Andrzej Boguslaw Hendrich

Summary

Country: Poland

Publications

  1. ncbi request reprint Lipids as a target for drugs modulating multidrug resistance of cancer cells
    A B Hendrich
    Department of Biophysics, Wroclaw Medical University, Chalubinskiego 10, Wroclaw 50 368, Poland
    Curr Drug Targets 4:23-30. 2003
  2. ncbi request reprint Flavonoid-membrane interactions: possible consequences for biological effects of some polyphenolic compounds
    Andrzej B Hendrich
    Department of Biophysics, Wroclaw Medical University, Poland
    Acta Pharmacol Sin 27:27-40. 2006
  3. ncbi request reprint Phase separation is induced by phenothiazine derivatives in phospholipid/sphingomyelin/cholesterol mixtures containing low levels of cholesterol and sphingomyelin
    Andrzej B Hendrich
    Department of Biophysics, Wrocław Medical University, ul Chałubińskiego 10, 50 368 Wrocław, Poland
    Biophys Chem 130:32-40. 2007
  4. ncbi request reprint Differential interaction of Sophora isoflavonoids with lipid bilayers
    Andrzej Boguslaw Hendrich
    Department of Biophysics, Wroclaw Medical University, ul Chalubinskiego 10, 50 368, Wroclaw, Poland
    Eur J Pharm Sci 16:201-8. 2002
  5. ncbi request reprint The alterations of lipid bilayer fluidity induced by newly synthesized phenothiazine derivative
    Andrzej B Hendrich
    Department of Biophysics, Wrocław Medical University, ul Chałubińskiego 10, 50 368, Wrocław, Poland
    Biophys Chem 98:275-85. 2002
  6. ncbi request reprint Neither lipophilicity nor membrane-perturbing potency of phenothiazine maleates correlate with the ability to inhibit P-glycoprotein transport activity
    Andrzej B Hendrich
    Department of Biophysics Wrocław Medical University ul Chalubinskiego 10 50 368 Wrocław, Poland
    Mol Membr Biol 20:53-60. 2003
  7. ncbi request reprint New phenothiazine-type multidrug resistance modifiers: anti-MDR activity versus membrane perturbing potency
    Andrzej B Hendrich
    Department of Biophysics, Wrocław Medical University, ul Chałubińskiego 10, 50 368, Wrocław, Poland
    Biochem Biophys Res Commun 304:260-5. 2003
  8. ncbi request reprint A study on the perturbation of model lipid membranes by phenoxazines
    Andrzej B Hendrich
    Department of Biophysics, Wrocław Medical University, Wrocław, Poland
    Bioorg Med Chem 14:5948-54. 2006
  9. ncbi request reprint Biochanin A similarly influences the fluidity of liposomes formed from charged and zwitterionic lipids
    Andrzej B Hendrich
    Department of Biophysics, Wrocław University of Medicine, Chałubińskiego 10, 50 368 Wrocław, Poland
    Cell Mol Biol Lett 7:284. 2002
  10. ncbi request reprint Influence of silybin on biophysical properties of phospholipid bilayers
    Olga Wesołowska
    Department of Biophysics, Wroclaw Medical University, ul Chalubinskiego 10, 50 368 Wroclaw, Poland
    Acta Pharmacol Sin 28:296-306. 2007

Collaborators

Detail Information

Publications20

  1. ncbi request reprint Lipids as a target for drugs modulating multidrug resistance of cancer cells
    A B Hendrich
    Department of Biophysics, Wroclaw Medical University, Chalubinskiego 10, Wroclaw 50 368, Poland
    Curr Drug Targets 4:23-30. 2003
    ..Some further consequences of the alteration of membrane state are also considered...
  2. ncbi request reprint Flavonoid-membrane interactions: possible consequences for biological effects of some polyphenolic compounds
    Andrzej B Hendrich
    Department of Biophysics, Wroclaw Medical University, Poland
    Acta Pharmacol Sin 27:27-40. 2006
    ....
  3. ncbi request reprint Phase separation is induced by phenothiazine derivatives in phospholipid/sphingomyelin/cholesterol mixtures containing low levels of cholesterol and sphingomyelin
    Andrzej B Hendrich
    Department of Biophysics, Wrocław Medical University, ul Chałubińskiego 10, 50 368 Wrocław, Poland
    Biophys Chem 130:32-40. 2007
    ..Among three phenothiazine derivatives studied, only trifluoperazine was able to induce a permanent phase separation in phosphatidylcholine/cholesterol/sphingomyelin systems...
  4. ncbi request reprint Differential interaction of Sophora isoflavonoids with lipid bilayers
    Andrzej Boguslaw Hendrich
    Department of Biophysics, Wroclaw Medical University, ul Chalubinskiego 10, 50 368, Wroclaw, Poland
    Eur J Pharm Sci 16:201-8. 2002
    ..Comparing our results with biological tests it seems that interactions with the hydrophobic core of membranes are responsible for the activity of the studied isoflavones...
  5. ncbi request reprint The alterations of lipid bilayer fluidity induced by newly synthesized phenothiazine derivative
    Andrzej B Hendrich
    Department of Biophysics, Wrocław Medical University, ul Chałubińskiego 10, 50 368, Wrocław, Poland
    Biophys Chem 98:275-85. 2002
    ..This structure is less co-operative than an unperturbed bilayer, but locally the mobility of lipid molecules is decreased...
  6. ncbi request reprint Neither lipophilicity nor membrane-perturbing potency of phenothiazine maleates correlate with the ability to inhibit P-glycoprotein transport activity
    Andrzej B Hendrich
    Department of Biophysics Wrocław Medical University ul Chalubinskiego 10 50 368 Wrocław, Poland
    Mol Membr Biol 20:53-60. 2003
    ..No clear relation was found between effects exerted by phenothiazine maleates on model membranes and their ability to modulate P-glycoprotein transport activity...
  7. ncbi request reprint New phenothiazine-type multidrug resistance modifiers: anti-MDR activity versus membrane perturbing potency
    Andrzej B Hendrich
    Department of Biophysics, Wrocław Medical University, ul Chałubińskiego 10, 50 368, Wrocław, Poland
    Biochem Biophys Res Commun 304:260-5. 2003
    ..It is concluded that the biological and biophysical activity of phenothiazine derivatives depends more on the type of ring substitution than on the nature of the side chain group...
  8. ncbi request reprint A study on the perturbation of model lipid membranes by phenoxazines
    Andrzej B Hendrich
    Department of Biophysics, Wrocław Medical University, Wrocław, Poland
    Bioorg Med Chem 14:5948-54. 2006
    ..These studies showed also that phenoxazine molecules are located close to the polar/apolar interface of bilayer. The results allow to conclude that phenoxazines rather weakly interact with lipid bilayers...
  9. ncbi request reprint Biochanin A similarly influences the fluidity of liposomes formed from charged and zwitterionic lipids
    Andrzej B Hendrich
    Department of Biophysics, Wrocław University of Medicine, Chałubińskiego 10, 50 368 Wrocław, Poland
    Cell Mol Biol Lett 7:284. 2002
  10. ncbi request reprint Influence of silybin on biophysical properties of phospholipid bilayers
    Olga Wesołowska
    Department of Biophysics, Wroclaw Medical University, ul Chalubinskiego 10, 50 368 Wroclaw, Poland
    Acta Pharmacol Sin 28:296-306. 2007
    ..Although membranes are postulated to be one of the cellular targets for silybin, little is known about its interaction with phospholipid bilayers...
  11. doi request reprint Perturbation of the lipid phase of a membrane is not involved in the modulation of MRP1 transport activity by flavonoids
    Olga Wesołowska
    Department of Biophysics, Wrocław Medical University, ul Chałubińskiego 10, 50 368 Wrocław, Poland
    Cell Mol Biol Lett 14:199-221. 2009
    ..We concluded that mechanisms other than perturbation of the lipid phase of membranes were responsible for inhibition of MRP1 by the flavonoids...
  12. ncbi request reprint Modulation of MRP1 protein transport by plant, and synthetically modified flavonoids
    Barbara Łania-Pietrzak
    Department of Biophysics, Wrocław Medical University, Chałubińskiego 10, 50 368 Wrocław, Poland
    Life Sci 77:1879-91. 2005
    ..In case of naturally occurring isoflavones the replacement of hydrogen at position 4' by hydrophobic ring structure seems also to be favourable for inhibition potency...
  13. ncbi request reprint Metabolic O-demethylation does not alter the influence of isoflavones on the biophysical properties of membranes and MRP1-like protein transport activity
    Barbara Łania-Pietrzak
    Department of Biophysics, Wrocław Medical University, Poland
    Arch Biochem Biophys 433:428-34. 2005
    ..Inhibition of MRP1-like protein transport activity by methylated and demethylated isoflavones was very similar. Their influence on lipid thermotropic properties and fluidity of lipid bilayer was not also significantly different...
  14. ncbi request reprint Presence of anionic phospholipids rules the membrane localization of phenothiazine type multidrug resistance modulator
    Olga Wesołowska
    Department of Biophysics, Wrocław Medical University, ul Chałubińskiego 10, 50 368 Wrocław, Poland
    Biophys Chem 109:399-412. 2004
    ..Behavior of equimolar PC:PS mixtures is similar to pure PS bilayers, while 2:1 or 1:2 (mole:mole) PC:PS mixtures resemble pure PC ones...
  15. ncbi request reprint [Role of cell membrane lipids in multidrug resistance and its modulation]
    Krystyna Michalak
    Katedra i Zakład Biofizyki, Akademia Medyczna we Wrocławiu, ul Chałubińskiego 10, 50 368 Wrocław
    Postepy Biochem 48:208-19. 2002
  16. ncbi request reprint A new phenothiazine derivative alters the fluidity and thermotropic behaviour of phosphatidylcholine model membranes
    Olga Wesołowska
    Department of Biophysics, Wrocław Medical University, ul Chałubińskiego 10, Wrocław, 50 368 Poland
    Cell Mol Biol Lett 7:303. 2002
  17. ncbi request reprint Lipid membrane perturbation caused by some isoflavones and phenothiazines, and the activity of these compounds as inhibitors of multidrug resistance
    Krystyna Michalak
    Department of Biophysics, Wrocław Medical University, Wrocław, Poland
    Cell Mol Biol Lett 7:293. 2002
  18. doi request reprint Genistein derivatives decrease liposome membrane integrity--calcein release and molecular modeling study
    Kamila Sroda
    Department of Biophysics, Wrocław Medical University, ul Chałubińskiego 10, 50 368 Wrocław, Poland
    Biophys Chem 138:78-82. 2008
    ..This conclusion may have some implications for QSAR studies in which mostly the dipole moments of entire molecules are considered...
  19. ncbi request reprint Thioridazine induces erythrocyte stomatocytosis due to interactions with negatively charged lipids
    Andrzej B Hendrich
    Department of Biophysics, Wrocław Medical University, Chałubińskiego 10, 50 368 Wrocław, Poland
    Cell Mol Biol Lett 7:1081-6. 2002
    ..We found that erythrocyte stomatocytosis induced by the drug might be related to preferential interaction of thioridazine with charged lipids...
  20. ncbi request reprint Giant unilamellar vesicles - a perfect tool to visualize phase separation and lipid rafts in model systems
    Olga Wesołowska
    Department of Biophysics, Wrocław Medical University, Wrocław, Poland
    Acta Biochim Pol 56:33-9. 2009
    ..The experience of the authors in setting up the GUV-forming equipment and production of GUVs is also presented...