Małgorzata Sznitowska

Summary

Country: Poland

Publications

  1. ncbi request reprint Dissolution test for ivermectin in oral veterinary paste
    M Sznitowska
    Department of Pharmaceutical Technology, Medical University of Gdansk, Poland
    Pharmazie 59:814-5. 2004
  2. ncbi request reprint Determination of diclofenac released from suppositories using UV spectrophotometry, spectra derivative spectrophotometry and HPLC
    Małgorzata Sznitowska
    Departament of Pharmaceutical Technology, Medical University of Gdansk, Hallera 107, 80 416 Gdansk, Poland
    Acta Pol Pharm 64:401-5. 2007
  3. doi request reprint Preliminary in vivo studies of a new lecithin-based formulation of paclitaxel
    Malgorzata Sznitowska
    Department of Pharmaceutical Technology, Medical University of Gdansk, Gdansk, Poland
    J Microencapsul 26:588-92. 2009
  4. ncbi request reprint Paclitaxel solubility in aqueous dispersions and mixed micellar solutions of lecithin
    Malgorzata Sznitowska
    Department of Pharmaceutical Technology, Medical University of Gdansk, Poland
    Chem Pharm Bull (Tokyo) 56:70-4. 2008
  5. ncbi request reprint The physical characteristics of lyophilized tablets containing a model drug in different chemical forms and concentrations
    Małgorzata Sznitowska
    Department of Pharmaceutical Technology, Medical University of Gdansk, 107 Hallera Str, 80 416 Gdansk, Poland
    Acta Pol Pharm 62:25-9. 2005
  6. ncbi request reprint Antimicrobial activity of parabens in submicron emulsions stabilized with lecithin
    Malgorzata Młynarczyk
    Bacteriological Laboratory, Warsaw Pharmaceutical Works POLFA S A, Warsaw, Poland
    Drug Dev Ind Pharm 34:355-62. 2008
  7. ncbi request reprint Feasibility of the Ph.Eur. flow-through cell for dissolution testing of the compounded rectal suppositories containing indomethacin or sodium diclofenac
    Brunon Woyczikowski
    Department of Pharmaceutical Technology, Medical University of Gdansk, 107 Hallera Str, 80 416 Gdansk, Poland
    Acta Pol Pharm 60:169-72. 2003
  8. doi request reprint Technology of stable, prolonged-release eye-drops containing Cyclosporine A, distributed between lipid matrix and surface of the solid lipid microspheres (SLM)
    Eliza Wolska
    Department of Pharmaceutical Technology, Medical University of Gdansk, ul Hallera 107, Gdansk 80 416, Poland
    Int J Pharm 441:449-57. 2013
  9. ncbi request reprint Self-emulsifying oils for ocular drug delivery. II. In vitro release of indomethacin and hydrocortisone
    Anna Czajkowska-Kośnik
    Department of Pharmaceutical Technology, Medical University of Białystok, 2C Mickiewicza St, 15 222 Bia ystok, Poland
    Acta Pol Pharm 69:309-17. 2012
  10. ncbi request reprint Stability of extemporaneous pediatric oral liquids compounded from tablets and drug substance: case of propranolol and theophylline
    Monika Muśko
    Department of Pharmaceutical Technology, Medical University of Bialystok, 2C Mickiewicza St, 15 222 Białystok, Poland
    Acta Pol Pharm 70:137-45. 2013

Collaborators

Detail Information

Publications30

  1. ncbi request reprint Dissolution test for ivermectin in oral veterinary paste
    M Sznitowska
    Department of Pharmaceutical Technology, Medical University of Gdansk, Poland
    Pharmazie 59:814-5. 2004
    ..5% as dissolution medium. By means of HPLC fast degradation of ivermectin was observed in HCl 0.1 M solution. Rotation speed of the paddle at 75 rpm was appropriate as demonstrated in a study comparing two different products...
  2. ncbi request reprint Determination of diclofenac released from suppositories using UV spectrophotometry, spectra derivative spectrophotometry and HPLC
    Małgorzata Sznitowska
    Departament of Pharmaceutical Technology, Medical University of Gdansk, Hallera 107, 80 416 Gdansk, Poland
    Acta Pol Pharm 64:401-5. 2007
    ....
  3. doi request reprint Preliminary in vivo studies of a new lecithin-based formulation of paclitaxel
    Malgorzata Sznitowska
    Department of Pharmaceutical Technology, Medical University of Gdansk, Gdansk, Poland
    J Microencapsul 26:588-92. 2009
    ..Daily intraperitoneal administrations (3 doses/day) in mice demonstrated that the new carrier solution was non-toxic and, relative to Taxol, the new formulation exhibited similar or less toxicity...
  4. ncbi request reprint Paclitaxel solubility in aqueous dispersions and mixed micellar solutions of lecithin
    Malgorzata Sznitowska
    Department of Pharmaceutical Technology, Medical University of Gdansk, Poland
    Chem Pharm Bull (Tokyo) 56:70-4. 2008
    ..The use of parenteral emulsions as solvents for the co-lyophilized PTX also failed to increase the solubility of the drug up to the target concentration...
  5. ncbi request reprint The physical characteristics of lyophilized tablets containing a model drug in different chemical forms and concentrations
    Małgorzata Sznitowska
    Department of Pharmaceutical Technology, Medical University of Gdansk, 107 Hallera Str, 80 416 Gdansk, Poland
    Acta Pol Pharm 62:25-9. 2005
    ..All formulations disintegrated in seconds in water, at a temperature of 37 degrees C...
  6. ncbi request reprint Antimicrobial activity of parabens in submicron emulsions stabilized with lecithin
    Malgorzata Młynarczyk
    Bacteriological Laboratory, Warsaw Pharmaceutical Works POLFA S A, Warsaw, Poland
    Drug Dev Ind Pharm 34:355-62. 2008
    ..Further studies are necessary to establish a stable and safe composition of such formulations...
  7. ncbi request reprint Feasibility of the Ph.Eur. flow-through cell for dissolution testing of the compounded rectal suppositories containing indomethacin or sodium diclofenac
    Brunon Woyczikowski
    Department of Pharmaceutical Technology, Medical University of Gdansk, 107 Hallera Str, 80 416 Gdansk, Poland
    Acta Pol Pharm 60:169-72. 2003
    ..The results demonstrate that slow and non-reproducible release occurs when the lipophilic suppository base does not melt. The feasibility of the test for the formulations, which do not melt during the procedure, is questionable...
  8. doi request reprint Technology of stable, prolonged-release eye-drops containing Cyclosporine A, distributed between lipid matrix and surface of the solid lipid microspheres (SLM)
    Eliza Wolska
    Department of Pharmaceutical Technology, Medical University of Gdansk, ul Hallera 107, Gdansk 80 416, Poland
    Int J Pharm 441:449-57. 2013
    ..The large part of Cs, added to SLM formulations (from 45 to 80%), was found on the surface of microparticles, but no drug crystallization occurred during a long-term storage...
  9. ncbi request reprint Self-emulsifying oils for ocular drug delivery. II. In vitro release of indomethacin and hydrocortisone
    Anna Czajkowska-Kośnik
    Department of Pharmaceutical Technology, Medical University of Białystok, 2C Mickiewicza St, 15 222 Bia ystok, Poland
    Acta Pol Pharm 69:309-17. 2012
    ..Analysis of the release kinetics from sus pension type formulations supports the hypothesis that it may be reasonable to propose SEDDS with the small access of the suspended drug as the most promising formulation...
  10. ncbi request reprint Stability of extemporaneous pediatric oral liquids compounded from tablets and drug substance: case of propranolol and theophylline
    Monika Muśko
    Department of Pharmaceutical Technology, Medical University of Bialystok, 2C Mickiewicza St, 15 222 Białystok, Poland
    Acta Pol Pharm 70:137-45. 2013
    ..Extemporaneous suspensions with T in an appropriate pediatric concentrations of the drug were not obtained because the problem of fast crystallization of T was not eliminated...
  11. ncbi request reprint Partitioning of parabens between phases of submicron emulsions stabilized with egg lecithin
    Dorota Watrobska-Swietlikowska
    Department of Pharmaceutical Technology, Medical University of Gdansk, Hallera 107, Gdansk 80 416, Poland
    Int J Pharm 312:174-8. 2006
    ..e. 3.0-6.0% for both preservatives. Substantial accumulation, i.e. 38-58% was found in the interface and the partitioning into this region was related to the oil/lecithin ratio rather than to lipophilicity of the preservative...
  12. ncbi request reprint [The mucoadhesion phenomena and importance in drug application]
    Marcin Płaczek
    Katedra i Zakład Farmacji Stosowanej Gdański Uniwersytet Medyczny
    Polim Med 39:49-64. 2009
    ..Furthermore, methods that are frequently used to study the adhesion forces between drug and mucus as well as application of mucoadhesive hydrogels as drug carriers for different mucosal membranes are also discussed...
  13. ncbi request reprint [Tricholoma equestre--animal toxicity study]
    Zygmunt Chodorowski
    I Klinika Chorób Wewnetrznych i Ostrych Zatruć, Akademii Medycznej w Gdansku
    Przegl Lek 61:351-2. 2004
    ..Mean serum creatine kinase activity in p-phenylenediamine group (265 +/- 63 U/L) was significantly higher than in group treated with water (p<0.01)...
  14. ncbi request reprint Physicochemical screening of antimicrobial agents as potential preservatives for submicron emulsions
    Malgorzata Sznitowska
    Department of Pharmaceutical Technology, Medical University of Gdansk, ul Hallera 107, Poland
    Eur J Pharm Sci 15:489-95. 2002
    ....
  15. ncbi request reprint Solubilizing potential of submicron emulsions and aqueous dispersions of lecithin
    Malgorzata Sznitowska
    Department of Pharmaceutical Technology, Medical University of Gdansk, ul Hallera 107, Poland
    Int J Pharm 246:203-6. 2002
    ..WLD obtained in a simple technological process may be considered as a carrier particularly for highly lipophilic drugs: solubility of estradiol in this system was 100-fold higher than in water...
  16. doi request reprint Comparison of cytotoxicity in vitro and irritation in vivo for aqueous and oily solutions of surfactants
    Anna Czajkowska-Kośnik
    Department of Pharmaceutical Technology, Medical University of Bialystok, Poland
    Drug Dev Ind Pharm 41:1232-6. 2015
    ..In conclusion, it is reported that the MTT assay does not correlate well with the Draize scores. ..
  17. doi request reprint Double layer adhesive silicone dressing as a potential dermal drug delivery film in scar treatment
    Krystyna Mojsiewicz-Pieńkowska
    Department of Physical Chemistry, Faculty of Pharmacy with Subfaculty of Laboratory Medicine, Medical University of Gdansk, 80 416 Gdansk, Al Gen Hallera 107, Poland Electronic address
    Int J Pharm 481:18-26. 2015
    ..Developed novel adhesive silicone films were considered an effective treatment of scars and keloids and a potential drug carrier able to improve the effectiveness of therapy...
  18. ncbi request reprint [Prolonged-release drug formulations for parenteral administration. Part l. Suspensions and oily solutions for injection]
    Marcin Płaczek
    Department of Pharmaceutical Technology, Medical University of Gdansk, Poland
    Pol Merkur Lekarski 35:391-6. 2013
    ..Here also the modified time course of insulin products achieved by selection of appropriate suspension form or insulin analogue is discussed...
  19. ncbi request reprint Development of modified-release dosage forms containing loratadine and pseudoephedrine sulfate
    Małgorzata Sznitowska
    Department of Pharmaceutical Technology, Medical University of Gdansk, 107 Hallera Str, 80 416 Gdansk, Poland
    Acta Pol Pharm 61:72-4. 2004
    ..It was assumed that, similarly to the original product, the total dose of L and the half dose of PES should be released during 1 h and the remaining dose of PES ought to be gradually released for up to 8 h...
  20. ncbi request reprint The expulsion of lipophilic drugs from the cores of solid lipid microspheres in diluted suspensions and in concentrates
    Justyna Pietkiewicz
    Department of Pharmaceutical Technology, Medical University of Gdansk, ul Hallera 107, Gdansk 80 416, Poland
    Int J Pharm 310:64-71. 2006
    ..The presence of hydrophilic polymers in the aqueous phase did not prevent the expulsion effect although drug precipitation was retarded. The expulsion effect did not correlate with the solubility of drugs determined in the bulk lipids...
  21. ncbi request reprint pH-induced modifications to stratum corneum lipids investigated using thermal, spectroscopic, and chromatographic techniques
    Małgorzata Sznitowska
    Department of Pharmaceutical Technology, Medical University of Gdansk, 80 416 Gdansk, Poland
    J Pharm Sci 92:173-9. 2003
    ..The changes provoked by the alkaline buffers are not dramatic and it may be concluded that the stratum corneum appears remarkably resilient to extended exposure in both highly acidic (pH 1) and highly alkaline (pH 12) environments...
  22. ncbi request reprint Solubility of ocular therapeutic agents in self-emulsifying oils. I. Self-emulsifying oils for ocular drug delivery: solubility of indomethacin, aciclovir and hydrocortisone
    Anna Czajkowska-Kośnik
    Department of Pharmaceutical Technology, Medical University of Białystok, 2C Mickiewicza St, 15 222 Białystok, Poland
    Acta Pol Pharm 66:709-13. 2009
    ..The results of the current study may be utilized to design a suitable composition of SEDDS and allow continuation of research on this type of drug carriers...
  23. ncbi request reprint Technology of an adhesive silicone film as drug carrier in transdermal therapy. I: Analytical methods used for characterization and design of the universal elastomer layers
    Krystyna Mojsiewicz-Pieńkowska
    Medical University of Gdansk, Faculty of Pharmacy, Department of Physical Chemistry, 80 416 Gdansk, Al Gen Hallera 107, Poland
    J Pharm Biomed Anal 56:131-8. 2011
    ..Adhesive silicone films can be used as universal materials for medical use, particularly for effective treatment of scars and keloids or as drug carriers in transdermal therapy...
  24. doi request reprint Choice of excipients for gelly-like pulp prepared ex tempore "on a spoon"- "placebo" and with sartans
    Eliza Wolska
    a Department of Pharmaceutical Technology, Medical University of Gdansk, Gdansk, Poland
    Drug Dev Ind Pharm 42:998-1007. 2016
    ..The aim of this study was to evaluate the viscosity-increasing substances and disintegrants, alone or in mixtures, as excipients suitable for preparing such formulations, with candesartan and valsartan chosen as model active substances...
  25. doi request reprint Development and validation of UHPLC method for the determination of cyclosporine A in biological samples
    Oliwia Szerkus
    Department of Biopharmaceutics and Pharmacodynamics, Medical University of Gdansk, Poland
    Biomed Chromatogr 28:802-9. 2014
    ..5 min) and simplicity make this method useful for the fast analysis of CsA in rabbit ocular tissues and fluids: lacrimal fluid, aqueous humor, cornea, conjunctiva and eye globe...
  26. ncbi request reprint Comparison of sublingual tablets with nitroglycerin complexed with beta-cyclodextrin or titrated with crosspovidone--technological approach
    Katarzyna Centkowska
    Department of Pharmaceutical Technology, Medical University of Gdansk, 107 Gen J Hallera St, 80 416 Gdansk, Poland
    Acta Pol Pharm 65:585-9. 2008
    ..Stability of NTG was better in NTG-CD tablets than in NTG-CP tablets, however, within 12 months of storage at 25 degrees C the loss of NTG in all formulations was still greater than 10%...
  27. ncbi request reprint The effect of cryoprotectants on the physical properties of large liposomes containing sodium diclofenac
    Stanisław Janicki
    Department of Pharmaceutical Technology, Medical University of Gdansk, Poland
    Acta Pol Pharm 59:187-91. 2002
    ..Large liposomes lyophilized in the presence of mannitol tend to increase in size and encapsulation efficacy, but the lipid bilayers are stabilized and less permeable to the drug...
  28. doi request reprint Characterisation of a novel conjugate of ibuprofen with 3-hydroxybutyric acid oligomers
    Pawel Stasiak
    Department of Pharmaceutical Technology, Medical University of Gdansk, Poland
    J Pharm Pharmacol 61:1119-24. 2009
    ..A conjugate of ibuprofen with 3-hydroxybutyric acid oligomers has been evaluated as a novel drug delivery model system...
  29. ncbi request reprint Effect of physicochemical properties of cyclic terpenes on their ex vivo skin absorption and elimination kinetics
    Krzysztof Cal
    Medical University of Gdansk, Department of Pharmaceutical Technology, Hallera 107, 80 416 Gdansk, Poland
    J Dermatol Sci 41:137-42. 2006
    ....
  30. ncbi request reprint Effect of adhesive matrix composition and terpinolene on indomethacin bioavailability in rats from transdermal therapeutic system
    Krzysztof Cal
    Department of Pharmaceutical Technology, Medical University of Gdansk, Gdansk, Poland
    Drug Dev Ind Pharm 34:1125-9. 2008
    ..The positive influence of a penetration enhancer on IND bioavailability was observed only for one type of polyacrylate matrices...