- [Parkinson's disease dementia and Lewy body dementia]
centre mémoire de ressource et de recherche, Service de Neurologie, Hopital Gui de Chauliac, CHU de Montpellier
Psychol Neuropsychiatr Vieil 4:S35-50. 2006
..It becomes essential to better define the boundaries of these cerebral neurodegenerative diseases. The perspective of common physiopathological mechanisms and certain vulnerability profiles could lead to new therapeutic pathways...
- Cognitive impairment in motor neuron disease with bulbar onset
Unité de Neurologie Comportementale et dégénérativel, Hĵpital Gui de Chauliac, Montpellier, France
Amyotroph Lateral Scler Other Motor Neuron Disord 2:23-9. 2001
..Cognitive impairment was defined by clinical evidence of dementia (DSM-IV and frontal evaluation) or by significant alteration indicated by neuropsychological testing (excluding patients with depression and major anxiety), or both...
- Very early onset AD with a de novo mutation in the presenilin 1 gene (Met 233 Leu)
UNCD, Gui de Chauliac Hospital, Montpellier, France
Neurology 61:1136-7. 2003
..The authors describe a 28-year-old woman with histopathologically confirmed early onset Alzheimer disease characterized by severe frontal lobe involvement associated with a de novo mutation in the presenilin 1 gene (PSEN1)...
- [What is a mild cognitive impairment?]
Centre mémoire ressources et recherche CM2R du Languedoc Roussillon, Neurologie B, Inserm E 361, CHU de Montpellier, 34295 Montpellier
Rev Prat 55:1891-4. 2005
..cognitive impairment does not have any repercussions on daily life, the subject may report difficulties concerning complex day-to-day activities; (5.) no dementia...
- Mild cognitive impairment (MCI) in medical practice: a critical review of the concept and new diagnostic procedure. Report of the MCI Working Group of the European Consortium on Alzheimer's Disease
Memory Research Resource Center for Alzheimer s Disease, Neurology B Department, Institut National de la Sante et de la Recherche Medicale, Montpellier Hospital, Montpellier, France
J Neurol Neurosurg Psychiatry 77:714-8. 2006
- Extrapyramidal signs before and after diagnosis of incident Alzheimer disease in a prospective population study
Memory Research Resource Center for Alzheimer s Disease, Neurology Department, U 888 Institut National de la Santé et de la Recherche Médicale, Centre Hospitalier Universitaire de Montpellier, France
Arch Neurol 66:1120-6. 2009
..Extrapyramidal signs (EPSs) are commonly accepted as a feature of Alzheimer disease (AD) and may influence both the profile of impairment and prognosis...
- Working memory performance is related to intrinsic resting state functional connectivity changes in community-dwelling elderly cohort
Institut d Imagerie Fonctionnelle Humaine, Department of Neuroradiology, Montpellier University Hospital Center, Gui de Chauliac Hospital, Montpellier, France Inserm U 1198, University of Montpellier II, France EPHE, Paris, France
Neurobiol Learn Mem 132:57-66. 2016
..Finally, this study suggests that performance modifications in healthy elderly subjects are associated with reorganization of functional connectivity within the DMN, SN, and CEN. ..
- Education modulates the impact of white matter lesions on the risk of mild cognitive impairment and dementia
INSERM, U1061, La Colombière Hospital, Montpellier, France University of Montpellier 1, Montpellier, France
Am J Geriatr Psychiatry 22:1336-45. 2014
..We hypothesized that education, a marker of cognitive reserve (CR), could modulate the effects of WML on the risk of mild cognitive impairment (MCI) or dementia...
- Spatial distribution of cerebral white matter lesions predicts progression to mild cognitive impairment and dementia
INSERM, U1061, La Colombière Hospital, Montpellier, France
PLoS ONE 8:e56972. 2013
..We sought to determine whether a particular WML profile, based on the density and location of lesions, could be associated with an increased risk of mild cognitive impairment (MCI) or dementia over the following 7 years...
- Mean arterial pressure change associated with cerebral blood flow in healthy older adults
Laboratoire Charles Coulomb, CNRS UMR 5221, Universite Montpellier II, Montpellier, France Intrasense, Montpellier, Herault, France Department of neuroradiology, Institut d Imagerie Fonctionnelle Humaine, I2FH, University Hospital Center, Gui de Chauliac Hospital, Montpellier, France Institut de Génomique Fonctionnelle, UMR 5203, INSERM U661, Universite Montpellier II, Universite Montpellier I, France Electronic address
Neurobiol Aging 46:49-57. 2016
..Our main result suggests that change in MAP is the most significant predictor of future CBF in older adults. ..
- Metabolic syndrome and localization of white matter hyperintensities in the elderly population
INSERM, Unit 1061, Neuropsychiatry, Epidemiological and Clinical Research, Montpellier, France
Alzheimers Dement 8:S88-95.e1. 2012
- [Mild cognitive impairment]
Service de Neurologie, CM2R du Languedoc Roussillon, Inserm E 361, CHU, Montpellier Cedex 05
Presse Med 36:1464-8. 2007
..Biological and radiological markers will provide greater and more systematic support for diagnosis in the near future, particularly for early detection of Alzheimer's disease...
- Caffeine, cognitive functioning, and white matter lesions in the elderly: establishing causality from epidemiological evidence
INSERM, U888, Montpellier, France and University of Montpellier 1, Montpellier, France
J Alzheimers Dis 20:S161-6. 2010
..The significant relationship observed between caffeine intake in women and lower cognitive decline is highly likely to be a true causal relationship and not a spurious association...
- Working memory activation of neural networks in the elderly as a function of information processing phase and task complexity
Institut d Imagerie Fonctionnelle Humaine, I2FH, Department of Neuroradiology, Montpellier University Hospital Center, Gui de Chauliac Hospital, University of Montpellier, Montpellier, France INSERM, Unit 1198, Molecular Mechanisms in Neurodegenerative Diseases, University of Montpellier, Montpellier, France
Neurobiol Learn Mem 125:211-23. 2015
..These findings support the hypothesis of an increased activation in salience and central executive networks and a decreased activation in default mode network concomitant to increasing task load. ..
- Olive oil and cognition: results from the three-city study
INSERM U888 Pathologies du Systeme Nerveux Recherche Epidemiologique et Clinique, Universite Montpellier 1, Montpellier, France
Dement Geriatr Cogn Disord 28:357-64. 2009
..Olive oil is a major component of the Mediterranean diet suggested to be beneficial to counteract Alzheimer's disease...
- 'I think therefore I am': improving cognition
French National Institute of Health and Medical Research INSERM, Unit E361 Pathologies of the Nervous System, La Colombière Hospital, Montpellier, France
Curr Opin Psychiatry 19:570-4. 2006
..In the absence of a specific treatment for dementia, the effective management of cognitive symptoms is a clinical priority...
- Depression in elderly persons subject to childhood maltreatment is not modulated by corpus callosum and hippocampal loss
INSERM, U1061, Montpellier, F 34093, France
J Affect Disord 141:294-9. 2012
..No association was found with childhood sexual and physical abuse...
- Functional Vitamin E deficiency in ApoE4 patients with Alzheimer's disease
Department of Biochemistry, Lapeyronie Hospital, Montpellier, France
Dement Geriatr Cogn Disord 21:198-204. 2006
..Our study strongly supports the hypothesis of an impairment of lipophilic antioxidant delivery to neuronal cells in AD leading to a tissular antioxidant deficiency which could facilitate oxidative stress...
- IANA task force on nutrition and cognitive decline with aging
S Gillette Guyonnet
Service de Medecine Interne et de Gerontologie Clinique, Pavillon J P Junod, Centre Hospitalier Universitaire La Grave Casselardit, Toulouse Cedex 9, France
J Nutr Health Aging 11:132-52. 2007
..These studies must control for the greatest number of known confounding factors and take into account the impact of the standard social determinants of food habits, such as the regional cultures, social status, and educational level...
- ["The 5 words": a simple and sensitive test for the diagnosis of Alzheimer's disease]
Inserm E007 et Fédération de neurologie, Hopital de la Salpetriere, Paris
Presse Med 31:1696-9. 2002
..The improvement in the diagnostic conditions of AD relies on the availability of a simple and reliable tool for screening memory disorders of organic origin...
- [Mild cognitive impairment: imaging data]
Unité de neurologie comportementale et dégénérative, Neurologie B, CHU Gui de Chauliac, 34295 Montpellier Cedex 05 INSERM E 99 30, CHU de Montpellier
Rev Neurol (Paris) 158:S21-9. 2002
..This latter technique, leading to the development of cognitive activation paradigms, is particularly promising...
- GuidAge study: a 5-year double blind, randomised trial of EGb 761 for the prevention of Alzheimer's disease in elderly subjects with memory complaints. i. rationale, design and baseline data
INSERM, U558, F 31073, Toulouse, France
Curr Alzheimer Res 5:406-15. 2008
..5% presented a CDR score of 0.5. This study will enable us to evaluate the efficacy of EGb761 in the prevention of AD, and to assess the usefulness of various baseline characteristics as predictors of conversion to AD in this population...
- Prognosis of Alzheimer's disease today: a two-year prospective study in 686 patients from the REAL-FR Study
Department of Internal Medicine and Clinical Gerontology, Centre Hospitalier Universitaire Purpan Casselardit, Toulouse, France
Alzheimers Dement 4:22-9. 2008
..The aim of the present study was to describe the long-term evolution of Alzheimer's disease (AD) in a prospective cohort of patients under treatment with a close follow-up...
- Risk profiles for mild cognitive impairment and progression to dementia are gender specific
INSERM U888, Nervous System Pathologies Epidemiological and Clinical Research, La Colombière Hospital, 34093 Montpellier Cedex 5, France
J Neurol Neurosurg Psychiatry 79:979-84. 2008
..To examine risk factors for mild cognitive impairment (MCI) and progression to dementia in a prospective community-based study of subjects aged 65 years and over...
- The neuroprotective effects of caffeine: a prospective population study (the Three City Study)
INSERM U888 Nervous System Pathologies, Epidemiological and Clinical Research, La Colombière Hospital, Montpellier, France
Neurology 69:536-45. 2007
..To examine the association between caffeine intake, cognitive decline, and incident dementia in a community-based sample of subjects aged 65 years and over...
- Six and 18-month changes in mild to moderate Alzheimer's patients treated with acetylcholinesterase inhibitors: what can we learn for clinical outcomes of therapeutic trials?
F Cortes, Alzheimer s Disease Research Centre, U 558, Toulouse, France
J Nutr Health Aging 11:330-7. 2007
..Clinical trials in Alzheimer's disease (AD) include patients benefiting from recent improvements in AD management...
- Endpoints for trials in Alzheimer's disease: a European task force consensus
INSERM U558, Toulouse, France
Lancet Neurol 7:436-50. 2008
..A clear and consensual definition of endpoints is crucial for the success of further clinical trials in the field and will allow comparison of data across studies...
- [Behavioral and psychological symptoms in dementia: description and management]
Centre Memoire de Ressources et de Recherche, Hopital Pasteur, 30, avenue de la Voie Romaine, BP 69, 06002 CHU de Nice Cedex 1, France
Rev Neurol (Paris) 161:357-66. 2005
..This report was updated with the most recent literature reports, and was adapted to the French environment. This paper is a synthesis of this meeting, validated and corrected by the entire Thema 2 group...
- Prevention trials in Alzheimer disease: one step forward?
Neurology Service, Guy de Chauliac Hospital, Montpellier, France
Neurology 67:S21-2. 2006
..A critical concern is the benefit and relative risk of giving a treatment to non-demented patients or to asymptomatic subjects. Some trials are under way and will perhaps move the field of prevention of dementia one big step forward...
- [Amyotrophic lateral sclerosis and cognitive disorders: review and analysis of the literature]
, Neurologie B, CHU Montpelier
Rev Neurol (Paris) 157:139-50. 2001
..Together with upper and lower motor neuron signs, sensory or cognitive impairment are not uncommon. The frequency of a multidegenerative profile in ALS with SOD1 mutations is also an argument for this. We reviewed the literature about:..