Raquel Seruca

Summary

Affiliation: Institute of Molecular Pathology and Immunology
Country: Portugal

Publications

  1. pmc Dissecting the signaling pathways associated with the oncogenic activity of MLK3 P252H mutation
    Sergia Velho
    Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Rua Dr, Roberto Frias, 4200 465 Porto, Portugal
    BMC Cancer 14:182. 2014
  2. doi request reprint Therapeutic targets associated to E-cadherin dysfunction in gastric cancer
    Patrícia Carneiro
    IPATIMUP, Institute of Molecular Pathology and Immunology of the University of Porto, Rua Dr Roberto Frias s n, 4200 465 Porto, Portugal 00351 225570700 00351 225570799
    Expert Opin Ther Targets 17:1187-201. 2013
  3. pmc Genetic screening for familial gastric cancer
    Carla Oliveira
    Instituto de Patologia e Imunologia Molecular da Universidade do Porto IPATIMUP, Porto, Portugal
    Hered Cancer Clin Pract 2:51-64. 2004
  4. pmc BRAF, KRAS and PIK3CA mutations in colorectal serrated polyps and cancer: primary or secondary genetic events in colorectal carcinogenesis?
    Sergia Velho
    Institute of Molecular Pathology and Immunology, University of Porto, Portugal
    BMC Cancer 8:255. 2008
  5. doi request reprint P-cadherin functional role is dependent on E-cadherin cellular context: a proof of concept using the breast cancer model
    Ana Sofia Ribeiro
    IPATIMUP, Institute of Molecular Pathology and Immunology of the University of Porto, Rua Dr Roberto Frias s n, Porto, Portugal
    J Pathol 229:705-18. 2013
  6. doi request reprint Tumor necrosis factor alpha extended haplotypes and risk of gastric carcinoma
    Paulo Canedo
    IPATIMUP Institute of Molecular Pathology and Immunology, Porto, Portugal
    Cancer Epidemiol Biomarkers Prev 17:2416-20. 2008
  7. doi request reprint Quantification of epigenetic and genetic 2nd hits in CDH1 during hereditary diffuse gastric cancer syndrome progression
    Carla Oliveira
    Institute of Molecular Pathology and Immunology, University of Porto IPATIMUP, Porto, Portugal
    Gastroenterology 136:2137-48. 2009
  8. ncbi request reprint A proinflammatory genetic profile increases the risk for chronic atrophic gastritis and gastric carcinoma
    Jose Carlos Machado
    Institute of Molecular Pathology and Immunology of the University of Porto, Rua Dr Roberto Frias, S N, 4200 465 Porto, Portugal
    Gastroenterology 125:364-71. 2003
  9. doi request reprint E-cadherin mutations and cell motility: a genotype-phenotype correlation
    Ana Rita Mateus
    Institute of Molecular Pathology and Immunology of the University of Porto IPATIMUP, 4200 465 Porto, Portugal
    Exp Cell Res 315:1393-402. 2009
  10. ncbi request reprint Concomitant RASSF1A hypermethylation and KRAS/BRAF mutations occur preferentially in MSI sporadic colorectal cancer
    Carla Oliveira
    Institute of Molecular Pathology and Immunology of the University of Porto, Rua Roberto Frias s n, Porto 4200 465, Portugal
    Oncogene 24:7630-4. 2005

Detail Information

Publications76

  1. pmc Dissecting the signaling pathways associated with the oncogenic activity of MLK3 P252H mutation
    Sergia Velho
    Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Rua Dr, Roberto Frias, 4200 465 Porto, Portugal
    BMC Cancer 14:182. 2014
    ..Nevertheless, the molecular mechanism underlying the oncogenic activity of P252H mutant remained elusive...
  2. doi request reprint Therapeutic targets associated to E-cadherin dysfunction in gastric cancer
    Patrícia Carneiro
    IPATIMUP, Institute of Molecular Pathology and Immunology of the University of Porto, Rua Dr Roberto Frias s n, 4200 465 Porto, Portugal 00351 225570700 00351 225570799
    Expert Opin Ther Targets 17:1187-201. 2013
    ..Emerging evidence established E-cadherin as a tumor suppressor and suggests that targeting E-cadherin or downstream signaling molecules may constitute effective cancer therapeutics...
  3. pmc Genetic screening for familial gastric cancer
    Carla Oliveira
    Instituto de Patologia e Imunologia Molecular da Universidade do Porto IPATIMUP, Porto, Portugal
    Hered Cancer Clin Pract 2:51-64. 2004
    ..This knowledge is a fundamental step towards accurate genetic counselling, in which a highly specialised pre-symptomatic therapeutic intervention should be offered...
  4. pmc BRAF, KRAS and PIK3CA mutations in colorectal serrated polyps and cancer: primary or secondary genetic events in colorectal carcinogenesis?
    Sergia Velho
    Institute of Molecular Pathology and Immunology, University of Porto, Portugal
    BMC Cancer 8:255. 2008
    ..In the series of polyps CIMP, MLH1 methylation and MSI were also studied...
  5. doi request reprint P-cadherin functional role is dependent on E-cadherin cellular context: a proof of concept using the breast cancer model
    Ana Sofia Ribeiro
    IPATIMUP, Institute of Molecular Pathology and Immunology of the University of Porto, Rua Dr Roberto Frias s n, Porto, Portugal
    J Pathol 229:705-18. 2013
    ..Our results show a role for E- and P-cadherin co-expression in breast cancer progression and highlight the potential benefit of targeting P-cadherin in the aggressive tumours expressing high levels of this protein...
  6. doi request reprint Tumor necrosis factor alpha extended haplotypes and risk of gastric carcinoma
    Paulo Canedo
    IPATIMUP Institute of Molecular Pathology and Immunology, Porto, Portugal
    Cancer Epidemiol Biomarkers Prev 17:2416-20. 2008
    ..This suggests that the association between the TNFA-308G>A polymorphism and increased risk of gastric carcinoma is dependent on linkage disequilibrium with an as yet unidentified locus...
  7. doi request reprint Quantification of epigenetic and genetic 2nd hits in CDH1 during hereditary diffuse gastric cancer syndrome progression
    Carla Oliveira
    Institute of Molecular Pathology and Immunology, University of Porto IPATIMUP, Porto, Portugal
    Gastroenterology 136:2137-48. 2009
    ..We quantified the different 2nd hits in CDH1 occurring in neoplastic lesions from HDGC patients...
  8. ncbi request reprint A proinflammatory genetic profile increases the risk for chronic atrophic gastritis and gastric carcinoma
    Jose Carlos Machado
    Institute of Molecular Pathology and Immunology of the University of Porto, Rua Dr Roberto Frias, S N, 4200 465 Porto, Portugal
    Gastroenterology 125:364-71. 2003
    ..We also investigated the extent to which the combined effect of proinflammatory genetic polymorphisms (IL-1B, IL-1RN, and TNF-alpha), and the combined effect of TNF-alpha and bacterial genotypes each influence such a risk...
  9. doi request reprint E-cadherin mutations and cell motility: a genotype-phenotype correlation
    Ana Rita Mateus
    Institute of Molecular Pathology and Immunology of the University of Porto IPATIMUP, 4200 465 Porto, Portugal
    Exp Cell Res 315:1393-402. 2009
    ..Our results allowed the identification of the E-cadherin domains pivotal for cell motility, further demonstrated a genotype-phenotype correlation, and defined a subset of HDGC cases which may benefit from EGFR inhibitors...
  10. ncbi request reprint Concomitant RASSF1A hypermethylation and KRAS/BRAF mutations occur preferentially in MSI sporadic colorectal cancer
    Carla Oliveira
    Institute of Molecular Pathology and Immunology of the University of Porto, Rua Roberto Frias s n, Porto 4200 465, Portugal
    Oncogene 24:7630-4. 2005
    ....
  11. doi request reprint Epithelial E- and P-cadherins: role and clinical significance in cancer
    Joana Paredes
    University of Porto, Porto, Portugal
    Biochim Biophys Acta 1826:297-311. 2012
    ..In this review, we will discuss the major properties of E- and P-cadherin molecules, its regulation in normal tissue, and their alterations and role in cancer, with a specific focus on gastric and breast cancer models...
  12. doi request reprint Somatic mutations in mismatch repair genes in sporadic gastric carcinomas are not a cause but a consequence of the mutator phenotype
    Mafalda Pinto
    IPATIMUP Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Rua Roberto Frias, 4200 465 Porto, Portugal
    Cancer Genet Cytogenet 180:110-4. 2008
    ..Other MMR genes are probably involved in MSI-H gastric cancer without MLH1 hypermethylation...
  13. ncbi request reprint E-cadherin and adherens-junctions stability in gastric carcinoma: functional implications of glycosyltransferases involving N-glycan branching biosynthesis, N-acetylglucosaminyltransferases III and V
    Salomé S Pinho
    Institute of Molecular Pathology and Immunology of the University of Porto IPATIMUP, Rua Dr Roberto Frias s n, 4200 465 Porto, Portugal
    Biochim Biophys Acta 1830:2690-700. 2013
    ..We have previously demonstrated the existence of a bi-directional cross-talk between E-cadherin and two major N-glycan processing enzymes, N-acetylglucosaminyltransferase-III or -V (GnT-III or GnT-V)...
  14. ncbi request reprint E-Cadherin (CDH1) and p53 rather than SMAD4 and Caspase-10 germline mutations contribute to genetic predisposition in Portuguese gastric cancer patients
    Carla Oliveira
    Institute of Molecular Pathology and Immunology of the University of Porto IPATIMUP, Rua Roberto Frias, S N, 4200 465 Porto, Portugal
    Eur J Cancer 40:1897-903. 2004
    ..No evidence was found for a role of germline mutations in SMAD4 and Caspase-10 in families lacking CDH1 mutations...
  15. ncbi request reprint The prevalence of PIK3CA mutations in gastric and colon cancer
    Sergia Velho
    Institute of Molecular Pathology and Immunology of the University of Porto IPATIMUP, Portugal
    Eur J Cancer 41:1649-54. 2005
    ..016). In colorectal carcinoma, PIK3CA mutations occur preferentially together with activating KRAS-BRAF mutations (MSI and MSS) while in gastric carcinomas PIK3CA mutations tend to occur as isolated events (MSI)...
  16. ncbi request reprint A subset of colorectal carcinomas express c-KIT protein independently of BRAF and/or KRAS activation
    Ana Preto
    Institute of Molecular Pathology and Immunology of the University of Porto, Rua Dr Roberto Frias s n, 4200 465 Porto, Portugal
    Virchows Arch 450:619-26. 2007
    ..STI571/Gleevec increases apoptosis in CRC cell lines independently of its genetic profile, suggesting that STI571/Gleevec is likely to be an alternative drug for the clinical trials of CRC...
  17. doi request reprint Gastric cancer: adding glycosylation to the equation
    Salomé S Pinho
    Institute of Molecular Pathology and Immunology of the University of Porto IPATIMUP, Rua Dr Roberto Frias s n, 4200 465 Porto, Portugal Institute of Biomedical Sciences of Abel Salazar ICBAS, University of Porto, Rua de Jorge Viterbo Ferreira n 228, 4050 313 Porto, Portugal
    Trends Mol Med 19:664-76. 2013
    ..Applications of these glycosylation alterations in the clinical management of gastric cancer patients are discussed. ..
  18. doi request reprint E-cadherin dysfunction in gastric cancer--cellular consequences, clinical applications and open questions
    Patrícia Carneiro
    IPATIMUP, Institute of Molecular Pathology and Immunology of the University of Porto, Rua Dr Roberto Frias s n, Porto, Portugal
    FEBS Lett 586:2981-9. 2012
    ..Herein, we discuss E-cadherin alterations found in a cancer context, associated cellular effects and signalling pathways, and we raise new key questions that will impact in the management of GC patients and families...
  19. ncbi request reprint The interleukin-8-251*T/*A polymorphism is not associated with risk for gastric carcinoma development in a Portuguese population
    Paulo Canedo
    IPATIMUP, Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal
    Eur J Cancer Prev 17:28-32. 2008
    ..In conclusion our results indicate that although the IL8-251 polymorphism might be a relevant host susceptibility factor for gastric carcinoma development, this association is likely to be ethnic-specific...
  20. pmc CCAAT/enhancer binding protein β (C/EBPβ) isoforms as transcriptional regulators of the pro-invasive CDH3/P-cadherin gene in human breast cancer cells
    Andre Albergaria
    Cancer Genetics Group, Institute of Molecular Pathology and Immunology of Porto University IPATIMUP, Porto, Portugal
    PLoS ONE 8:e55749. 2013
    ..Taken together, our data show that CDH3 is a newly defined transcriptional target gene of C/EBPβ isoforms in breast cancer, and we also identified the binding sites that are relevant for this activation...
  21. doi request reprint Oncogenic mutations in gastric cancer with microsatellite instability
    Giovanni Corso
    Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal
    Eur J Cancer 47:443-51. 2011
    ....
  22. ncbi request reprint Role of pathology in the identification of hereditary diffuse gastric cancer: report of a Portuguese family
    Carla Oliveira
    Institute of Molecular Pathology and Immunology, University of Porto IPATIMUP, Rua Dr Roberto Frias s n, 4200 465, Porto, Portugal
    Virchows Arch 446:181-4. 2005
    ..We conclude that there are morphological hints that may help in the identification of HDGC...
  23. doi request reprint C/EBP alpha expression is associated with homeostasis of the gastric epithelium and with gastric carcinogenesis
    Gonçalo Regalo
    IPATIMUP Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal
    Lab Invest 90:1132-9. 2010
    ..In GC, loss of C/EBP alpha may be associated with the switch from a cellular differentiation to a cellular proliferation program, presumably as a consequence of Ras/MAPK pathway activation...
  24. doi request reprint Hereditary gastric cancer
    Carla Oliveira
    Institute of Molecular Pathology and Immunology of the University of Porto IPATIMUP, Porto, Portugal
    Best Pract Res Clin Gastroenterol 23:147-57. 2009
    ..In this chapter we review the pathophysiology and clinicopathological features of HDGC and discuss issues related with genetic testing and management of family members...
  25. pmc Epidermal growth factor receptor structural alterations in gastric cancer
    Catia Moutinho
    Instituto de Patologia e Imunologia Molecular da Universidade do Porto IPATIMUP, 4200 465 Porto, Portugal
    BMC Cancer 8:10. 2008
    ..Given its possible therapeutic relevance, we aimed to determine the frequency and type of structural alterations of the EGFR gene in a series of primary gastric carcinomas...
  26. pmc The importance of E-cadherin binding partners to evaluate the pathogenicity of E-cadherin missense mutations associated to HDGC
    Joana Figueiredo
    IPATIMUP, Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal
    Eur J Hum Genet 21:301-9. 2013
    ....
  27. ncbi request reprint Intragenic deletion of CDH1 as the inactivating mechanism of the wild-type allele in an HDGC tumour
    Carla Oliveira
    Institute of Molecular Pathology and Immunology of the University of Porto IPATIMUP, 4200 465 Porto, Portugal
    Oncogene 23:2236-40. 2004
    ..Our results show that a CDH1 intragenic deletion is the second hit inactivating the wild-type allele, in one of the tumours in this family...
  28. ncbi request reprint NOD2/CARD15 and TNFA, but not IL1B and IL1RN, are associated with Crohn's disease
    António Carlos Ferreira
    Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal
    Inflamm Bowel Dis 11:331-9. 2005
    ..The aim of this study was to determine the association of polymorphisms in the CARD15, TNFA, IL1B, and IL1RN genes with risk of development of CD and with the clinicopathological profile of CD patients...
  29. ncbi request reprint A model to infer the pathogenic significance of CDH1 germline missense variants
    Gianpaolo Suriano
    Institute of Molecular Pathology and Immunology, University of Porto IPATIMUP, Rua Dr Roberto Frias S N 4200 465, Porto, Portugal
    J Mol Med (Berl) 84:1023-31. 2006
    ..The model described in this study provides an important tool that can ultimately improve the genetic counseling offered to the carriers of the germline CDH1 missense variants...
  30. doi request reprint The role of N-acetylglucosaminyltransferase III and V in the post-transcriptional modifications of E-cadherin
    Salomé S Pinho
    Institute of Molecular Pathology and Immunology of the University of Porto IPATIMUP, Rua Dr Roberto Frias s n, 4200 465 Porto, Portugal
    Hum Mol Genet 18:2599-608. 2009
    ..This study opens new insights into the post-transcriptional modifications of E-cadherin in its biological function, in a tumor context...
  31. ncbi request reprint Model of the early development of diffuse gastric cancer in E-cadherin mutation carriers and its implications for patient screening
    Fatima Carneiro
    Institute of Molecular Pathology and Immunology of the University of Porto IPATIMUP, Porto, Portugal
    J Pathol 203:681-7. 2004
    ..An in situ precursor of signet ring carcinoma was identified and a model for neoplastic progression in the setting of HDGC is proposed...
  32. ncbi request reprint Distinct patterns of KRAS mutations in colorectal carcinomas according to germline mismatch repair defects and hMLH1 methylation status
    Carla Oliveira
    Institute of Molecular Pathology and Immunology, The University of Porto, IPATIMUP, 4200 465 Porto, Portugal
    Hum Mol Genet 13:2303-11. 2004
    ....
  33. pmc Mixed lineage kinase 3 gene mutations in mismatch repair deficient gastrointestinal tumours
    Sergia Velho
    IPATIMUP Institute of Molecular Pathology and Immunology of the University of Porto, 4200 465 Porto, Portugal
    Hum Mol Genet 19:697-706. 2010
    ..Further, we demonstrated that MLK3 missense mutations found in MSI gastrointestinal carcinomas are functionally relevant...
  34. ncbi request reprint Genetics, pathology, and clinics of familial gastric cancer
    Carla Oliveira
    Institute of Molecular Pathology and Immunology of the University of Porto IPATIMUP, Porto, Portugal
    Int J Surg Pathol 14:21-33. 2006
    ....
  35. ncbi request reprint BRAF mutations characterize colon but not gastric cancer with mismatch repair deficiency
    Carla Oliveira
    Instituto de Patologia e Imunologia Molecular da Universidade do Porto IPATIMUP, Porto 4200 465, Portugal
    Oncogene 22:9192-6. 2003
    ..Accordingly, our results show evidences that BRAF mutations characterize colon but not gastric tumors with MMR deficiency and are not involved in the tumorigenesis of gastric cancer of the mutator phenotype pathway...
  36. doi request reprint E-cadherin impairment increases cell survival through Notch-dependent upregulation of Bcl-2
    António Carlos Ferreira
    IPATIMUP Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal
    Hum Mol Genet 21:334-43. 2012
    ..These findings highlight the possibility of new targeted therapeutical strategies for the treatment of tumours associated with E-cadherin inactivation...
  37. pmc Loss and recovery of Mgat3 and GnT-III Mediated E-cadherin N-glycosylation is a mechanism involved in epithelial-mesenchymal-epithelial transitions
    Salomé S Pinho
    Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal
    PLoS ONE 7:e33191. 2012
    ....
  38. pmc Proliferation and survival molecules implicated in the inhibition of BRAF pathway in thyroid cancer cells harbouring different genetic mutations
    Ana Preto
    Institute of Molecular Pathology and Immunology of the University of Porto IPATIMUP, 4200 465, Porto, Portugal
    BMC Cancer 9:387. 2009
    ..In order to fill this lack of knowledge we studied the proliferation and survival pathways and associated molecules induced by BRAF inhibition in thyroid carcinoma cell lines harbouring distinct genetic backgrounds...
  39. doi request reprint CagA associates with c-Met, E-cadherin, and p120-catenin in a multiproteic complex that suppresses Helicobacter pylori-induced cell-invasive phenotype
    Maria Jose Oliveira
    Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal
    J Infect Dis 200:745-55. 2009
    ..We investigated whether E-cadherin has a role in H. pylori-induced, c-Met phosphorylation-dependent cell-invasive phenotype...
  40. ncbi request reprint EGFR regulates RhoA-GTP dependent cell motility in E-cadherin mutant cells
    Ana Rita Mateus
    Instituto de Patologia e Imunologia Molecular da Universidade do Porto IPATIMUP, 4200 465 Porto, Portugal
    Hum Mol Genet 16:1639-47. 2007
    ..Furthermore, we demonstrate that E-cadherin-dependent EGFR activation contributes to enhanced cell motility, in a mechanism involving RhoA activation...
  41. doi request reprint De novo expression of CD44 variants in sporadic and hereditary gastric cancer
    Cristiana Branco da Cunha
    IPATIMUP, Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal
    Lab Invest 90:1604-14. 2010
    ..Further, our results raise the hypothesis of using CD44v6 as a marker of early invasive intramucosal carcinoma in HDGC CDH1 mutation carriers that lack CDH1 expression in their tumors...
  42. pmc Intricate Macrophage-Colorectal Cancer Cell Communication in Response to Radiation
    Ana T Pinto
    I3S Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal
    PLoS ONE 11:e0160891. 2016
    ..Overall, the establishment of primary human macrophage-cancer cell co-cultures revealed an intricate cell communication in response to ionizing radiation, which should be considered when developing therapies adjuvant to radiotherapy. ..
  43. doi request reprint E-cadherin alterations in hereditary disorders with emphasis on hereditary diffuse gastric cancer
    Carla Oliveira
    Expression Regulation in Cancer Group, Institute of Molecular Pathology and Immunology of the University of Porto IPATIMUP, Porto, Portugal
    Prog Mol Biol Transl Sci 116:337-59. 2013
    ..In this chapter, we discuss CDH1-associated syndromes, frequency and type of CDH1 germline alterations, clinical criteria, and guidelines for genetic counseling, molecular pathology, and available animal/cell line models of the disease...
  44. ncbi request reprint Loss of functional E-cadherin renders cells more resistant to the apoptotic agent taxol in vitro
    Paulo Ferreira
    Instituto de Patologia e Imunologia Molecular da Universidade do Porto IPATIMUP, 4200 Porto, Portugal
    Exp Cell Res 310:99-104. 2005
    ..We found that in vitro functional E-cadherin renders cells more sensitive to the effect of taxol. Our results also indicate that this effect is associated to decreased level of the anti-apoptotic bcl-2 protein...
  45. doi request reprint CPEB1, a novel gene silenced in gastric cancer: a Drosophila approach
    Joana Caldeira
    Institute of Molecular Pathology and Immunology of University of Porto IPATIMUP, Porto, Portugal
    Gut 61:1115-23. 2012
    ..Although many genes have been implicated in its development, many cases remain genetically unexplained. Hence, there is an urgent need to find new disease-related genes...
  46. pmc ADP-ribosylation factor 6 mediates E-cadherin recovery by chemical chaperones
    Joana Figueiredo
    Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal
    PLoS ONE 6:e23188. 2011
    ..We propose that this influence should be taken into account when exploring the therapeutic potential of this type of chemicals in genetic diseases associated to protein-misfolding...
  47. doi request reprint MSI phenotype and MMR alterations in familial and sporadic gastric cancer
    Marina Leite
    Institute of Molecular Pathology and Immunology of the University of Porto, Portugal
    Int J Cancer 128:1606-13. 2011
    ..Moreover, we observed that the frequency of MLH1 hypermethylation is similar in sporadic and familial cases suggesting that in both settings MSI is not associated to MMR genetic alterations but in contrast to epigenetic deregulation...
  48. doi request reprint Endoplasmic reticulum quality control: a new mechanism of E-cadherin regulation and its implication in cancer
    Joana Simões-Correia
    IPATIMUP, Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal
    Hum Mol Genet 17:3566-76. 2008
    ..We show that ERQC plays a major role in E-cadherin regulation and propose that overcoming this regulation may represent an approach to rescue E-cadherin expression and functionality in cancer...
  49. pmc E-cadherin destabilization accounts for the pathogenicity of missense mutations in hereditary diffuse gastric cancer
    Joana Simões-Correia
    IPATIMUP Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal
    PLoS ONE 7:e33783. 2012
    ....
  50. doi request reprint P-cadherin is coexpressed with CD44 and CD49f and mediates stem cell properties in basal-like breast cancer
    André Filipe Vieira
    IPATIMUP Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal
    Stem Cells 30:854-64. 2012
    ..In summary, we demonstrated, for the first time, that P-cadherin mediates stem cell properties, which could be explored in order to better define the CSC phenotype of basal-like breast tumors and the cell-of-origin of this malignancy...
  51. ncbi request reprint Genetics of hereditary diffuse gastric cancer: progress and future challenges
    Gianpaolo Suriano
    Institute of Molecular Pathology and Immunology of the University of Porto, Rua Dr Roberto Frias S N 4200 465, Porto, Portugal
    Future Oncol 2:363-70. 2006
    ..Since most of the HDGC families reported to date are negative for E-cadherin germline mutations, the identification of alternative genes underlying the tumorigenesis of diffuse gastric has become an important target for research...
  52. ncbi request reprint MBD4 mutations are rare in gastric carcinomas with microsatellite instability
    Mafalda Pinto
    IPATIMUP Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Porto, Portugal
    Cancer Genet Cytogenet 145:103-7. 2003
    ..We conclude that MBD4 mutations in the entire coding sequence, including the two poly(A) tracts, are rare in MSI gastric carcinomas. MBD4 is likely to be a bystander target gene in MSI-H tumors...
  53. doi request reprint P-cadherin role in normal breast development and cancer
    Andre Albergaria
    Institute of Molecular Pathology and Immunology of the University of Porto, Rua Dr Roberto Frias s n, Porto, Portugal
    Int J Dev Biol 55:811-22. 2011
    ..In this review, the most important findings about the role of P-cadherin in normal breast development and cancer will be illustrated and discussed, with emphasis on the most recent data...
  54. pmc Crosstalk between Helicobacter pylori and gastric epithelial cells is impaired by docosahexaenoic acid
    Marta Correia
    Institute of Molecular Pathology and Immunology of the University of Porto IPATIMUP, Rua Dr Roberto Frias s n, Porto, Portugal
    PLoS ONE 8:e60657. 2013
    ..pylori-related inflammation...
  55. ncbi request reprint Promoter methylation of TGFbeta receptor I and mutation of TGFbeta receptor II are frequent events in MSI sporadic gastric carcinomas
    Mafalda Pinto
    IPATIMUP Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Porto, Portugal
    J Pathol 200:32-8. 2003
    ....
  56. ncbi request reprint The intracellular E-cadherin germline mutation V832 M lacks the ability to mediate cell-cell adhesion and to suppress invasion
    Gianpaolo Suriano
    Instituto de Patologia e Imunologia Molecular da Universidade do Porto IPATIMUP, 4200 Porto, Portugal
    Oncogene 22:5716-9. 2003
    ....
  57. doi request reprint Colorectal cancer and RASSF family--a special emphasis on RASSF1A
    Maria Sofia Fernandes
    Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal
    Int J Cancer 132:251-8. 2013
    ..This review focus on the current knowledge of RASSF inactivation in CRC, particularly RASSF1A, and on the implications RASSFs may have as potential biomarkers and for the development of new targeted therapies for CRC...
  58. doi request reprint KRAS signaling pathway alterations in microsatellite unstable gastrointestinal cancers
    Sergia Velho
    Institute of Molecular Pathology and Immunology of the University of Porto, Portugal
    Adv Cancer Res 109:123-43. 2010
    ....
  59. doi request reprint Specific inhibition of p110α subunit of PI3K: putative therapeutic strategy for KRAS mutant colorectal cancers
    Maria Sofia Fernandes
    Instituto de Investigação e Inovação em Saúde Institute for Research and Innovation in Health I3S, University of Porto, Porto, Portugal
    Oncotarget . 2016
    ..Overall, this study demonstrates that specific inhibition of PI3K p110α could provide an alternative therapeutic approach for CRC patients, particularly those harboring KRAS mutations...
  60. pmc E-cadherin-defective gastric cancer cells depend on Laminin to survive and invade
    Joana Caldeira
    Institute of Molecular Pathology and Immunology of the University of Porto IPATIMUP, Porto, Portugal, Andalusian Centre for Developmental Biology CABD, Seville, Spain, Instituto de Engenharia Biomédica INEB, Instituto de Investigação e Inovação em Saúde i3S
    Hum Mol Genet 24:5891-900. 2015
    ..This opens new avenues for using LM-γ2 signalling regulators as molecular targets to impair gastric cancer progression. ..
  61. doi request reprint Adherens junctions as targets of microorganisms: a focus on Helicobacter pylori
    Angela Margarida Costa
    IPATIMUP Institute of Molecular Pathology and Immunology of the University of Porto, Portugal
    FEBS Lett 587:259-65. 2013
    ..Here, we provide an overview of the interactions between microorganisms and the adherens junctions with an emphasis on H. pylori...
  62. doi request reprint DNAJB4 molecular chaperone distinguishes WT from mutant E-cadherin, determining their fate in vitro and in vivo
    Joana Simões-Correia
    IPATIMUP Institute of Molecular Pathology and Immunology of the University of Porto, Porto 4200 465, Portugal
    Hum Mol Genet 23:2094-105. 2014
    ..Additionally, the expression of DNAJB4 and Ecad is concomitantly decreased in human gastric carcinomas. Altogether, we demonstrate that DNAJB4 is a sensor of Ecad structural features that might contribute to gastric cancer progression. ..
  63. pmc Docosahexaenoic acid inhibits Helicobacter pylori growth in vitro and mice gastric mucosa colonization
    Marta Correia
    Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal
    PLoS ONE 7:e35072. 2012
    ..DHA treatment is also associated with a lower recurrence of H. pylori infection in combination with ST. These observations pave the way to consider DHA as an adjunct agent in H. pylori eradication treatment...
  64. ncbi request reprint Helicobacter pylori and interleukin 1 genotyping: an opportunity to identify high-risk individuals for gastric carcinoma
    Ceu Figueiredo
    C Figueiredo, Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Porto, Portugal
    J Natl Cancer Inst 94:1680-7. 2002
    ..pylori infection. We investigated whether there are any combinations of bacterial and host genotypes that are particularly associated with the occurrence of gastric carcinoma...
  65. doi request reprint Familial gastric cancer: genetic susceptibility, pathology, and implications for management
    Carla Oliveira
    Ipatimub Institute of Molecular Pathology and Immunology and Instituto Instituto de Investigação e Inovação em Saúde, University of Porto, Porto, Portugal Department of Pathology and Oncology, Faculty of Medicine, University of Porto, Porto, Portugal
    Lancet Oncol 16:e60-70. 2015
    ....
  66. ncbi request reprint Identification of CDH1 germline missense mutations associated with functional inactivation of the E-cadherin protein in young gastric cancer probands
    Gianpaolo Suriano
    Instituto de Patologia e Imunologia Molecular da Universidade do Porto, 4200 Porto, Portugal
    Hum Mol Genet 12:575-82. 2003
    ....
  67. ncbi request reprint Molecular targets and biological modifiers in gastric cancer
    Fatima Carneiro
    Institute of Molecular Pathology and Immunology of the University of Porto IPATIMUP, Porto, Portugal
    Semin Diagn Pathol 25:274-87. 2008
    ..In this review, we will discuss the involvement of E-cadherin, EGFR, ERBB2, MMR genes, KRAS, and PIK3CA in the development and progression of gastric cancer and their role as biomarkers or as novel putative targets for therapy...
  68. pmc Causes and consequences of microsatellite instability in gastric carcinogenesis
    Sergia Velho
    Sérgia Velho, Maria Sofia Fernandes, Marina Leite, Ceu Figueiredo, Raquel Seruca, IPATIMUP Institute of Molecular Pathology and Immunology of the University of Porto, 4200 465 Porto, Portugal
    World J Gastroenterol 20:16433-42. 2014
    ..Additionally, current therapeutic strategies for GC and their applicability in the MSI subset are also discussed. ..
  69. doi request reprint Biomarkers for gastric cancer: prognostic, predictive or targets of therapy?
    Cecília Durães
    Institute of Molecular Pathology and Immunology of the University of Porto IPATIMUP, Porto, Portugal
    Virchows Arch 464:367-78. 2014
    ..Prognostic and predictive biomarkers may nevertheless be extremely valuable to correctly stratify gastric cancer patients for treatment and, ultimately, improve survival...
  70. ncbi request reprint Genetic screening for hereditary diffuse gastric cancer
    Carlo Oliveira
    Instituto de Patologia e Imunologia Molecular da Universidade do Porto, Portugal
    Expert Rev Mol Diagn 3:201-15. 2003
    ..This knowledge is a fundamental step towards accurate genetic counselling, in which a highly specialized presymptomatic therapeutic intervention should be offered...
  71. doi request reprint High-throughput molecular profiling of a P-cadherin overexpressing breast cancer model reveals new targets for the anti-cancer bacterial protein azurin
    Nuno Bernardes
    Institute for Biotechnology and Bioengineering, Center for Biological and Chemical Engineering, Instituto Superior Tecnico, Lisbon, Portugal Institute of Molecular Pathology and Immunology of the University of Porto IPATIMUP, Porto, Portugal
    Int J Biochem Cell Biol 50:1-9. 2014
    ..Altogether, our results further enlighten the anti-cancer effects mediated by azurin in P-cadherin overexpression breast cancer models. ..
  72. ncbi request reprint Sequence diversity at the proximal 14q32.1 SERPIN subcluster: evidence for natural selection favoring the pseudogenization of SERPINA2
    Susana Seixas
    Institute of Molecular Pathology and Immunology of the University of Porto, Porto, Portugal
    Mol Biol Evol 24:587-98. 2007
    ....
  73. ncbi request reprint Role of site-specific promoter hypomethylation in aberrant MUC2 mucin expression in mucinous gastric carcinomas
    Patrícia Mesquita
    Institute of Molecular Pathology and Immunology IPATIMUP, University of Porto, Rua Dr Roberto Frias s n, 4200 Porto, Portugal
    Cancer Lett 189:129-36. 2003
    ....
  74. ncbi request reprint BRAF mutations and RET/PTC rearrangements are alternative events in the etiopathogenesis of PTC
    Paula Soares
    Institute of Molecular Pathology and Immunology of the University of Porto, IPATIMUP, Rua Roberto Frias s n, 4200 465 Porto, Portugal
    Oncogene 22:4578-80. 2003
    ..BRAF(V599E) may represent an alternative pathway to oncogenic MAPK activation in PTCs without RET/PTC activation...
  75. pmc The bacterial protein azurin impairs invasion and FAK/Src signaling in P-cadherin-overexpressing breast cancer cell models
    Nuno Bernardes
    Institute for Biotechnology and Bioengineering, Center for Biological and Chemical Engineering, Instituto Superior Tecnico, Lisbon, Portugal
    PLoS ONE 8:e69023. 2013
    ..Therefore, azurin could possibly be considered a therapeutic tool to treat poor-prognosis breast carcinomas overexpressing P-cadherin in a wild type E-cadherin context. ..
  76. ncbi request reprint Loss of heterozygosity and promoter methylation, but not mutation, may underlie loss of TFF1 in gastric carcinoma
    Ralph Carvalho
    Institute of Molecular Pathology and Immunology, University of Porto, Porto, Portugal
    Lab Invest 82:1319-26. 2002
    ..Our results further support the role of TFF1 inactivation in gastric carcinogenesis, in agreement with the results obtained in the Tff1-knockout mice model...