Fernanda Marques

Summary

Affiliation: University of Minho
Country: Portugal

Publications

  1. doi request reprint The choroid plexus in health and in disease: dialogues into and out of the brain
    Fernanda Marques
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Braga, Portugal ICVS 3B s PT Government Associate Laboratory, Braga Guimarães, Portugal Electronic address
    Neurobiol Dis . 2016
  2. pmc Lipocalin-2 is involved in emotional behaviors and cognitive function
    Ana C Ferreira
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho Braga, Portugal ICVS 3B s PT Government Associate Laboratory Braga Guimarães, Portugal
    Front Cell Neurosci 7:122. 2013
  3. pmc Modulation of iron metabolism in aging and in Alzheimer's disease: relevance of the choroid plexus
    Sandro D Mesquita
    School of Health Sciences, Life and Health Sciences Research Institute ICVS, University of Minho Braga, Portugal
    Front Cell Neurosci 6:25. 2012
  4. pmc The Adhesion GPCR GPR125 is specifically expressed in the choroid plexus and is upregulated following brain injury
    Chris Pickering
    Uppsala University, Department of Neuroscience, Functional Pharmacology, BMC, Box 593, SE 75124, Uppsala, Sweden
    BMC Neurosci 9:97. 2008
  5. pmc The choroid plexus response to a repeated peripheral inflammatory stimulus
    Fernanda Marques
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Campus Gualtar, 4710 057 Braga, Portugal
    BMC Neurosci 10:135. 2009
  6. doi request reprint Kinetic profile of the transcriptome changes induced in the choroid plexus by peripheral inflammation
    Fernanda Marques
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Campus Gualtar, Braga, Portugal
    J Cereb Blood Flow Metab 29:921-32. 2009
  7. ncbi request reprint Lipocalin 2 is a choroid plexus acute-phase protein
    Fernanda Marques
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Campus Gualtar, Braga, Portugal
    J Cereb Blood Flow Metab 28:450-5. 2008
  8. doi request reprint The choroid plexus transcriptome reveals changes in type I and II interferon responses in a mouse model of Alzheimer's disease
    Sandro Dá Mesquita
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Campus Gualtar, 4710 057 Braga, Portugal ICVS 3B s PT Government Associate Laboratory, Braga Guimarães, Portugal
    Brain Behav Immun 49:280-92. 2015
  9. doi request reprint Unbiased stereological method to assess proliferation throughout the subependymal zone
    Ana Mendanha Falcão
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Braga, Portugal
    Methods Mol Biol 1035:141-52. 2013
  10. pmc Neudesin is involved in anxiety behavior: structural and neurochemical correlates
    Ashley Novais
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho Braga, Portugal ICVS 3B s PT Government Associate Laboratory Braga Guimarães, Portugal
    Front Behav Neurosci 7:119. 2013

Collaborators

  • Nuno Sousa
  • Joana A Palha
  • Giovanni Coppola
  • Daniel H Geschwind
  • Jens Pahnke
  • Helena Brentani
  • Rui Mata
  • João Carlos Sousa
  • Ana C Ferreira
  • João C Sousa
  • Sandro Dá Mesquita
  • Ana Mendanha Falcão
  • Margarida Correia-Neves
  • Ashley Novais
  • João J Cerqueira
  • Ana Catarina Ferreira
  • José M Pêgo
  • Luis R Jacinto
  • Vitor H Pereira
  • Liliana R Pires
  • Gabriela Tavares
  • Fábio G Teixeira
  • Pedro Morgado
  • Christina Dalla
  • Osborne F X Almeida
  • Ana J Rodrigues
  • Sandro D Mesquita
  • Ana P Ventura-Silva
  • Chris Pickering
  • Vânia Lages
  • Rita Assunção-Silva
  • Filipa G Pereira
  • João Cerqueira
  • João Filipe Oliveira
  • Sofia Pereira das Neves
  • Joana Sofia Correia
  • Manuella Martins
  • Antonio J Salgado
  • Alexandre Patchev
  • Rui Lima
  • Inês Mendes Pinto
  • Sónia Guerra-Gomes
  • Joana Almeida-Palha
  • Nuno A Silva
  • Eduardo D Gomes
  • Vanessa Morais Sardinha
  • Natália L Vasconcelos
  • Fuying Gao
  • Nikos Kokras
  • Hugo Leite-Almeida
  • Beatriz Ribeiro
  • Nikolaos Kokras
  • Ana David-Pereira
  • Filipa L Campos
  • Vitor Pinto
  • Nadine C Santos
  • Ana R Marques
  • Malin C Lagerström
  • Robert Fredriksson
  • Linn Waller
  • Joanna Szmydynger-Chodobska
  • Helgi B Schioth
  • Maria Hägglund
  • Adam Chodobski
  • Isabel Cardoso
  • Maria Joao Saraiva
  • João José Cerqueira
  • Eduardo Dias-Ferreira

Detail Information

Publications28

  1. doi request reprint The choroid plexus in health and in disease: dialogues into and out of the brain
    Fernanda Marques
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Braga, Portugal ICVS 3B s PT Government Associate Laboratory, Braga Guimarães, Portugal Electronic address
    Neurobiol Dis . 2016
    ....
  2. pmc Lipocalin-2 is involved in emotional behaviors and cognitive function
    Ana C Ferreira
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho Braga, Portugal ICVS 3B s PT Government Associate Laboratory Braga Guimarães, Portugal
    Front Cell Neurosci 7:122. 2013
    ....
  3. pmc Modulation of iron metabolism in aging and in Alzheimer's disease: relevance of the choroid plexus
    Sandro D Mesquita
    School of Health Sciences, Life and Health Sciences Research Institute ICVS, University of Minho Braga, Portugal
    Front Cell Neurosci 6:25. 2012
    ....
  4. pmc The Adhesion GPCR GPR125 is specifically expressed in the choroid plexus and is upregulated following brain injury
    Chris Pickering
    Uppsala University, Department of Neuroscience, Functional Pharmacology, BMC, Box 593, SE 75124, Uppsala, Sweden
    BMC Neurosci 9:97. 2008
    ..We also identified a Drosophila sequence, DmCG15744, which shares a common ancestor with the entire Group III of Adhesion GPCRs, and also contains Ig, LRR and HBD domains which were observed in mammalian GPR125...
  5. pmc The choroid plexus response to a repeated peripheral inflammatory stimulus
    Fernanda Marques
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Campus Gualtar, 4710 057 Braga, Portugal
    BMC Neurosci 10:135. 2009
    ..As part of the barriers that separate the blood from the brain, the choroid plexus conveys inflammatory immune signals into the brain, largely through alterations in the composition of the cerebrospinal fluid...
  6. doi request reprint Kinetic profile of the transcriptome changes induced in the choroid plexus by peripheral inflammation
    Fernanda Marques
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Campus Gualtar, Braga, Portugal
    J Cereb Blood Flow Metab 29:921-32. 2009
    ..By modulating the composition of the cerebrospinal fluid, which will ultimately influence the brain parenchyma, the choroid plexus response to inflammation may be of relevance in brain homeostasis in health and disease...
  7. ncbi request reprint Lipocalin 2 is a choroid plexus acute-phase protein
    Fernanda Marques
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Campus Gualtar, Braga, Portugal
    J Cereb Blood Flow Metab 28:450-5. 2008
    ..This study shows that the LCN2 is produced by the CP as a component of the innate immune response that protects the central nervous system from infection...
  8. doi request reprint The choroid plexus transcriptome reveals changes in type I and II interferon responses in a mouse model of Alzheimer's disease
    Sandro Dá Mesquita
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Campus Gualtar, 4710 057 Braga, Portugal ICVS 3B s PT Government Associate Laboratory, Braga Guimarães, Portugal
    Brain Behav Immun 49:280-92. 2015
    ..Altogether, these findings provide new insights on a possible interplay between type I and II IFN responses in AD and point to IFNs as targets for modulation in cognitive decline. ..
  9. doi request reprint Unbiased stereological method to assess proliferation throughout the subependymal zone
    Ana Mendanha Falcão
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Braga, Portugal
    Methods Mol Biol 1035:141-52. 2013
    ..This approach takes into consideration clear SEZ anatomical divisions, both on the anterior-posterior and dorsal-ventral axes, which will standardize future studies on the SEZ. ..
  10. pmc Neudesin is involved in anxiety behavior: structural and neurochemical correlates
    Ashley Novais
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho Braga, Portugal ICVS 3B s PT Government Associate Laboratory Braga Guimarães, Portugal
    Front Behav Neurosci 7:119. 2013
    ..These findings lead us to suggest that neudesin is a novel relevant player in the maintenance of the anxiety circuitry. ..
  11. ncbi request reprint Transthyretin influences spatial reference memory
    João Carlos Sousa
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Campus de Gualtar, 4710 057 Braga, Portugal
    Neurobiol Learn Mem 88:381-5. 2007
    ..As a result, no significant differences were found in this spatial reference task in old mice. Our data show that the absence of TTR seems to accelerate the poorer cognitive performance normally associated with aging...
  12. doi request reprint From the periphery to the brain: Lipocalin-2, a friend or foe?
    Ana C Ferreira
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Braga, Portugal ICVS 3B s PT Government Associate Laboratory, Braga Guimarães, Portugal
    Prog Neurobiol 131:120-36. 2015
    ..Herein, these various perspectives are reviewed and a comprehensive and cohesive view of the general function of LCN2, particularly in the brain, is provided. ..
  13. pmc Transcriptome signature of the adult mouse choroid plexus
    Fernanda Marques
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Campus Gualtar, 4710 057 Braga, Portugal
    Fluids Barriers CNS 8:10. 2011
    ..A better characterization of the CP transcriptome can provide key insights into its functions as one of the barriers that separate the brain from the periphery and in the production of cerebrospinal fluid...
  14. doi request reprint Stress shifts the response of the bed nucleus of the stria terminalis to an anxiogenic mode
    Ana P Ventura-Silva
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Campus de Gualtar, 4710 057 Braga, Portugal
    Eur J Neurosci 36:3396-406. 2012
    ..In summary, these data reveal that chronic stress shifts the pattern of response of the BNST to an anxiogenic mode and provide new information on the underlying mechanisms of the stress-induced hypercorticalism and hyperanxious status...
  15. doi request reprint Insights on the pathophysiology of Alzheimer's disease: The crosstalk between amyloid pathology, neuroinflammation and the peripheral immune system
    Sandro Dá Mesquita
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Campus Gualtar, 4710 057 Braga, Portugal ICVS 3B s PT Government Associate Laboratory, Braga, Guimaraes, Portugal
    Neurosci Biobehav Rev 68:547-62. 2016
    ..Herein, we scrutinize some important traits of the pathophysiology of aging and AD, focusing on the interplay between the amyloidogenic pathway, neuroinflammation and the peripheral immune system. ..
  16. pmc The path from the choroid plexus to the subventricular zone: go with the flow!
    Ana Mendanha Falcão
    School of Health Sciences, Life and Health Sciences Research Institute ICVS, University of Minho Braga, Portugal
    Front Cell Neurosci 6:34. 2012
    ..By giving particular emphasizes to growth factors and axonal guidance molecules we will illustrate how CP-born molecules might play an important role in the SVZ niche cell population dynamics...
  17. pmc Lipocalin 2 is present in the EAE brain and is modulated by natalizumab
    Fernanda Marques
    School of Health Sciences, Life and Health Sciences Research Institute ICVS, University of Minho Braga, Portugal
    Front Cell Neurosci 6:33. 2012
    ..The findings support lipocalin 2 as a valuable molecule for the diagnostic/monitoring panel of MS...
  18. pmc Blood-brain-barriers in aging and in Alzheimer's disease
    Fernanda Marques
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Campus Gualtar, Braga 4710 057, Portugal
    Mol Neurodegener 8:38. 2013
    ..Herein, we provide a review on how the brain barriers change during aging and in AD and how these processes impact on brain function. ..
  19. doi request reprint Stress induced risk-aversion is reverted by D2/D3 agonist in the rat
    Pedro Morgado
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Braga, Portugal ICVS 3Bs PT Government Associate Laboratory, Braga, Guimaraes, Portugal
    Eur Neuropsychopharmacol 25:1744-52. 2015
    ..These results suggest that the brain mechanisms related to risk-based decision-making are altered after chronic stress, but can be modulated by manipulation of dopaminergic transmission...
  20. pmc Topographical analysis of the subependymal zone neurogenic niche
    Ana Mendanha Falcão
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Braga, Portugal
    PLoS ONE 7:e38647. 2012
    ..Herein we propose an anatomical division of the SEZ that should be considered in future studies addressing proliferation in this neural stem cell niche...
  21. pmc Glucose intolerance after chronic stress is related with downregulated PPAR-γ in adipose tissue
    Vitor H Pereira
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Campus de Gualtar, 4710 057, Braga, Portugal
    Cardiovasc Diabetol 15:114. 2016
    ..With the aim of gaining insights into the latter, this study examined the metabolic profile of young adult male rats that were exposed to chronic unpredictable stress...
  22. doi request reprint Detection of the glucocorticoid receptors in brain protein extracts by SDS-PAGE
    Fernanda Marques
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Campus Gualtar, Braga, 4710 057, Portugal
    Methods Mol Biol 1204:233-42. 2014
    ..Here, we describe the detection by Western blotting of the GR (α and β isoforms) protein, using macrodissected brain tissue. ..
  23. pmc Do genes and environment meet to regulate cerebrospinal fluid dynamics? Relevance for schizophrenia
    Joana A Palha
    Life and Health Sciences Research Institute, School of Health Sciences, University of Minho Braga, Portugal
    Front Cell Neurosci 6:31. 2012
    ..Here we propose that altered CP/CSF dynamics during neurodevelopment may be considered a risk, causative and/or participating factor for development of schizophrenia...
  24. doi request reprint Bioengineered cell culture systems of central nervous system injury and disease
    Fábio G Teixeira
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Braga, Portugal ICVS 3B s, PT Government Associate Laboratory, Braga Guimarães, Portugal
    Drug Discov Today 21:1456-63. 2016
    ..Given the importance of such systems for the future of CNS-related research, we discuss here the most recent advances in the field, particularly those dealing with neurodegeneration, neurodevelopmental disorders, and trauma. ..
  25. doi request reprint The habenula as a critical node in chronic stress-related anxiety
    Luis R Jacinto
    Life and Health Sciences Research Institute, University of Minho Campus de Gualtar, 4710 057 Braga, Portugal ICVS 3B s PT Government Associate Laboratory, Braga Guimarães, Portugal
    Exp Neurol . 2016
    ..This study highlights the role of the habenula in the stress responses and how its sub-regions are structurally impacted by chronic stress with physiological and behavioral consequences...
  26. pmc Nano- and micro-based systems for immunotolerance induction in multiple sclerosis
    Liliana R Pires
    a International Iberian Nanotechnology Laboratory, Braga, Portugal
    Hum Vaccin Immunother 12:1886-90. 2016
    ..Microneedle patches for the delivery of specific antigens to restore immunotolerance in the context of multiple sclerosis. ..
  27. ncbi request reprint Employing an open-source tool to assess astrocyte tridimensional structure
    Gabriela Tavares
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Campus de Gualtar, 4710 057, Braga, Portugal
    Brain Struct Funct . 2016
    ..While SNT is simple to learn, and does not require advanced computational skills, it provides reproducible results, in different brain regions or pathophysiological states...
  28. ncbi request reprint Transthyretin and Alzheimer's disease: where in the brain?
    João Carlos Sousa
    Life and Health Sciences Research Institute ICVS, School of Health Sciences, University of Minho, Campus Gualtar, 4710 057 Braga, Portugal
    Neurobiol Aging 28:713-8. 2007
    ..The relevance of TTR to AD should now take into consideration TTR production by the choroid plexus and its ability, in the CSF, to sequester the amyloid beta peptide...