Piotr Kuna

Summary

Affiliation: University of Lodz
Country: Poland

Publications

  1. pmc Effect of budesonide/formoterol maintenance and reliever therapy on asthma exacerbations
    P Kuna
    Department of Pneumonology and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland
    Int J Clin Pract 61:725-36. 2007
  2. ncbi A randomized, double-blind, double-dummy, parallel-group, multicenter, dose-reduction trial of the minimal effective doses of budesonide and fluticasone dry-powder inhalers in adults with mild to moderate asthma
    Piotr Kuna
    Division of Pneumonology and Allergology, Medical University of Lodz, Lodz, Poland
    Clin Ther 25:2182-97. 2003
  3. ncbi Symbicort Turbuhaler: a new concept in asthma management
    P Kuna
    Department of Pneumonology and Allergy, Medical University of Lodz, Lodz, Poland
    Int J Clin Pract 56:797-803. 2002
  4. ncbi [Current recommendation for asthma treatment]
    Piotr Kuna
    Klinika Pneumonologii i Alergologii Instytutu Medycyny Wewnetrznej Uniwersytetu Medycznego w Lodzi
    Pol Merkur Lekarski 16:24-9. 2004
  5. ncbi Once-daily dosing with budesonide/formoterol compared with twice-daily budesonide/formoterol and once-daily budesonide in adults with mild to moderate asthma
    P Kuna
    Division of Pneumonology and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland
    Respir Med 100:2151-9. 2006
  6. ncbi Effect of different antiasthmatic treatments on exercise-induced bronchoconstriction in children with asthma
    Iwona Stelmach
    Department of Pediatrics and Allergy, Medical University of Lodz, Lodz, Poland
    J Allergy Clin Immunol 121:383-9. 2008
  7. ncbi A randomized, double-blind trial of the effect of anti-asthma treatment on lung function in children with asthma
    Iwona Stelmach
    Department of Pediatrics and Allergy, N Copernicus Hospital, Lodz, Poland
    Pulm Pharmacol Ther 20:691-700. 2007
  8. doi Ranitidine (150 mg daily) inhibits wheal, flare, and itching reactions in skin-prick tests
    Maciej Kupczyk
    Department of Pneumonology and Allergology, Medical University of Lodz, Lodz, Poland
    Allergy Asthma Proc 28:711-5. 2007
  9. doi Treatment comparison of budesonide/formoterol with salmeterol/fluticasone propionate in adults aged > or =16 years with asthma: post hoc analysis of a randomized, double-blind study
    Piotr Kuna
    Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland
    Clin Drug Investig 30:565-79. 2010
  10. doi Montelukast treatment may alter the early efficacy of immunotherapy in children with asthma
    Paweł Majak
    Department of Pediatrics and Allergy, Medical University of Lodz, Lodz, Poland
    J Allergy Clin Immunol 125:1220-7. 2010

Detail Information

Publications79

  1. pmc Effect of budesonide/formoterol maintenance and reliever therapy on asthma exacerbations
    P Kuna
    Department of Pneumonology and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland
    Int J Clin Pract 61:725-36. 2007
    ..Budesonide/formoterol for maintenance and relief reduces asthma exacerbations and maintains similar daily asthma control at a lower overall drug load compared with fixed-dose salmeterol/fluticasone and budesonide/formoterol...
  2. ncbi A randomized, double-blind, double-dummy, parallel-group, multicenter, dose-reduction trial of the minimal effective doses of budesonide and fluticasone dry-powder inhalers in adults with mild to moderate asthma
    Piotr Kuna
    Division of Pneumonology and Allergology, Medical University of Lodz, Lodz, Poland
    Clin Ther 25:2182-97. 2003
    ..Clinical trials comparing inhaled corticosteroids must take into consideration that because of their excellent effect at low doses, they typically induce a near-maximal response in asthma patients...
  3. ncbi Symbicort Turbuhaler: a new concept in asthma management
    P Kuna
    Department of Pneumonology and Allergy, Medical University of Lodz, Lodz, Poland
    Int J Clin Pract 56:797-803. 2002
    ..More convenient treatment represents another important benefit for patients with asthma, as ease of use can also result in improved adherence, leading to better disease control...
  4. ncbi [Current recommendation for asthma treatment]
    Piotr Kuna
    Klinika Pneumonologii i Alergologii Instytutu Medycyny Wewnetrznej Uniwersytetu Medycznego w Lodzi
    Pol Merkur Lekarski 16:24-9. 2004
    ..Atopic asthma can be also treated with immunotherapy. With new drugs for asthma we can achieve full control of disease symptoms without unwanted side effects...
  5. ncbi Once-daily dosing with budesonide/formoterol compared with twice-daily budesonide/formoterol and once-daily budesonide in adults with mild to moderate asthma
    P Kuna
    Division of Pneumonology and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland
    Respir Med 100:2151-9. 2006
    ..Budesonide/formoterol administered once daily in the evening is a convenient treatment regimen that is as effective in improving asthma control as twice-daily dosing in patients with mild to moderate persistent asthma...
  6. ncbi Effect of different antiasthmatic treatments on exercise-induced bronchoconstriction in children with asthma
    Iwona Stelmach
    Department of Pediatrics and Allergy, Medical University of Lodz, Lodz, Poland
    J Allergy Clin Immunol 121:383-9. 2008
    ..Exercise-induced bronchoconstriction occurs in a large proportion of children with asthma, limiting everyday activities important for their physical and social development...
  7. ncbi A randomized, double-blind trial of the effect of anti-asthma treatment on lung function in children with asthma
    Iwona Stelmach
    Department of Pediatrics and Allergy, N Copernicus Hospital, Lodz, Poland
    Pulm Pharmacol Ther 20:691-700. 2007
    ..The aim of our study was to determine the effects of anti-asthma treatment in children, equally on FEV(1), FEF25-75%, R(int) and SR(aw) values...
  8. doi Ranitidine (150 mg daily) inhibits wheal, flare, and itching reactions in skin-prick tests
    Maciej Kupczyk
    Department of Pneumonology and Allergology, Medical University of Lodz, Lodz, Poland
    Allergy Asthma Proc 28:711-5. 2007
    ....
  9. doi Treatment comparison of budesonide/formoterol with salmeterol/fluticasone propionate in adults aged > or =16 years with asthma: post hoc analysis of a randomized, double-blind study
    Piotr Kuna
    Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland
    Clin Drug Investig 30:565-79. 2010
    ..Many of the studies supporting the use of budesonide/formoterol combination therapies have included populations of adolescents and adults aged >11 years...
  10. doi Montelukast treatment may alter the early efficacy of immunotherapy in children with asthma
    Paweł Majak
    Department of Pediatrics and Allergy, Medical University of Lodz, Lodz, Poland
    J Allergy Clin Immunol 125:1220-7. 2010
    ..Allergen-specific immunotherapy (SIT) is the only available potentially curative approach in the management of allergic diseases. Therapies that boost regulatory T cell induction during SIT might further enhance its effectiveness...
  11. ncbi Identification of Relationships Between Interleukin 15 mRNA and Brain-Derived Neurotrophic Factor II mRNA Levels With Formal Components of Temperament in Asthmatic Patients
    Michał Panek
    Department of Internal Medicine, Asthma and Allergy, Medical University of Lodz, 22 Kopcinskiego St, 90 153, Lodz, Poland
    Mol Neurobiol . 2016
    ..This hypothesis requires further studies on protein functional models. The obtained data confirms the role of IL-15 and BDNFII in the pathomechanisms of depression and formation of selected traits defining the temperament in asthmatics...
  12. doi The NR3C1 Glucocorticoid Receptor Gene Polymorphisms May Modulate the TGF-beta mRNA Expression in Asthma Patients
    Michał Panek
    Department of Internal Medicine, Asthma and Allergy, Medical University of Lodz, 22 Kopcińskiego Str, 90 153, Lodz, Poland
    Inflammation 38:1479-92. 2015
    ..In the case of the occurrence of Tth111I and N363S polymorphic forms of the gene studied, a reduced ability of GCs to inhibit the TGF-β 1 expression can be observed. ..
  13. doi The N363S and I559N single nucleotide polymorphisms of the h-GR/NR3C1 gene in patients with bronchial asthma
    Michał Panek
    Department of Internal Medicine, Asthma and Allergy, Medical University of Lodz, Lodz, Poland
    Int J Mol Med 30:142-50. 2012
    ..This observation needs to be confirmed in a larger group of subjects...
  14. pmc The role of functional single nucleotide polymorphisms of the human glucocorticoid receptor gene NR3C1 in Polish patients with bronchial asthma
    Michał Panek
    Department of Internal Medicine, Asthma and Allergy, Medical University of Lodz, Kopcinskiego 22, 90 153, Lodz, Poland
    Mol Biol Rep 39:4749-57. 2012
    ..The N363S polymorphism of NR3C1 gene is significantly associated with bronchial asthma, susceptibility to the development of moderate to severe form of uncontrolled bronchial asthma...
  15. doi AZD9668, a neutrophil elastase inhibitor, plus ongoing budesonide/formoterol in patients with COPD
    Piotr Kuna
    Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland
    Respir Med 106:531-9. 2012
    ..Neutrophil elastase (NE) is implicated in chronic obstructive pulmonary disease (COPD). AZD9668 is a reversible and selective inhibitor of NE, well tolerated at doses of 60 mg bid during Phase I/IIa development...
  16. doi A novel approach to understanding the role of polymorphic forms of the NR3C1 and TGF-β1 genes in the modulation of the expression of IL-5 and IL-15 mRNA in asthmatic inflammation
    Michał Panek
    Department of Internal Medicine, Asthma and Allergy, Medical University of Lodz, Lodz 90 153, Poland
    Mol Med Rep 13:4879-87. 2016
    ..Therefore, genetic variation affects inflammation in asthma and the clinical course of the disease. ..
  17. pmc The whole-genome expression analysis of peripheral blood mononuclear cells from aspirin sensitive asthmatics versus aspirin tolerant patients and healthy donors after in vitro aspirin challenge
    Joanna Wieczfinska
    Department of Immunopathology, Medical University of Lodz, Chair of Allergology, Immunology and Dermatology, 7 9 Zeligowskiego, 90 752, Lodz, Poland
    Respir Res 16:147. 2015
    ....
  18. pmc Perennial is more effective than preseasonal subcutaneous immunotherapy in the treatment of seasonal allergic rhinoconjunctivitis
    Damian Tworek
    Divisiont of Internal Diseases, Asthma and Allergy, Barlicki University Hospital, Lodz, Poland
    Am J Rhinol Allergy 27:304-8. 2013
    ..The aim of this study was to compare the efficacy and safety of perennial IT (PIT) and preseasonal IT (PSIT) in patients suffering from seasonal rhinoconjunctivitis...
  19. pmc Temperament and stress coping styles in bronchial asthma patients
    Michał Panek
    Department of Internal Medicine, Asthma and Allergy, Medical University of Lodz, Lodz, Poland
    Postepy Dermatol Alergol 33:469-474. 2016
    ..Temperament, defined as the formal characteristics of behavior, is a personality trait which can influence the clinical presentation and course of bronchial asthma. It determines susceptibility to stress as well as stress coping styles...
  20. pmc Identification and association of the single nucleotide polymorphisms, C-509T, C+466T and T+869C, of the TGF-β1 gene in patients with asthma and their influence on the mRNA expression level of TGF-β1
    Michał Panek
    Department of Internal Medicine, Asthma and Allergy, Medical University of Lodz, 90 153 Lodz, Poland
    Int J Mol Med 34:975-86. 2014
    ..0255). This study demonstrates that the C-509T SNP is a significant clinical risk factor for asthma and that the TGF-β1 cytokine contributes to the progression of the illness...
  21. doi Exacerbating factors induce different gene expression profiles in peripheral blood mononuclear cells from asthmatics, patients with chronic obstructive pulmonary disease and healthy subjects
    Ewa Pniewska
    Division of Allergology, Immunology and Dermatology, Department of Immunopathology, Faculty of Biomedical Sciences and Postgraduate Training, Medical University of Lodz, Lodz, Poland
    Int Arch Allergy Immunol 165:229-43. 2014
    ....
  22. ncbi The effect of 4 weeks treatment with desloratadine (5mg daily) on levels of interleukin (IL)-4, IL-10, IL-18 and TGF beta in patients suffering from seasonal allergic rhinitis
    Damian Tworek
    Division of Pneumonology and Allergy, Medical University of Lodz, 22 Kopcińskiego Str, 90 153 Lodz, Poland
    Pulm Pharmacol Ther 20:244-9. 2007
    ..Unless in vitro DL demonstrates not only anti-allergic but also anti-inflammatory activities data from this in vivo study in a group of patients suffering from SAR do not support previous pre-clinical findings...
  23. pmc The Bcl I single nucleotide polymorphism of the human glucocorticoid receptor gene h-GR/NR3C1 promoter in patients with bronchial asthma: pilot study
    Tadeusz Pietras
    Department of Pneumology and Allergology, Medical University of Lodz, Kopcinskiego 22, 90 153, Lodz, Poland
    Mol Biol Rep 38:3953-8. 2011
    ..The Bcl I polymorphism of h-GR/NR3C1 gene is significantly associated with bronchial asthma, susceptibility to the development of severe form and resistance to GCs in Polish population...
  24. doi Combined occurrence of filaggrin mutations and IL-10 or IL-13 polymorphisms predisposes to atopic dermatitis
    Aleksandra Lesiak
    Department of Dermatology, Medical University of Lodz, Lodz, Poland
    Exp Dermatol 20:491-5. 2011
    ....
  25. doi Efficacy and safety of immunotherapy for allergies to Alternaria alternata in children
    Piotr Kuna
    Department of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland
    J Allergy Clin Immunol 127:502-508.e1-6. 2011
    ..The safety and efficacy of specific immunotherapy for mold allergy are not known in children and adolescents...
  26. ncbi [Prevalence of atopy and atopic diseases in children living in an orphanage in Lodz area--pilot study]
    Iwona Stelmach
    Uniwersytet Medyczny w Lodzi, Oddział Kliniczny Interny Dzieciecej i Alergologii III Katedry Pediatrii
    Pol Merkur Lekarski 20:531-4. 2006
    ..Over the past three decades there has been an increase in the prevelance of allergic diseases, specially among children...
  27. pmc Preliminary studies: differences in microRNA expression in asthma and chronic obstructive pulmonary disease
    Małgorzata Pietrusińska
    Department of Pneumology and Allergology, Institute of Onternal Medicine, Medical University of Lodz, Lodz, Poland
    Postepy Dermatol Alergol 33:276-80. 2016
    ..Recent research has attempted to determine the associations of microRNA with the pathogenesis of pulmonary diseases...
  28. pmc Efficacy and safety of AZD3199 vs formoterol in COPD: a randomized, double-blind study
    Piotr Kuna
    Barlicki University Hospital, Medical University of Lodz, Kopcinskiego 22, 90 153 Łódź, ul Lodz, Poland
    Respir Res 14:64. 2013
    ..We investigated the efficacy and safety of AZD3199, a novel inhaled ultra-LABA, with the main aim of establishing a dose that would maintain 24-hour bronchodilation in patients with COPD...
  29. pmc The imbalance in serum concentration of Th-1- and Th-2-derived chemokines as one of the factors involved in pathogenesis of atopic dermatitis
    Joanna Narbutt
    Department of Dermatology, Medical University of Lodz, Lodz, Poland
    Mediators Inflamm 2009:269541. 2009
    ..In Group 2 serum concentration of CXCL-12, CCL-17, CCL-22 was higher than in Control 2. The obtained results indicate the imbalance in chemokine serum levels in AD what suggests their role in the disease pathogenesis...
  30. ncbi Decreased markers of atopy in children with presumed early exposure to allergens, unhygienic conditions, and infections
    Iwona Stelmach
    Department of Pediatrics and Allergy, Medical University of Lodz, Lodz, Poland
    Ann Allergy Asthma Immunol 99:170-7. 2007
    ..Furthermore, there is consistent evidence that the prevalence of atopy increases with higher socioeconomic status. The knowledge about risk factors and preventive factors for atopy needs to be improved...
  31. ncbi Aspirin intolerance and allergy to house dust mites: important factors associated with development of severe asthma
    Maciej Kupczyk
    Department of Pneumonology and Allergy, Medical University of Lodz, Lodz, Poland
    Ann Allergy Asthma Immunol 92:453-8. 2004
    ..Although the occurrence of bronchial asthma is still increasing, the possible factors associated with the development of severe asthma have not been completely determined...
  32. pmc Effectiveness of the Polish program for the treatment of severe allergic asthma with omalizumab: a single-center experience
    Izabela Kuprys-Lipinska
    Department of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Kopcinskiego 22, 90 153, Łódź, Poland
    BMC Pulm Med 16:61. 2016
    ..This observational study evaluated the effectiveness of the Polish OMA program and monitored asthma control after treatment discontinuation...
  33. doi The epidemiology of asthma and its comorbidities in Poland--Health problems of patients with severe asthma as evidenced in the Province of Lodz
    Michał Panek
    Department of Internal Medicine, Asthma and Allergy, Medical University of Lodz, 22 Kopcinskiego St, 90 153, Lodz, Poland Electronic address
    Respir Med 112:31-8. 2016
    ..Population studies supply interesting data regarding the epidemiology, comorbidity and risk factors of asthma, which have direct clinical implications for patients...
  34. doi Tiotropium and its efficacy in the treatment of COPD
    Maciej Kupczyk
    Division of Internal Medicine, Asthma and Allergy, Medical University of Lodz, Poland
    Pneumonol Alergol Pol 83:229-37. 2015
    ..This review presents the results of those studies with the main goal to evaluate the efficacy of treatment with tiotropium in terms of prevention and course of exacerbations. ..
  35. doi The statement of the Polish Society of Allergology experts on the treatment of difficult-to-treat asthma
    Anna Bodzenta-Łukaszyk
    Division of Internal Medicine Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Lodz, Poland
    Pneumonol Alergol Pol 83:324-34. 2015
    ..It is recommended as an add-on therapy at asthma treatment steps 4 and 5 according to GINA (Global Initiative for Asthma) 2014. The optimal asthma control is important from the medical as well as the economical point of view. ..
  36. pmc Pharmacokinetics and pharmacodynamics of an extrafine fixed pMDI combination of beclometasone dipropionate/formoterol fumarate in adolescent asthma
    Piotr Kuna
    Division of Internal Medicine, Asthma and Allergy, Barlicki University Hospital, Medical University of Lodz, Poland
    Br J Clin Pharmacol 80:569-80. 2015
    ..The aim was to investigate the pharmacokinetics and pharmacodynamics of an extrafine pressurized metered-dose inhaler (pMDI) fixed combination of beclometasone dipropionate (BDP)/formoterol fumarate (FF) in adolescent and adult asthma...
  37. pmc The step further to understand the role of cytosolic phospholipase A2 alpha and group X secretory phospholipase A2 in allergic inflammation: pilot study
    Ewa Pniewska
    Department of Immunopathology, Faculty of Biomedical Sciences and Postgraduate Training, Medical University of Lodz, 7 9, Zeligowskiego Street, 90 752 Lodz, Poland
    Biomed Res Int 2014:670814. 2014
    ..Summarizing, Der p1 and Fel d1 involve phospholipase A2 enzymes in their action. sPLA2X seems to be one of important PLA2 isoform in allergic inflammation, especially caused by house dust mite allergens. ..
  38. doi Two patterns of changes in nasal nitric oxide after lysine aspirin nasal challenge in patients with aspirin-exacerbated respiratory disease
    Damian Tworek
    Division of Internal Diseases, Asthma and Allergy, Barlicki University Hospital, Lodz, Poland
    Am J Rhinol Allergy 26:428-32. 2012
    ....
  39. ncbi The effect of montelukast (10mg daily) and loratadine (10mg daily) on wheal, flare and itching reactions in skin prick tests
    Maciej Kupczyk
    Department of Pneumonology and Allergy, Medical University of Łódź, 22 Kopcińskiego Str, 90 153 Łódź, Poland
    Pulm Pharmacol Ther 20:85-9. 2007
    ..The influence of montelukast on skin reactivity has not been clearly evaluated. The aim of this study was to determine the effect of montelukast on wheal, flare and itching in skin prick tests (SPTs)...
  40. ncbi Long-term deterioration of lung function in asthmatic outpatients
    Maciej Kupczyk
    Department of Pneumonology and Allergy, Medical University of Lodz, Poland
    Respiration 71:233-40. 2004
    ..Although the long-term deterioration of lung function in asthmatic patients has been described, the exact mechanism remains to be determined...
  41. doi A 4-year trial of tiotropium in chronic obstructive pulmonary disease
    Donald P Tashkin
    David Geffen School of Medicine at the University of California, Los Angeles 90095 1690, USA
    N Engl J Med 359:1543-54. 2008
    ..Previous studies showing that tiotropium improves multiple end points in patients with chronic obstructive pulmonary disease (COPD) led us to examine the long-term effects of tiotropium therapy...
  42. ncbi [Lack of correlation between exhaled nitric oxide (eNO) and clinical indicators of the disease activity and quality of life in mild and moderate asthmatics]
    Damian Tworek
    Klinika Chorób Wewnetrznych, Astmy i Alergii, Łodzi, Poland
    Pneumonol Alergol Pol 74:391-5. 2006
    ..The aim of the study was to determine the usefulness of eNO measurements in assessing the inflammation in a heterogeneous, in relation to atopic and smoking status, group of patients...
  43. ncbi [IL-10 serum levels in children with moderate asthma]
    Iwona Stelmach
    Samodzielny Oddział Kliniczny Interny Dzieciecej i Alergologii I P AM w Łodzi
    Pneumonol Alergol Pol 70:25-33. 2002
    ..094 and p = 0.09 respectively). This study demonstrates that one possible way by which triamcinolone contribute to inhibition of inflammation is by effect on IL-10...
  44. ncbi Improvement of aspirin-intolerant asthma by montelukast, a leukotriene antagonist: a randomized, double-blind, placebo-controlled trial
    Sven Erik Dahlen
    Experimental Asthma and Allergy Research, The National Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden
    Am J Respir Crit Care Med 165:9-14. 2002
    ..Addition of a leukotriene receptor antagonist such as montelukast improves asthma in aspirin-intolerant patients over and above what can be achieved by glucocorticosteroids...
  45. ncbi [Recent results of clinical studies of synergistic treatment in obstructive respiratory tract diseases]
    Piotr Kuna
    Klinika Pneumonologii i Alergologii Instytutu Medycyny Wewnetrznej Uniwersytetu Medycznego w Łodzi
    Pol Merkur Lekarski 14:663-5. 2003
    ..Symbicort is recommended for regular treatment and could also be used "as needed" due to the rapid onset of the bronchodilatory effect of formoterol...
  46. ncbi The effect of inhaled heparin on airway responsiveness to histamine and leukotriene D4
    Iwona Stelmach
    Department of Pediatrics and Allergy, M Curie Hospital, 35 Parzeczewska Street, 95 100 Zgierz, Poland
    Allergy Asthma Proc 24:59-65. 2003
    ..Results of our study suggest that inhaled heparin, because of its antiallergic and/or anti-inflammatory properties, modifies airway hyperresponsiveness in children with allergic asthma...
  47. ncbi The prevalence of mouse allergen in inner-city homes
    Iwona Stelmach
    M Curie Hospital, Department of Pediatrics and Allergy, Zgierz, Poland
    Pediatr Allergy Immunol 13:299-302. 2002
    ..In Polish children, mouse allergen is an important factor of sensitivity and should be recognized in the diagnosis of allergic diseases as well as in allergen-reduction programmes...
  48. ncbi [Cockroach allergen Bla g 2 levels in houses in Lodz]
    Iwona Stelmach
    Samodzielny Kliniczny Oddział Interny Dzieciecej i Alergologii Instytutu Pediatrii AM w Łodzi Wojewódzki Szpital Specjalistyczny w Zgierzu, P O
    Pol Merkur Lekarski 12:462-5. 2002
    ..Our results showed that concentrations of Bla g 2 antigen in homes in Łódź region, are higher than previously reported in other countries and is strongly related to the house characteristics...
  49. ncbi A randomized, double-blind trial of the effect of treatment with formoterol on clinical and inflammatory parameters of asthma in children
    Iwona Stelmach
    Department of Pediatrics and Allergy, M Curie Hospital, Zgierz, Poland
    Ann Allergy Asthma Immunol 89:67-73. 2002
    ..In addition to their bronchodilating effect, long-acting inhaled beta-agonists have recently been shown to have some anti-inflammatory properties...
  50. ncbi [The effect of nedocromil sodium on levels of IL-4 and IgE in serum of children with bronchial asthma]
    Iwona Stelmach
    Samodzielny Oddział Kliniczny Interny Dzieciecej i Alergologii Instytutu Pediatrii Akademii Medycznej w Łodzi
    Pol Merkur Lekarski 12:214-7. 2002
    ..83 IU/ml +/- 201.3 and 485 IU/ml +/- 200.5 respectively (p < 0.02). This study demonstrate that one possible way by which nedocromil contribute to inhibition of allergic inflammation is by decreasing IL-4 and IgE levels...
  51. ncbi [Effect of triamcinolone acetonide, montelukast, nedocromil sodium and formoterol on eosinophil blood counts, ECP serum levels and clinical progression of asthma in children]
    Iwona Stelmach
    Samodzielny Oddział Kliniczny Interny Dzieciecej i Alergologii Instytutu Pediatrii Akademii Medycznej w Łodzi
    Pol Merkur Lekarski 12:208-13. 2002
    ..This study shows that triamcinolon, montelukast contribute to inhibition of allergic inflammation by decreasing eosinophil blood counts and ECP. The serum level of ECP seems to be a good clinical marker of monitoring the disease...
  52. ncbi [Precision and economy of skin prick tests]
    Maciej Kupczyk
    Klinika Pneumonologii i Alergologii Instytutu Medycyny Wewnetrznej Akademii Medycznej w Łodzi
    Pol Merkur Lekarski 12:190-3. 2002
    ..For financial reasons multiple test method can be used in screening and epidemiological studies where atopy is studied and there is no need to identify the specific allergen...
  53. ncbi [The effect of triamcinolone acetonide, montelukast, nedocromil sodium, formoterol on levels levels of sICAM-1, sIL-2R in serum and clinical course of asthma in children]
    Iwona Stelmach
    Samodzielny Oddział Kliniczny Interny Dzieciecej i Alergologii Instytutu Pediatrii Akademii Medycznej w Łodzi
    Pol Merkur Lekarski 12:99-103. 2002
    ..The serum level of sIL-2R and sICAM-1 seem to be a good clinical marker of monitoring the disease; their levels decrease after treatment together with improvement in hyperresponsiveness and clinical parameters...
  54. ncbi [The effect of inhaled heparin on post-leukotriene bronchoconstriction in children with bronchial asthma]
    Iwona Stelmach
    Samodzielny Oddział Kliniczny Interny Dzieciecej i Alergologii Instytutu Pediatrii Akademii Medycznej w Łodzi
    Pol Merkur Lekarski 12:95-8. 2002
    ..In our study heparin was inhaled just before leukotriene provocation test and thus the effect of heparin on eosinophil proteins is less likely possible...
  55. ncbi A randomized, double-blind trial of the effect of treatment with montelukast on bronchial hyperresponsiveness and serum eosinophilic cationic protein (ECP), soluble interleukin 2 receptor (sIL-2R), IL-4, and soluble intercellular adhesion molecule 1 (sICA
    Iwona Stelmach
    Department of Pediatrics and Allergy, M Curie Hospital, Zgierz, Poland
    J Allergy Clin Immunol 109:257-63. 2002
    ..Anti-inflammatory properties of leukotriene modifiers and their effect on bronchial hyperresponsiveness have not been studied in children with asthma...
  56. ncbi Comparative effect of triamcinolone, nedocromil and montelukast on asthma control in children: A randomized pragmatic study
    Iwona Stelmach
    The M Curie Hospital, Department of Pediatrics and Allergy, Zgierz, Poland
    Pediatr Allergy Immunol 15:359-64. 2004
    ..The study showed the strongest effect of low-dose inhaled steroids on clinical symptoms, lung function, bronchial hyper-reactivity and eosinophil blood count when compared to other asthma medications...
  57. ncbi The effect of montelukast and different doses of budesonide on IgE serum levels and clinical parameters in children with newly diagnosed asthma
    Iwona Stelmach
    The M Curie Hospital, Department of Pediatrics and Allergy, Zgierz, Poland
    Pulm Pharmacol Ther 18:374-80. 2005
    ..The present study was conducted to determine the effects of a 6-month treatment with different doses of inhaled budesonide and montelukast sodium in children with newly diagnosed atopic asthma...
  58. ncbi [Cockroach hypersensitivity in children suffering from perennial allergic rhinitis]
    Jadwiga Kaczmarek
    Klinika Pneumonologii i Alergologii Instytutu Medycyny Wewnetrznej Uniwersytetu Medycznego, Lodzi
    Pol Merkur Lekarski 18:400-3. 2005
    ..Published studies show a high variability in frequency of hypersensitivity to cockroaches. The aim of our work was to study the possible role of cockroach allergy in children suffering from perennial allergic rhinitis...
  59. ncbi [The influence of mononucleosis infection on atopic disease development in children]
    Anna Stańczyk-Przyłuska
    Klinika Propedeutyki Pediatrii i Chorób Metabolicznych Kości Uniwersytetu Medycznego w Lodzi
    Pneumonol Alergol Pol 73:18-22. 2005
    ..0001) than in general population of children in Lódź (16%). The frequency of positive skin prick tests with common allergens was also significantly higher (60% vs 27%, respectively)...
  60. ncbi Budesonide/formoterol improves lung function compared with budesonide alone in children with asthma
    Petr Pohunek
    University Hospital Motol, Prague, Czech Republic
    Pediatr Allergy Immunol 17:458-65. 2006
    ..Adverse-event profiles were similar in all groups; there were no serious asthma-related adverse events in any treatment group...
  61. ncbi [The effect of desloratadine on use of rescue beta2-agonists and symptoms in patients suffering from seasonal allergic rhinitis and asthma]
    Maciej Kupczyk
    Klinika Pneumonologii i Alergologii Instytutu Medycyny Wewnetrznej UM w Łodzi
    Pol Merkur Lekarski 18:129-32. 2005
    ..Decrease of beta2-agonist use and reduction of diseases symptoms was documented in patients with seasonal allergic rhinitis and asthma...
  62. ncbi Efficacy and safety of high-dose budesonide/formoterol (Symbicort) compared with budesonide administered either concomitantly with formoterol or alone in patients with persistent symptomatic asthma
    Christine Jenkins
    Woolcock Institute of Medical Research, Camperdown, New South Wales, Australia
    Respirology 11:276-86. 2006
    ..The authors assessed the efficacy and safety of a higher dose of budesonide/formoterol in patients with persistent symptomatic asthma...
  63. ncbi The ECP/Eo count ratio in children with asthma
    Iwona Stelmach
    Department of Pediatrics and Allergy, M Curie Hospital, Zgierz, Poland
    J Asthma 41:539-46. 2004
    ..84; 95% CI: 1.02-3.34) a risk of moderate asthma. These data show that the ECP/Eo ratio is a better and more useful marker than ECP or peripheral blood eosinophil count separately in assessing asthma in children...
  64. ncbi [Mucolytics in acute and chronic respiratory tract disorders. II. Uses for treatment and antioxidant properties]
    Maciej Kupczyk
    Klinika Pneumonologii i Alergologii Instytutu Medycyny Wewnetrznej Akademii Medycznej w Łodzi
    Pol Merkur Lekarski 12:248-52. 2002
    ..Ambroxol is able to inhibit mediator release involved in the pathogenesis of allergic inflammation. As mucolytics are cheap and well-tolerated they are beneficial in the therapy of patients suffering from respiratory tract disorders...
  65. ncbi [Lipoxins--new view on old mediators carrying potent anti-inflammatory action]
    Katarzyna Jarmakowska
    Klinika Pneumonologii i Alergologii Instytutu Medycyny Wewnetrznej Uniwersytetu Medycznego w Lodzi
    Pol Merkur Lekarski 18:491-5. 2005
    ..Here, we present an overview of the recent knowledge about the biosynthesis and bioactions of these anti-inflammatory lipid mediators...
  66. ncbi [The role of interleukin 10 in allergic inflammation]
    Damian Tworek
    Klinika Pneumonologii i Alergologii Instytutu Medycyny Wewnetrznej UM w Łodzi
    Pol Merkur Lekarski 18:125-8. 2005
    ..It plays crucial role in induction and maintenance of T cells anergy. It was also noticed that some medicines can accomplish their antiinflammatory effects by increasing the production of IL-10...
  67. ncbi [Asthma as a mask of other respiratory diseases]
    Wojciech J Piotrowski
    Z Kliniki Pneumonologii i Alergologii Uniwersytetu Medycznego w Lodzi
    Wiad Lek 59:424-8. 2006
    ..Safety precautions have been also recollected. If safety rules are met, severe bronchoconstriction in patients with bronchial hyperreactivity can be avoided...
  68. ncbi [Role of ciclesonide in asthma therapy]
    Izabela Kuprys-Lipinska
    Klinika Chorób Wewnetrznych, Astmy i Alergii, Uniwersytecki Szpital Kliniczny nr 1 im Lodzi
    Pneumonol Alergol Pol 76:37-43. 2008
    ..This article is a review of clinical trials on efficacy and safety of ciclesonide as the resume of authors' clinical experience...
  69. ncbi [Bronchial asthma--epidemiology, public and economic problems]
    Włodzimierz Stelmach
    Samodzielny Kliniczny Oddział Interny Dzieciecej i Alergologii Instytutu Pediatrii AM w Łodzi
    Pol Merkur Lekarski 12:509-14. 2002
    ..The review also focused on variety of preventive and counteraction programs, for example the national health program--'Prevention and treatment of asthma and allergic diseases'...
  70. ncbi [Level of interleukin-12 and interferon gamma in blood serum of children with neoplasms and allergy]
    Anna Charubczyk
    Uniwersytet Medyczny w Lodzi, Klinika Chorob Dzieci
    Pol Merkur Lekarski 19:761-4. 2005
    ..Interleukin-12 (IL-12) shows strong antineoplasm properties...
  71. ncbi Severe asthma attacks after sexual intercourse
    Piotr Kuna
    Am J Respir Crit Care Med 170:344-5. 2004
  72. ncbi [Comparison of injection-related and local immunotherapy]
    Piotr Kuna
    Klinika Pneumonologii i Alergologii Instytutu Medycyny Wewnetrznej Uniwersytetu Medycznego w Łodzi
    Pol Merkur Lekarski 14:695-9. 2003
    ..One question is presently beyond discussion: it is better to administer sublingual immunotherapy in patients with allergic diseases than not to give immunotherapy at all...
  73. ncbi [Exploring new therapeutic approaches to the treatment of inflammatory disorders--lipoxins]
    Katarzyna Jarmakowska
    Klinika Pneumonologii i Alergologii Instytutu Medycyny Wewnetrznej Uniwersytetu Medycznego w Lodzi
    Pol Merkur Lekarski 18:578-80. 2005
    ..Taken together, the available data suggests that lipoxins may have broad therapeutic potential in inflammatory disorders and could provide an alternative to corticosteroids in certain clinical settings...
  74. ncbi [Contemporary views on the pathological mechanism of asthma]
    Piotr Kuna
    Klinika Pneumonologii i Alergologii Instytutu Medycyny Wewnetrznej Uniwersytetu Medycznego w Łodzi
    Pol Merkur Lekarski 14:519-21. 2003
    ..An important role in the obturation is played by smooth muscle hypertrophy and deposition of proteins under the basal membranes of respiratory epithelium...
  75. ncbi [Cytokines in allergic inflammation]
    Piotr Kuna
    Klinika Pneumonologii i Alergologii Instytutu Medycyny Wewnetrznej Uniwersytetu Medycznego w Łodzi
    Pol Merkur Lekarski 14:497-9. 2003
    ..Recently it has been proven that IL-10 and other cytokines from the IL-10 family, and TGF-beta have anti-inflammatory properties in allergy...
  76. ncbi [Epidemics of allergic diseases: a new health problem in the modern world]
    Izabela Kupryś
    Klinika Pneumonologii i Alergologii Instytutu Medycyny Wewnetrznej Uniwersytetu Medycznego w Łodzi
    Pol Merkur Lekarski 14:453-5. 2003
    ..Allergy has become one of the major public health problems. This article presents the impact of allergy on health state...
  77. ncbi [Diagnosis and therapy of chronic obstructive pulmonary disease--recommendations of the Polish Phtisiopneumonology Society]
    Jerzy Kozielski
    Klinika Ftizjopneumonologii S A M w Zabrzu
    Pneumonol Alergol Pol 70:2-42. 2002
  78. ncbi [The Churg-Strauss syndrome and antileukotriene agents]
    Damian Tworek
    Klinika Pneumunologii i Alergologii Instytutu Medycyny Wewngtrznej Uniwersytetu Medycznego, Lodzi
    Pol Merkur Lekarski 19:203-5. 2005
    ..The pathogenesis of CSS is not clear, but it is suspected that antileukotriene agents, used in the treatment of asthma, are probably involved in. However, this association has not been unequivocally proved until now...
  79. ncbi [Safety of venom immunotherapy in patients pretreated with antihistamines--a retrospective study]
    Damian Tworek
    Z Kliniki Chorób Wewnetrznych, Astmy i Alergii Katedry Pulmonologii i Alergologii Uniwersytetu Medycznego, Łodzi
    Pneumonol Alergol Pol 74:153-8. 2006
    ....