Anetta Undas

Summary

Country: Poland

Publications

  1. ncbi Statins and blood coagulation
    Anetta Undas
    Department of Medicine, Jagiellonian University School of Medicine, Krakow, Poland
    Arterioscler Thromb Vasc Biol 25:287-94. 2005
  2. ncbi Early antithrombotic and anti-inflammatory effects of simvastatin versus fenofibrate in patients with hypercholesterolemia
    Anetta Undas
    Dept of Medicine, Jagiellonian University School of Medicine, 8 Skawinska Str, 31 066 Cracow, Poland
    Thromb Haemost 94:193-9. 2005
  3. doi Plasma fibrin clot properties in atopic dermatitis: links between thrombosis and atopy
    Magdalena Nastałek
    Department of Dermatology, Jagiellonian University School of Medicine, Krakow, Poland
    J Thromb Thrombolysis 30:121-6. 2010
  4. ncbi Reduced clot permeability and susceptibility to lysis in patients with acute coronary syndrome: effects of inflammation and oxidative stress
    Anetta Undas
    Institute of Cardiology, Jagiellonian University School of Medicine, 80 Pradnicka Str 31 202 Cracow, Poland
    Atherosclerosis 196:551-7. 2008
  5. doi Blood coagulation and fibrinolysis in aortic valve stenosis: links with inflammation and calcification
    J Natorska
    Anetta Undas, Institute of Cardiology, Jagiellonian University School of Medicine, 80 Pradnicka St, 31 202 Cracow, Poland, Tel 48 12 6143004, Fax 48 12 6143143, E mail
    Thromb Haemost 114:217-27. 2015
  6. doi Arterial and venous thromboembolism in chronic obstructive pulmonary disease: from pathogenic mechanisms to prevention and treatment
    Filip Mejza
    II Department of Internal Medicine, Jagiellonian University Medical College, Krakow, Poland Institute of Cardiology, Jagiellonian University Medical College, Krakow, Poland
    Pneumonol Alergol Pol 83:485-94. 2015
  7. ncbi Fibrinogen Krakow: a novel hypo/dysfibrinogenemia mutation in fibrinogen gamma chain (Asn325Ile) affecting fibrin clot structure and function
    Anetta Undas
    Institute of Cardiology, Jagiellonian University School of Medicine, 80 Pradnicka St, 31 202 Cracow, Poland
    Thromb Haemost 101:975-6. 2009
  8. doi Altered fibrin clot structure/function in patients with antiphospholipid syndrome: association with thrombotic manifestation
    M Celinska-Lowenhoff
    Anetta Undas, MD, PhD, Institute of Cardiology, Jagiellonian University Medical College, 80 Pradnicka St, 31 202 Krakow, Poland, Tel 48 12 6143004, Fax 48 12 4233900, E mail
    Thromb Haemost 112:287-96. 2014
  9. doi Fibrin clot properties and their modulation in thrombotic disorders
    A Undas
    Anetta Undas, MD, PhD, Institute of Cardiology, Jagiellonian University School of Medicine, 80 Pradnicka St, 31 202 Krakow, Poland, Tel 48 12 6143004, Fax 48 12 4233900, E mail
    Thromb Haemost 112:32-42. 2014
  10. doi Anticoagulant effects of statins and their clinical implications
    A Undas
    Anetta Undas, MD, PhD, Institute of Cardiology, Jagiellonian University School of Medicine, 80 Pradnicka St, 31 202 Krakow, Poland, Tel 48 12 6143004, Fax 48 12 4233900, E mail
    Thromb Haemost 111:392-400. 2014

Detail Information

Publications106 found, 100 shown here

  1. ncbi Statins and blood coagulation
    Anetta Undas
    Department of Medicine, Jagiellonian University School of Medicine, Krakow, Poland
    Arterioscler Thromb Vasc Biol 25:287-94. 2005
    ..Treatment with statins can lead to a significant downregulation of the blood coagulation cascade, most probably as a result of decreased tissue factor expression, which leads to reduced thrombin generation...
  2. ncbi Early antithrombotic and anti-inflammatory effects of simvastatin versus fenofibrate in patients with hypercholesterolemia
    Anetta Undas
    Dept of Medicine, Jagiellonian University School of Medicine, 8 Skawinska Str, 31 066 Cracow, Poland
    Thromb Haemost 94:193-9. 2005
    ..However, in contrast to statins, fibrates have no influence on platelet function within one month of therapy...
  3. doi Plasma fibrin clot properties in atopic dermatitis: links between thrombosis and atopy
    Magdalena Nastałek
    Department of Dermatology, Jagiellonian University School of Medicine, Krakow, Poland
    J Thromb Thrombolysis 30:121-6. 2010
    ..03). Altered plasma fibrin clot properties associated with reduced efficiency of fibrinolysis can be detected in AD patients, which might represent a novel mechanism that modulates a hemostatic balance in atopy...
  4. ncbi Reduced clot permeability and susceptibility to lysis in patients with acute coronary syndrome: effects of inflammation and oxidative stress
    Anetta Undas
    Institute of Cardiology, Jagiellonian University School of Medicine, 80 Pradnicka Str 31 202 Cracow, Poland
    Atherosclerosis 196:551-7. 2008
    ..Stable angina is associated with unfavorable fibrin structure/function. It is not known how acute coronary syndromes (ACS) affect fibrin architecture...
  5. doi Blood coagulation and fibrinolysis in aortic valve stenosis: links with inflammation and calcification
    J Natorska
    Anetta Undas, Institute of Cardiology, Jagiellonian University School of Medicine, 80 Pradnicka St, 31 202 Cracow, Poland, Tel 48 12 6143004, Fax 48 12 6143143, E mail
    Thromb Haemost 114:217-27. 2015
    ..This review summarises the available data on blood coagulation and fibrinolysis in AS with the emphasis on their interactions with inflammation and calcification. ..
  6. doi Arterial and venous thromboembolism in chronic obstructive pulmonary disease: from pathogenic mechanisms to prevention and treatment
    Filip Mejza
    II Department of Internal Medicine, Jagiellonian University Medical College, Krakow, Poland Institute of Cardiology, Jagiellonian University Medical College, Krakow, Poland
    Pneumonol Alergol Pol 83:485-94. 2015
    ..We discuss multiple mechanisms potentially linking these conditions and available pharmacological interventions reducing the risk of thrombotic arterial and venous events with special attention paid to new oral anticoagulants. ..
  7. ncbi Fibrinogen Krakow: a novel hypo/dysfibrinogenemia mutation in fibrinogen gamma chain (Asn325Ile) affecting fibrin clot structure and function
    Anetta Undas
    Institute of Cardiology, Jagiellonian University School of Medicine, 80 Pradnicka St, 31 202 Cracow, Poland
    Thromb Haemost 101:975-6. 2009
  8. doi Altered fibrin clot structure/function in patients with antiphospholipid syndrome: association with thrombotic manifestation
    M Celinska-Lowenhoff
    Anetta Undas, MD, PhD, Institute of Cardiology, Jagiellonian University Medical College, 80 Pradnicka St, 31 202 Krakow, Poland, Tel 48 12 6143004, Fax 48 12 4233900, E mail
    Thromb Haemost 112:287-96. 2014
    ..We conclude that APS is associated with prothrombotic plasma fibrin clot phenotype, with more pronounced abnormalities in arterial thrombosis. Molecular background for this novel prothrombotic mechanism in APS remains to be established. ..
  9. doi Fibrin clot properties and their modulation in thrombotic disorders
    A Undas
    Anetta Undas, MD, PhD, Institute of Cardiology, Jagiellonian University School of Medicine, 80 Pradnicka St, 31 202 Krakow, Poland, Tel 48 12 6143004, Fax 48 12 4233900, E mail
    Thromb Haemost 112:32-42. 2014
    ..Moreover, factors will be presented that in vivo unfavourably determine altered fibrin clot properties in thrombotic disorders and modalities that can improve clot phenotype. ..
  10. doi Anticoagulant effects of statins and their clinical implications
    A Undas
    Anetta Undas, MD, PhD, Institute of Cardiology, Jagiellonian University School of Medicine, 80 Pradnicka St, 31 202 Krakow, Poland, Tel 48 12 6143004, Fax 48 12 4233900, E mail
    Thromb Haemost 111:392-400. 2014
    ....
  11. pmc Active tissue factor and activated factor XI in patients with acute ischemic cerebrovascular events
    Anetta Undas
    Institute of Cardiology, Jagiellonian University Medical College, Krakow, Poland
    Eur J Clin Invest 42:123-9. 2012
    ..We sought to investigate whether circulating activated FXI (FXIa) and TF on admission can predict clinical outcomes in patients with acute cerebrovascular events...
  12. doi Altered fibrin clot properties are associated with residual vein obstruction: effects of lipoprotein(a) and apolipoprotein(a) isoform
    Anetta Undas
    Institute of Cardiology, Jagiellonian University School of Medicine, Krakow, Poland
    Thromb Res 130:e184-7. 2012
    ..In conclusion, prothrombotic plasma fibrin clot phenotype related to elevated lipoprotein(a) with smaller apolipoprotein(a) isoforms might represent a novel risk factor for RVO...
  13. pmc Reduced coronary flow reserve in Anderson-Fabry disease measured by transthoracic Doppler echocardiography
    Paweł Petkow Dimitrow
    2nd Department of Cardiology, Collegium Medicum Jagiellonian University, Cracow, Poland
    Cardiovasc Ultrasound 3:11. 2005
    ..In small intramyocardial arteries coronary flow was also disturbed. Accordingly, retrograde systolic flow and accelerated anterograde diastolic flow were documented...
  14. ncbi Altered fibrin clot properties in patients on long-term haemodialysis: relation to cardiovascular mortality
    Anetta Undas
    Institute of Cardiology, Jagiellonian University School of Medicine, Cracow, Poland
    Nephrol Dial Transplant 23:2010-5. 2008
    ....
  15. doi Fibrin clot properties in acute ischemic stroke: relation to neurological deficit
    Anetta Undas
    Institute of Cardiology, Jagiellonian University School of Medicine, Cracow, Poland
    Thromb Res 125:357-61. 2010
    ..Hypercoagulable state occurs in patients with acute vascular events. We wondered whether clot structure/function is altered in acute ischemic stroke (AIS), like in acute myocardial infarction...
  16. doi Altered plasma fibrin clot properties are associated with in-stent thrombosis
    Anetta Undas
    Institute of Cardiology, Jagiellonian University School of Medicine, 31 202 Cracow, Poland
    Arterioscler Thromb Vasc Biol 30:276-82. 2010
    ..We sought to investigate whether patients with in-stent thrombosis (IST) display altered plasma fibrin clot properties...
  17. ncbi Autoantibodies against N-homocysteinylated proteins in patients on long-term haemodialysis
    Anetta Undas
    Institute of Cardiology, Jagiellonian University School of Medicine, 80 Pradnicka Street, 31 202 Cracow, Poland
    Nephrol Dial Transplant 22:1685-9. 2007
    ....
  18. ncbi Simvastatin increases clot permeability and susceptibility to lysis in patients with LDL cholesterol below 3.4 mmol/l
    Anetta Undas
    Institute of Cardiology, Jagiellonian University School of Medicine, Krakow, Poland
    Pol Arch Med Wewn 119:354-9. 2009
    ..Moreover, we have described simvastatin-induced improvement of fibrin clot properties, the formation of which represents the final step of blood coagulation...
  19. doi Altered fibrin clot structure/function in patients with idiopathic venous thromboembolism and in their relatives
    Anetta Undas
    Institute of Cardiology, Jagiellonian University School of Medicine, 31 202 Krakow, Poland
    Blood 114:4272-8. 2009
    ..Similar features can be detected in VTE relatives. Fibrin properties might represent novel risk factors for thrombosis...
  20. ncbi Thrombin formation and platelet activation at the site of vascular injury in patients with coronary artery disease treated with clopidogrel combined with aspirin
    Anetta Undas
    Instytut Kardiologii, Uniwersytet Jagielloński Collegium Medicum, ul Pradnicka 80, 31 202 Krakow, Poland
    Kardiol Pol 67:591-8. 2009
    ..Data on the effects of oral antiplatelet agents on blood coagulation in vivo are conflicting. The platelet glycoprotein (GP) IIIa PlA2 allele has been suggested to modulate antithrombotic actions of clopidogrel...
  21. pmc Hyperglycemia is associated with enhanced thrombin formation, platelet activation, and fibrin clot resistance to lysis in patients with acute coronary syndrome
    Anetta Undas
    Institute of Cardiology, Jagiellonian University School of Medicine, Cracow, Poland
    Diabetes Care 31:1590-5. 2008
    ..Postulated mechanisms of this observation include prothrombotic effects. The aim of this study was to evaluate the effect of elevated glucose levels on blood clotting in acute coronary syndrome patients...
  22. ncbi Switching from acenocoumarol to warfarin in patients with unstable anticoagulation and its effect on anticoagulation control
    Anetta Undas
    Institute of Cardiology, Jagiellonian University School of Medicine, Krakow, Poland
    Pol Arch Med Wewn 119:360-5. 2009
    ..Acenocoumarol use has been reported to be associated with two-fold higher risk for instability of anticoagulation control compared to warfarin administration...
  23. doi Altered fibrin clot structure/function in patients with cryptogenic ischemic stroke
    Anetta Undas
    Institute of Cardiology, Jagiellonian University School of Medicine, Cracow, Poland
    Stroke 40:1499-501. 2009
    ..We tested the hypothesis that fibrin structure/function is unfavorably altered in patients with cryptogenic ischemic stroke...
  24. doi Tissue factor +5466A>G polymorphism determines thrombin formation following vascular injury and thrombin-lowering effects of simvastatin in patients with ischemic heart disease
    Anetta Undas
    Institute of Cardiology, Jagiellonian University School of Medicine, 80 Pradnicka Str, 31 202 Cracow, Poland
    Atherosclerosis 204:567-72. 2009
    ..We examined the hypothesis that the +5466A>G variant (rs3917643) of the tissue factor (TF) gene is associated with thrombin formation following simvastatin in patients with ischemic heart disease (IHD)...
  25. ncbi [Antiplatelet effects of micronized fenofibrate in subjects with dyslipidemia]
    Anetta Undas
    II Katedra Chorób Wewnętrznych, Collegium Medicum Uniwersytetu Jagiellońiskiego, Krakow
    Pol Arch Med Wewn 117:235-40. 2007
    ..Fibrates produce additional actions such as reduction of inflammatory state, insulin resistance and activation of blood coagulation, along with stimulation of fibrinolysis. It is not known whether fibrates can attenuate platelet activation...
  26. doi Fibrin clot properties are altered in patients with chronic obstructive pulmonary disease. Beneficial effects of simvastatin treatment
    Anetta Undas
    Institute of Cardiology Jagiellonian University School of Medicine, Cracow, Poland
    Thromb Haemost 102:1176-82. 2009
    ..Our study shows that fibrin clots in COPD patients are composed of much denser networks that are more resistant to lysis, and these properties can be improved by statin administration...
  27. doi The effect of chronic kidney disease on fibrin clot properties in patients with acute coronary syndrome
    Anetta Undas
    Institute of Cardiology, Jagiellonian University School of Medicine, 80 Pradnicka Street, Krakow, Poland
    Blood Coagul Fibrinolysis 21:522-7. 2010
    ..006) and tPA (P = 0.002). This study indicates that ACS patients with CKD display unfavorable fibrin clot properties including impaired fibrinolysis, which might contribute to worse outcome in this population...
  28. ncbi New nonlipid effects of statins and their clinical relevance in cardiovascular disease
    Anetta Undas
    Department of Medicine, Jagiellonian University School of Medicine, Krakow, Poland
    Thromb Haemost 91:1065-77. 2004
    ..However, the clinical relevance of multiple protective effects induced by statins has not been clarified yet...
  29. ncbi Acquired dysfibrinogenemia in atherosclerotic vascular disease
    Anetta Undas
    Institute of Cardiology, Jagiellonian University, Medical College and John Paul II Hospital, Krakow, Poland
    Pol Arch Med Wewn 121:310-9. 2011
    ..The review summarizes current knowledge on the links between fibrin clot phenotype and atherosclerotic vascular disease and describes a wide spectrum of cardiovascular risk factors as modifiers of fibrin network characteristics...
  30. pmc Circulating activated factor XI and active tissue factor as predictors of worse prognosis in patients following ischemic cerebrovascular events
    Anetta Undas
    Institute of Cardiology, Jagiellonian University Medical College, Krakow, Poland
    Thromb Res 128:e62-6. 2011
    ..Activated FXI (FXIa) and tissue factor (TF) have not been studied following stroke. The aim of the current study was to evaluate circulating FXIa and TF in patients with prior cerebrovascular events...
  31. pmc Thrombin generation in chronic obstructive pulmonary disease: dependence on plasma factor composition
    Anetta Undas
    Institute of Cardiology, Jagiellonian University Medical College, Krakow, Poland
    Thromb Res 128:e24-8. 2011
    ..Chronic obstructive pulmonary disease (COPD) is associated with an increased risk for thromboembolic events. We investigated thrombin generation profiles in COPD patients and their dependence on plasma factor/inhibitor composition...
  32. doi Ezetimibe combined with simvastatin compared with simvastatin alone results in a greater suppression of oxidative stress and enhanced fibrinolysis in patients after acute coronary events
    Anetta Undas
    Institute of Cardiology, Jagiellonian University School of Medicine, Krakow, Poland
    J Cardiovasc Pharmacol 58:167-72. 2011
    ....
  33. ncbi Homocysteine and thrombosis: from basic science to clinical evidence
    Anetta Undas
    Department of Medicine, Jagiellonian University School of Medicine, Krakow, Poland
    Thromb Haemost 94:907-15. 2005
    ..Ongoing clinical trials might help clarify this issue...
  34. doi Abnormal plasma fibrin clot characteristics are associated with worse clinical outcome in patients with peripheral arterial disease and thromboangiitis obliterans
    Anetta Undas
    Institute of Cardiology, Jagiellonian University School of Medicine, Krakow, Poland
    Atherosclerosis 215:481-6. 2011
    ..A role of blood coagulation in the pathogenesis of peripheral arterial disease (PAD) and Buerger's disease, or thromboangiitis obliterans (TAO), remains unclear...
  35. doi Fibrin presence within aortic valves in patients with aortic stenosis: association with in vivo thrombin generation and fibrin clot properties
    Joanna Natorska
    Institute of Cardiology, Jagiellonian University School of Medicine, 80 Pradnicka St, 31 202 Krakow, Poland
    Thromb Haemost 105:254-60. 2011
    ..In vivo thrombin generation and fibrin clot formation are associated with the extent of Fn presence within leaflets, which might contribute to the AS progression...
  36. ncbi Lipoprotein(a) as a modifier of fibrin clot permeability and susceptibility to lysis
    A Undas
    Institute of Cardiology, Jagiellonian University School of Medicine, 80 Pradnicka Street, 31 022 Cracow, Poland
    J Thromb Haemost 4:973-5. 2006
  37. doi Simvastatin administration reduces thromboxane production in subjects taking aspirin: links between aspirin resistance and thrombin generation
    Anetta Undas
    The Institute of Cardiology, Jagiellonian University School of Medicine, Krakow, Poland
    Int J Cardiol 154:59-64. 2012
    ..We investigated the relationships between thromboxane production, thrombin generation, and oxidative stress in patients receiving aspirin before and after statin administration...
  38. doi Effect of aortic valve stenosis on haemostasis is independent from vascular atherosclerotic burden
    Pawel Petkow Dimitrow
    Institute of Cardiology, Collegium Medicum Jagiellonian University, ul Kopernika 17, 31 501 Krakow, Poland
    Atherosclerosis 204:e103-8. 2009
    ..The aim of study was to assess whether activation of blood coagulation and platelets is enhanced in aortic stenosis (AS) and if so, to determine factors that might modulate these processes...
  39. doi Reduced thrombin formation and altered fibrin clot properties induced by polyunsaturated omega-3 fatty acids on top of dual antiplatelet therapy in patients undergoing percutaneous coronary intervention (OMEGA-PCI clot)
    Grzegorz Gajos
    Department of Coronary Disease, Institute of Cardiology, Jagiellonian University Medical College, Krakow, Poland
    Arterioscler Thromb Vasc Biol 31:1696-702. 2011
    ....
  40. ncbi Plasma homocysteine affects fibrin clot permeability and resistance to lysis in human subjects
    Anetta Undas
    Institute of Cardiology, Jagiellonian University School of Medicine, Krakow, Poland
    Arterioscler Thromb Vasc Biol 26:1397-404. 2006
    ..Homocysteine (Hcy) is a risk factor for thrombosis. We investigated a hypothesis that the clot permeability and its resistance to fibrinolysis is associated with plasma total Hcy (tHcy) in human subjects...
  41. doi Factors associated with the presence of circulating active tissue factor and activated factor XI in stable angina patients
    Michał Zabczyk
    Institute of Cardiology, Jagiellonian University Medical College, Krakow, Poland
    Blood Coagul Fibrinolysis 23:189-94. 2012
    ..Moreover, FXIa is also related to oxidative stress, indicating additional links between coagulation and free radical generation in stable angina...
  42. ncbi Interleukin-6 -174 G/C promoter polymorphism and effects of fenofibrate and simvastatin on inflammatory markers in hypercholesterolemic patients
    Daniel P Potaczek
    Department of Medicine, Jagellonian University School of Medicine, Cracow, Poland
    Blood Coagul Fibrinolysis 17:35-8. 2006
    ..A relationship between the -174 G/C IL-6 polymorphism and the anti-inflammatory action of fenofibrate reported might be useful in the optimization of the treatment regimen in patients receiving this class of drugs...
  43. ncbi No-reflow phenomenon after acute myocardial infarction is associated with reduced clot permeability and susceptibility to lysis
    Jaroslaw Zalewski
    Institute of Cardiology, Jagiellonian University School of Medicine, and John Paul II Hospital, 80 Pradnicka Street, 31 202 Cracow, Poland
    Arterioscler Thromb Vasc Biol 27:2258-65. 2007
    ..We assessed the relationship between fibrin clot properties and the no-reflow phenomenon after primary coronary intervention (PCI)...
  44. pmc Thrombin generation in rheumatoid arthritis: dependence on plasma factor composition
    Anetta Undas
    Institute of Cardiology, Jagiellonian University School of Medicine, Krakow, Poland
    Thromb Haemost 104:224-30. 2010
    ..Simulations of thrombin formation suggest that blood plasma composition, i.e. a marked increase in FVIII, somewhat counterbalanced by free TFPI, contributes to the prothrombotic phenotype in RA patients...
  45. ncbi Folic acid administration and antibodies against homocysteinylated proteins in subjects with hyperhomocysteinemia
    Anetta Undas
    Institute of Cardiology, Jagiellonian University of Medicine, Cracow, Poland
    Thromb Haemost 96:342-7. 2006
    ..These observations might explain at least in part the failure of vitamin therapy to reduce the risk of cardiovascular events as recently reported...
  46. doi Factor XIII expression within aortic valves and its plasma activity in patients with aortic stenosis: association with severity of disease
    Przemyslaw Kapusta
    John Paul II Hospital, Cracow, Poland
    Thromb Haemost 108:1172-9. 2012
    ..Our findings might suggest that FXIII in the stenotic valves is presented in AAM and may be involved in the AS progression...
  47. pmc Does diabetes accelerate the progression of aortic stenosis through enhanced inflammatory response within aortic valves?
    Joanna Natorska
    Institute of Cardiology, Jagiellonian University Medical College, 80 Pradnicka Str, 31 202 Kracow, Poland
    Inflammation 35:834-40. 2012
    ..84, p = 0.036). Diabetes mellitus is associated with enhanced inflammation within AS valves, measured by CRP expression, which may contribute to faster AS progression...
  48. doi Unfavorably altered fibrin clot properties in patients with active rheumatoid arthritis
    Beata Kwasny-Krochin
    Department of Rheumatology, Jagiellonian University School of Medicine, Krakow, Poland
    Thromb Res 126:e11-6. 2010
    ..Given increased prevalence of CVD in patients with rheumatoid arthritis (RA), we investigated whether fibrin characteristics are also altered in RA patients...
  49. pmc Systemic blood coagulation activation in acute coronary syndromes
    Anetta Undas
    Institute of Cardiology, Jagiellonian University School of Medicine, Krakow, Poland
    Blood 113:2070-8. 2009
    ..AMI-induced systemic activation of blood coagulation markedly modifies the pattern of coagulant reactions at the site of injury in peripheral vessels compared with that in stable CAD patients...
  50. ncbi Blood coagulation at the site of microvascular injury in healthy and coumadin-treated subjects heterogenous for factor V Leiden mutation
    Anetta Undas
    Department of Medicine, Jagiellonian University School of Medicine, Crakow, Poland
    Thromb Haemost 98:1024-30. 2007
    ..Inactivation of FVa by the APC mechanism is attenuated significantly in carriers of FV Leiden but the magnitude of this effect is smaller than that observed in most purified systems...
  51. ncbi Factor XIII Val34Leu polymorphism as a modulator of fibrin clot permeability and resistance to lysis in patients with severe coronary artery disease
    Ewa Stepien
    Department of Cardiac Surgery, Anesthesiology and Experimental Cardiology, Institute of Cardiology, Jagiellonian University Collegium Medicum, Krakow, Poland
    Kardiol Pol 67:947-55. 2009
    ..Data on the effects of Leu34 allele on cardiovascular thromboembolic events in vivo are conflicting...
  52. ncbi Platelet activation and microvascular injury in patients with ST-segment elevation myocardial infarction
    Jarosław Zalewski
    Centre for Interventional Treatment of Cardiovascular Diseases, The John Paul II Hospital, Krakow, Poland
    Kardiol Pol 70:677-84. 2012
    ..Dual antiplatelet therapy reduces the risk of thrombotic complications after primary percutaneous coronary intervention (PCI)...
  53. doi Impaired responsiveness to clopidogrel and aspirin in patients with recurrent stent thrombosis following percutaneous intervention for peripheral artery disease
    Piotr Mazur
    Institute of Cardiology, Jagiellonian University Medical College, Krakow, Poland
    Platelets 24:151-5. 2013
    ..This indicates that atherosclerosis burden affects platelet function and might contribute to stent thrombosis following percutaneous intervention in peripheral arteries...
  54. pmc Activated factor XI and tissue factor in aortic stenosis: links with thrombin generation
    Joanna Luszczak
    Institute of Cardiology, Jagiellonian University School of Medicine, Krakow, Poland
    Blood Coagul Fibrinolysis 22:473-9. 2011
    ..207±64 pM, P<0.001). Detectable FXIa and TF activity was observed for the first time in aortic stenosis patients, primarily in severe ones. This activity correlates with thrombin generation in those patients...
  55. doi Acute CO poisoning is associated with impaired fibrinolysis and increased thrombin generation
    Tomasz Gawlikowski
    Department of Clinical Toxicology, Jagiellonian University School of Medicine, Krakow, Poland
    Basic Clin Pharmacol Toxicol 112:352-6. 2013
    ..In conclusion, this report is the first to demonstrate that acute CO poisoning in human beings is linked to increased thrombin generation and impaired fibrinolysis, which might contribute to ischaemic complications...
  56. doi Increased thrombin generation and platelet activation are associated with deficiency in high molecular weight multimers of von Willebrand factor in patients with moderate-to-severe aortic stenosis
    Joanna Natorska
    John Paul II Hospital, Krakow, Poland
    Heart 97:2023-8. 2011
    ..It has also been reported that AS is associated with increased activation of blood coagulation...
  57. doi Altered fibrin clot properties in patients with chronic heart failure and sinus rhythm: a novel prothrombotic mechanism
    Ilona Palka
    Institute of Cardiology, Jagiellonian University School of Medicine, 80 Pradnicka Str 31 202, Kracow, Poland
    Heart 96:1114-8. 2010
    ..Thromboembolic complications occur more frequently in patients with chronic heart failure (CHF) than in the general population. Formation of a compact fibrin clot resistant to lysis has been shown in arterial and venous thrombosis...
  58. doi Effect of the E-selectin gene polymorphism (S149R) on platelet activation and adverse events after coronary artery surgery
    Ewa Stepien
    Department of Clinical Biochemistry, Jagiellonian University Medical College, Krakow, Poland
    Arch Med Res 42:375-81. 2011
    ..Associations between the S149R polymorphism and an increased risk of perioperative acute thrombotic events with regards to a platelet count and activity were analyzed...
  59. doi High tea and vegetable consumption is associated with low ADMA generation in older healthy subjects
    Tadeusz Goralczyk
    Central Laboratory, John Paul II Hospital, Cracow, Poland
    Metabolism 61:1171-6. 2012
    ..37, P < .0001), although these associations were less potent after adjustment for dietary factors. Higher tea and vegetable intake is associated with lower plasma ADMA levels in healthy middle-aged subjects...
  60. doi A history of early stent thrombosis is associated with prolonged clot lysis time
    Oksana Pankiw-Bembenek
    John Paul II Hospital, Krakow, Poland
    Thromb Haemost 107:513-20. 2012
    ..Concluding, impaired fibrinolytic potential, that is in part determined by plasma PAI-1 antigen and TAFI activity, characterises patients with a history of acute and subacute IST, which might help identify patients at higher risk of IST...
  61. ncbi Polyunsaturated omega-3 fatty acids improve responsiveness to clopidogrel after percutaneous coronary intervention in patients with cytochrome P450 2C19 loss-of-function polymorphism
    Grzegorz Gajos
    Department of Coronary Heart Disease, Jagiellonian University Medical College, Krakow, Poland
    Kardiol Pol 70:439-45. 2012
    ..It is unknown whether omega-3 PUFA can enhance platelet inhibition on standard aspirin and clopidogrel treatment in the setting of CYP2C19 loss-of-function polymorphism...
  62. pmc Fibrinogen beta-chain -C148T polymorphism is associated with increased fibrinogen, C-reactive protein, and interleukin-6 in patients undergoing coronary artery bypass grafting
    Ewa Wypasek
    Institute of Cardiology, Jagiellonian University Medical College, 80 Pradnicka St, 31 202 Cracow, Poland
    Inflammation 35:429-35. 2012
    ..The results indicate that the presence of the -148T FGB allele determines higher pre- and postoperative levels of inflammatory markers, which might be associated with in-hospital clinical outcomes...
  63. pmc Activated factor XI and tissue factor in chronic obstructive pulmonary disease: links with inflammation and thrombin generation
    Milosz Jankowski
    Department of Medicine, Jagiellonian University School of Medicine, Krakow, Poland
    Thromb Res 127:242-6. 2011
    ..Previously, circulating active tissue factor (TF) and factor XIa (FXIa) have been reported to be associated with acute coronary syndromes...
  64. ncbi Antibodies to N-homocysteinylated albumin as a marker for early-onset coronary artery disease in men
    Anetta Undas
    Department of Medicine, Jagiellonian University School of Medicine, 8 Skawinska Street, 31 066 Cracow, Poland
    Thromb Haemost 93:346-50. 2005
    ..An autoimmune response to Nepsilon-Hcy-albumin may represent a novel mechanism involved in the early development of CAD...
  65. ncbi The I allele of the angiotensin-converting enzyme gene polymorphism may determine an increase in homocysteine levels in fibrate-treated subjects
    Daniel P Potaczek
    Department of Medicine, Jagellonian University School of Medicine, 8 Skawinska Str, 31 066 Cracow, Poland
    Cardiovasc Drugs Ther 20:229-32. 2006
    ..Interestingly, fenofibrate treatment led to a significant increase in homocysteine levels (p = 0.03) only in carriers of the I allele. In conclusion, ACE genotype might help identify patients prone to this effect of fibrates...
  66. ncbi Aspirin alters the cardioprotective effects of the factor XIII Val34Leu polymorphism
    Anetta Undas
    Department of Medicine, Jagiellonian University School of Medicine, Cracow, Poland
    Circulation 107:17-20. 2003
    ....
  67. pmc Architecture of fibrin network inside thrombotic material obtained from the right atrium and pulmonary arteries: flow and location matter
    Piotr Mazur
    Institute of Cardiology, Jagiellonian University Medical College, 80 Pradnicka St, 31 202, Krakow, Poland
    J Thromb Thrombolysis 35:127-9. 2013
    ..Our findings describe the relation between thrombus architecture and location, and might help to elucidate thrombus resistance to anticoagulant therapy in some PE patients...
  68. doi Reduced plasma fibrin clot permeability and susceptibility to lysis in patients with inflammatory bowel disease: a novel prothrombotic mechanism
    Danuta Owczarek
    Department of Gastroenterology, Hepatology and Infectious Diseases, Jagiellonian University Medical College, Krakow, Poland Department of Bioinformatics and Telemedicine, Jagiellonian University Medical College, Krakow, Poland and Institute of Cardiology, Jagiellonian University Medical College, and John Paul II Hospital, Krakow, Poland
    Inflamm Bowel Dis 19:2616-24. 2013
    ..Its mechanism is still unclear. Altered fibrin clot properties have been reported in patients with thromboembolism and those with chronic inflammatory states. We investigated whether fibrin characteristics are abnormal in IBD...
  69. ncbi Protein C and protein S deficiency - practical diagnostic issues
    Ewa Wypasek
    The John Paul II Hospital, Krakow, Poland
    Adv Clin Exp Med 22:459-67. 2013
    ....
  70. doi Antithrombin Krakow II (c.624+1 G > T): a novel mutation leading to type 1 antithrombin deficiency
    Magdalena Celinska-Lowenhoff
    II Department of Internal Medicine, Jagiellonian University Medical College, Krakow, Poland
    Blood Coagul Fibrinolysis 23:454-5. 2012
    ..The substitution might be detrimental taking account for its position in a donor splice site. To the best of our knowledge this mutation has not been previously described, so it was named antithrombin Krakow II...
  71. doi Fibrin clot properties in acute stroke: what differs cerebral hemorrhage from cerebral ischemia?
    Joanna Pera
    Department of Neurology, Jagiellonian University, Krakow, Poland
    Stroke 43:1412-4. 2012
    ..Fibrin clot formation is important in acute intracerebral hemorrhage (ICH). We investigated plasma fibrin clot characteristics in acute ICH compared with acute ischemic stroke (IS) and nonstroke conditions...
  72. ncbi Aspirin resistance
    Andrzej Szczeklik
    Department of Medicine, Jagiellonian University School of Medicine, Skawinska 8, PL 31 066, Krakow, Poland
    Pharmacol Rep 57:33-41. 2005
    ..In addition, we do not know whether any alteration in therapy may improve clinical outcome in a subject identified as aspirin-resistant...
  73. ncbi Plasma biomarkers of endothelial dysfunction in patients with hypertrophic cardiomyopathy
    Paweł P Dimitrow
    2nd Department of Cardiology, Collegium Medicum, Jagiellonian University, Kopernika 17, PL 31 501 Krakow, Poland
    Pharmacol Rep 59:715-20. 2007
    ..HCM patients show specific features of endothelial dysfunction detectable in peripheral blood, involving increased sTM and TFPI, but not vWF, along with increased ADMA levels...
  74. ncbi Evidence for tissue factor expression in aortic valves in patients with aortic stenosis
    Joanna Natorska
    John Paul II Hospital, Krakow, Poland
    Pol Arch Med Wewn 119:636-43. 2009
    ..The role of blood coagulation in the pathogenesis of aortic stenosis (AS) is unknown. Recently, tissue factor (TF) expression in stenotic aortic valves has been reported in animal model...
  75. pmc Antithrombotic properties of aspirin and resistance to aspirin: beyond strictly antiplatelet actions
    Anetta Undas
    Institute of Cardiology, Jagiellonian University School of Medicine, Krakow, Poland
    Blood 109:2285-92. 2007
    ..Elucidation of the actual impacts of aspirin other than antiaggregation effects could be important in view of the widespread use of this drug in the prevention of thrombotic manifestations of atherosclerosis...
  76. ncbi Enhanced oxidative stress in hypertrophic cardiomyopathy
    Paweł P Dimitrow
    2nd Department of Cardiology, Collegium Medicum, Jagiellonian University, Kopernika 17, PL 31 501 Krakow, Poland
    Pharmacol Rep 61:491-5. 2009
    ..05, respectively). This study is the first to show that HCM is characterized by enhanced oxidative stress as evidenced by higher 8-iso-PGF(2alpha), which achieves its highest values in the presence of LVOT obstruction in HCM patients...
  77. doi Prior simvastatin treatment is associated with reduced thrombin generation and platelet activation in patients with acute ST-segment elevation myocardial infarction
    Maciej Pastuszczak
    Institute of Cardiology, Jagiellonian University School of Medicine, Krakow, Poland
    Thromb Res 125:382-6. 2010
    ..The aim of this study was to investigate the effect of prior statin treatment on thrombin generation and platelet activation in patients with ST-segment elevation myocardial infarction (STEMI)...
  78. doi Effects of polyunsaturated omega-3 fatty acids on responsiveness to dual antiplatelet therapy in patients undergoing percutaneous coronary intervention: the OMEGA-PCI (OMEGA-3 fatty acids after pci to modify responsiveness to dual antiplatelet therapy) st
    Grzegorz Gajos
    Department of Coronary Disease, John Paul II Hospital, Cracow, Poland
    J Am Coll Cardiol 55:1671-8. 2010
    ....
  79. doi Elevated concentrations of Nɛ-homocysteinyl-lysine isopeptide in acute myocardial infarction: links with ADMA formation
    Michał Zaąbczyk
    Institute of Cardiology, Jagiellonian University Medical College, Krakow, Poland
    Clin Chem Lab Med 49:729-35. 2011
    ..Proteolytic turnover of N-homocysteinylated proteins generates the isopeptide Nɛ-homocysteinyl-lysine (N-Hcy-Lys)...
  80. ncbi [Antibodies to N-homocysteinylated albumin in patients with systemic lupus erythematosus]
    Agnieszka Padjas
    II Katedra Chorób Wewnętrznych, Collegium Medicum Uniwersytetu Jagielloriskiego, Krakow
    Pol Arch Med Wewn 117:20-5. 2007
    ..It has been shown that elevated plasma total homocysteine (tHcy) results in protein N-homocysteinylation and production o autoantibodies against N-homocysteinylated (N-Hcy) proteins...
  81. doi Architecture of the thrombi removed from coronary artery bypass grafts in a patient with acute myocardial infarction
    Grzegorz Marek
    Institute of Cardiology, Jagiellonian University School of Medicine, 80 Pradnicka Str, 31 202 Krakow, Poland
    J Thromb Thrombolysis 30:372-4. 2010
    ..These findings help explain resistance of such thrombi to fibrinolysis and faster plaque growth related to fibrin accumulation...
  82. pmc Active tissue factor and activated factor XI in circulating blood of patients with systolic heart failure due to ischemic cardiomyopathy
    Michał Zabczyk
    Institute of Cardiology, Jagiellonian University Medical College, Krakow, Poland
    Pol Arch Med Wewn 120:334-40. 2010
    ..Circulating activated factor XI (FXIa) and active tissue factor (TF) can be detected in acute coronary syndromes and stable angina...
  83. doi Fibrin clot structure and function: a role in the pathophysiology of arterial and venous thromboembolic diseases
    Anetta Undas
    Institute of Cardiology, Jagiellonian University School of Medicine, Krakow, Poland
    Arterioscler Thromb Vasc Biol 31:e88-99. 2011
    ..Growing evidence indicates that abnormal fibrin properties represent a novel risk factor for arterial and venous thrombotic events, particularly of unknown etiology in young and middle-aged patients...
  84. doi Life-threatening cardiac manifestations of primary antiphospholipid syndrome
    Rafal Grzybczak
    Institute of Cardiology, Jagiellonian University Medical College, John Paul II Hospital, 80 Pradnicka Street, 31 202 Krakow, Poland
    Heart Vessels 25:267-9. 2010
    ..Further studies are needed to determine the best therapeutic strategy for APS patients with acute coronary syndrome...
  85. ncbi Architecture of a native mitral valve thrombus in a patient with hypereosinophilic syndrome
    Marek Zółciński
    Institute of Cardiology, Jagiellonian University Medical College, Cracow, Poland
    J Heart Valve Dis 19:596-8. 2010
    ..It may also represent a novel prothrombotic mechanism that operates in HES...
  86. ncbi Plasma asymmetric dimethylarginine (ADMA) is associated with retinopathy in type 2 diabetes
    Maciej T Malecki
    Department of Metabolic Diseases, Jagiellonian University, 15 Kopernika St, 31 501 Krakow, Poland
    Diabetes Care 30:2899-901. 2007
  87. ncbi Thrombin formation in platelet-rich plasma after oral methionine loading: preliminary report
    Teresa B Domagala
    Department of Medicine, Jagiellonian University School of Medicine, 8 Skawinska Street, Cracow 31 066, Poland
    Thromb Res 105:503-6. 2002
  88. doi Architecture of intraluminal thrombus removed from abdominal aortic aneurysm
    Paweł Matusik
    Institute of Cardiology, Jagiellonian University School of Medicine, Cracow, Poland
    J Thromb Thrombolysis 30:7-9. 2010
    ..The structure of ILT may differ largely among AAA patients contrary to previous findings and may reveal large dense fibrin-rich areas deprived of cells, which impair fibrinolysis and stabilize the thrombus size...
  89. ncbi Selected parameters of blood coagulation and fibrinolysis prior to and after surgical treatment of squamous cell carcinoma of the oral cavity
    Jadwiga Knapik
    Regional Blood Center, Krakow, Poland
    Anticancer Res 22:1873-5. 2002
    ..We conclude that, in patients treated surgically because of carcinoma of the oral cavity, there might be increased activity of the fibrinolytic system both prior to and after operation...
  90. ncbi Anti-inflammatory and antithrombotic effects of statins in the management of coronary artery disease
    Anetta Undas
    Department of Medicine, Jagiellonian University School of Medicine, Cracow, Poland
    Clin Lab 48:287-96. 2002
    ..Further studies will answer the question whether markers of inflammation, other than C-reactive protein and possibly indices of thrombin formation, might improve cardiovascular risk stratification...
  91. doi Severe bleeding and miscarriages in a hypofibrinogenemic woman heterozygous for the gamma Ala82Gly mutation
    Joanna Zdziarska
    Department of Hematology, Jagiellonian University School of Medicine, Krakow, Poland
    Blood Coagul Fibrinolysis 20:374-6. 2009
    ..No other coagulation, platelet or liver function tests yielded abnormal results. Antiphospholipid syndrome was excluded. This report suggests that the fibrinogen gamma Ala82Gly mutation could have variable clinical presentation...
  92. ncbi The angiotensin-converting enzyme gene insertion/deletion polymorphism and effects of quinapril and atorvastatin on haemostatic parameters in patients with coronary artery disease
    Daniel P Potaczek
    Thromb Haemost 94:224-5. 2005
  93. pmc Simvastatin given for 3 days can inhibit thrombin generation and activation of factor V and enhance factor Va inactivation in hypercholesterolemic patients
    Anetta Undas
    Arterioscler Thromb Vasc Biol 25:1524-5. 2005
  94. ncbi Letter by Undas and Jakubowski regarding article, "Relationship between homocysteine and mortality in chronic kidney disease"
    Anetta Undas
    Circulation 114:e547; author reply e548. 2006
  95. ncbi Effects of hypolipemic drugs on the osteoprotegerin - sRANKL system in patients with coronary artery disease
    Magdalena Celinska-Lowenhoff
    Thromb Haemost 97:868-70. 2007
  96. ncbi [Nonlipid effects of fibrates]
    Magdalena Celinska-Lowenhoff
    II Katedra Chorób Wewnętrznych, Collegium Medicum Uniwersytetu Jagiellonskiego w Krakowie
    Przegl Lek 61:99-101. 2004
    ..Further studies are required to prove that clinical relevance of these additional effects of fibrates is independent of their beneficial effects on lipid profile...
  97. doi Factor XIa and tissue factor activity in patients with coronary artery disease
    Saulius Butenas
    University of Vermont, Department of Biochemistry, Burlington, Vermont, USA
    Thromb Haemost 99:142-9. 2008
    ..59 and 0.39, respectively) and between FXIa and TAT (R(2) = 0.64 and 0.63, respectively). In conclusion, the majority of ACS and CAD-MI patients have circulating FXIa that correlates with markers of coagulation and inflammation...
  98. ncbi Lack of aspirin-induced decrease in thrombin formation in subjects resistant to aspirin
    Anetta Undas
    Thromb Haemost 97:1056-8. 2007
  99. ncbi Effects of simvastatin on angiogenic growth factors released at the site of microvascular injury
    Anetta Undas
    Thromb Haemost 95:1045-7. 2006
  100. ncbi [Thrombophilia as a risk factor for central retinal vein occlusion]
    Anetta Undas
    II Katedry Chorób Wewnetrznych Collegium Medicum Uniwersytetu Jagiellońskiego w Krakowie
    Klin Oczna 105:221-4. 2003
    ..Other probable causes of thrombophilia related to retinal vein occlusion include increased levels of plasminogen activator inhibitor 1 and lipoprotein (a), which impair fibrinolysis...
  101. ncbi Autoantibodies against N-homocysteinylated proteins in humans: implications for atherosclerosis
    Anetta Undas
    Department of Microbiology and Molecular Genetics, UMDNJ New Jersey Medical School, International Center for Public Health, Newark, NJ 07101, USA
    Stroke 35:1299-304. 2004
    ..This study was undertaken to provide evidence for anti-Nepsilon-Hcy-Lys-protein antibody and to examine associations between the antibody level, Hcy, and stroke in humans...