J Tarasiuk

Summary

Affiliation: University of Szczecin
Country: Poland

Publications

  1. pmc The role of bioreductive activation of doxorubicin in cytotoxic activity against leukaemia HL60-sensitive cell line and its multidrug-resistant sublines
    D Kostrzewa-Nowak
    Department of Biochemistry, University of Szczecin, 3a Felczaka St, 71 412 Szczecin, Poland
    Br J Cancer 93:89-97. 2005
  2. pmc Anthrapyridones, a novel group of antitumour non-cross resistant anthraquinone analogues. Synthesis and molecular basis of the cytotoxic activity towards K562/DOX cells
    J Tarasiuk
    Department of Pharmaceutical Technology and Biochemistry, Technical University of Gdansk, Poland
    Br J Pharmacol 135:1513-23. 2002
  3. ncbi request reprint Molecular basis of the low activity of antitumor anthracenediones, mitoxantrone and ametantrone, in oxygen radical generation catalyzed by NADH dehydrogenase. Enzymatic and molecular modelling studies
    Jolanta Tarasiuk
    Department of Pharmaceutical Technology and Biochemistry, Gdansk University of Technology, Gdansk, Poland
    Eur J Med Chem 40:321-8. 2005
  4. ncbi request reprint The role of structural factors in the kinetics of cellular uptake of pyrazoloacridines and pyrazolopyrimidoacridines: implications for overcoming multidrug resistance towards leukaemia K562/DOX cells
    Jolanta Tarasiuk
    Department of Pharmaceutical Technology and Biochemistry, Technical University of Gdansk, Poland
    Biochem Pharmacol 68:1815-23. 2004
  5. ncbi request reprint Transport of new non-cross-resistant antitumor compounds of the benzoperimidine family in multidrug resistant cells
    K Tkaczyk-Gobis
    Department of Pharmaceutical Technology and Biochemistry, Technical University Gdansk, Gdansk, Poland
    Eur J Pharmacol 413:131-41. 2001
  6. ncbi request reprint The ability of new sugar-modified derivatives of antitumor anthracycline, daunorubicin, to stimulate NAD(P)H oxidation in different cellular oxidoreductase systems: NADH dehydrogenase, NADPH cytochrome P450 reductase, and xanthine oxidase
    Jolanta Pawłowska
    Department of Pharmaceutical Technology and Biochemistry, Technical University of Gdansk, Narutowicza St 11 12, 80 952 Gdansk, Poland
    Oncol Res 14:469-74. 2004
  7. ncbi request reprint The activity of latent benzoperimidine esters to inhibit P-glycoprotein and multidrug resistance-associated protein 1 dependent efflux of pirarubicin from several lines of multidrug resistant tumor cells
    Dorota Głowacka-Rogacka
    Department of Pharmaceutical Technology and Biochemistry, Technical University of Gdansk, Poland
    Cancer Detect Prev 28:283-93. 2004
  8. ncbi request reprint Differential ability of cytostatics from anthraquinone group to generate free radicals in three enzymatic systems: NADH dehydrogenase, NADPH cytochrome P450 reductase, and xanthine oxidase
    Jolanta Pawłowska
    Department of Pharmaceutical Technology and Biochemistry, Technical University of Gdansk, Narutowicza St 11 12, 80 952 Gdansk, Poland
    Oncol Res 13:245-52. 2003
  9. ncbi request reprint [The inhibition of apoptosis in cancer cells resistant to anticancer drugs]
    Robert Nowak
    Katedra Biochemii, Wydział Nauk Przyrodniczych, Uniwersytet Szczecifiski ul Felczaka 3a, 71 412 Szczecin
    Postepy Biochem 50:330-43. 2004
  10. ncbi request reprint The effect of new non-cross resistant antitumour agents on the energy state of human erythrocytes
    Robert Nowak
    Department of Biochemistry, University of Szczecin, Poland
    Acta Biochim Pol 52:953-7. 2005

Collaborators

  • E Borowski
  • Ippolito Antonini
  • Robert Nowak
  • Dorota Kostrzewa-Nowak
  • Katarzyna Skupień
  • Jolanta Pawłowska
  • Mark J I Paine
  • C Roland Wolf
  • Agnieszka Maruszewska
  • Jan Oszmianski
  • D Kostrzewa-Nowak
  • Dorota Głowacka-Rogacka
  • K Tkaczyk-Gobis
  • Jerzy Gebicki
  • Jan Adamus
  • Katarzyna Czupryńska
  • Dominika Maryniak
  • Sylwia Piotrowska
  • Anna Korytowska
  • Katarzyna Serwatka
  • C R Wolf
  • M J I Paine
  • Agnieszka Kupiec
  • Małgorzata Arciemiuk
  • Waldemar Priebe
  • Maria M Bontemps-Gracz
  • B Stefanska
  • A Garnier-Suillerot
  • O Seksek

Detail Information

Publications14

  1. pmc The role of bioreductive activation of doxorubicin in cytotoxic activity against leukaemia HL60-sensitive cell line and its multidrug-resistant sublines
    D Kostrzewa-Nowak
    Department of Biochemistry, University of Szczecin, 3a Felczaka St, 71 412 Szczecin, Poland
    Br J Cancer 93:89-97. 2005
    ..In contrast, an important increase in cytotoxic activity of DOX after its reductive conversion by CPR was observed against HL60 as well as HL60/VINC and HL60/DOX cells...
  2. pmc Anthrapyridones, a novel group of antitumour non-cross resistant anthraquinone analogues. Synthesis and molecular basis of the cytotoxic activity towards K562/DOX cells
    J Tarasiuk
    Department of Pharmaceutical Technology and Biochemistry, Technical University of Gdansk, Poland
    Br J Pharmacol 135:1513-23. 2002
    ..7. We also studied, using confocal microscopy, the intracellular distribution of anthrapyridones in NIH-3T3 cells. Our data showed that these compounds were strongly accumulated in the nucleus and lysosomes...
  3. ncbi request reprint Molecular basis of the low activity of antitumor anthracenediones, mitoxantrone and ametantrone, in oxygen radical generation catalyzed by NADH dehydrogenase. Enzymatic and molecular modelling studies
    Jolanta Tarasiuk
    Department of Pharmaceutical Technology and Biochemistry, Gdansk University of Technology, Gdansk, Poland
    Eur J Med Chem 40:321-8. 2005
    ....
  4. ncbi request reprint The role of structural factors in the kinetics of cellular uptake of pyrazoloacridines and pyrazolopyrimidoacridines: implications for overcoming multidrug resistance towards leukaemia K562/DOX cells
    Jolanta Tarasiuk
    Department of Pharmaceutical Technology and Biochemistry, Technical University of Gdansk, Poland
    Biochem Pharmacol 68:1815-23. 2004
    ..Our data showed that a nearly linear relation exists between the resistance factor (RF) and lnV+ reflecting the impact of the cellular uptake rate (V+) on the ability of these compounds to overcome MDR...
  5. ncbi request reprint Transport of new non-cross-resistant antitumor compounds of the benzoperimidine family in multidrug resistant cells
    K Tkaczyk-Gobis
    Department of Pharmaceutical Technology and Biochemistry, Technical University Gdansk, Gdansk, Poland
    Eur J Pharmacol 413:131-41. 2001
    ..In conclusion, the fast uptake kinetics of the benzoperimidines counterbalance their efflux by P-glycoprotein and MRP1...
  6. ncbi request reprint The ability of new sugar-modified derivatives of antitumor anthracycline, daunorubicin, to stimulate NAD(P)H oxidation in different cellular oxidoreductase systems: NADH dehydrogenase, NADPH cytochrome P450 reductase, and xanthine oxidase
    Jolanta Pawłowska
    Department of Pharmaceutical Technology and Biochemistry, Technical University of Gdansk, Narutowicza St 11 12, 80 952 Gdansk, Poland
    Oncol Res 14:469-74. 2004
    ..More similarities were observed in their interaction with NADH dehydrogenase and NADPH cytochrome P450 reductase than with xanthine oxidase...
  7. ncbi request reprint The activity of latent benzoperimidine esters to inhibit P-glycoprotein and multidrug resistance-associated protein 1 dependent efflux of pirarubicin from several lines of multidrug resistant tumor cells
    Dorota Głowacka-Rogacka
    Department of Pharmaceutical Technology and Biochemistry, Technical University of Gdansk, Poland
    Cancer Detect Prev 28:283-93. 2004
    ..In contrast, examined esters were less active in vitro in restoration of pirarubicin cytotoxicity towards resistant cells because an enzymatic cleavage of esters occurs in presence of serum esterases...
  8. ncbi request reprint Differential ability of cytostatics from anthraquinone group to generate free radicals in three enzymatic systems: NADH dehydrogenase, NADPH cytochrome P450 reductase, and xanthine oxidase
    Jolanta Pawłowska
    Department of Pharmaceutical Technology and Biochemistry, Technical University of Gdansk, Narutowicza St 11 12, 80 952 Gdansk, Poland
    Oncol Res 13:245-52. 2003
    ....
  9. ncbi request reprint [The inhibition of apoptosis in cancer cells resistant to anticancer drugs]
    Robert Nowak
    Katedra Biochemii, Wydział Nauk Przyrodniczych, Uniwersytet Szczecifiski ul Felczaka 3a, 71 412 Szczecin
    Postepy Biochem 50:330-43. 2004
  10. ncbi request reprint The effect of new non-cross resistant antitumour agents on the energy state of human erythrocytes
    Robert Nowak
    Department of Biochemistry, University of Szczecin, Poland
    Acta Biochim Pol 52:953-7. 2005
    ..This is a very promising result in view of their potential use in the clinic as antitumour drugs against multidrug resistant cancers...
  11. ncbi request reprint Bioreductive activation of mitoxantrone by NADPH cytochrome P450 reductase. Implications for increasing its ability to inhibit the growth of sensitive and multidrug resistant leukaemia HL60 cells
    Dorota Kostrzewa-Nowak
    Department of Biochemistry, University of Szczecin, 3c Felczaka St, 71 412 Szczecin, Poland
    Cancer Lett 245:252-62. 2007
    ..In contrast, an important increase in antiproliferative activity of MX after its reductive activation by CPR at high NADPH concentration was observed against HL60/VINC as well as HL60/DOX cells...
  12. doi request reprint The ability of selected pyridinium salts to increase the cytotoxic activity of vincristine but not doxorubicin towards sensitive and multidrug resistant promyelocytic leukaemia HL60 cells
    Agnieszka Maruszewska
    Department of Biochemistry, University of Szczecin, 3c Felczaka St, 71 412 Szczecin, Poland
    J Pharm Pharmacol 60:647-53. 2008
    ..This could explain the inefficiency of these salts to increase the cytotoxic activity of DOX against examined leukaemic HL60 cell line and its MDR sublines, HL60/VINC and HL60/DOX...
  13. ncbi request reprint In vitro antileukaemic activity of extracts from berry plant leaves against sensitive and multidrug resistant HL60 cells
    Katarzyna Skupień
    Department of Processing and Storage of Plant Raw Materials, Agricultural Academy of Szczecin, 17 Słowackiego St, 71 434 Szczecin, Poland
    Cancer Lett 236:282-91. 2006
    ..The values of resistance factor (RF) found for these extracts were very low lying in the range 0.32/2.0...
  14. doi request reprint In vitro antileukaemic activity of extracts from chokeberry (Aronia melanocarpa [Michx] Elliott) and mulberry (Morus alba L.) leaves against sensitive and multidrug resistant HL60 cells
    Katarzyna Skupień
    Department of Processing and Storage of Plant Raw Materials, Agricultural Academy of Szczecin, 17 Słowackiego St, 71 434 Szczecin, Poland
    Phytother Res 22:689-94. 2008
    ..The values of resistance factor (RF) found for these extracts were very low lying in the range 1.2-1.6...