T Drewa

Summary

Affiliation: Medical University
Country: Poland

Publications

  1. ncbi Does the presence of unwanted dermal fibroblasts limit the usefulness of autologous epidermal keratinocyte grafts?
    T Drewa
    Department of Tissue Engineering, N Copernicus University, Bydgoszcz, Poland
    Transplant Proc 38:3088-91. 2006
  2. ncbi [Comparison of growth of the follicle and mesenchymal stem cells to urothelial cells and fibroblasts on collagen scaffold]
    Tomasz Drewa
    Zakład Inzynierii Tkankowej, Katedra Biologii Medycznej, Uniwersytet im M Kopernika, Bydgoszcz, Polska
    Polim Med 38:33-42. 2008
  3. pmc Radiofrequency ablation of small renal masses as an alternative to nephron-sparing surgery: preliminary results
    Milosz Jasinski
    Department of Urology, Institute of Oncology, Bydgoszcz, Poland Department of Tissue Engineering, Nicolaus Copernicus University, Bydgoszcz, Poland
    Wideochir Inne Tech Malo Inwazyjne 6:242-5. 2011
  4. pmc Lymph node dissection during laparoscopic (LRC) and open (ORC) radical cystectomy due to muscle invasive bladder urothelial cancer (pT2-3, TCC)
    Piotr Chlosta
    Department of Urology, Institute of Oncology, Kielce, Poland University of Humanities and Sciences, Faculty of Health, Kielce, Poland
    Wideochir Inne Tech Malo Inwazyjne 6:127-31. 2011
  5. doi Hair follicle stem cells can be driven into a urothelial-like phenotype: an experimental study
    Tomasz Drewa
    Tissue Engineering Department, Nicolaus Copernicus University, Bydgoszcz, Poland
    Int J Urol 20:537-42. 2013
  6. doi Tissue engineering for the oncologic urinary bladder
    Tomasz Drewa
    Tissue Engineering Department, Nicolaus Copernicus University, Karlowicza 24, Bydgoszcz 85 092, Poland
    Nat Rev Urol 9:561-72. 2012
  7. ncbi The urothelium cell culture on the starch scaffold
    Tomasz Drewa
    Department of Tissue Engineering, Copernicus University, Bydgoszcz, Poland
    Acta Pol Pharm 63:153-5. 2006
  8. doi Bone marrow progenitors from animals with chronic renal failure lack capacity of in vitro proliferation
    T Drewa
    Department of Tissue Engineering, Chair of Medical Biology, Medical College, Nicolaus Copernicus University, Bydgoszcz, Poland
    Transplant Proc 40:1668-73. 2008
  9. ncbi Progenitor cells are responsible for formation of human prostate epithelium primary cultures
    T Drewa
    Department of Urology, Nicolaus Copernicus University NCU, Bydgoszcz, Poland
    Exp Oncol 30:148-52. 2008
  10. ncbi Uric acid plasma level and urine pH in rats treated with ambroxol
    Tomasz Drewa
    Department of Tissue Engineering, Chair of Medical Biology, N Copernicus University, Bydgoszcz, Poland
    Acta Pol Pharm 64:565-7. 2007

Collaborators

  • T Kloskowski
  • Jan Styczynski
  • A Marszałek
  • Piotr Chłosta
  • J Adamowicz
  • Rafał Czajkowski
  • A Kaznica
  • A Grzanka
  • Arun Sharma
  • Joanna Szczepanek
  • T Kowalski
  • Alina Wozniak
  • Celestyna Mila Kierzenkowska
  • A Sionkowska
  • Olivier Cussenot
  • Anna Bajek
  • Dorota Olszewska-Słonina
  • Celestyna Mila-Kierzenkowska
  • Bartosz Wozniak
  • B Wozniak
  • Marta Pokrywczynska
  • Milosz Jasinski
  • Piotr Chlosta
  • Gerard Drewa
  • M Pokrywczynska
  • Przemyslaw Adamczyk
  • M Nowacki
  • G Drewa
  • Dariusz Musiałkiewicz
  • K Kasperczyk
  • Jerzy Siekiera
  • Krzysztof Olszewski
  • E Krzyzynska-Malinowska
  • R Makarewicz
  • C Mila-Kierzenkowska
  • Romana Joachimiak
  • Sylwia Drewa
  • Alina Woiniak
  • Ewa Krzyzyńska-Malinowska
  • Zbigniew Wolski
  • K Juszczak
  • A P Terzyk
  • M Bodnar
  • Ł Nazarewski
  • A Jundziłł
  • M Wisniewski
  • K Werengowska-Ciećwierz
  • K Pietkun
  • Małgorzata Tafil-Klawe
  • A Marszalek
  • K Walasik
  • R Joachimiak
  • M Bednarczyk
  • Andrzej Petrus
  • Krzysztof Kamecki
  • Jarosław Jaskulski
  • Witold Mikolajczak
  • Andrzej Wronczewski
  • Krzysztof Kraśnicki
  • Witold Mikołajczak
  • Mateusz Obarzanowski
  • Zaneta Cieślak
  • K Szmytkowska
  • Marcin Porzych
  • M Sopońska
  • A Jundzill
  • Magdalena Musiałkiewicz
  • J Lysik
  • K Kedziora-Kornatowska
  • Grzegorz Planutis
  • Heliodor A Kasprzak
  • Bogumiła Chesy
  • R Ceraficki
  • Małgorzata Sopońska
  • Dietrich O Schachtschabel
  • Kornelia Kedziora-Kornatowska
  • Roman Makarewicz
  • Dorota Olszewska
  • Róza Kozłowska
  • Konrad Włodarczyk
  • Jacek Klawe
  • Irena Ponikowska
  • Joanna Drewa

Detail Information

Publications78

  1. ncbi Does the presence of unwanted dermal fibroblasts limit the usefulness of autologous epidermal keratinocyte grafts?
    T Drewa
    Department of Tissue Engineering, N Copernicus University, Bydgoszcz, Poland
    Transplant Proc 38:3088-91. 2006
    ..The aim of this study was to determine the possibility of fibroblast elimination from culture to prevent fibroblast overgrowth and obtain a pure monolayer of keratinocytes...
  2. ncbi [Comparison of growth of the follicle and mesenchymal stem cells to urothelial cells and fibroblasts on collagen scaffold]
    Tomasz Drewa
    Zakład Inzynierii Tkankowej, Katedra Biologii Medycznej, Uniwersytet im M Kopernika, Bydgoszcz, Polska
    Polim Med 38:33-42. 2008
    ..The aim of this study was to compare growth of hair follicles epithelial stem cells and mesenchymal stem cells to urothelial cells and fibroblasts cells on scaffold prepared from rat collagen type I...
  3. pmc Radiofrequency ablation of small renal masses as an alternative to nephron-sparing surgery: preliminary results
    Milosz Jasinski
    Department of Urology, Institute of Oncology, Bydgoszcz, Poland Department of Tissue Engineering, Nicolaus Copernicus University, Bydgoszcz, Poland
    Wideochir Inne Tech Malo Inwazyjne 6:242-5. 2011
    ..We analysed patients who could be qualified for radical treatment due to T1a renal tumour...
  4. pmc Lymph node dissection during laparoscopic (LRC) and open (ORC) radical cystectomy due to muscle invasive bladder urothelial cancer (pT2-3, TCC)
    Piotr Chlosta
    Department of Urology, Institute of Oncology, Kielce, Poland University of Humanities and Sciences, Faculty of Health, Kielce, Poland
    Wideochir Inne Tech Malo Inwazyjne 6:127-31. 2011
    ..The aim of the study was to compare the number of nodes dissected during laparoscopic and open radical cystoprostatectomy in men or anterior exenteration in women due to muscle invasive bladder urothelial cancer (IBC)...
  5. doi Hair follicle stem cells can be driven into a urothelial-like phenotype: an experimental study
    Tomasz Drewa
    Tissue Engineering Department, Nicolaus Copernicus University, Bydgoszcz, Poland
    Int J Urol 20:537-42. 2013
    ..Smooth muscle conditioned medium resulted in a loss of cells in culture. Hair follicle stem cells are capable of differentiating into urothelial-like cells in vitro when exposed to a bladder-specific microenvironment...
  6. doi Tissue engineering for the oncologic urinary bladder
    Tomasz Drewa
    Tissue Engineering Department, Nicolaus Copernicus University, Karlowicza 24, Bydgoszcz 85 092, Poland
    Nat Rev Urol 9:561-72. 2012
    ..For example, the differentiation mesenchymal stem cells from various sources can be difficult and the smooth muscle cells formed do not precisely mimic the natural cells...
  7. ncbi The urothelium cell culture on the starch scaffold
    Tomasz Drewa
    Department of Tissue Engineering, Copernicus University, Bydgoszcz, Poland
    Acta Pol Pharm 63:153-5. 2006
    ..The athor postulate that urothelial cells have affinity to the complex sugar compounds. There is strong evidence that sugar complex compounds could be used in the treatment of the IC...
  8. doi Bone marrow progenitors from animals with chronic renal failure lack capacity of in vitro proliferation
    T Drewa
    Department of Tissue Engineering, Chair of Medical Biology, Medical College, Nicolaus Copernicus University, Bydgoszcz, Poland
    Transplant Proc 40:1668-73. 2008
    ..An interesting way to regenerate a kidney is an autologous bone marrow transplantation. The aim of this study was to examine whether chronic kidney disease influenced bone marrow progenitors...
  9. ncbi Progenitor cells are responsible for formation of human prostate epithelium primary cultures
    T Drewa
    Department of Urology, Nicolaus Copernicus University NCU, Bydgoszcz, Poland
    Exp Oncol 30:148-52. 2008
    ..To analyze cell viability and morphology of primary cell cultures from CD133 immunolabeled and sorted cells from epithelium of patients suffering from benign prostate hyperplasia (BPH)...
  10. ncbi Uric acid plasma level and urine pH in rats treated with ambroxol
    Tomasz Drewa
    Department of Tissue Engineering, Chair of Medical Biology, N Copernicus University, Bydgoszcz, Poland
    Acta Pol Pharm 64:565-7. 2007
    ..The influence of ambroxol on urinary tract GAG layer and the balance between xanthine and CaOx in the urine should be checked...
  11. doi Using hair-follicle stem cells for urinary bladder-wall regeneration
    Tomasz Drewa
    Department of Tissue Engineering, Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, ul Karlowicza 24, 85 092 Bydgoszcz, Poland
    Regen Med 3:939-44. 2008
    ..The hypothesis is that hair-follicle stem cells can be used, with the guarantee of the sufficient cell number, for a construction in vitro of the urinary bladder wall replacement...
  12. ncbi The short term exposition of AgNO3 on 3T3 mouse fibroblasts cell line
    Tomasz Drewa
    Department of Tissue Engineering, Chair of Medical Biology N, Copernicus University, Bydgoszcz, Poland
    Acta Pol Pharm 64:175-8. 2007
    ..In conclusion, the silver nitrate has the similar toxic effect on 3T3 fibroblasts during the short and long exposition. Attention should be paid when catheter has a close contact to injured urothelium even for a short period of time...
  13. ncbi The artificial conduit for urinary diversion in rats: a preliminary study
    T Drewa
    Departments of Tissue Engineering and Urology, Nicolaus Copernicus University, Karlowicza 24, 85 092 Bydgoszcz, Poland
    Transplant Proc 39:1647-51. 2007
    ..Small intestinal submucosa forms a scaffold for tubular construction. The aim of this study was to build the artificial conduit using small intestinal submucosa (SIS) and 3T3 fibroblasts for urinary diversion in rats...
  14. ncbi Parenteral ambroxol treatment causes xanthine and calcium oxalate stones in rats
    Tomasz Drewa
    Department of Urology, University Hospital, N Copernicus University, Bydgoszcz, Poland
    Int J Urol 14:463-5. 2007
    ..Ambroxol (ABX) is known to promote bronchial secretion and is used as an expectorant. This study was undertaken to document the connection between ambroxol parenteral treatment and bladder stones in rats...
  15. ncbi The influence of alpha1-antagonist on the expression pattern of TNF receptor family in primary culture of prostate epithelial cells from BPH patients
    T Drewa
    Department of General, Oncologic and Pediatric Urology, Ludwik Rydygier Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland
    Prostate Cancer Prostatic Dis 11:88-93. 2008
    ..TNF receptor self-assembly process should be checked as a potential mechanism leading to apoptosis after doxazosin treatment...
  16. doi Can conception of prostate cancer stem cells influence treatment dedicated to patients with disseminated disease?
    Tomasz Drewa
    Department of Tissue Engineering, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland
    Med Hypotheses 71:694-9. 2008
    ..Disseminated prostate cancer must be treated with agents directed toward stem cells, while hormone-therapy must be only an additional treatment leading to the decrease of tumor burden...
  17. ncbi Comparison of 3T3 fibroblasts growth on alginate and polyasparagine (PAA) scaffolds in mouse model
    Tomasz Drewa
    Department of Tissue Engineering, Chair of Medical Biology, Nicolaus Copernicus University, Bydgoszcz, Poland
    Polim Med 38:21-31. 2008
    ..The aim of this study was to evaluate polyasparagine (PAA), a new, promising scaffold. PAA was compared with alginate, which is used in cell transplantations and may be regarded as a standard...
  18. ncbi Testosterone replacement therapy in obese males
    Tomasz Drewa
    Department of Urology, Institute of Oncology, Romanowskiej 2, 85 796 Bydgoszcz, Poland
    Acta Pol Pharm 68:623-7. 2011
    ..The question related to rational indications for testosterone replacement therapy in obese males seems to be still actual...
  19. ncbi Prostate cancer which affects an elderly man is a feature of senescence (cellular) - a biology phenomenon
    T Drewa
    Department of Urology, Institute of Oncology, Romanowskiej 2, Bydgoszcz 85 796, Poland
    Exp Oncol 32:228-32. 2010
    ..Potential mechanisms leading to development of the late-life clinically indolent prostate cancer are discussed. It seems that the key abnormalities are proteins involved in control of regenerative potential and cell senescence...
  20. ncbi Testosterone supplementation and prostate cancer, controversies still exist
    Tomasz Drewa
    Department of Urology, N Copernicus University, Bydgoszcz, Karłowicza 24, 85 092 Bydgoszcz, Poland
    Acta Pol Pharm 67:543-6. 2010
    ..The risk that testosterone treatment would trigger prostate cancer was not fully recognized. The aim of this mini review is to present a risk of carcinogenesis within the prostate related to testosterone treatment...
  21. doi Hair stem cells for bladder regeneration in rats: preliminary results
    T Drewa
    Department of Tissue Engineering, Nicolaus Copernicus University, ul Karlowicza 24, 85 092 Bydgoszcz, Poland
    Transplant Proc 41:4345-51. 2009
    ....
  22. doi Primary cultures from rat vibrissae as a potential cell source for in vitro construction of urinary bladder wall grafts
    T Drewa
    Department of Tissue Engineering, CM UMK, Bydgoszcz, Poland
    Transplant Proc 41:1932-5. 2009
    ..The aim of the present study was to examine the potential of rat vibrissae hair follicle cells to form cultures, which could serve as a source for in vitro creation of urinary bladder wall grafts...
  23. ncbi The proapoptotic influence of AgNO3 on human keratinocytes and fibroblasts in vitro, the impact for burned patient management
    Tomasz Drewa
    Department of Tissue Engineering, Nicolaus Copernicus University, Bydgoszcz, Poland
    Acta Pol Pharm 65:515-9. 2008
    ..The ointments containing nitrates should be used with caution especially in conditions where the epithelial layer is destroyed. The nitrate can negatively affect wound healing...
  24. ncbi Is the cancer stem cell population "a player" in multi-drug resistance?
    Tomasz Drewa
    Department of Tissue Engineering, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland
    Acta Pol Pharm 65:493-500. 2008
    ....
  25. doi Chitosan scaffold enhances nerve regeneration within the in vitro reconstructed bladder wall: an animal study
    Tomasz Drewa
    Department of Tissue Engineering, N Copernicus University, Bydgoszcz, Poland
    Urol Int 81:330-4. 2008
    ..Polyglycolic acid (PGA) is used as cell vehicle. Chitosan supported the adhesion and differentiation of neurons. The aim of the study was to compare PGA with PGA/chitosan 'sandwich' grafts for bladder regeneration...
  26. ncbi The influence of staphylococcin T (StT) on the mouse fibroblasts (3T3) viability, an in vitro experiment
    Tomasz Drewa
    Department of Tissue Engineering, Chair of Medical Biology, N Copernicus University, Bydgoszcz, Poland
    Acta Pol Pharm 63:543-6. 2006
    ..There were no changes in morphology of cells in all groups. It follows that StT had unimportant influence on the fibroblasts (3T3) viability in culture. StT may be considered for future animal trails...
  27. ncbi Progenitor cells are responsible for formation primary epithelial cultures in the prostate epithelial model
    Tomasz Drewa
    Department of Tissue Engineering, Chair of Medical Biology, Nicolaus Copernicus University, Karlowicza 24, 85 092, Bydgoszcz, Poland
    Int Urol Nephrol 39:851-7. 2007
    ..The primary epithelial cell culture collapsed in a few days after the CD133-positive ASC were removed. We concluded that the epithelial progenitor cells are responsible for establishing primary prostate epithelial cultures in vitro...
  28. ncbi The FAS-related apoptosis signaling pathway in the prostate intraepithelial neoplasia and cancer lesions
    Tomasz Drewa
    Department of Tissue Engineering, N Copernicus University, Bydgoszcz, Poland
    Acta Pol Pharm 63:311-5. 2006
    ..The mediators of apoptotic signal can be very important in prostate cancer prophylaxis and management...
  29. ncbi Abdominal wall repair using a biodegradable scaffold seeded with cells
    Tomasz Drewa
    Department of Urology, The L Rydygier Medical University, 85 094 Bydgoszcz, Poland
    J Pediatr Surg 40:317-21. 2005
    ..The repair of large abdominal wall defects is still a challenge for pediatric surgeons. Synthetic materials, however, may lead to high complication rates. This study was aimed at applying tissue-engineering methods to abdominal wall repair...
  30. ncbi The influence of ambroxol and capsaicin on the isolated rabbit bladder wall
    Tomasz Drewa
    Department of Tissue Engineering, Chair of Medical Biology, L Rydygier Medical College Bydgoszcz, N Copernicus University, Torun, Poland
    Acta Pol Pharm 62:399-403. 2005
    ..ABX as well as CAPSA influence on transepithelial ion transport pathways in bladder epithelium is dependent on sensory stimulation. ABX can be suspected to suppress bladder contractions...
  31. ncbi [Application of autologous and allogenic keratynocyte cultures in burn management]
    Tomasz Drewa
    Zakład Inzynierii Tkankowej, Katedra Biologii Medycznej, Collegium Medicum im L Rydygiera, Uniwersytet M Kopernika, Torun
    Przegl Lek 62:934-7. 2005
    ..Cells are also seeded on matrixes made from glicosamonogycans, collagen, elastin or fibrin. These products are used as a skin substitutes...
  32. ncbi Lack of local anesthetic properties of lidocaine gel in an experimental model
    T Drewa
    Department of Urology, L Rydygier Medical Academy, Bydgoszcz, Poland
    Urol Int 76:359-63. 2006
    ..Many reports negate the anesthetic properties of lidocaine gel placed in the urethra during catheterization. The anesthetic action of lidocaine is inseparably associated with the toxic action of this compound on cells...
  33. doi Will tissue-engineered urinary bladders change indications for a laparoscopic cystectomy?
    Tomasz Drewa
    Nicolaus Copernicus University, Bydgoszcz, Poland, Institute of Oncology, Bydgoszcz, Poland
    Surg Innov 17:295-9. 2010
    ..LapRC with tissue-engineered urinary diversion could become a management of choice for muscle invasive bladder cancer...
  34. ncbi [Eyelid conjunctiva can be a potential cells source for conjunctival sack reconstruction purpose]
    Tomasz Drewa
    Uniwersytet Mikołaja Kopernika w Toruniu, Collegium Medicum w Bydgoszczy, Zakład Inzynierii Tkankowej, Katedra Biologii Medycznej
    Pol Merkur Lekarski 20:333-6. 2006
    ..There is no ideal culture establishing method for the conjunctival sac reconstruction. Two methods of primary conjunctival culture establishing were compared...
  35. ncbi Scaffold seeded with cells is essential in urothelium regeneration and tissue remodeling in vivo after bladder augmentation using in vitro engineered graft
    T Drewa
    The Laboratory for Tissue Engineering, Medical Biology Department, N Copernicus University, ul Karlowicza 24, 85 092 Bydgoszcz, Torun, Poland
    Transplant Proc 38:133-5. 2006
    ..The aim of the study was to induce in vivo urothelial growth on implanted scaffolds previously seeded with stromal cells as compared with matrices implanted without cells for rat cystoplasty augmentation...
  36. ncbi The effect of combined therapy on activity of cathepsin D and alpha-1-antitrypsin in the blood serum of women with cervical cancer
    B Wozniak
    Department and Clinic of Neurosurgery and Neurotraumatology, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland
    Eur J Gynaecol Oncol 29:617-9. 2008
    ..The aim of the study was to determine the activity of cathepsin D (CTSD) and alpha-1-antitrypsin (AAT) in the blood serum of women with cervical carcinoma treated with different modes of therapy...
  37. ncbi Influence of two Pt(IV) complexes on viability, apoptosis and cell cycle of B16 mouse melanoma tumors
    A Kaznica
    Chair of Medical Biology, Nicolaus Copernicus University, Bydgoszcz 85 092, Poland
    Exp Oncol 31:33-6. 2009
    ..Several platinum(IV) complexes are showing considerable promise in initial trials, producing reactive intermediates that then interact with DNA...
  38. doi In vitro optimization of the Gallus domesticus oviduct epithelial cells culture
    K Kasperczyk
    Animal Biotechnology Department, Bydgoszcz University of Technology and Life Sciences, Bydgoszcz, Poland
    Theriogenology 77:1834-45. 2012
    ....
  39. doi Urine is a highly cytotoxic agent: does it influence stem cell therapies in urology?
    J Adamowicz
    Department of Tissue Engineering, Nicolaus Copernicus University, Bydgoszcz, Poland
    Transplant Proc 44:1439-41. 2012
    ..The cell number was significantly lower in all groups exposed on medium mixed with urine and urine alone. The results showed that urine is a highly cytotoxic agent whose role in urologic regenerative medicine is underestimated...
  40. doi Morphological and urodynamic evaluation of urinary bladder wall regeneration: muscles guarantee contraction but not proper function--a rat model research study
    J Adamowicz
    Department of Tissue Engineering, Medical College, N Copernicus University, Torun, Poland
    Transplant Proc 44:1429-34. 2012
    ..This study was performed to evaluate bone marrow mesenchymal stem cells (BMSC) seeded on to amniotic membranes fixed to Tachosil sponges as grafts for urinary bladder muscle layer augmentation in a syngenic rat model...
  41. ncbi Activity of antioxidant enzymes and concentrations of thiobarbituric acid reactive substances (TBARS) in melanotic and amelanotic Bomirski melanoma tissues in the golden hamster (Mesocricetus auratus, Waterhouse)
    A Wozniak
    Department of Biology, Ludwik Rydygier Medical University, Bydgoszcz, Poland
    Neoplasma 49:401-4. 2002
    ..It is presumed that it is strictly connected with intensified production of quinone and semiquinone radicals in the process of melanogenesis...
  42. ncbi Activity of cathepsin D and alpha(1)-antitrypsin in the blood serum of patients with mammary carcinoma
    A Wozniak
    Department of Medical Biology, Nicolaus Copernicus University, Bydgoszcz, Poland
    Exp Oncol 27:233-7. 2005
    ..THE AIM of this study was to determine the activity of cathepsin D and alpha(1)-antitrypsin in the blood serum of patients with mammary carcinoma...
  43. ncbi Influence of the management of cervical carcinoma on the activity of catalase and glutathione peroxidase in erythrocytes
    B Wozniak
    Department and Clinic of Neurosurgery and Neurotraumatology, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland
    Eur J Gynaecol Oncol 28:461-3. 2007
    ..The aim of the study was to determine the effect of different types of management on the activity of catalase (CAT) and glutathione peroxidase (GPx) in women with cervical carcinoma...
  44. ncbi Activity of superoxide dismutase (SOD) and concentration of thiobarbituric acid reactive substances (TBARS) in liver and muscles of some fish
    Celestyna Mila-Kierzenkowska
    Department of Medical Biology, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland
    Acta Biol Hung 56:399-401. 2005
    ..The highest SOD activity was observed in the cod while the highest TBARS concentration was in the flounder. The observed differences are probably an effect of the different living mode of the compared fish...
  45. ncbi The in vitro study of influence of four novel platinum compounds on rodent melanoma cells
    T Drewa
    Department of Human Biology, Ludwik Rydygier Medical University, Bydgoszcz, Poland
    Acta Pol Pharm 58:169-74. 2001
    ..We suppose that cytotoxic and soluble properties ot Pt-dmtp and Pt-rib-1 could be modified and improved...
  46. ncbi Lack of changes in the concentration of thiobarbituric acid-reactive substances (TBARS) and in the activities of erythrocyte antioxidant enzymes in alcohol-dependent patients after detoxification
    Bartosz Wozniak
    Department and Clinic of Neurosurgery and Neurotraumatology, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland
    Med Sci Monit 14:CR32-36. 2008
    ....
  47. doi New application of carbon nanotubes in haemostatic dressing filled with anticancer substance
    M Nowacki
    N Copernicus University, Chair of Regenerative Medicine, Tissue Engineering Department, Ludwik Rydygier Collegium Medicum in Bydgoszcz, Karłowicza St 24, 85 092 Bydgoszcz, Poland
    Biomed Pharmacother 69:349-54. 2015
    ..In our study, it is shown that CDDP filled SWCNT inhibit cancer recurrence in animal model NSS study, and can be successfully applied as haemostatic dressings for local chemoprevention. ..
  48. doi Alginate is not a good material for growth of rapidly proliferating cells
    M Pokrywczynska
    Department of Tissue Engineering, Chair of Medical Biology, Collegium Medicum of Nicolaus Copernicus University, Bydgoszcz, Poland
    Transplant Proc 40:1664-7. 2008
    ..Alginate scaffolds are widely used in tissue engineering. The aim of this study was to evaluate alginate as a scaffold for 3D cultures of rapidly proliferating cells...
  49. ncbi Lipid peroxidation and antioxidant capacity in selected tissues of healthy black C57BL/6J mice and B16 melanoma-bearing mice
    A Wozniak
    Department of Biology, Ludwik Rydygier Medical University, 85 092 Bydgoszcz, Poland
    Melanoma Res 13:19-22. 2003
    ..The antioxidant capacity, however, was lower in the tissues of melanoma-bearing mice. The results obtained demonstrate an increase in oxidative stress in the tissues of mice bearing a transplanted B16 melanoma...
  50. ncbi The effect of brachytherapy on antioxidant status and lipid peroxidation in patients with cancer of the uterine cervix
    Celestyna Mila-Kierzenkowska
    Department of Medical Biology, Ludwik Rydygier Medical University, Karłowicza 24, PL 85 092 Bydgoszcz, Poland
    Cell Mol Biol Lett 9:511-8. 2004
    ..However, the normalisation of catalase and glutathione peroxidase activity and erythrocyte TBARS level observed six months after the end of therapy may be due to the arrest of the progression of the disease...
  51. ncbi The effect of antitumor drugs on oxidative stress in B16 and S91 melanoma cells in vitro
    Alina Woiniak
    Department of Medical Biology, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland
    Med Sci Monit 11:BR22-9. 2005
    ....
  52. ncbi Influence of sodium butyrate on hepatocellular carcinoma (hepG2) and glioblastoma (C6) cell lines in vitro
    Romana Joachimiak
    Department of Tissue Engineering, Chair of Medical Biology, 24 Karlowicza Str, Collegium Medicum, Nicolaus Copernicus University, 85 092 Bydgoszcz, Poland
    Acta Pol Pharm 64:561-3. 2007
    ..91 and 0.631 for C6 and HepG2, respectively). C6 line was more resistant to NaB than HepG2. Both cell lines were sensitive to NaB treatment, which gives the promise that NaB can be used against broader spectrum of neoplasms in the future...
  53. ncbi [Mesenchymal stem cells as a therapeutic tool in tissue and organ regeneration]
    Anna Bajek
    Zakład Inżynierii Tkankowej Katedry Biologii Medycznej, Collegium Medicum im Ludwika Rydygiera w Bydgoszczy, UMK Toruń
    Postepy Hig Med Dosw (Online) 65:124-32. 2011
    ..The aim of this publication is to present characteristic and biological properties of mesenchymal stem cells isolated from bone marrow...
  54. doi Urine--a waste or the future of regenerative medicine?
    T Kloskowski
    Chair of Regenerative Medicine, Department of Tissue Engineering, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland Electronic address
    Med Hypotheses 84:344-9. 2015
    ..Cells derived from urine can be isolated, stored, and used for the creation of urine stem cell banks. In the future, urine holds great potential to become a main source of cells for tissue engineering and regenerative medicine. ..
  55. doi How to isolate urothelial cells? Comparison of four different methods and literature review
    T Kloskowski
    Department of Tissue Engineering, Ludwik Rydygier Collegium Medicum in Bydgoszcz Nicolaus Copernicus University in Toruń, Karlowicza Str 24, 85 092, Bydgoszcz, Poland
    Hum Cell 27:85-93. 2014
    ..Our results and the literature review showed that the best method for urothelium bladder isolation is dissection of the epithelium layer from other bladder parts and digestion of mechanically prepared tissue in a collagenase solution. ..
  56. doi Ciprofloxacin as a prophylactic agent against prostate cancer: a "two hit" hypothesis
    T Kloskowski
    Tissue Engineering Department, Chair of Medical Biology, Collegium Medicum, Nicolaus Copernicus University in Bydgoszcz, Poland
    Med Hypotheses 78:235-8. 2012
    ..Ciprofloxacin accumulates mainly in the prostate after oral intake thus ciprofloxacin seems to be a perfect candidate as a prophylactic agent...
  57. ncbi Effect of adriblastin on viability, cell cycle and apoptosis in B16 and cloudman s91 mouse melanoma cells in vitro
    Dorota Olszewska-Słonina
    Department of Human Biology, Collegium Medicum, Nicolaus Copernikus University, 85 092 Bydgoszcz, Poland
    Acta Pol Pharm 61:439-46. 2004
    ..Adriblastin induced cell arrest in G1 and S cell cycle phase in both B16 and Cl S91 cell lines...
  58. ncbi The influence of ciprofloxacin on hamster ovarian cancer cell line CHO AA8
    Tomasz Kloskowski
    Department of Tissue Engineering, Chair of Medical Biology, Nicolaus Copermicus University, Karłowicza 24, 85 092 Bydgoszcz, Poland
    Acta Pol Pharm 67:345-9. 2010
    ..No living cells were observed after 96 h of incubation times and ciprofloxacin concentrations of 800 and 1000 micrpg/mL. These promising results deserved future studies on chinolones and ovarian cancer...
  59. doi Does ciprofloxacin have an obverse and a reverse?
    Tomasz Kloskowski
    Department of Tissue Engineering, Chair of Medical Biology, Nicolaus Copernicus University, Bydgoszcz, Poland
    Pulm Pharmacol Ther 23:373-5. 2010
    ....
  60. ncbi Lipid peroxidation and activity of some antioxidant enzymes in patients with glioblastoma and astrocytoma
    Bartosz Wozniak
    Department and Clinic of Neurosurgery and Neurotraumatology, Ludwik Rydygier Medical University, Sklodowska Curie 9, 85 094, Bydgoszcz, Poland
    J Neurooncol 81:21-6. 2007
    ..Neither the histological type of tumour nor surgery has an effect on the tested biochemical parameters...
  61. ncbi Leukemic stem cells: from metabolic pathways and signaling to a new concept of drug resistance targeting
    Jan Styczynski
    Department of Pediatric Hematology and Oncology, Collegium Medicum, Nicolaus Copernicus University, Bydgoszcz, Poland
    Acta Biochim Pol 54:717-26. 2007
    ..The molecules and pathways specific for cancer stem cells, which contribute to their drug resistance, are potential targets for new therapeutic strategies...
  62. ncbi Rare neoplasm of genito-urinary tract. Genito-urinary sarcomas: chemotherapy
    Przemyslaw Adamczyk
    aDepartment of General and Oncological Urology, Nicolaus Copernicus Hospital, Torun bDepartment of Urology, Memorial Rydygier Hospital, Cracow cDepartment of Urology, Nicolaus Copernicus University, Bydgoszcz, Poland
    Curr Opin Urol 27:80-84. 2017
    ..The purpose of this article was to describe the systemic therapy of genito-urinary sarcomas...
  63. ncbi Activity of some lysosomal enzymes in serum and in tumors of patients with squamous cell lung carcinoma
    A Wozniak
    Department of Biology, Ludwik Rydygier Medical University, Bydgoszcz, Poland
    Neoplasma 49:10-5. 2002
    ..Higher lysosomal enzyme activity may be a useful factor in diagnosing and monitoring of lung cancer. However, further investigations are needed...
  64. ncbi Cell cycle in sporadic melanoma
    Rafał Czajkowski
    Department of Dermatology, Ludwik Rydygier Medical University, Bydgoszcz, Poland
    Int J Dermatol 41:550-6. 2002
    ..The present paper discusses disorders in the control of phase G1 of the cell cycle in sporadic melanoma...
  65. ncbi Establishing melanocyte cultures in a serum-free system for transplantation in vitiligo patients
    Rafał Czajkowski
    Department of Dermatology, Nicolaus Copernicus University, Ludwik Rydygier Medical College, Bydgoszcz, Poland
    Med Sci Monit 12:CR63-9. 2006
    ....
  66. ncbi [Islet isolation outcome is influenced by pancreas preparation method]
    Marta Pokrywczynska
    Uniwersytet Mikołaja Kopernika w Toruniu, Collegium Medicum w Bydgoszczy, Katedra Biologii Medycznej, Zakład Inzynierii Tkankowej
    Pol Merkur Lekarski 25:240-3. 2008
    ..Pancreatic islet transplantation is a treatment method for type I diabetes. Its outcome is influenced by numerous factors, islet quantity and function being important ones of them...
  67. ncbi Autologous cultured melanocytes in vitiligo treatment
    Rafal Czajkowski
    Department of Dermatology and Department of Tissue Engineering, Nicolaus Copernicus University, Ludwik Rydygier Medical College, Bydgoszcz, Poland
    Dermatol Surg 33:1027-36; discussion 1035-6. 2007
    ..Surgical treatment of vitiligo is indicated when lesions are localized in poorly responding areas...
  68. ncbi B16 and CLS91 mouse melanoma cells susceptibility to apoptosis after vincristin treatment in vitro
    Dorota Olszewska-Słonina
    Department of Medical Biology, Ludwik Rydygier Medical University, 24 Karlowicza Str, 85 092 Bydgoszcz, Poland
    Acta Pol Pharm 61:113-21. 2004
    ..Vincristin induced both B16 and ClS91 cell lines arrest in G2/M cell cycle phase. It was found a correlation between apoptosis occurrence in the melanoma cells and vincristin resistance...
  69. doi Transplantation of cultured autologous melanocytes: hope or danger?
    Rafal Czajkowski
    Department of Tissue Engineering, Nicolaus Copernicus University in Torun, Bydgoszcz, Poland
    Cell Transplant 19:639-43. 2010
    ..In order to assess the total safety of the transplantation of cultured melanocytes, it is necessary to carry out further studies on other signaling pathways as well as carry out biological tests on an animal model...
  70. ncbi Comparison of viability of B16 and Cl S91 cells in three cytotoxicity tests: cells counting, MTT and flow cytometry after cytostatic drug treatment
    Dorota Olszewska-Słonina
    Department of Medical Biology, 2 Department and Clinic of Orthopedics and Traumathology, Rydygier Medical University, 24 Karlowicza Str, 85 092 Bydgoszcz, Poland
    Acta Pol Pharm 61:31-7. 2004
    ..cytosine arabinoside, cisplatin and dacarbazine than mouse melanoma Cl S91 cells. Mouse melanoma Cl S91 cells are more sensitive to vincristine than B16 cells...
  71. ncbi [Treatment of liver failure using tissue engineering techniques]
    Marta Pokrywczynska
    Ward of Tissue Engineering, Nicolaus Copernicus University of Torun, Collegium Medicum in Bydgoszcz, Poland
    Pol Merkur Lekarski 23:66-9. 2007
    ..The methods of liver support using bioartificial liver and isolated hepatocytes transplantation were described...
  72. ncbi Ozone therapy and the activity of selected lysosomal enzymes in blood serum of patients with lower limb ischaemia associated with obliterative atheromatosis
    Małgorzata Tafil-Klawe
    Department of Physiology, L Rydygier Medical University in Bydgoszcz, Poland
    Med Sci Monit 8:CR520-5. 2002
    ..The paper compares the effects of ozone therapy and conventional balneological methods on health condition of patients with obliterative atheromatosis and on serum activity of three lysosomal enzymes...
  73. ncbi Influence of a novel platinum compound--cis-dichloro (dimethylsulphoxide) (1-beta-D-rybofuranosyl-1,2,4-triazolo-3-arboxyamide) platinum (II)--"Pt-rib-1"--on cell cycle and apoptosis in ClS91 and B16 mouse melanoma in vitro
    Tomasz Drewa
    Department of Medical Biology, L Rydygier Medical University, 24 Karlowicza Str, 85 092 Bydgoszcz, Poland
    Acta Pol Pharm 61:39-44. 2004
    ..2 to 2.0 x 10(-5) M/dm3). Pt-rib-1 partially exhibits action of cisplatin. which has no specific influence on cell cycle and ribavirin. probably responsible for DNA synthesis delay...
  74. ncbi [Silicone and latex urinary catheters cytotoxicity on primary cultured rabbit urothelial cells]
    Tomasz Drewa
    Katedra i Klinika Urologii, Akademii Medycznej w Bydgoszczy
    Pol Merkur Lekarski 16:228-31. 2004
    ..In everyday urological practice, the use of urinary catheters creates problems such as epithelial hyperplasia, edema or erosion...
  75. ncbi [Hereditary prostate cancer]
    Zbigniew Wolski
    Klinika Urologii AM w Bydgoszczy
    Pol Merkur Lekarski 16:565-7. 2004
    ..The third brother with spreading disease died after androgen blockade management. We did not find any linkage between chosen markers of PCaP region (Predisposing for Prostate Cancer) and prostate cancer occurrence in this family...
  76. ncbi [Programmed cell death in the pathogenesis of human diseases]
    Tomasz Drewa
    Katedra i Zakład Biologii AM w Bydgoszczy
    Pol Merkur Lekarski 12:336-41. 2002
    ..Programmed cell death induction using gene therapy methods is tested in preclinical examinations. The results of these tests are thought to have an important significance in therapy of many diseases...