Beata Smolarz

Summary

Affiliation: Medical University
Country: Poland

Publications

  1. ncbi request reprint Association between -41657C/T single nucleotide polymorphism of DNA repair gene XRCC2 and endometrial cancer risk in Polish women
    Magdalena M Michalska
    Beata Smolarz, Laboratory of Cancer Genetics, Department of Pathology, Institute of Polish Mother s Memorial Hospital, Rzgowska 281 289, 93 338 Lodz, Poland, tel 48 42 271 12 81, E mail
    Pol J Pathol 66:67-71. 2015
  2. pmc Association between single nucleotide polymorphisms (SNPs) of XRCC2 and XRCC3 homologous recombination repair genes and triple-negative breast cancer in Polish women
    Beata Smolarz
    Laboratory of Molecular Genetics, Department of Pathology, Institute of Polish Mother s Memorial Hospital, Rzgowska 281 289, 93 338, Lodz, Poland
    Clin Exp Med 15:151-7. 2015
  3. pmc DNA repair mechanisms and human cytomegalovirus (HCMV) infection
    Beata Smolarz
    Department of Fetal Maternal Medicine and Gynaecology, Polish Mother s Memorial Hospital Research Institute, 281 289 Rzgowska Street, Lodz, 93 338, Poland
    Folia Microbiol (Praha) 60:199-209. 2015
  4. pmc Gly322Asp and Asn127Ser single nucleotide polymorphisms (SNPs) of hMSH2 mismatch repair gene and the risk of triple-negative breast cancer in Polish women
    Beata Smolarz
    Laboratory of Molecular Genetics, Department of Pathology, Institute of Polish Mother s Memorial Hospital, Rzgowska 281 289, 93 338, Lodz, Poland
    Fam Cancer 14:81-8. 2015
  5. pmc Association of polymorphisms in the 5' untranslated region of RAD51 gene with risk of endometrial cancer in the Polish population
    Magdalena M Michalska
    Department of Obstetrics and Gynaecology, Regional Hospital in Kalisz, Kalisz, Poland
    Arch Gynecol Obstet 290:985-91. 2014
  6. pmc Polymorphism of the DNA repair genes RAD51 and XRCC2 in smoking- and drinking-related laryngeal cancer in a Polish population
    Hanna Romanowicz-Makowska
    Laboratory of Molecular Genetics, Department of Pathology, Institute of Polish Mother s Memorial Hospital, Lodz, Poland
    Arch Med Sci 8:1065-75. 2012
  7. pmc Evaluation of expression of the PTEN gene, oestrogen and progesterone receptors as diagnostic and predictive factors in endometrial cancer
    Dariusz Samulak
    Cathedral of Mother s and Child s Health, Poznan University of Medical Sciences, ul Polna 33, 60 535, Poznan, Poland
    Pathol Oncol Res 20:191-6. 2014
  8. pmc Single nucleotide polymorphisms (SNPs) of ERCC2, hOGG1, and XRCC1 DNA repair genes and the risk of triple-negative breast cancer in Polish women
    Beata Smolarz
    Laboratory of Molecular Genetics, Department of Pathology, Institute of Polish Mother s Memorial Hospital, Rzgowska 281 289, 93 338, Lodz, Poland
    Tumour Biol 35:3495-502. 2014
  9. pmc DNA repair mechanisms and Toxoplasma gondii infection
    Beata Smolarz
    Department of Fetal Maternal Medicine and Gynecology, Polish Mother s Memorial Hospital Research Institute, 281 289 Rzgowska Street, 93 338, Lodz, Poland
    Arch Microbiol 196:1-8. 2014
  10. ncbi request reprint Association between polymorphisms of the DNA repair gene RAD51 and ovarian cancer
    B Smolarz
    Beata Smolarz MD, PhD, Laboratory of Molecular Genetics, Department of Pathology, Institute of Polish Mother s, Memorial Hospital, Rzgowska 281 289, 93 338 Lodz, Poland, tel 48 42 271 11 12, E mail
    Pol J Pathol 64:290-5. 2013

Collaborators

Detail Information

Publications58

  1. ncbi request reprint Association between -41657C/T single nucleotide polymorphism of DNA repair gene XRCC2 and endometrial cancer risk in Polish women
    Magdalena M Michalska
    Beata Smolarz, Laboratory of Cancer Genetics, Department of Pathology, Institute of Polish Mother s Memorial Hospital, Rzgowska 281 289, 93 338 Lodz, Poland, tel 48 42 271 12 81, E mail
    Pol J Pathol 66:67-71. 2015
    ..Current literature provides clear evidence that XRCC2 polymorphisms may be associated with the development of certain types of cancer; however, still little is known about their association with endometrial cancer (EC)...
  2. pmc Association between single nucleotide polymorphisms (SNPs) of XRCC2 and XRCC3 homologous recombination repair genes and triple-negative breast cancer in Polish women
    Beata Smolarz
    Laboratory of Molecular Genetics, Department of Pathology, Institute of Polish Mother s Memorial Hospital, Rzgowska 281 289, 93 338, Lodz, Poland
    Clin Exp Med 15:151-7. 2015
    ..In conclusion, XRCC2 Arg188His and XRCC3 Thr241Met polymorphisms may be regarded as predictive factors of triple-negative breast cancer in female population...
  3. pmc DNA repair mechanisms and human cytomegalovirus (HCMV) infection
    Beata Smolarz
    Department of Fetal Maternal Medicine and Gynaecology, Polish Mother s Memorial Hospital Research Institute, 281 289 Rzgowska Street, Lodz, 93 338, Poland
    Folia Microbiol (Praha) 60:199-209. 2015
    ..Changes in the activity of DNA repair proteins during viral infection can cause disturbances in the DNA repair system and change its mechanisms. This report reviews results from studies, assaying a DNA repair system in HCMV infection. ..
  4. pmc Gly322Asp and Asn127Ser single nucleotide polymorphisms (SNPs) of hMSH2 mismatch repair gene and the risk of triple-negative breast cancer in Polish women
    Beata Smolarz
    Laboratory of Molecular Genetics, Department of Pathology, Institute of Polish Mother s Memorial Hospital, Rzgowska 281 289, 93 338, Lodz, Poland
    Fam Cancer 14:81-8. 2015
    ..71; 95 % CI 1.36-10.10). However the risk of TNBC was not alter by polymorphism Asn127Ser of the hMSH2 gene. The Gly322Asp polymorphism of the hMSH2 gene may be linked with TNBC occurrence in Polish women. ..
  5. pmc Association of polymorphisms in the 5' untranslated region of RAD51 gene with risk of endometrial cancer in the Polish population
    Magdalena M Michalska
    Department of Obstetrics and Gynaecology, Regional Hospital in Kalisz, Kalisz, Poland
    Arch Gynecol Obstet 290:985-91. 2014
    ..This reaction is mainly determined by DNA repair efficacy which, in turn, may be influenced by the variability of DNA repair genes, expressed by their polymorphisms...
  6. pmc Polymorphism of the DNA repair genes RAD51 and XRCC2 in smoking- and drinking-related laryngeal cancer in a Polish population
    Hanna Romanowicz-Makowska
    Laboratory of Molecular Genetics, Department of Pathology, Institute of Polish Mother s Memorial Hospital, Lodz, Poland
    Arch Med Sci 8:1065-75. 2012
    ..In the present work we investigated the association between polymorphisms of two HRR genes, XRCC2 and RAD51, and tobacco- and alcohol-related larynx cancer in a Polish population...
  7. pmc Evaluation of expression of the PTEN gene, oestrogen and progesterone receptors as diagnostic and predictive factors in endometrial cancer
    Dariusz Samulak
    Cathedral of Mother s and Child s Health, Poznan University of Medical Sciences, ul Polna 33, 60 535, Poznan, Poland
    Pathol Oncol Res 20:191-6. 2014
    ....
  8. pmc Single nucleotide polymorphisms (SNPs) of ERCC2, hOGG1, and XRCC1 DNA repair genes and the risk of triple-negative breast cancer in Polish women
    Beata Smolarz
    Laboratory of Molecular Genetics, Department of Pathology, Institute of Polish Mother s Memorial Hospital, Rzgowska 281 289, 93 338, Lodz, Poland
    Tumour Biol 35:3495-502. 2014
    ..No significant associations between Ser326Cys and Arg194Trp genotype and TNBC were observed. We suggest that the Lys751Gln polymorphism of the ERCC2 gene may be risk factors for triple-negative breast cancer development in Polish women...
  9. pmc DNA repair mechanisms and Toxoplasma gondii infection
    Beata Smolarz
    Department of Fetal Maternal Medicine and Gynecology, Polish Mother s Memorial Hospital Research Institute, 281 289 Rzgowska Street, 93 338, Lodz, Poland
    Arch Microbiol 196:1-8. 2014
    ....
  10. ncbi request reprint Association between polymorphisms of the DNA repair gene RAD51 and ovarian cancer
    B Smolarz
    Beata Smolarz MD, PhD, Laboratory of Molecular Genetics, Department of Pathology, Institute of Polish Mother s, Memorial Hospital, Rzgowska 281 289, 93 338 Lodz, Poland, tel 48 42 271 11 12, E mail
    Pol J Pathol 64:290-5. 2013
    ..However, this gene requires further understanding of its interaction with other genes involved in tumour development...
  11. ncbi request reprint Comparison of one-step nucleic acid amplification (OSNA) method and routine histological investigation for intraoperative detection of lymph node metastasis in Polish women with breast cancer
    B Smolarz
    Beata Smolarz, Laboratory of Molecular Genetics, Department of Pathology, Institute of Polish Mother s Memorial Hospital, Rzgowska 281 289, 93 338 Lodz, Poland, tel 48 42 271 12 80, E mail
    Pol J Pathol 64:104-8. 2013
    ..Intraoperative molecular analysis for SLN metastases using the OSNA method reduces the number of admission days and duration of surgery. To our knowledge this is the first study referring to Polish women. ..
  12. ncbi request reprint RAD51 genotype and triple-negative breast cancer (TNBC) risk in Polish women
    Beata Smolarz
    Laboratory of Molecular Genetics, Department of Pathology, Institute of Polish Mother s Memorial Hospital, Lodz, Poland
    Pol J Pathol 64:39-43. 2013
    ..In conclusion, RAD51 polymorphisms may be regarded as predictive factors of triple-negative breast cancer in the female population. Large studies are needed to confirm our findings...
  13. ncbi request reprint A single nucleotide polymorphism in the 5' untranslated region of RAD51 and ovarian cancer risk in Polish women
    H Romanowicz-Makowska
    Laboratory of Molecular Genetics, Department of Pathology, Institute of Polish Mother s Memorial Hospital, Lodz, Poland
    Eur J Gynaecol Oncol 33:406-10. 2012
    ..Aims. We investigated the association of polymorphisms in the DNA repair genes RAD51-135G > C and 172G >T with ovarian cancer risk...
  14. ncbi request reprint Single nucleotide polymorphism (SNP) Thr241Met in the XRCC3 gene and breast cancer risk in Polish women
    Hanna Romanowicz-Makowska
    Department of Pathology, Institute of Polish Mother s Memorial Hospital, Łódź, Poland
    Pol J Pathol 63:121-5. 2012
    ..The XRCC3 protein plays a critical role in Homologous Recombination Repair (HRR) accounting for repair of DNA double-strand breaks (DSB)...
  15. ncbi request reprint The association between polymorphisms of the RAD51-G135C, XRCC2-Arg188His and XRCC3-Thr241Met genes and clinico-pathologic features in breast cancer in Poland
    H Romanowicz-Makowska
    Laboratory of Molecular Genetics, Department of Pathology, Institute of Polish Mother s Memorial Hospital, Lodz
    Eur J Gynaecol Oncol 33:145-50. 2012
    ..XRCC2 and XRCC3 genes are structurally and functionally related to RAD51 which plays an important role in homologous recombination, the process frequently involved in cancer transformation...
  16. ncbi request reprint Germline BRCA1 mutations and G/C polymorphism in the 5'-untranslated region of the RAD51 gene in Polish women with breast cancer
    Hanna Romanowicz-Makowska
    Laboratory of Molecular Genetics, Department of Pathology, Institute of Polish Mother s Memorial Hospital, Lodz
    Pol J Pathol 56:161-5. 2005
    ..The lack of detectable BRCA1 germ-line mutations in most cases suggests that there are probably additional, as yet unidentified genes predisposing to this disease...
  17. ncbi request reprint Estrogen receptor alpha (ER-alpha) gene polymorphism in patients from the Lodz region of Poland with sporadic endometrial cancer
    A Sobczuk
    Department of Menopausal Disease, Institute of Polish Mother s Memorial Hospital Lodz, Poland
    Eur J Gynaecol Oncol 30:431-4. 2009
    ..Estrogens play a crucial role in the pathogenesis and progression of endometrial cancer. The gene ER-alpha is polymorphic and gene variability could contribute to the level of protein biosynthesis...
  18. ncbi request reprint Analysis of the polymorphisms in non-homologous DNA end joining (NHEJ) gene Ku70 and Ligase IV in sporadic breast cancer in women
    Anna Sobczuk
    Beata Smolarz MD, PhD, Institute of Polish Mother s Memorial Hospital, ul Rzgowska 281 289, 93 338 Łódź, E mail
    Pol J Pathol 61:27-31. 2010
    ..Double-stranded breaks are repaired in two pathways: homologous recombination (HR) and non-homologous DNA end joining (NHEJ). It is not known whether these repair pathways are affected in sporadic breast tumours...
  19. ncbi request reprint The role of BRCA1 gene mutations and apoptosis phenomenon in sporadic breast cancer
    Hanna Romanowicz-Makowska
    Laboratory of Molecular Genetics, Department of Pathology, Institute of Polish Mother s Memorial Hospital, Lodz
    Pol J Pathol 56:111-4. 2005
    ..Our study implies that apoptosis may be involved not only in sporadic breast carcinoma without BRCA1 mutations, but also in BRCA1-associated breast carcinoma...
  20. ncbi request reprint Analysis of microsatellite instability and BRCA1 mutations in patients from hereditary nonpolyposis colorectal cancer (HNPCC) family
    Hanna Romanowicz-Makowska
    Laboratory of Molecular Genetics, Department of Pathology, Institute of Polish Mother s Memorial Hospital, Lodz
    Pol J Pathol 56:21-6. 2005
    ..The lack of detectable germ-line mutations in most cases suggests that there are probably additional, as yet unidentified genes predisposing to this disease...
  21. ncbi request reprint Genetic analysis of microsatellite markers in patients from hereditary nonpolyposis colorectal cancer (HNPCC) families
    Beata Smolarz
    Laboratory of Molecular Genetics, Department of Pathology, Institute of Polish Mother s Memorial Hospital, Lodz, Poland
    Exp Oncol 26:205-9. 2004
    ..The role of MSI in familial predisposition to colorectal cancer was investigated in this study by both microsatellite analysis and mutation screening of the two major MMR genes MLH1 and MSH2 among familial cases...
  22. ncbi request reprint 135G>C and 172G>T polymorphism in the 5' untranslated region of RAD51 and sporadic endometrial cancer risk in Polish women
    Beata Smolarz
    Department of Pathology, Institute of Polish Mother s Memorial Hospital, Łódź, Poland
    Pol J Pathol 62:157-62. 2011
    ..The genetic variability in RAD51 may contribute to the appearance and progression of various cancers including EC...
  23. ncbi request reprint Plasminogen activator inhibitor 1 (PAI-1) 1334G/A genetic polymorphism in colorectal cancer
    Beata Smolarz
    Laboratory of Molecular Genetics, Department of Pathology, Institute of Polish Mother s Memorial Hospital, Rzgowska 281 289, 93 338 Łódź, Poland
    Acta Biochim Pol 50:489-95. 2003
    ..05). The results support the hypothesis that the 1334G/A polymorphism may be associated with the incidence of colorectal cancer...
  24. ncbi request reprint Ser326Cys polymorphism in DNA repair genes hOGG1 in breast cancer women
    Hanna Romanowicz-Makowska
    Laboratory of Molecular Genetics, Department of Pathology, Institute of Polish Mother s Memorial Hospital, Łódź
    Pol J Pathol 59:201-4. 2008
    ..The results suggest that the Ser326Cys polymorphism of hOGG1 gene may not be linked with appearance and development of breast cancer in polish women...
  25. ncbi request reprint The CYP17 and CYP19 gene single nucleotide polymorphism in women with sporadic breast cancer
    Anna Sobczuk
    Institute of Polish Mother s Memorial Hospital, ul Rzgowska 281 289, 93 338 Łódź
    Pol J Pathol 60:163-7. 2009
    ..05) from those predicted by the Hardy-Weinberg distribution. The results support the hypothesis that the T/C polymorphism of CYP17 gene may be associated with the incidence of breast cancer in women from Lodz region of Poland...
  26. ncbi request reprint XRCC1 and XRCC3 DNA repair gene polymorphisms in breast cancer women from the Lodz region of Poland
    Anna Sobczuk
    Department of Menopausal Diseases, Institute of Polish Mother s Memorial Hospital, Łódź
    Pol J Pathol 60:76-80. 2009
    ..Genetic polymorphism in XRCC1 and XRCC3 genes may influence DNA repair capacity and, in turn, confer predisposition to breast cancer...
  27. ncbi request reprint PCR analysis of matrix metalloproteinase 3 (MMP-3) gene promoter polymorphism in ovarian cancer
    Beata Smolarz
    Laboratory of Molecular Genetics, Department of Pathology, Institute of Polish Mother s Memorial Hospital, Lodz
    Pol J Pathol 54:233-8. 2003
    ..05) in genotype distributions and allele frequencies between subgroups assigned to histological stage. The results suggest that the 5A/6A polymorphism of MMP-3 gene may not be linked with appearance and/or progression of ovarian cancer...
  28. ncbi request reprint RAD51 gene polymorphisms and sporadic colorectal cancer risk in Poland
    Hanna Romanowicz-Makowska
    Department of Pathology, Institute of Polish Mother s Memorial Hospital, Lodz, Poland
    Pol J Pathol 63:193-8. 2012
    ..The aim of the study was to compare the distribution of genotypes of RAD51 135G>C and 172G>T polymorphism between colorectal cancer patients and controls...
  29. ncbi request reprint [Analysis of loss of heterozygosity and microsatellite instability RAD52, RAD54 and RAD54B gene and BRCA1 gene mutation in breast cancer]
    Hanna Romanowicz-Makowska
    Department of Molecular Biology, Polish Mother s Memorial Research Institute, Lodz, Poland
    Pol Merkur Lekarski 21:548-50. 2006
    ..The objectives of this study were to determine the frequency of BRCA1 germ-line mutations and the RAD52, RAD54 and RAD54B microsatellite instability (MSI) and loss of heterozygosity (LOH) in patients with breast cancer...
  30. doi request reprint Clinical significance of interleukin-6 (IL-6) gene polymorphism and IL-6 serum level in pancreatic adenocarcinoma and chronic pancreatitis
    Renata Talar-Wojnarowska
    Department of Digestive Tract Diseases, Medical University of Lodz, Kopcinskiego 22, Lodz, 90 153, Poland
    Dig Dis Sci 54:683-9. 2009
    ..Our findings indicate that -174G/C Il-6 gene polymorphism influences circulating Il-6 levels. Increased Il-6 serum levels may be correlated with tumor size and the presence of liver metastases in patients with pancreatic adenocarcinoma...
  31. ncbi request reprint Detection and analysis of apoptosis in breast and ovarian cancer subjects--genetic studies
    Elźbieta Kozłowska
    Laboratory of Molecular Genetics, Department of Pathology, Institute of Polish Mother s Memorial Hospital, Lodz
    Pol J Pathol 54:25-9. 2003
    ..The high frequency of apoptotic peripheral blood cells in breast and ovarian tumours suggests a potential role of apoptosis in cancer appearance and/or progression...
  32. ncbi request reprint The polymorphisms of the CYP17 and CYP19 genes in endometrial cancer patients
    Krzysztof Szyłło
    Department of Surgical Gynecology, Institute of Polish Mother s Memorial Hospital, Lodz
    Pol J Pathol 57:35-40. 2006
    ..The results suggest that the C/T polymorphism of CYP17 gene as well as G/A polymorphism of CYP19 may not be linked with appearance and development of endometrial cancer...
  33. ncbi request reprint Comparative evaluation of p53 mutation in pancreatic adenocarcinoma and chronic pancreatitis
    Renata Talar-Wojnarowska
    Department of Digestive Tract Diseases, Medical University, Lodz, Poland
    Hepatogastroenterology 53:608-12. 2006
    ..The purpose of the study was to compare the prevalence of p53 mutations in PA and CP in order to evaluate their usefulness in differential diagnosis of those diseases...
  34. ncbi request reprint [The analysis of estrogen receptor alpha (ER-alpha) gene Pvull and Xbal polymorphisms in postmenopausal women with breast cancer]
    Anna Sobczuk
    Department of Menopausal Disease, Institute of Polish Mother s Memorial Hospital, Lodz, Poland
    Pol Merkur Lekarski 25:43-5. 2008
    ..In the present work the distribution of genotypes and frequency of alleles of the Pvull polymorphism and Xbal polymorphism of ER-alpha gene in subjects with breast cancer were investigated...
  35. ncbi request reprint XPD Lys751Gln polymorphism analysis in women with sporadic breast cancer
    Hanna Romanowicz-Makowska
    Laboratory of Molecular Genetics, Department of Pathology, Institute of Polish Mother s Memorial Hospital, Lodz
    Pol J Pathol 58:245-9. 2007
    ..05). The results support the hypothesis that the Lys751Gln polymorphism of XPD gene may be associated with the incidence of breast cancer...
  36. ncbi request reprint Genetics polymorphism in DNA repair genes by base excision repair pathway (XRCC1) and homologous recombination (XRCC2 and RAD51) and the risk of breast carcinoma in the Polish population
    Hanna Romanowicz
    Department of Laboratory, Institute of Polish Mother s Memorial Hospital, Łódź, Poland
    Pol J Pathol 61:206-12. 2010
    ..05). Conclusion : These results suggest that 399Gln allele of XRCC1 Arg399Gln may be a risk factor for breast cancer in the Polish population...
  37. ncbi request reprint Single nucleotide polymorphisms in the homologous recombination repair genes and breast cancer risk in Polish women
    Hanna Romanowicz-Makowska
    Laboratory of Molecular Genetics, Department of Pathology, Institute of Polish Mother s Memorial Hospital, Lodz, Poland
    Tohoku J Exp Med 224:201-8. 2011
    ..In conclusion, RAD51 G135C, XRCC2 Arg188His and XRCC3 Thr241Met polymorphisms may be regarded as predictive factors of sporadic breast cancer in female population...
  38. ncbi request reprint Single nucleotide polymorphism in DNA base excision repair genes XRCC1 and hOGG1 and the risk of endometrial carcinoma in the Polish population
    Hanna Romanowicz-Makowska
    Department of Pathology, Institute of Polish Mother s Memorial Hospital, Łódź, Poland
    Pol J Pathol 62:89-94. 2011
    ..Polymorphisms in the human oxoguanine glycosylase 1 ( hOGG1 ) and X-ray repair cross-complementing 1 ( XRCC1 ) genes have been extensively studied in the association with various human cancers such as endometrial cancer...
  39. pmc Association between C3435T polymorphism of MDR1 gene and the incidence of drug-resistant epilepsy in the population of Polish children
    Mariusz Stasiołek
    Department of Neurology, Polish Mother s Memorial Hospital Research Institute, Rzgowska 281 289, 93 338, Lodz, Poland
    Behav Brain Funct 12:21. 2016
    ..The presented studies analysed the association between C3435T polymorphism of MDR1 gene and the incidence of drug-resistant epilepsy in the population of Polish children...
  40. ncbi request reprint Polymorphisms of codon 72 of the TP53 gene in endometrial carcinoma of postmenopausal women
    Agnieszka Zając
    Department of Gynecology and Gynecologic Oncology in Polish Mother s Memorial Hospital, Research Institute, Łódź, Poland
    Postepy Hig Med Dosw (Online) 67:1312-8. 2013
    ....
  41. ncbi request reprint Frequency analysis of apoptosis in sporadic breast cancer
    Elźbieta Kozłowska
    Laboratory of Molecular Genetics, Department of Pathology, Institute of Polish Mother s Memorial Hospital, Lodz
    Pol J Pathol 57:199-204. 2006
    ..The high frequency of apoptotic cells in breast tumours suggests a potential role of apoptosis in cancer appearance and/or progression...
  42. pmc The prevalence of cationic trypsinogen (PRSS1) and serine protease inhibitor, Kazal type 1 (SPINK1) gene mutations in Polish patients with alcoholic and idiopathic chronic pancreatitis
    Anita Gasiorowska
    Department of Digestive Tract Diseases, Medical University of Lodz, Kopcinskiego 22, 90 153, Lodz, Poland
    Dig Dis Sci 56:894-901. 2011
    ..Mutations of the PRSS1 and SPINK 1 have been mostly implicated in hereditary and idiopathic CP, but their presence in other types of this disease have also been reported...
  43. ncbi request reprint Genetic analysis of HER-2/neu gene amplification in paraffin embedded tumour tissue in women with breast cancer
    Marek Zadrozny
    Department of Oncology, Institute of Polish Mother s Memorial Hospital, Lodz
    Pol J Pathol 53:189-93. 2002
    ..The results suggest that the presence of amplification of HER-2/neu gene may be linked with the appearance and/or progression of breast cancer...
  44. ncbi request reprint Clinical significance of K-ras and c-erbB-2 mutations in pancreatic adenocarcinoma and chronic pancreatitis
    Renata Talar-Wojnarowska
    Department of Digestive Tract Diseases, Medical University, Lodz, Poland
    Int J Gastrointest Cancer 35:33-41. 2005
    ..The purpose of this study was to compare the prevalence of K-ras and c-erbB-2 mutations in PA and CP in order to evaluate their usefulness in differential diagnosis of those diseases...
  45. pmc TP53 and MDM2 polymorphisms and the risk of endometrial cancer in postmenopausal women
    Agnieszka Zając
    Department of Gynecology and Gynecologic Oncology, Polish Mother s Memorial Hospital, Research Institute, 281 289 Rzgowska St, 93 338, Lodz, Poland
    Med Oncol 31:286. 2014
    ..Co-occurrence of some MDM2 SNP309 and TP53 codon 72 polymorphisms seems to influence EC risk, involving grading and staging of this neoplasm at the same time...
  46. ncbi request reprint Association between MDM2 SNP309 polymorphism and endometrial cancer risk in Polish women
    Agnieszka Zając
    Department of Pathology, Institute of Polish Mother s Memorial Hospital, Lodz, Poland
    Pol J Pathol 63:278-83. 2012
    ..The results support the hypothesis that the SNP309 polymorphism of the MDM2 gene may be associated with the incidence of endometrial cancer in the female population...
  47. ncbi request reprint Concentration of cadmium, nickel and aluminium in female breast cancer
    Hanna Romanowicz-Makowska
    Department of Pathology, Research Institute of Polish Mother s Memorial Hospital, Łódź, Poland
    Pol J Pathol 62:257-61. 2011
    ..The aim of this study was to investigate the cadmium (Cd), nickel (Ni) and aluminium (Al) concentrations in female breast cancer and normal tissue...
  48. ncbi request reprint MMAC/PTEN gene expression in endometrial cancer: RT-PCR studies
    Anna Sobczuk
    Department of Menopausal Diseases, Institute of Polish Mother s Memorial Hospital, Lodz, Poland
    Pol J Pathol 57:137-40. 2006
    ..05) was observed between the expression of MMAC/PTEN in stage III versus lower stages of endometrial cancer. The results support the hypothesis that the MMAC/PTEN gene expression may be associated with the incidence of endometrial cancer...
  49. doi request reprint Association Between Single Nucleotide Polymorphism +276G > T (rs1501299) in ADIPOQ and Endometrial Cancer
    Jan Bieńkiewicz
    Department of Surgical and Endoscopic Gynecology and Gynecologic Oncology, Polish Mothers Memorial Hospital Research Institute, Lodz, Poland
    Pathol Oncol Res 22:135-8. 2016
    ..Single nucleotide polymorphism +276G > T (rs1501299) in ADIPOQ may be considered to be a risk factor of endometrial cancer. Further research on SNP in EC is warranted to obtain more conclusive outcomes. ..
  50. ncbi request reprint Associations between MDR1 C3435T polymorphism and drug-resistant epilepsy in the Polish population
    Dominik Skalski
    Department of Neurology, Regional Hospital Dr Charles Jonscher, Lodz, Poland
    Acta Neurol Belg . 2016
    ..41; 95 % confidence interval (CI) 0.26-0.67]. The results indicate that the C3435T polymorphism of MDR1 gene may be associated with the incidence of DRE observed in the Polish population...
  51. doi request reprint Association of R156R single nucleotide polymorphism of the ERCC2 gene with the susceptibility to ovarian cancer
    Hanna Romanowicz
    Laboratory of Cancer Genetics, Department of Pathology, Polish Mother s Memorial Hospital Research Institute, Rzgowska 281 289, 93 338 Lodz, Poland
    Eur J Obstet Gynecol Reprod Biol 208:36-40. 2017
    ..The reported study was designed to explore associations between the ERCC2- R156R gene single nucleotide polymorphism (SNP) and the risk of ovarian cancer...
  52. pmc Intraoperative diagnosis of sentinel lymph node metastases in breast cancer treatment with one-step nucleic acid amplification assay (OSNA)
    Paweł Szychta
    Department of Oncological Surgery and Breast Diseases, Institute of Polish Mother s Memorial Hospital, Lodz, Poland
    Arch Med Sci 12:1239-1246. 2016
    ....
  53. doi request reprint Single nucleotide polymorphisms of RAD51 G135C, XRCC2 Arg188His and XRCC3 Thr241Met homologous recombination repair genes and the risk of sporadic endometrial cancer in Polish women
    Hanna Romanowicz-Makowska
    Laboratory of Molecular Genetics, Department of Pathology, Medical University of Lodz, Lodz, Poland
    J Obstet Gynaecol Res 38:918-24. 2012
    ..Therefore, genetic variability in these genes may contribute to the occurrence and progression of endometrial cancer...
  54. doi request reprint Analysis of DNA Repair Genes Polymorphisms in Breast Cancer
    Hanna Romanowicz
    Laboratory of Cancer Genetics, Department of Pathology, Institute of Polish Mother s Memorial Hospital, Rzgowska 281 289, 93 338, Lodz, Poland
    Pathol Oncol Res 23:117-123. 2017
    ..98-3.55; p < 0.001). Furthermore, we found an association of the G/T WRN gene polymorphism with increased risk of carcinoma. The hOGG1, ERCC1, XPC and WRN genes polymorphisms may be related to development of breast cancer...
  55. ncbi request reprint New single nucleotide polymorphisms (SNPs) in homologous recombination repair genes detected by microarray analysis in Polish breast cancer patients
    Hanna Romanowicz
    Laboratory of Cancer Genetics, Department of Clinical Pathomorphology, Polish Mother s Memorial Hospital Research Institute, Rzgowska 281 289, 93 338, Lodz, Poland
    Clin Exp Med . 2016
    ..Further studies on larger groups are warranted to support the hypothesis of correlation between the abovementioned genetic variants and breast cancer risk...
  56. pmc Metallothionein 2A genetic polymorphisms and risk of ductal breast cancer
    Anna Krzeslak
    Department of Cytobiochemistry, University of Łódź, Pomorska 141 143, 90 236, Lodz, Poland
    Clin Exp Med 14:107-13. 2014
    ..58, CI: 0.41-6.33, p global = 0.03). Our data suggest that the rs28366003 SNP in MT2A is associated with risk of breast cancer in Polish population...
  57. doi request reprint A comparative analysis of K-ras mutation and carcinoembryonic antigen in pancreatic cyst fluid
    Renata Talar-Wojnarowska
    Department of Digestive Tract Diseases, Medical University of Lodz, Lodz, Poland
    Pancreatology 12:417-20. 2012
    ..The aim of our study was to assess the diagnostic utility of carcinoembryonic antigen (CEA) and K-ras gene mutation in pancreatic cysts fluid...
  58. pmc Association between the c.*229C>T polymorphism of the topoisomerase IIβ binding protein 1 (TopBP1) gene and breast cancer
    Ewa Forma
    Department of Cytobiochemistry, University of Łódź, Pomorska 141 143, 90 236 Lodz, Poland
    Mol Biol Rep 40:3493-502. 2013
    ..Most carriers of minor allele had a high grade (G3) tumors classified as T2-T4N1M0. Our study raises a possibility that a genetic variation of TopBP1 may be implicated in the etiology of breast cancer...