S Qin

Summary

Publications

  1. pmc The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions
    S Qin
    LeukoSite, Inc, Cambridge, Massachusetts 02142, USA
    J Clin Invest 101:746-54. 1998
  2. pmc Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils
    P D Ponath
    LeukoSite, Inc, Cambridge, Massachusetts 02142, USA
    J Exp Med 183:2437-48. 1996
  3. pmc Chemokine receptor usage by human eosinophils. The importance of CCR3 demonstrated using an antagonistic monoclonal antibody
    H Heath
    LeukoSite, Inc, Cambridge, Massachusetts 02142, USA
    J Clin Invest 99:178-84. 1997
  4. pmc Human G protein-coupled receptor GPR-9-6/CC chemokine receptor 9 is selectively expressed on intestinal homing T lymphocytes, mucosal lymphocytes, and thymocytes and is required for thymus-expressed chemokine-mediated chemotaxis
    B A Zabel
    LeukoSite, Inc, Cambridge, Massachusetts 02142, USA
    J Exp Med 190:1241-56. 1999
  5. ncbi Discrete steps in binding and signaling of interleukin-8 with its receptor
    L Wu
    LeukoSite, Incorporated, Cambridge, Massachusetts 02142, USA
    J Biol Chem 271:31202-9. 1996
  6. ncbi Importance of ICOS-B7RP-1 costimulation in acute and chronic allograft rejection
    E Ozkaynak
    Millennium Pharmaceuticals, Inc, 75 Sidney Street, Cambridge, MA 02139, USA
    Nat Immunol 2:591-6. 2001
  7. pmc Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils
    P D Ponath
    LeukoSite, Inc, Cambridge, Massachusetts 02142, USA
    J Clin Invest 97:604-12. 1996
  8. ncbi Unique subpopulations of CD56+ NK and NK-T peripheral blood lymphocytes identified by chemokine receptor expression repertoire
    J J Campbell
    Joint Program in Transfusion Medicine, Children s Hospital, 300 Longwood Avenue, Room BD 401, Boston, MA 02115
    J Immunol 166:6477-82. 2001
  9. ncbi Selective lymphocyte chemokine receptor expression in the rheumatoid joint
    J H Ruth
    Northwestern University Medical School, Department of Medicine, Section of Rheumatology, Chicago, IL 60611, USA
    Arthritis Rheum 44:2750-60. 2001
  10. ncbi Differential expression of chemokine receptors on peripheral blood, synovial fluid, and synovial tissue monocytes/macrophages in rheumatoid arthritis
    K J Katschke
    Northwestern University Medical School, Chicago, Illinois 60611, USA
    Arthritis Rheum 44:1022-32. 2001

Collaborators

Detail Information

Publications22

  1. pmc The chemokine receptors CXCR3 and CCR5 mark subsets of T cells associated with certain inflammatory reactions
    S Qin
    LeukoSite, Inc, Cambridge, Massachusetts 02142, USA
    J Clin Invest 101:746-54. 1998
    ..Moreover, CXCR3 and CCR5 appear to identify subsets of T cells in blood with a predilection for homing to these sites...
  2. pmc Molecular cloning and characterization of a human eotaxin receptor expressed selectively on eosinophils
    P D Ponath
    LeukoSite, Inc, Cambridge, Massachusetts 02142, USA
    J Exp Med 183:2437-48. 1996
    ..The restricted expression of CKR-3 on eosinophils and the fidelity of eotaxin binding to CKR-3, provides a potential mechanism for the selective recruitment and migration of eosinophils within tissues...
  3. pmc Chemokine receptor usage by human eosinophils. The importance of CCR3 demonstrated using an antagonistic monoclonal antibody
    H Heath
    LeukoSite, Inc, Cambridge, Massachusetts 02142, USA
    J Clin Invest 99:178-84. 1997
    ..These results demonstrate the importance of CCR3 for eosinophil responses, and the feasibility of completely antagonizing this receptor...
  4. pmc Human G protein-coupled receptor GPR-9-6/CC chemokine receptor 9 is selectively expressed on intestinal homing T lymphocytes, mucosal lymphocytes, and thymocytes and is required for thymus-expressed chemokine-mediated chemotaxis
    B A Zabel
    LeukoSite, Inc, Cambridge, Massachusetts 02142, USA
    J Exp Med 190:1241-56. 1999
    ..The selective expression of TECK and GPR-9-6 in thymus and small intestine implies a dual role for GPR-9-6/CCR-9, both in T cell development and the mucosal immune response...
  5. ncbi Discrete steps in binding and signaling of interleukin-8 with its receptor
    L Wu
    LeukoSite, Incorporated, Cambridge, Massachusetts 02142, USA
    J Biol Chem 271:31202-9. 1996
    ....
  6. ncbi Importance of ICOS-B7RP-1 costimulation in acute and chronic allograft rejection
    E Ozkaynak
    Millennium Pharmaceuticals, Inc, 75 Sidney Street, Cambridge, MA 02139, USA
    Nat Immunol 2:591-6. 2001
    ..These data demonstrate a key role for the ICOS-B7RP-1 pathway in acute and chronic rejection and highlight the benefits of targeting this pathway in combination with the use of conventional immunosuppressive agent...
  7. pmc Cloning of the human eosinophil chemoattractant, eotaxin. Expression, receptor binding, and functional properties suggest a mechanism for the selective recruitment of eosinophils
    P D Ponath
    LeukoSite, Inc, Cambridge, Massachusetts 02142, USA
    J Clin Invest 97:604-12. 1996
    ..Thus eotaxin in humans is a potent and selective eosinophil chemoattractant that is expressed by a variety cell types in certain inflammatory conditions...
  8. ncbi Unique subpopulations of CD56+ NK and NK-T peripheral blood lymphocytes identified by chemokine receptor expression repertoire
    J J Campbell
    Joint Program in Transfusion Medicine, Children s Hospital, 300 Longwood Avenue, Room BD 401, Boston, MA 02115
    J Immunol 166:6477-82. 2001
    ..These findings describe a diverse population of cells that may have trafficking patterns entirely different from each other, and from other lymphocyte types...
  9. ncbi Selective lymphocyte chemokine receptor expression in the rheumatoid joint
    J H Ruth
    Northwestern University Medical School, Department of Medicine, Section of Rheumatology, Chicago, IL 60611, USA
    Arthritis Rheum 44:2750-60. 2001
    ..CONCLUSION: These results identify CCR4, CCR5, CXCR3, and CX3CR1 as critical chemokine receptors in RA...
  10. ncbi Differential expression of chemokine receptors on peripheral blood, synovial fluid, and synovial tissue monocytes/macrophages in rheumatoid arthritis
    K J Katschke
    Northwestern University Medical School, Chicago, Illinois 60611, USA
    Arthritis Rheum 44:1022-32. 2001
    ..The differential expression of chemokine receptors suggests that certain receptors aid in monocyte recruitment from the circulation while others are important in monocyte retention in the joint...
  11. ncbi Expression of chemokine receptors by lung T cells from normal and asthmatic subjects
    J J Campbell
    Institute for Lung Health and Division of Respiratory Medicine, Leicester University School of Medicine, Leicester, United Kingdom
    J Immunol 166:2842-8. 2001
    ....
  12. ncbi T cell phenotypes of the normal nasal mucosa: induction of Th2 cytokines and CCR3 expression by IL-4
    S Till
    Upper Respiratory Medicine, National Heart and Lung Institute Division, and Leukocyte Biology Section, Biomedical Sciences Division, Imperial College School of Medicine, London, United Kingdom
    J Immunol 166:2303-10. 2001
    ..In contrast, T cell expression of CCR1 was higher in the nose than in the blood regardless of the culture medium cytokine environment in keeping with a role for this receptor in tissue homing or lymphocyte activation...
  13. ncbi Chemokine and chemokine receptor interactions provide a mechanism for selective T cell recruitment to specific liver compartments within hepatitis C-infected liver
    P L Shields
    Liver Research Laboratories and Department of Rheumatology, Medical Research Council Centre for Immune Regulation, University of Birmingham, Birmingham, United Kingdom
    J Immunol 163:6236-43. 1999
    ....
  14. ncbi The chemokine receptor CCR4 in vascular recognition by cutaneous but not intestinal memory T cells
    J J Campbell
    Department of Pathology, Stanford University School of Medicine, California 94305, USA
    Nature 400:776-80. 1999
    ..Our results suggest that CCR4 and TARC are important in the recognition of skin vasculature by circulating T cells and in directing lymphocytes that are involved in systemic as opposed to intestinal immunity to their target tissues...
  15. pmc Interleukin-8 receptor modulates IgE production and B-cell expansion and trafficking in allergen-induced pulmonary inflammation
    G T De Sanctis
    Combined Program in Pulmonary and Critical Care Medicine, Brigham and Women s Hospital and Harvard Medical School, Boston, Massachusetts 02115
    J Clin Invest 103:507-15. 1999
    ..The data demonstrate that the IL-8r modulates IgE production, airway responsiveness, and the composition of the cells (B cells and neutrophils) recruited to the airway lumen in response to antigen...
  16. ncbi Differential expression of chemokines and chemokine receptors shapes the inflammatory response in rejecting human liver transplants
    S Goddard
    Liver Research Laboratories, MRC Centre for Immune Regulation, The University of Birmingham, UK
    Transplantation 72:1957-67. 2001
    ..Although ligands for the receptors CXCR3 and CCR5 are important for recruitment, the restriction of SDF to bile ducts suggests that CXCR4 may be involved in the retention of alloactivated lymphocytes at sites of graft damage...
  17. ncbi Chemokine-receptor expression on T cells in lung compartments of challenged asthmatic patients
    T Kallinich
    Department of Pediatric Pneumology and Immunology, Charite Campus Virchow Klinikum, Humboldt University, Berlin, Germany
    Clin Exp Allergy 35:26-33. 2005
    ..The interaction of chemokines with their receptors strongly influences the migration of leucocytes...
  18. pmc An antagonist of retinoic acid receptors more effectively inhibits growth of human prostate cancer cells than normal prostate epithelium
    R G Keedwell
    Divisions of Immunity and Infection, University of Birmingham Medical School, Edgbaston, Birmingham B15 2TT, UK
    Br J Cancer 91:580-8. 2004
    ..The ability of AGN 194310 to induce apoptosis of prostate cancer cells and its differential effect on malignant and normal prostate epithelial cells suggests that this compound may be useful in the treatment of prostate cancer...
  19. ncbi [Antigen presentation of eosinophils in mice]
    H Shi
    Respiratory Department, First Affiliated Hospital, Guangxi Medical University, Nanning 530021, China
    Zhonghua Yi Xue Za Zhi 81:544-8. 2001
    ..CONCLUSIONS: Eosinophils within the lumina of airways can process inhaled antigens, traffick to regional lymph nodes and function in vivo as antigen-presenting cells to stimulate responses of CD4(+) T cells...
  20. ncbi [Cytotoxic T lymphocyte activity induced by genetic immunization with NV-HC/NS]
    L Zhao
    Key Laboratory of Molecular Biology for Infectious Diseases of Sichuan Province, First University Hospital, West China Medical Center, Sichuan University, Chengdu 610041, China
    Zhonghua Gan Zang Bing Za Zhi 9:203-5. 2001
    ..CONCLUSIONS: Specific immune activity could be induced by immunization with NV-HC/NS(3). Such effects are immunoprophylactic and immunotherapeutic...
  21. pmc The beta-chemokine receptor D6 is expressed by lymphatic endothelium and a subset of vascular tumors
    R J Nibbs
    Cancer Research Campaign Laboratories, The Beatson Institute for Cancer Research, Garscube Estate, Switchback Rd, Bearsden, Glasgow G61 1BD Scotland
    Am J Pathol 158:867-77. 2001
    ....
  22. pmc A comprehensive approach toward novel serum biomarkers for benign prostatic hyperplasia: the MPSA Consortium
    Chris Mullins
    National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, Maryland, USA
    J Urol 179:1243-56. 2008
    ....