Piotr Trzonkowski

Summary

Country: Poland

Publications

  1. ncbi request reprint CD4+CD25+ T regulatory cells inhibit cytotoxic activity of T CD8+ and NK lymphocytes in the direct cell-to-cell interaction
    Piotr Trzonkowski
    Department of Histology and Immunology, Medical University, Gdansk, Poland
    Clin Immunol 112:258-67. 2004
  2. doi request reprint From bench to bedside and back: the SENIEUR Protocol and the efficacy of influenza vaccination in the elderly
    Piotr Trzonkowski
    Department of Histology and Immunology, Medical University of Gdansk, Poland
    Biogerontology 10:83-94. 2009
  3. doi request reprint Homeostatic repopulation by CD28-CD8+ T cells in alemtuzumab-depleted kidney transplant recipients treated with reduced immunosuppression
    P Trzonkowski
    Transplantation Research Immunology Group and Oxford Transplant Centre, Nuffield Department of Surgery, University of Oxford, UK
    Am J Transplant 8:338-47. 2008
  4. ncbi request reprint Long-term therapy with recombinant human erythropoietin increases CD8+ T-cell apoptosis in haemodialysis patients
    Piotr Trzonkowski
    Department of Histology and Immunology, Medical University of Gdansk, ul Debinki 1, 80 211 Gdansk, Poland
    Nephrol Dial Transplant 20:367-76. 2005
  5. ncbi request reprint Treatment with recombinant human erythropoietin is associated with rejuvenation of CD8+ T cell compartment in chronic renal failure patients
    Piotr Trzonkowski
    Department of Histology and Immunology, Medical University of Gdansk, ul Debinki 1, 80 211 Gdansk, Poland
    Nephrol Dial Transplant 22:3221-7. 2007
  6. doi request reprint Ex vivo expansion of CD4(+)CD25(+) T regulatory cells for immunosuppressive therapy
    Piotr Trzonkowski
    Medical University of Gdansk, Poland
    Cytometry A 75:175-88. 2009
  7. ncbi request reprint CD4+CD25+ T regulatory cells inhibit cytotoxic activity of CTL and NK cells in humans-impact of immunosenescence
    Piotr Trzonkowski
    Department of Histology and Immunology, Medical University of Gdansk, ul Debinki 1, 80 211 Gdansk, Poland
    Clin Immunol 119:307-16. 2006
  8. doi request reprint First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127- T regulatory cells
    Piotr Trzonkowski
    Department of Clinical Immunology and Transplantology, Medical University of Gdansk, ul Debinki 1, 80 211 Gdansk, Poland
    Clin Immunol 133:22-6. 2009
  9. doi request reprint Immunosenescence increases the rate of acceptance of kidney allotransplants in elderly recipients through exhaustion of CD4+ T-cells
    Piotr Trzonkowski
    Department of Clinical Immunology and Transplantology, Medical University of Gdansk, ul Debinki 1, 80 211 Gdansk, Poland
    Mech Ageing Dev 131:96-104. 2010
  10. ncbi request reprint Immune consequences of the spontaneous pro-inflammatory status in depressed elderly patients
    Piotr Trzonkowski
    Department of Histology and Immunology, Medical University of Gdansk, ul Debinki 1, 80 211 Gdansk, Poland
    Brain Behav Immun 18:135-48. 2004

Collaborators

Detail Information

Publications64

  1. ncbi request reprint CD4+CD25+ T regulatory cells inhibit cytotoxic activity of T CD8+ and NK lymphocytes in the direct cell-to-cell interaction
    Piotr Trzonkowski
    Department of Histology and Immunology, Medical University, Gdansk, Poland
    Clin Immunol 112:258-67. 2004
    ..Treg decreased the number of T CD8+ cells attached to the target cells, while the mechanism underlying a decrease in NK cytotoxicity remained unclear...
  2. doi request reprint From bench to bedside and back: the SENIEUR Protocol and the efficacy of influenza vaccination in the elderly
    Piotr Trzonkowski
    Department of Histology and Immunology, Medical University of Gdansk, Poland
    Biogerontology 10:83-94. 2009
    ..Those patients predicted to respond poorly could be considered for alternative treatment...
  3. doi request reprint Homeostatic repopulation by CD28-CD8+ T cells in alemtuzumab-depleted kidney transplant recipients treated with reduced immunosuppression
    P Trzonkowski
    Transplantation Research Immunology Group and Oxford Transplant Centre, Nuffield Department of Surgery, University of Oxford, UK
    Am J Transplant 8:338-47. 2008
    ..This delay might be associated with the clinical outcome as CD4(+) T cells, notably CD4(+) T effector memory cells, were shown to be associated with rejection...
  4. ncbi request reprint Long-term therapy with recombinant human erythropoietin increases CD8+ T-cell apoptosis in haemodialysis patients
    Piotr Trzonkowski
    Department of Histology and Immunology, Medical University of Gdansk, ul Debinki 1, 80 211 Gdansk, Poland
    Nephrol Dial Transplant 20:367-76. 2005
    ..We intended to assess the intensity of apoptosis in the CD4+ and CD8+ T-lymphocytes of haemodialysis (HD) patients on recombinant human erythropoietin (rHuEpo)...
  5. ncbi request reprint Treatment with recombinant human erythropoietin is associated with rejuvenation of CD8+ T cell compartment in chronic renal failure patients
    Piotr Trzonkowski
    Department of Histology and Immunology, Medical University of Gdansk, ul Debinki 1, 80 211 Gdansk, Poland
    Nephrol Dial Transplant 22:3221-7. 2007
    ..A growing body of evidence suggests an impact of rHuEpo on the immune system...
  6. doi request reprint Ex vivo expansion of CD4(+)CD25(+) T regulatory cells for immunosuppressive therapy
    Piotr Trzonkowski
    Medical University of Gdansk, Poland
    Cytometry A 75:175-88. 2009
    ..In the experience of our laboratory, as well as some published reports, Treg adoptive therapy is a promising tool in immunosuppressive therapy, and should be considered for clinical trials...
  7. ncbi request reprint CD4+CD25+ T regulatory cells inhibit cytotoxic activity of CTL and NK cells in humans-impact of immunosenescence
    Piotr Trzonkowski
    Department of Histology and Immunology, Medical University of Gdansk, ul Debinki 1, 80 211 Gdansk, Poland
    Clin Immunol 119:307-16. 2006
    ..Concluding, we found that Treg accumulated as a result of ageing and/or medical conditions were capable of decreasing cytotoxic activity of CD8+ T and NK cells and production of IL2...
  8. doi request reprint First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127- T regulatory cells
    Piotr Trzonkowski
    Department of Clinical Immunology and Transplantology, Medical University of Gdansk, ul Debinki 1, 80 211 Gdansk, Poland
    Clin Immunol 133:22-6. 2009
    ....
  9. doi request reprint Immunosenescence increases the rate of acceptance of kidney allotransplants in elderly recipients through exhaustion of CD4+ T-cells
    Piotr Trzonkowski
    Department of Clinical Immunology and Transplantology, Medical University of Gdansk, ul Debinki 1, 80 211 Gdansk, Poland
    Mech Ageing Dev 131:96-104. 2010
    ....
  10. ncbi request reprint Immune consequences of the spontaneous pro-inflammatory status in depressed elderly patients
    Piotr Trzonkowski
    Department of Histology and Immunology, Medical University of Gdansk, ul Debinki 1, 80 211 Gdansk, Poland
    Brain Behav Immun 18:135-48. 2004
    ..The aim of the study was to describe the interrelationship between senescence, depression, and immunity...
  11. ncbi request reprint Mycobacterial heat shock protein-induced blood T lymphocytes subsets and cytokine pattern: comparison of sarcoidosis with tuberculosis and healthy controls
    Anna Dubaniewicz
    Department of Pathophysiology, Medical University of Gdansk, Gdansk, Poland
    Respirology 12:346-54. 2007
    ..Sarcoidosis (SA) is a disorder of unknown aetiology. Mycobacterium tuberculosis heat shock proteins (Mtb-hsp) have been considered as causative agents of SA. The role of Mtb-hsp in the immune response in SA has not been investigated...
  12. ncbi request reprint Long-term therapy with recombinant human erythropoietin decreases percentage of CD152(+) lymphocytes in primary glomerulonephritis haemodialysis patients
    Piotr Trzonkowski
    Department of Histology and Immunology, Medical University of Gdansk, Gdansk, Poland
    Nephrol Dial Transplant 17:1070-80. 2002
    ....
  13. ncbi request reprint Recipient memory-like lymphocytes remain unresponsive to graft antigens after CAMPATH-1H induction with reduced maintenance immunosuppression
    Piotr Trzonkowski
    Transplantation Research Immunology Group and Oxford Transplant Centre, Nuffield Department of Surgery, University of Oxford, Oxford, United Kingdom
    Transplantation 82:1342-51. 2006
    ..Treatment with CAMPATH-1H at the time of transplantation allows reduced maintenance immunosuppression. We hypothesized that CAMPATH-1H induction would modulate the response of repopulating leukocytes to donor alloantigens...
  14. ncbi request reprint Association between cytomegalovirus infection, enhanced proinflammatory response and low level of anti-hemagglutinins during the anti-influenza vaccination--an impact of immunosenescence
    Piotr Trzonkowski
    Department of Histology and Immunology, Medical University of Gdansk, ul Debinki 1, 80 211 Gdansk, Poland
    Vaccine 21:3826-36. 2003
    ..Concluding, CMV carrier status eliciting elevated proinflammatory potential could contribute to unresponsiveness to the anti-influenza vaccine...
  15. ncbi request reprint Lower percentage of CD8(high+)CD152(+) but not CD8(high+)CD28(+) T lymphocytes in the elderly may be reverted by interleukin 2 in vitro
    Piotr Trzonkowski
    Department of Histology and Immunology, Medical University, ul Debinki 1, 80 211, Gdansk, Poland
    Mech Ageing Dev 123:1283-93. 2002
    ..An age-related decrease of an expression of the co-stimulatory molecules CD28 and CD152 on the surface of lymphocytes, found in our study, may be compatible with a hypothesis of a 'remodelling' of immune response in the healthy elderly...
  16. doi request reprint Analogues of muramyl dipeptide (MDP) and tuftsin limit infection and inflammation in murine model of sepsis
    Anna Wardowska
    Laboratory of Clinical Immunology and Transplantology, Medical University of Gdansk, 1 Debinki Street, 80 210 Gdansk, Poland
    Vaccine 27:369-74. 2009
    ..To evaluate cytokines levels (TNFalpha, IFNgamma, IL6, IL10) we used real-time PCR. The most promising immunomodulatory properties were displayed by the analogue T2 and two conjugates: 8a, 8c...
  17. ncbi request reprint Differences in kinetics of donor lymphoid cells in response to G-CSF administration may affect the incidence and severity of acute GvHD in respective HLA-identical sibling recipients
    Piotr Trzonkowski
    Department of Histology and Immunology, Medical University of Gdansk, ul Debinki 1, 80 211 Gdansk, Poland
    Med Oncol 21:81-94. 2004
    ..However, owing to the small number of donor-recipient pairs studied, our results must be verified in a larger group of patients...
  18. doi request reprint Increased migratory properties of aortal smooth muscle cells exposed to calcitriol in culture
    Cecylia Tukaj
    Department of Electron Microscopy, Medical University of Gdansk, 80 210 Gdansk, Poland
    J Steroid Biochem Mol Biol 121:208-11. 2010
    ..It has been also suggested that such responses of SMCs to calcitriol play a beneficial role in fibrous cap formation during atherosclerotic process...
  19. ncbi request reprint Serum IL-10 and IL-12 levels reflect the response to chemotherapy but are influenced by G-CSF therapy and sepsis in children with soft tissue sarcomas
    Ewa Bien
    Department of Paediatrics, Haematology and Oncology, Medical University of Gdansk, Gdansk, Poland
    Postepy Hig Med Dosw (Online) 67:517-28. 2013
    ..Pre-treatment serum IL-10/IL-12 balance has been recently found deregulated in childhood soft tissue sarcomas (STS). Its role in STS monitoring and assessment of response to therapy is unknown...
  20. doi request reprint The time is crucial for ex vivo expansion of T regulatory cells for therapy
    Natalia Marek
    Department of Clinical Immunology and Transplantology, Medical University of Gdansk, Gdańsk Poland
    Cell Transplant 20:1747-58. 2011
    ..Thorough quality check, preferentially with the assessment of FoxP3 expression and IFN-γ suppression assay, should be applied to assess suppressive activity of the cells...
  21. pmc Treatment of graft-versus-host disease with naturally occurring T regulatory cells
    Piotr Trzonkowski
    Department of Clinical Immunology and Transplantology, Medical University of Gdansk, ul Debinki 1, 80 211, Gdansk, Poland
    BioDrugs 27:605-14. 2013
    ..We then critically evaluate specific requirements for Treg therapy in GvHD and therapies with Tregs currently under clinical investigation, including our experience and future perspectives on this kind of cellular treatment. ..
  22. ncbi request reprint Ex vivo apoptotic potential of peripheral blood mononuclear cells of the elderly human subject
    Ewa Szmit
    Department of Histology and Immunology, Medical University of Gdansk, Gdansk, Poland
    Cell Biol Int 26:517-27. 2002
    ..Different patterns of apoptosis after stimulation may be associated with the cell cycle arrest of the PBMC in the elderly...
  23. doi request reprint Changed phagocytic activity and pattern of Fcγ and complement receptors on blood monocytes in sarcoidosis
    Anna Dubaniewicz
    Department of Pneumonology, Medical University of Gdansk, Debinki 7 str, 80 211 Gdansk, Poland
    Hum Immunol 73:788-94. 2012
    ..In conclusion, altered expression of FcγR and CR on CD14(+) monocytes and its increased phagocytic activity may be responsible for high antigen load, persistent antigenemia and immunocomplexemia in SA patients...
  24. doi request reprint Decreased angiogenin concentration in vitreous and serum in proliferative diabetic retinopathy
    Natalia Marek
    Department of Clinical Immunology and Transplantology, Medical University of Gdansk, ul Debinki 7, 80 211 Gdansk, Poland
    Microvasc Res 82:1-5. 2011
    ..Further studies will elucidate if angiogenin can be used to improve the insufficient angiogenesis in diabetes and prevent retinal ischemia after retinopathy treatment with anti-VEGF agents...
  25. pmc Factors affecting long-term efficacy of T regulatory cell-based therapy in type 1 diabetes
    Natalia Marek-Trzonkowska
    Laboratory of Immunoregulation and Cellular Therapies, Department of Family Medicine, Medical University of Gdansk, Dębinki 2, 80 210, Gdansk, Poland
    J Transl Med 14:332. 2016
    ..Recent studies suggest that immunotherapy using T regulatory cells (Tregs) prolongs remission in type 1 diabetes (T1DM). Here, we report factors that possibly affect the efficacy of this treatment...
  26. doi request reprint In Vitro Evaluation of the Allergic Potential of Antibacterial Peptides: Camel and Citropin
    Michał Pikuła
    Department of Clinical Immunology and Transplantology, Medical University of Gdansk, Debinki 7, 80 211, Gdansk, Poland
    Chem Biol Drug Des 87:562-8. 2016
    ..Our study proved that BAT, together with other biological tests and specific databases of allergenic compounds, may serve as an initial selection of new active peptides and proteins. ..
  27. ncbi request reprint Partial characterization of human choriocarcinoma cell line JAR cells in regard to oxidative stress
    Anna Hallmann
    Department of Pharmaceutical Biochemistry, Medical University of Gdansk, Gdansk, Poland
    Acta Biochim Pol 51:1023-38. 2004
    ..The resistance of JAR cells to oxygen free radical-induced cytotoxicity may be advantageous for intrauterine fetal life...
  28. doi request reprint Anti-TNF rescue CD4+Foxp3+ regulatory T cells in patients with type 1 diabetes from effects mediated by TNF
    Monika Ryba
    Department of Immunology, Medical University of Gdansk, Debinki 1, 80 210 Gdansk, Poland
    Cytokine 55:353-61. 2011
    ..It indicates that TNF reduces the number and frequency of regulatory CD4(+)Foxp3(+) T cells in children with diabetes type 1 and that in vitro treatment with anti-TNF antibody seems to rescue this cell subset from its defective effects...
  29. pmc NK cell compartment in patients with coronary heart disease
    Łukasz Hak
    Department of Histology and Immunology, Medical University of Gdansk, Gdansk, Poland
    Immun Ageing 4:3. 2007
    ..NK cells, as a first line of defense against those infections, may play a role in CHD development. Thus, the main aim of our study was to determine NK cell compartment in patients with CHD undergoing coronary artery by-pass grafting...
  30. doi request reprint Therapy of type 1 diabetes with CD4(+)CD25(high)CD127-regulatory T cells prolongs survival of pancreatic islets - results of one year follow-up
    Natalia Marek-Trzonkowska
    Department of Family Medicine, Medical University of Gdansk, Dębinki 2, 80 210 Gdansk, Poland
    Clin Immunol 153:23-30. 2014
    ..Repetitive administration of Tregs is safe and can prolong survival of β-cells in DM1 (registration: ISRCTN06128462). ..
  31. doi request reprint Adipose tissue-derived stem cells in clinical applications
    Michał Pikuła
    Medical University of Gdansk, Department of Clinical Immunology and Transplantology, ul Debinki 7, 80 210 Gdansk, Poland
    Expert Opin Biol Ther 13:1357-70. 2013
    ..ASCs can be easily harvested with low morbidity, which is their main advantage over mesenchymal stem cells (MSCs) derived from other sources...
  32. ncbi request reprint New conjugates of tuftsin and muramyl dipeptide as stimulators of human monocyte-derived dendritic cells
    Anna Wardowska
    Laboratory of Clinical Immunology and Transplantology, Medical University of Gdansk, Poland
    Protein Pept Lett 20:200-4. 2013
    ..The obtained results suggest further development of the experiments concerning the influence of MDP and tuftsin analogues on the activity of dendritic cells...
  33. doi request reprint Vitamin B6 and the immunity in kidney transplant recipients
    Magdalena Jankowska
    Department of Nephrology, Transplantology and Internal Medicine, Medical University of Gdansk, Gdansk, Poland
    J Ren Nutr 23:57-64. 2013
    ..The study aimed to determine vitamin B6 status in elderly (age ≥ 60 years) and younger (age <60 years) recipients of allogeneic kidney graft and to investigate associations between vitamin B6 status and immunity markers...
  34. doi request reprint Membrane potential of CD4+ T cells is a subset specific feature that depends on the direct cell-to-cell contacts with monocytes
    Natalia Marek
    Department of Clinical Immunology and Transplantology, Medical University of Gdansk, Gdansk, Poland
    Hum Immunol 71:666-75. 2010
    ..The data indicate that membrane potential of CD4(+) T cells is a subset specific feature maintained by direct contact with monocytes. In addition, monocytes were found to control Ca(2+) influx in CD4(+) T cells...
  35. doi request reprint Identification of patients with increased immunological risk among potential kidney recipients in the Polish population
    Grazyna Moszkowska
    Department of Clinical Immunology and Transplantology, Medical University of Gdansk, Debinki 7, 80 210 Gdansk, Poland Electronic address
    Hum Immunol 75:650-5. 2014
    ..Hence, the presented algorithm of solid phase assays has become a new standard for the identification of allosensitized patients awaiting kidney transplantation in Poland...
  36. doi request reprint Deregulated systemic IL-10/IL-12 balance in advanced and poor prognosis paediatric soft tissue sarcomas
    Ewa Bien
    Department of Paediatrics, Haematology, Oncology and Endocrinology, Medical University of Gdansk, Gdansk, Poland
    Biomarkers 18:204-15. 2013
    ..The roles of interleukin 10 (IL-10) and IL-12 in regulation of cancer growth and Th1/Th2 immune responses towards cancer are unclear...
  37. ncbi request reprint Comparative analysis of mycobacterial heat shock proteins-induced apoptosis of peripheral blood mononuclear cells in sarcoidosis and tuberculosis
    Anna Dubaniewicz
    Department of Pathophysiology, Medical University of Gdansk, Gdansk, Poland
    J Clin Immunol 26:243-50. 2006
    ..It seems likely that dysregulated apoptosis of CD4+ T-cells and resistant apoptosis monocytes may be involved in pathogenesis of SA...
  38. ncbi request reprint Immunomodulatory properties of new conjugates of muramyl dipeptide and nor-muramyl dipeptide with retro-tuftsin (Arg-Pro-Lys-Thr-OMe)
    A Wardowska
    Department of Histology and Immunology, Medical University of Gdansk, 1 Debinki Street, 80 210 Gdansk, Poland
    Int Immunopharmacol 6:1560-8. 2006
    ..MDP in conjugates was responsible for compound-induced synthesis of TNFalpha. The results of our study imply usefulness of the examine compounds (mainly A and B), as potential therapeutic agents...
  39. ncbi request reprint Lower interleukin-2 and higher serum tumor necrosis factor-a levels are associated with perimenstrual, recurrent, facial Herpes simplex infection in young women
    J Mysliwska
    Department of Histology and Immunology, Medical University of Gdanesk, ul D6ebinki 1, 80 210 Gdanesk, Poland
    Eur Cytokine Netw 11:397-406. 2000
    ..The results indicate that a decrease of IL-2 together with an increase of TNF-alpha and IL-6 in the serum seem to be related to recurrent perimenstrual Herpes simplex infection...
  40. ncbi request reprint Compensatory effect of TNFalpha on low natural killer activity in the elderly
    J Mysliwska
    Department of Immunology, Medical University of Gdansk, Poland
    Acta Biochim Pol 47:301-11. 2000
    ..Thus, an overproduction of TNFalpha seems to be a mechanism compensating, in the non-fully healthy elderly, for the decreased IL2 production, promoting efficient cytotoxic reaction...
  41. ncbi request reprint Luteal phase of the menstrual cycle in young healthy women is associated with decline in interleukin 2 levels
    P Trzonkowski
    Department of Histology, Medical University of Gdansk, Poland
    Horm Metab Res 33:348-53. 2001
    ..On the other hand, the decrease of IL2 may be seen as a start of the immune suppression necessary for an embryo's nidation...
  42. ncbi request reprint Recombinant human erythropoietin stimulates production of interleukin 2 by whole blood cell cultures of hemodialysis patients
    E Bryl
    Department of Immunology, Medical University of Gdansk, Poland
    Artif Organs 23:809-16. 1999
    ..Our studies show that the therapy with rhEPO affects IL-2 secretion...
  43. ncbi request reprint Biological activity of conjugates of muramyl dipeptides with batracylin derivatives
    P Trzonkowski
    Department of Histology and Immunology, Medical University of Gdansk, ul Debinki 1, 80 211 Gdansk, Poland
    Int Immunopharmacol 5:241-51. 2005
    ..Low toxicity and ability to induce apoptosis suggested usefulness of some analogues, mainly 11c, as antitumour drugs in limited range of tumours of certain tissue origin, such as WEHI 164...
  44. ncbi request reprint Immunomodulating effect of influenza vaccination in the elderly differing in health status
    J Mysliwska
    Department of Histology and Immunology, Medical University of Gdansk, ul Debinki 1, 80 210 Gdansk, Poland
    Exp Gerontol 39:1447-58. 2004
    ..High pre- and post-vaccination NK activity predisposes elderly people to the protective humoral anti-hemagglutinin response and gives better protection from respiratory tract infections...
  45. doi request reprint Cystatin C peptidomimetic derivative with antimicrobial properties as a potential compound against wound infections
    Michał Pikuła
    Department of Clinical Immunology and Transplantology, Medical University of Gdansk, Poland Electronic address
    Bioorg Med Chem . 2017
    ..The results indicate that A20 is effective against the multiantibiotic-resistant bacteria and has a high safety profile, which makes it a promising antimicrobial drug candidate...
  46. pmc Ex vivo expanded human regulatory T cells can prolong survival of a human islet allograft in a humanized mouse model
    Douglas C Wu
    1 Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, John Radcliffe Hospital, University of Oxford, Oxford, UK 2 Currently, Department of Clinical Immunology and Transplantology, Medical University of Gdansk, Gdansk, Poland 3 Address correspondence to Professor Kathryn J Wood, D Phil, Transplantation Research Immunology Group, Nuffield Department of Surgical Sciences, John Radcliffe Hospital, University of Oxford, Oxford OX3 9DU, UK
    Transplantation 96:707-16. 2013
    ..Here, we evaluated the ability of ex vivo expanded human Treg to prevent the rejection of islets of Langerhans in a humanized mouse model and examined the mechanisms involved...
  47. doi request reprint Increased spontaneous production of VEGF by CD4+ T cells in type 1 diabetes
    Natalia Marek
    Department of Clinical Immunology and Transplantology, Medical University of Gdansk, Poland
    Clin Immunol 137:261-70. 2010
    ..In our opinion alterations in the proportions of CD4(+) T cell subsets and their VEGF production may be a useful tool for early assessment of the risk of DR onset and progression...
  48. ncbi request reprint The biological activity of new tuftsin derivatives--induction of phagocytosis
    Anna Wardowska
    Department of Histology and Immunology, Medical University of Gdansk, Debinki 1 Street, 80 210 Gdansk, Poland
    Acta Pol Pharm 63:378-81. 2006
    ..The results of the study show that all of the examined conjugates are able to generate oxidative burst. The most promising analogues proved to be kd6 and kd7...
  49. pmc Heat shock proteins (HSPs) in the homeostasis of regulatory T cells (Tregs)
    Tomasz Koliński
    Laboratory of Immunoregulation and Cellular Therapies, Department of Family Medicine, Medical University of Gdansk, Poland
    Cent Eur J Immunol 41:317-323. 2016
    ..Together HSPs and Tregs are potential tools for future clinical interventions in autoimmune disease...
  50. ncbi request reprint Peripheral and Intestinal T-regulatory Cells are Upregulated in Children with Inflammatory Bowel Disease at Onset of Disease
    Katarzyna Sznurkowska
    A Department of Pediatrics, Pediatric Gastroenterology, Hepatology and Nutrition, Medical University of Gdansk, Gdansk, Poland
    Immunol Invest . 2016
    ....
  51. pmc Synthesis and Evaluation of Biological Activity of Antimicrobial--Pro-Proliferative Peptide Conjugates
    Paulina Kosikowska
    Department of Biochemistry, Faculty of Chemistry, University of Gdansk, Gdansk, Poland
    PLoS ONE 10:e0140377. 2015
    ....
  52. pmc Inhibition of human and yeast 20S proteasome by analogues of trypsin inhibitor SFTI-1
    Dawid Debowski
    Department of Bioorganic Chemistry, Faculty of Chemistry, University of Gdansk, Gdansk, Poland
    PLoS ONE 9:e89465. 2014
    ..We found that some SFTI-1 analogues up-regulated exclusively the chymotrypsin-like activity of latent yeast 20S proteasome. ..
  53. ncbi request reprint Changes in physicochemical properties of microtubules lead to the formation of a single spherical structure of mitochondrial assembly enveloping nuclear chromatins
    Jakub Kedzior
    Department of Cell Biology and Molecular Pathology, Medical University of Gdansk, ul Debinki 1, 80 210 Gdansk, Poland
    J Electron Microsc (Tokyo) 53:659-70. 2004
    ..Taking into consideration the previous data reported from our laboratory, the present results may assist in elucidation of the behaviour of mitochondria during the dividing processes of mammalian cells, which is yet to be clarified...
  54. ncbi request reprint Safety profile of antimicrobial peptides: camel, citropin, protegrin, temporin a and lipopeptide on HaCaT keratinocytes
    Wioletta Barańska-Rybak
    Department of Dermatology, Venereology and Allergology, Faculty of Medicine, Medical University of Gdansk, Debinki 7, 80 211 Gdansk, Poland
    Acta Pol Pharm 70:795-801. 2013
    ..The most promising seem to be citropin 1.1 and temporin A, as they were toxic only in two highest concentration (50 and 100 microg/mL), with relatively low MIC values...
  55. doi request reprint Clinical application of regulatory T cells in type 1 diabetes
    Natalia Marek-Trzonkowska
    Department of Family Medicine, Medical University of Gdansk, Gdansk, Poland
    Pediatr Diabetes 14:322-32. 2013
    ..Additionally, Tregs can be a useful tool for local protection of transplanted pancreatic islets. Isolation and expansion of antigen-specific Tregs is one of the directions for future studies on cellular therapy of DM1. ..
  56. pmc Administration of CD4+CD25highCD127- regulatory T cells preserves β-cell function in type 1 diabetes in children
    Natalia Marek-Trzonkowska
    Department of Clinical Immunology and Transplantology, Medical University of Gdansk, Gdansk, Poland
    Diabetes Care 35:1817-20. 2012
    ..Here, we show for the first time that the infusion of autologous Tregs prolongs remission in recently diagnosed type 1 diabetes in children...
  57. ncbi request reprint Regulatory effects of 1,25-dihydroxyvitamin D3 on vascular smooth muscle cells
    Stefan Tukaj
    Department of Plant Physiology and Biotechnology, University of Gdansk, Poland
    Acta Biochim Pol 59:395-400. 2012
    ..The results of our study suggest that 1,25(OH)(2)D(3) may serve as a natural anti-inflammatory agent and may therefore play a beneficial role in the physiology of VSMC in some contexts of atherosclerosis...
  58. doi request reprint Flow cytometric sorting and analysis of human epidermal stem cell candidates
    Michał Pikuła
    Department of Clinical Immunology and Transplantology, Medical University of Gdansk, Debinki 1, 80211 Gdansk, Poland
    Cell Biol Int 34:911-5. 2010
    ..We also performed a flow cytometric analysis of sorted cells using a cell tracer...
  59. ncbi request reprint Quantifying division of aortal smooth muscle cells in culture stimulated by 1,25(OH)2D3
    Cecylia Tukaj
    Laboratory of Electron Microscopy, Medical University of Gdansk, 80 210 Gdansk, Poland
    J Steroid Biochem Mol Biol 103:525-8. 2007
    ..None of the applied concentrations of calcitriol caused apoptosis. The findings well support our morphological (LM) and ultrastructural (TEM and SEM) observations...
  60. doi request reprint Investigations on the immunosuppressive activity of derivatives of mycophenolic acid in immature dendritic cells
    Dorota Iwaszkiewicz-Grzes
    Department of Organic Chemistry, Gdansk University of Technology, ul G Narutowicza 11 12, 80 233 Gdansk, Poland Department of Clinical Immunology and Transplantology, Medical University of Gdansk, ul Debinki 7, 80 211 Gdansk, Poland
    Int Immunopharmacol 44:137-142. 2017
    ..Acridone derivatives of MPA are therefore good immunosuppressive drug candidates for further testing...
  61. doi request reprint Fluorescent analogs of trypsin inhibitor SFTI-1 isolated from sunflower seeds--synthesis and applications
    Adam Lesner
    Faculty of Chemistry, Gdansk University, Wita Stwosza 63, 80 952, Gdansk, Poland
    Biopolymers 102:124-35. 2014
    ..We found that such compounds were rapidly internalized by the fibroblast or cancer cells with no cytotoxic effects...
  62. doi request reprint G-CSF therapy and catheter-related Gram-positive sepsis increase serum IL-2 receptor α level and may falsely suggest a relapse in children with soft tissue sarcomas unless serum beta2-microglobulin, lactate dehydrogenase and C-reactive protein levels are
    Ewa Bien
    Department of Pediatrics, Hematology, Oncology and Endocrinology, Medical University of Gdansk, 7 Debinki Street, 80 211 Gdansk, Poland
    Cytokine 55:347-52. 2011
    ..Determination of serum B2-M, LDH and CRP together with sIL-2Rα may help to distinguish between "real" relapse and "false" sIL-2Rα increase due to G-CSF administration or CVC-related sepsis...
  63. ncbi request reprint Homeostatic proliferation of NK cells: friend or foe in cellular immunotherapy?
    Natalia Marek
    Department of Clinical Immunology and Transplantology, Medical University of Gdansk, ul Debinki 7, 80 952 Gdansk, Poland
    Immunotherapy 3:727-9. 2011
    ..As homeostatically driven NK cells are long-lived effectors, such therapies can exert prolonged effects for the immunity of the patients...
  64. ncbi request reprint Synthesis and biological activity of tuftsin, its analogue and conjugates containing muramyl dipeptides or nor-muramyl dipeptides
    K Dzierzbicka
    Department of Organic Chemistry, Gdansk University of Technology, 11 12 G Narutowicza Street, 80 952 Gdansk, Poland
    J Pept Sci 11:123-35. 2005
    ..An in vivo assay on animal models will be performed...