- Paediatric multiple sclerosis and acute disseminated encephalomyelitis in Germany: results of a nationwide survey
Department of Paediatrics and Paediatric Neurology, Georg August University, Robert Koch Strasse 40, 37075, Gottingen, Germany
Eur J Pediatr 166:405-12. 2007
..With an estimated minimum of 50 new cases per year, the incidence of paediatric MS in Germany is much more frequent than previously believed...
- Epidemiology, immunopathogenesis and management of pediatric central nervous system inflammatory demyelinating conditions
Children s Hospital of Eastern Switzerland, St Gallen, Switzerland
Curr Opin Neurol 21:366-72. 2008
..This review discusses characteristics of these disorders with focus on epidemiology and treatment of acute disseminated encephalomyelitis, neuromyelitis optica and multiple sclerosis...
- High seroprevalence of Epstein-Barr virus in children with multiple sclerosis
Brauweg 19, 37073 Goettingen, Germany
Neurology 67:2063-5. 2006
..6% vs 72.1% in controls, p = 0.001) but did not display serologic evidence for a recent EBV infection. EBV antibody concentrations of pediatric patients with MS were significantly higher vs controls...
- Common infectious agents in multiple sclerosis: a case-control study in children
Department of Virology, Georg August University Goettingen, Germany
Mult Scler 14:136-9. 2008
..Additional investigations, however, make it highly unlikely that a relevant number of children have experienced infections with HSV-2. In general this study supports and emphasizes a complex infectious and immunologic background of MS...
- Pediatric multiple sclerosis: detection of clinically silent lesions by multimodal evoked potentials
Department of Pediatrics and Pediatric Neurology, Georg August University Goettingen, Germany
J Pediatr 149:125-7. 2006
..In 46% of 85 childhood patients with MS, spatial dissemination was detected by EP before the second clinical attack. EP may constitute an important tool for earlier diagnosis of pediatric MS...
- Tau, phospho-tau, and S-100B in the cerebrospinal fluid of children with multiple sclerosis
Department of Pediatrics and Pediatric Neurology, Georg August University, Gottingen, Germany
J Child Neurol 20:822-5. 2005
..These data indicate that axonal injury is not restricted to adult multiple sclerosis but can already occur in children with multiple sclerosis...
- Self-antigen tetramers discriminate between myelin autoantibodies to native or denatured protein
Kevin C O'Connor
Center for Neurologic Diseases, Brigham and Women s Hospital, 77 Avenue Louis Pasteur, Boston, Massachusetts 02115, USA
Nat Med 13:211-7. 2007
..MOG-specific autoantibodies were identified in a subset of ADEM but only rarely in adult-onset MS cases, indicating that MOG is a more prominent target antigen in ADEM than MS...
- Differential diagnosis and evaluation in pediatric multiple sclerosis
Jin S Hahn
Department of Neurology and Neurological Sciences, Stanford University, Stanford, CA 94305, USA
Neurology 68:S13-22. 2007
..The evaluation is determined by the clinical and neuroradiologic presentation. A minimal diagnostic battery is proposed. More expanded evaluations are indicated for specific or atypical clinical presentations...
- Treatment of early onset multiple sclerosis with subcutaneous interferon beta-1a
Department of Pediatrics and Pediatric Neurology, Georg August University Goettingen, Robert Koch Strasse 40, 37075 Germany E mail
Neurology 64:888-90. 2005
..Laboratory abnormalities included asymptomatic leukopenia (27%) and elevated hepatic transaminases (35%). Treatment with IFNbeta-1a was safe and well tolerated in the majority of children and adolescents...
- Diagnosing paediatric multiple sclerosis versus acute disseminated encephalomyelitis
Dev Med Child Neurol 49:884. 2007
- Myelin oligodendrocyte gene polymorphisms and childhood multiple sclerosis
Abteilung Pädiatrie, Schwerpunkt Neuropadiatrie, Georg August Universitat, 37075 Gottingen, Germany
Pediatr Res 52:175-9. 2002
..A putative C1q binding site in the C"-D loop of the Ig superfamily motif encompasses R66. In conclusion, the polymorphisms observed do not provide evidence to support a significant role for MOG in multiple sclerosis susceptibility...