Front Oncol 6:109. 2016
    ..In this article, we review the current status of the discovery and development of chemical lectin inhibitors and discuss novel strategies to limit cancer progression by targeting lectin-glycan interactions. ..
  58. doi request reprint Ligand-mediated Galectin-1 endocytosis prevents intraneural H2O2 production promoting F-actin dynamics reactivation and axonal re-growth
    Héctor R Quintá
    Departamento de Quimica Biologica, Instituto de Química y Físico Química Biológica, Universidad de Buenos Aires, Buenos Aires C1113AAD, Argentina
    Exp Neurol 283:165-78. 2016
    ....
  59. ncbi request reprint Circulating anti-galectin-1 antibodies are associated with the severity of ocular disease in autoimmune and infectious uveitis
    Marta D Romero
    División Immunogenética, Facultad de Medicina, Universidad de Buenos Aires, Buenos Aires, Argentina
    Invest Ophthalmol Vis Sci 47:1550-6. 2006
    ..The purpose of this work was to investigate the occurrence of circulating anti-Gal-1 antibodies in patients with autoimmune and infectious uveitis as potential determinant factors of disease progression...