Grazyna Kostka

Summary

Affiliation: National Institute of Hygiene
Country: Poland

Publications

  1. doi request reprint Di-butyl phthalate-induced hypomethylation of the c-myc gene in rat liver
    Grazyna Kostka
    Department of Environmental Toxicology, National Institute of Public Health National Institute of Hygiene, Chocimska, Warsaw, Poland
    Toxicol Ind Health 26:407-16. 2010
  2. ncbi request reprint [Cumulative exposure to pesticide residues in food]
    Grazyna Kostka
    Zakład Toksykologii Srodowiskowej, Narodowy Instytut Zdrowia Publicznego Państwowy Zakład Higieny, Warszawa
    Rocz Panstw Zakl Hig 62:127-36. 2011
  3. ncbi request reprint [Toxicogenomics in hazard assessment of chemicals]
    Grazyna Kostka
    Zakład Toksykologii Srodowiskowej, Narodowy Instytut Zdrowia Publicznego Państwowy Zakład Higieny, Warszawa
    Rocz Panstw Zakl Hig 61:119-27. 2010
  4. ncbi request reprint [Phenobarbital-induced hypermethylation of the p53 promoter region in the liver of Wistar rats]
    Grazyna Kostka
    Zakład Toksykologii Srodowiskowej, Narodowy Instytut Zdrowia Publicznego Państwowy Zakład Higieny, 00 791 Warszawa, ul Chocimska 24
    Rocz Panstw Zakl Hig 59:455-65. 2008
  5. ncbi request reprint The effect of phenobarbital on the methylation level of the p16 promoter region in rat liver
    Grazyna Kostka
    Department of Environmental Toxicology, National Institute of Hygiene, Chocimska 24, 00 791, Warsaw, Poland
    Toxicology 239:127-35. 2007
  6. ncbi request reprint [Violations of mrls for pesticide residues in food reported for risk assessment according to RASFF procedures in Poland]
    Jan Krzysztof Ludwicki
    Zakład Toksykologii Srodowiskowej, Narodowy Instytut Zdrowia Publicznego Państwowy Zakład Higieny, 00 791 Warszawa, ul Chocimska 24
    Rocz Panstw Zakl Hig 59:389-96. 2008
  7. ncbi request reprint Hepatocellular peroxisome proliferation and DNA synthesis in Wistar rats treated with herbicide fluazifop
    Grazyna Kostka
    Department of Environmental Toxicology, National Institute of Hygiene, Chocimska 24, 00 791 Warsaw, Poland
    Toxicology 178:221-8. 2002
  8. ncbi request reprint [The effect of dibutyl phthalate (DBP) on the methylation and expression level of p53 gene in the liver of Wistar rats]
    Katarzyna Urbanek-Olejnik
    Zakład Toksykologii i Oceny Ryzyka, Narodowy Instytut Zdrowia Publicznego Państwowy Zakład Higieny, Warszawa
    Rocz Panstw Zakl Hig 63:425-32. 2012
  9. doi request reprint Changes of c-Myc and DNMT1 mRNA and protein levels in the rat livers induced by dibutyl phthalate treatment
    Katarzyna Urbanek-Olejnik
    Department of Toxicology and Risk Assessment, National Institute of Public Health National Institute of Hygiene, Warsaw, Poland
    Toxicol Ind Health 32:801-8. 2016
  10. ncbi request reprint The effect of phenobarbital on gene expression levels of p53 and Dnmt1 in the liver of Wistar rats
    Katarzyna Urbanek-Olejnik
    Department of Toxicology and Risk Assessment, National Institute of Public Health National Institute of Hygiene, Warsaw, Poland
    Rocz Panstw Zakl Hig 65:199-203. 2014

Collaborators

  • Jan Krzysztof Ludwicki
  • Katarzyna Urbanek-Olejnik
  • Monika Liszewska
  • Alicja Winczura
  • Danuta Palut
  • Bozena Wiadrowska
  • Robert Bańkowski

Detail Information

Publications14

  1. doi request reprint Di-butyl phthalate-induced hypomethylation of the c-myc gene in rat liver
    Grazyna Kostka
    Department of Environmental Toxicology, National Institute of Public Health National Institute of Hygiene, Chocimska, Warsaw, Poland
    Toxicol Ind Health 26:407-16. 2010
    ..We hypothesize that DBP-induced demethylation of the c-myc gene was an active mechanism, not associated with DNMTs activity and DNA replication...
  2. ncbi request reprint [Cumulative exposure to pesticide residues in food]
    Grazyna Kostka
    Zakład Toksykologii Srodowiskowej, Narodowy Instytut Zdrowia Publicznego Państwowy Zakład Higieny, Warszawa
    Rocz Panstw Zakl Hig 62:127-36. 2011
    ..The article discusses various aspects of estimation of cumulative risk for consumers associated with exposure to mixtures of pesticide residues in food...
  3. ncbi request reprint [Toxicogenomics in hazard assessment of chemicals]
    Grazyna Kostka
    Zakład Toksykologii Srodowiskowej, Narodowy Instytut Zdrowia Publicznego Państwowy Zakład Higieny, Warszawa
    Rocz Panstw Zakl Hig 61:119-27. 2010
    ..New research strategies within the field of toxicology (transcriptomics, proteomics, metabolomics) offer conditions to assess the hazards associated with the effects of chemicals with both established and suspected toxic potentials...
  4. ncbi request reprint [Phenobarbital-induced hypermethylation of the p53 promoter region in the liver of Wistar rats]
    Grazyna Kostka
    Zakład Toksykologii Srodowiskowej, Narodowy Instytut Zdrowia Publicznego Państwowy Zakład Higieny, 00 791 Warszawa, ul Chocimska 24
    Rocz Panstw Zakl Hig 59:455-65. 2008
    ..After prolonged administration (14 days), no changes in DNMTs activity nor DNA synthesis were observed. It is proposed that PB-induced de novo methylation of the p53 gene was not associated with DNMTs activity...
  5. ncbi request reprint The effect of phenobarbital on the methylation level of the p16 promoter region in rat liver
    Grazyna Kostka
    Department of Environmental Toxicology, National Institute of Hygiene, Chocimska 24, 00 791, Warsaw, Poland
    Toxicology 239:127-35. 2007
    ..Thus, transient changes in methylation of the p16 gene, although their direct role in the mechanisms of PB toxicity, including its carcinogenic action, remains doubtful, may therefore be a significant element of such processes...
  6. ncbi request reprint [Violations of mrls for pesticide residues in food reported for risk assessment according to RASFF procedures in Poland]
    Jan Krzysztof Ludwicki
    Zakład Toksykologii Srodowiskowej, Narodowy Instytut Zdrowia Publicznego Państwowy Zakład Higieny, 00 791 Warszawa, ul Chocimska 24
    Rocz Panstw Zakl Hig 59:389-96. 2008
    ..This means 2.5% of the overall number of analyzed samples. However, as much as 0.39% of the samples taken for analysis posed a real, considerable risk for consumers health, and the small children seem to be the group at greatest risk...
  7. ncbi request reprint Hepatocellular peroxisome proliferation and DNA synthesis in Wistar rats treated with herbicide fluazifop
    Grazyna Kostka
    Department of Environmental Toxicology, National Institute of Hygiene, Chocimska 24, 00 791 Warsaw, Poland
    Toxicology 178:221-8. 2002
    ..The value for hepatomegaly and catalase activity was 56 mg/kg body weight per day. The results presented in this paper demonstrated that fluazifop can be classified as a weak rodent PPs...
  8. ncbi request reprint [The effect of dibutyl phthalate (DBP) on the methylation and expression level of p53 gene in the liver of Wistar rats]
    Katarzyna Urbanek-Olejnik
    Zakład Toksykologii i Oceny Ryzyka, Narodowy Instytut Zdrowia Publicznego Państwowy Zakład Higieny, Warszawa
    Rocz Panstw Zakl Hig 63:425-32. 2012
    ..Currently, nongenotoxic carcinogens-induced changes in DNA methylation profile are considered as mechanism of their toxicity, including carcinogenic action...
  9. doi request reprint Changes of c-Myc and DNMT1 mRNA and protein levels in the rat livers induced by dibutyl phthalate treatment
    Katarzyna Urbanek-Olejnik
    Department of Toxicology and Risk Assessment, National Institute of Public Health National Institute of Hygiene, Warsaw, Poland
    Toxicol Ind Health 32:801-8. 2016
    ....
  10. ncbi request reprint The effect of phenobarbital on gene expression levels of p53 and Dnmt1 in the liver of Wistar rats
    Katarzyna Urbanek-Olejnik
    Department of Toxicology and Risk Assessment, National Institute of Public Health National Institute of Hygiene, Warsaw, Poland
    Rocz Panstw Zakl Hig 65:199-203. 2014
    ..Furthermore, PB induced DNA-methyltransferases (DNMTs) activity was also demonstrated; being the enzymes that catalyze methyl group transfer to cytosine in CpG dinucleotides...
  11. ncbi request reprint [DNA methylation--alternative mechanism of chemical carcinogenesis]
    Grazyna Kostka
    Zakład Toksykologii Srodowiskowej, Państwowy Zakład Higieny, 00 791 Warszawa
    Rocz Panstw Zakl Hig 56:1-14. 2005
    ....
  12. ncbi request reprint [The use of biomarkers in the assessment of health risk from environmental exposure to chemical carcinogens]
    Grazyna Kostka
    Zakład Toksykologii Srodowiskowej, Państwowy Zakad Higieny, Warszawa
    Rocz Panstw Zakl Hig 54:30-1. 2003
  13. doi request reprint The effect of acute dichlorodiphenyltrichloroethane exposure on hypermethylation status and down-regulation of p53 and p16INK4a genes in rat liver
    Grazyna Kostka
    Department of Toxicology and Risk Assessment, National Institute of Public Health National Institute of Hygiene, Chocimska 24, 00 791, Warsaw, Poland
    Environ Toxicol 31:584-92. 2016
    ..Concluding, our data suggests that epigenetically mediated changes in gene expression may play an important role in the mechanism of DDT toxicity, including carcinogenic action...
  14. ncbi request reprint [Effect of diclofop on the activity of some drug-metabolizing enzymes in the liver of male Wistar rats]
    Danuta Palut
    Zakład Toksykologii Srodowiskowej Państwowy Zakład Higieny, 00 791 Warszawa
    Rocz Panstw Zakl Hig 53:1-9. 2002
    ..2 and 56 mg/kg b.w. per day, respectively. It should be noted that this form of enzyme inactivates during II phase of biotransformation most chemical carcinogens and other xenobiotics...