Maciej Cedzynski

Summary

Affiliation: Polish Academy of Sciences
Country: Poland

Publications

  1. doi request reprint L-ficolin (ficolin-2) insufficiency is associated with combined allergic and infectious respiratory disease in children
    Maciej Cedzynski
    Institute of Medical Biology, Polish Academy of Sciences, Lodz, Poland
    Mol Immunol 47:415-9. 2009
  2. pmc Factors of the lectin pathway of complement activation and their clinical associations in neonates
    Maciej Cedzynski
    Laboratory of Immunobiology of Infections, Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93 232 Lodz, Poland
    J Biomed Biotechnol 2012:363246. 2012
  3. pmc Extremes of L-ficolin concentration in children with recurrent infections are associated with single nucleotide polymorphisms in the FCN2 gene
    M Cedzynski
    Laboratory of Immunobiology of Infections, Centre of Medical Biology, Polish Academy of Sciences, Lodz, Poland
    Clin Exp Immunol 150:99-104. 2007
  4. doi request reprint Two factors of the lectin pathway of complement, l-ficolin and mannan-binding lectin, and their associations with prematurity, low birthweight and infections in a large cohort of Polish neonates
    Anna St Swierzko
    Laboratory of Immunobiology of Infections, Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93 232 Lodz, Poland
    Mol Immunol 46:551-8. 2009
  5. doi request reprint H-ficolin (ficolin-3) concentrations and FCN3 gene polymorphism in neonates
    Mateusz Michalski
    Laboratory of Immunobiology of Infections, Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93 232 Lodz, Poland
    Immunobiology 217:730-7. 2012
  6. doi request reprint Mannan-binding lectin genotypes and genotype-phenotype relationships in a large cohort of Polish neonates
    Anna St Swierzko
    Institute of Medical Biology, Polish Academy of Sciences, Lodz, Poland
    Hum Immunol 70:68-72. 2009
  7. pmc Ficolin-2 and ficolin-3 in women with malignant and benign ovarian tumours
    Agnieszka Szala
    Laboratory of Immunobiology of Infections, Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93 232, Lodz, Poland
    Cancer Immunol Immunother 62:1411-9. 2013
  8. doi request reprint Components of the lectin pathway of complement activation in paediatric patients of intensive care units
    Anna S Swierzko
    Laboratory of Immunobiology of Infections, Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93 232 Lodz, Poland
    Immunobiology 221:657-69. 2016
  9. pmc Mannose-Binding Lectin (MBL) and MBL-associated serine protease-2 (MASP-2) in women with malignant and benign ovarian tumours
    Anna St Swierzko
    Laboratory of Immunobiology of Infections, Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93 232, Lodz, Poland
    Cancer Immunol Immunother 63:1129-40. 2014
  10. doi request reprint Mannan-binding lectin-associated serine protease-2 (MASP-2) in a large cohort of neonates and its clinical associations
    Anna St Swierzko
    Laboratory of Immunobiology of Infections, Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93 232 Lodz, Poland
    Mol Immunol 46:1696-701. 2009

Collaborators

Detail Information

Publications24

  1. doi request reprint L-ficolin (ficolin-2) insufficiency is associated with combined allergic and infectious respiratory disease in children
    Maciej Cedzynski
    Institute of Medical Biology, Polish Academy of Sciences, Lodz, Poland
    Mol Immunol 47:415-9. 2009
    ..MBL insufficiency and MASP-2 deficiency are risk factors for recurrence of infections independently of allergic disease...
  2. pmc Factors of the lectin pathway of complement activation and their clinical associations in neonates
    Maciej Cedzynski
    Laboratory of Immunobiology of Infections, Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93 232 Lodz, Poland
    J Biomed Biotechnol 2012:363246. 2012
    ..Our preliminary conclusion is that these soluble defense lectins play a protective role in the neonate, and that insufficiency of such factors contributes to the adverse consequences of prematurity and low birthweight...
  3. pmc Extremes of L-ficolin concentration in children with recurrent infections are associated with single nucleotide polymorphisms in the FCN2 gene
    M Cedzynski
    Laboratory of Immunobiology of Infections, Centre of Medical Biology, Polish Academy of Sciences, Lodz, Poland
    Clin Exp Immunol 150:99-104. 2007
    ..Conversely, high l-ficolin levels were associated with variant alleles of ss32469537 and ss32469544. FCN2 genotyping should be a valuable additional tool for disease association studies...
  4. doi request reprint Two factors of the lectin pathway of complement, l-ficolin and mannan-binding lectin, and their associations with prematurity, low birthweight and infections in a large cohort of Polish neonates
    Anna St Swierzko
    Laboratory of Immunobiology of Infections, Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93 232 Lodz, Poland
    Mol Immunol 46:551-8. 2009
    ..Some similar trends were found with facets of MBL deficiency, but the observed relationships were weaker and less consistent...
  5. doi request reprint H-ficolin (ficolin-3) concentrations and FCN3 gene polymorphism in neonates
    Mateusz Michalski
    Laboratory of Immunobiology of Infections, Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93 232 Lodz, Poland
    Immunobiology 217:730-7. 2012
    ..This neonate was however previously found to be mannan-binding lectin (MBL) as well as MBL-associated serine protease-2 (MASP-2) deficient and also had low serum L-ficolin...
  6. doi request reprint Mannan-binding lectin genotypes and genotype-phenotype relationships in a large cohort of Polish neonates
    Anna St Swierzko
    Institute of Medical Biology, Polish Academy of Sciences, Lodz, Poland
    Hum Immunol 70:68-72. 2009
    ....
  7. pmc Ficolin-2 and ficolin-3 in women with malignant and benign ovarian tumours
    Agnieszka Szala
    Laboratory of Immunobiology of Infections, Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93 232, Lodz, Poland
    Cancer Immunol Immunother 62:1411-9. 2013
    ..In case of FCN3 gene, its expression levels in OC group inversely correlated with serum ficolin-3 and were lower in comparison with controls...
  8. doi request reprint Components of the lectin pathway of complement activation in paediatric patients of intensive care units
    Anna S Swierzko
    Laboratory of Immunobiology of Infections, Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93 232 Lodz, Poland
    Immunobiology 221:657-69. 2016
    ..With the possible exception of MBL, inherited lectin pathway insufficiencies do not seem to predispose to sepsis, rather changes in protein concentrations reflect alterations in disease course...
  9. pmc Mannose-Binding Lectin (MBL) and MBL-associated serine protease-2 (MASP-2) in women with malignant and benign ovarian tumours
    Anna St Swierzko
    Laboratory of Immunobiology of Infections, Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93 232, Lodz, Poland
    Cancer Immunol Immunother 63:1129-40. 2014
    ..It is concluded that the expression of MBL and MASP-2 is altered in ovarian cancer, possibly indicating involvement of the lectin pathway of complement activation in the disease...
  10. doi request reprint Mannan-binding lectin-associated serine protease-2 (MASP-2) in a large cohort of neonates and its clinical associations
    Anna St Swierzko
    Laboratory of Immunobiology of Infections, Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93 232 Lodz, Poland
    Mol Immunol 46:1696-701. 2009
    ..Moreover, no association of this SNP was apparent with prematurity, low birthweight or perinatal infections...
  11. doi request reprint Mannan-binding lectin deficiency in pediatric patients with inflammatory bowel disease
    Leokadia Bak-Romaniszyn
    Unit of Nutrition in Digestive Tract Disease, Medical University of Lodz, Lodz, Poland
    Scand J Gastroenterol 46:1275-8. 2011
    ..The aim of this study was to investigate the possible role of MBL in Crohn's disease (CD) and ulcerative colitis (UC) in children...
  12. pmc Cost-effective procedures for genotyping of human FCN2 gene single nucleotide polymorphisms
    Agnieszka Szala
    Laboratory of Immunobiology of Infections, Institute of Medical Biology, Polish Academy of Sciences, Lodz, Poland
    Immunogenetics 65:439-46. 2013
    ..Since several L-ficolin clinical associations have been reported, FCN2 genotyping seems to be a valuable tool for disease association studies...
  13. pmc A New Ligand-Based Method for Purifying Active Human Plasma-Derived Ficolin-3 Complexes Supports the Phenomenon of Crosstalk between Pattern-Recognition Molecules and Immunoglobulins
    Aleksandra Man-Kupisinska
    Department of Immunochemistry, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wroclaw, Poland
    PLoS ONE 11:e0156691. 2016
    ..Thus our purification procedure provides Ig-ficolin-3/MASP complexes that might be useful for gaining further insight into the crosstalk and biological activity of ficolin-3. ..
  14. doi request reprint Mannan-binding lectin-2 (MBL2) gene polymorphisms in prenatal and perinatal cytomegalovirus infections
    Agnieszka Szala
    Laboratory of Immunobiology of Infections, Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93 232 Lodz, Poland
    Mol Immunol 48:2203-6. 2011
    ..The distribution of MBL2 haplotypes was similar between the groups studied. These data suggest MBL does not have a major influence on susceptibility to prenatal or perinatal CMV infections...
  15. ncbi request reprint Mannan-binding lectin (MBL) in women with tumours of the reproductive system
    A St Swierzko
    Laboratory of Immunobiology of Infections, Centre of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93 232 Łódź, Poland
    Cancer Immunol Immunother 56:959-71. 2007
    ..However, it cannot be excluded that mbl-2 mutant alleles may be in linkage disequilibrium with an unidentified tumour susceptibility gene(s)...
  16. doi request reprint Mycobacterial antigen 85 complex (Ag85) as a target for ficolins and mannose-binding lectin
    Anna S Swierzko
    Laboratory of Immunobiology of Infections, Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93 232 Lodz, Poland
    Int J Med Microbiol 306:212-21. 2016
    ..Furthermore, those PRMs also bound to fibronectin and therefore might influence the Ag85 complex-dependent interaction of Mycobacterium with the extracellular matrix. ..
  17. doi request reprint Primary Ficolin-3 deficiency--Is it associated with increased susceptibility to infections?
    Mateusz Michalski
    Laboratory of Immunobiology of Infections, Institute of Medical Biology, Polish Academy of Sciences, Lodz, Poland Institute of Microbiology, Biotechnology and Immunology, University of Lodz, Lodz, Poland
    Immunobiology 220:711-3. 2015
    ....
  18. doi request reprint Ficolin-3 activity towards the opportunistic pathogen, Hafnia alvei
    Mateusz Michalski
    Institute of Medical Biology, Polish Academy of Sciences, Lodowa 106, 93 232 Lodz, Poland Institute of Microbiology, Biotechnology and Immunology, University of Lodz, Banacha 12 16, 90 237 Lodz, Poland
    Immunobiology 220:117-23. 2015
    ....
  19. doi request reprint New functional ligands for ficolin-3 among lipopolysaccharides of Hafnia alvei
    Anna Swierzko
    Laboratory of Immunobiology of Infections, Institute for Medical Biology, Polish Academy of Sciences, Lodowa 106, Lodz, Poland
    Glycobiology 22:267-80. 2012
    ....
  20. doi request reprint Mannan-binding lectin in malignancy
    Anna S Swierzko
    Laboratory of Immunobiology of Infections, Institute of Medical Biology, Polish Academy of Sciences, Lodz, Poland
    Mol Immunol 55:16-21. 2013
    ..In this paper, possible cancer associations of one of the factors activating complement via the lectin pathway, mannan-binding lectin (MBL), are discussed...
  21. pmc Possible disease-modifying factors: the mannan-binding lectin pathway and infections in hereditary angioedema of children and adults
    Maciej Cedzynski
    Laboratory of Immunobiology of Infections, Center of Medical Biology, Polish Academy of Sciences, Łódź, Poland
    Arch Immunol Ther Exp (Warsz) 56:69-75. 2008
    ....
  22. pmc Mannan-binding lectin insufficiency in children with recurrent infections of the respiratory system
    M Cedzynski
    Laboratory of Immunobiology of Infections, Centre of Medical Biology and Microbiology, Polish Academy of Sciences, Lodz, Poland
    Clin Exp Immunol 136:304-11. 2004
    ....
  23. ncbi request reprint Role of the complement-lectin pathway in anaphylactoid reaction induced with lipopolysaccharide in mice
    Anna St Swierzko
    Microbiology and Virology Centre, Polish Academy of Sciences, Łódź, Poland
    Eur J Immunol 33:2842-52. 2003
    ..RaRF also activated fibrinogen in vitro suggesting the involvement of the coagulation system in the process investigated...
  24. pmc L-ficolin in children with recurrent respiratory infections
    A P M Atkinson
    Scottish National Blood Transfusion Service, National Science Laboratory, Edinburgh, Scotland, UK
    Clin Exp Immunol 138:517-20. 2004
    ..02) and were associated most strongly with children having co-existing atopic disorders (11%; P=0.002). We suggest that L-ficolin may have a role in protection from microorganisms complicating allergic disease...