Rong Qi

Summary

Publications

  1. pmc PEG-conjugated PAMAM dendrimers mediate efficient intramuscular gene expression
    Rong Qi
    Peking University Institute of Cardiovascular Sciences, Peking University Health Science Center, Peking University, Beijing, China
    AAPS J 11:395-405. 2009
  2. doi request reprint G5 PAMAM dendrimer versus liposome: a comparison study on the in vitro transepithelial transport and in vivo oral absorption of simvastatin
    Rong Qi
    Peking University Institute of Cardiovascular Sciences, Peking University, Beijing, China Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, China Electronic address
    Nanomedicine 11:1141-51. 2015
  3. doi request reprint Recent Advances in Dendrimer Research for Cardiovascular Diseases
    Maomao Yu
    Peking University Institute of Cardiovascular Sciences, Peking University Health Science Center, Beijing 100191, China
    Biomacromolecules 16:2588-98. 2015
  4. pmc Efficient in vitro siRNA delivery and intramuscular gene silencing using PEG-modified PAMAM dendrimers
    Yin Tang
    Peking University Institute of Cardiovascular Sciences, Peking University Health Science Center, Peking University, 38 Xueyuan Road, Beijing, 100083, China
    Mol Pharm 9:1812-21. 2012
  5. doi request reprint Aggravated restenosis and atherogenesis in ApoCIII transgenic mice but lack of protection in ApoCIII knockouts: the effect of authentic triglyceride-rich lipoproteins with and without ApoCIII
    Haibo Li
    Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Peking University Health Science Center, Beijing 100191, China
    Cardiovasc Res 107:579-89. 2015
  6. pmc Oral absorption enhancement of probucol by PEGylated G5 PAMAM dendrimer modified nanoliposomes
    Qian Ma
    Peking University Institute of Cardiovascular Sciences, Peking University Health Science Center, Peking University, Beijing 100191, China
    Mol Pharm 12:665-74. 2015
  7. doi request reprint Protective effects and mechanisms of G5 PAMAM dendrimers against acute pancreatitis induced by caerulein in mice
    Yin Tang
    Peking University Institute of Cardiovascular Sciences, Peking University Health Science Center, Beijing, China
    Biomacromolecules 16:174-82. 2015
  8. doi request reprint G5-PEG PAMAM dendrimer incorporating nanostructured lipid carriers enhance oral bioavailability and plasma lipid-lowering effect of probucol
    Rong Qi
    Peking University Institute of Cardiovascular Sciences, Peking University Health Science Center, Peking University, Beijing 100191, China Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, China Electronic address
    J Control Release 210:160-8. 2015
  9. pmc The role of caveolin-1 and syndecan-4 in the internalization of PEGylated PAMAM dendrimer polyplexes into myoblast and hepatic cells
    Wenwen Shen
    Peking University Institute of Cardiovascular Sciences, Peking University Health Science Center, Beijing, China Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, China
    Eur J Pharm Biopharm 88:658-63. 2014
  10. doi request reprint Reduced high density lipoprotein cholesterol in severe hypertriglyceridemic ApoCIII transgenic mice via lowered hepatic ApoAI synthesis
    Yingchun Han
    Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Peking University Health Science Center, Beijing, 100191, China
    Biochem Biophys Res Commun 462:420-5. 2015

Collaborators

  • Qiang Zhang
  • Siling Wang
  • Yun He
  • Yu Gao
  • Wei Huang
  • Lu Liu
  • Yingchun Han
  • George Liu
  • Maomao Yu
  • Yin Tang
  • Wenwen Shen
  • Mark M Banaszak Holl
  • Lu Xu
  • Qian Ma
  • Huayu Zhang
  • Yuhui Wang
  • Cong Chen
  • Haibo Li
  • Yini Cao
  • Yanzhi Li
  • Mallory A van Dongen
  • Brian Rodrigues
  • Ya Nan Shu
  • Bing He
  • Xu Jie
  • Xinfeng Liu
  • Yunan Wang
  • Mei Han
  • Xiaohong Zhang
  • Mengyu Wang
  • Wanli Shen
  • Guan Lian
  • Xin Cui
  • Danielle M Zurcher
  • Mallory van Dongen
  • Bo Wang
  • Ri Yuan Lin
  • Xiao Yan Gu
  • Yang Bing Li

Detail Information

Publications12

  1. pmc PEG-conjugated PAMAM dendrimers mediate efficient intramuscular gene expression
    Rong Qi
    Peking University Institute of Cardiovascular Sciences, Peking University Health Science Center, Peking University, Beijing, China
    AAPS J 11:395-405. 2009
    ..Therefore, G5-8% PEG and G6-8% PEG possess a great potential for gene delivery both in vivo and in vitro...
  2. doi request reprint G5 PAMAM dendrimer versus liposome: a comparison study on the in vitro transepithelial transport and in vivo oral absorption of simvastatin
    Rong Qi
    Peking University Institute of Cardiovascular Sciences, Peking University, Beijing, China Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, China Electronic address
    Nanomedicine 11:1141-51. 2015
    ..The overall better oral absorption of SMV-liposomes as compared to SMV/G5-NH2 molecular complexes appeared to arise from better liposomal solubilization and encapsulation of SMV and more efficient intracellular SMV delivery...
  3. doi request reprint Recent Advances in Dendrimer Research for Cardiovascular Diseases
    Maomao Yu
    Peking University Institute of Cardiovascular Sciences, Peking University Health Science Center, Beijing 100191, China
    Biomacromolecules 16:2588-98. 2015
    ....
  4. pmc Efficient in vitro siRNA delivery and intramuscular gene silencing using PEG-modified PAMAM dendrimers
    Yin Tang
    Peking University Institute of Cardiovascular Sciences, Peking University Health Science Center, Peking University, 38 Xueyuan Road, Beijing, 100083, China
    Mol Pharm 9:1812-21. 2012
    ..We further demonstrated in vivo that intramuscular delivery of GFP-siRNA using PEG-modified dendrimer significantly suppressed GFP expression in both transiently adenovirus infected C57BL/6 mice and GFP transgenic mice...
  5. doi request reprint Aggravated restenosis and atherogenesis in ApoCIII transgenic mice but lack of protection in ApoCIII knockouts: the effect of authentic triglyceride-rich lipoproteins with and without ApoCIII
    Haibo Li
    Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Peking University Health Science Center, Beijing 100191, China
    Cardiovasc Res 107:579-89. 2015
    ..We sought to investigate ApoCIII in restenosis and clarify how smooth muscle cells (SMCs) respond to authentic triglyceride-rich lipoproteins (TRLs) with or without ApoCIII (TRLs ± ApoCIII)...
  6. pmc Oral absorption enhancement of probucol by PEGylated G5 PAMAM dendrimer modified nanoliposomes
    Qian Ma
    Peking University Institute of Cardiovascular Sciences, Peking University Health Science Center, Peking University, Beijing 100191, China
    Mol Pharm 12:665-74. 2015
    ..Our results demonstrated that PB-liposome/G5-PEG significantly increased the oral absorption of PB and therefore significantly improved its pharmacodynamic effects. ..
  7. doi request reprint Protective effects and mechanisms of G5 PAMAM dendrimers against acute pancreatitis induced by caerulein in mice
    Yin Tang
    Peking University Institute of Cardiovascular Sciences, Peking University Health Science Center, Beijing, China
    Biomacromolecules 16:174-82. 2015
    ....
  8. doi request reprint G5-PEG PAMAM dendrimer incorporating nanostructured lipid carriers enhance oral bioavailability and plasma lipid-lowering effect of probucol
    Rong Qi
    Peking University Institute of Cardiovascular Sciences, Peking University Health Science Center, Peking University, Beijing 100191, China Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, China Electronic address
    J Control Release 210:160-8. 2015
    ..Therefore, G5-PEG incorporating NLC can be exploited as a promising drug delivery system to improve oral bioavailability and lipid-lowering effect of PB. ..
  9. pmc The role of caveolin-1 and syndecan-4 in the internalization of PEGylated PAMAM dendrimer polyplexes into myoblast and hepatic cells
    Wenwen Shen
    Peking University Institute of Cardiovascular Sciences, Peking University Health Science Center, Beijing, China Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, China
    Eur J Pharm Biopharm 88:658-63. 2014
    ..This study gives a clue how to take strategies by up- or down-regulation of the expressions of syndecan-4 and caveolin-1 to improve in vivo gene delivery efficiency of the PEG-PAMAM dendrimers in clinical transgenic therapy...
  10. doi request reprint Reduced high density lipoprotein cholesterol in severe hypertriglyceridemic ApoCIII transgenic mice via lowered hepatic ApoAI synthesis
    Yingchun Han
    Institute of Cardiovascular Sciences and Key Laboratory of Molecular Cardiovascular Sciences, Ministry of Education, Peking University Health Science Center, Beijing, 100191, China
    Biochem Biophys Res Commun 462:420-5. 2015
    ..Further examination demonstrated that hepatic but not intestinal ApoAI mRNA was significantly reduced. Therefore, the decreased ApoAI synthesis might be accounted for the lower plasma HDL level in ApoCIII transgenic mice. ..
  11. pmc The mechanism of polyplex internalization into cells: testing the GM1/caveolin-1 lipid raft mediated endocytosis pathway
    Rong Qi
    Peking University Institute of Cardiovascular Sciences, Peking University Health Science Center, Peking University, Beijing 100083, China
    Mol Pharm 7:267-79. 2010
    ..Cholera toxin B subunit was employed as a positive control for uptake in all cases. No evidence was found for a GM1/caveolin-1 lipid raft mediated endocytosis mechanism for the generation 5 and 7 poly(amidoamine) dendrimer polyplexes...
  12. ncbi request reprint Recent advances of dendrimers in delivery of genes and drugs
    Yu Gao
    Institute of Cardiovascular Science, Peking University, Beijing, P R China
    Mini Rev Med Chem 8:889-900. 2008
    ..In the paper the recent advances of dendrimer in gene transfer vehicles and drug delivery are separately reviewed. These advances illustrate the direction of the future development of dendrimers...