Pedro A Piedra

Summary

Publications

  1. ncbi request reprint Clinical experience with respiratory syncytial virus vaccines
    Pedro A Piedra
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Pediatr Infect Dis J 22:S94-9. 2003
  2. ncbi request reprint Human metapneumovirus and respiratory syncytial virus infections in older children with cystic fibrosis
    Daniel F Garcia
    Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Pediatr Pulmonol 42:66-74. 2007
  3. ncbi request reprint Development of a cotton rat-human metapneumovirus (hMPV) model for identifying and evaluating potential hMPV antivirals and vaccines
    Philip R Wyde
    Department of Molecular Virology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Antiviral Res 66:57-66. 2005
  4. ncbi request reprint Conserved CTL epitopes on the adenovirus hexon protein expand subgroup cross-reactive and subgroup-specific CD8+ T cells
    Ann M Leen
    Center for Cell and Gene Therapy, Department of Pediatrics, 6621 Fannin St, MC 3 3320, Houston, TX, USA
    Blood 104:2432-40. 2004
  5. pmc Picornavirus, the most common respiratory virus causing infection among patients of all ages hospitalized with acute respiratory illness
    Robert L Atmar
    Viral Respiratory Pathogens Research Unit and the Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA
    J Clin Microbiol 50:506-8. 2012
  6. pmc Direct and indirect effectiveness of influenza vaccination delivered to children at school preceding an epidemic caused by 3 new influenza virus variants
    W Paul Glezen
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Infect Dis 202:1626-33. 2010
  7. pmc LDH concentration in nasal-wash fluid as a biochemical predictor of bronchiolitis severity
    Federico R Laham
    Baylor College of Medicine, Department of Pediatrics, One Baylor Plaza, Room 248E MS280, Houston, TX 77030, USA
    Pediatrics 125:e225-33. 2010
  8. ncbi request reprint Comparison of the inhibition of human metapneumovirus and respiratory syncytial virus by NMSO3 in tissue culture assays
    Philip R Wyde
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Antiviral Res 63:51-9. 2004
  9. doi request reprint The search for adenovirus 14 in children in Houston, Texas
    Federico R Laham
    Department of Pediatrics, Section of Infectious Diseases, Baylor College of Medicine, Houston, TX, USA
    Pediatr Infect Dis J 27:653-4. 2008
  10. pmc Bordetella pertussis is an uncommon pathogen in children hospitalized with bronchiolitis during the winter season
    Pedro A Piedra
    From the Departments of Molecular Virology and Microbiology and Pediatrics, Baylor College of Medicine, Houston, TX Department of Medicine, Boston Children s Hospital, Harvard Medical School, Boston, MA Department of Paediatrics, University of Auckland, Auckland, New Zealand and Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA
    Pediatr Infect Dis J 34:566-70. 2015

Collaborators

Detail Information

Publications35

  1. ncbi request reprint Clinical experience with respiratory syncytial virus vaccines
    Pedro A Piedra
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Pediatr Infect Dis J 22:S94-9. 2003
    ....
  2. ncbi request reprint Human metapneumovirus and respiratory syncytial virus infections in older children with cystic fibrosis
    Daniel F Garcia
    Department of Pediatrics, Baylor College of Medicine, Houston, TX 77030, USA
    Pediatr Pulmonol 42:66-74. 2007
    ..Its epidemiology remains to be defined in children with cystic fibrosis (CF). We describe the epidemiology and clinical impact of hMPV in CF children and compared it to respiratory syncytial virus (RSV)...
  3. ncbi request reprint Development of a cotton rat-human metapneumovirus (hMPV) model for identifying and evaluating potential hMPV antivirals and vaccines
    Philip R Wyde
    Department of Molecular Virology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Antiviral Res 66:57-66. 2005
    ....
  4. ncbi request reprint Conserved CTL epitopes on the adenovirus hexon protein expand subgroup cross-reactive and subgroup-specific CD8+ T cells
    Ann M Leen
    Center for Cell and Gene Therapy, Department of Pediatrics, 6621 Fannin St, MC 3 3320, Houston, TX, USA
    Blood 104:2432-40. 2004
    ..Thus, by exploiting these peptide targets, it is possible to prepare a T-cell population capable of reacting with most adenoviruses that cause disease in immunocompromised patients...
  5. pmc Picornavirus, the most common respiratory virus causing infection among patients of all ages hospitalized with acute respiratory illness
    Robert L Atmar
    Viral Respiratory Pathogens Research Unit and the Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA
    J Clin Microbiol 50:506-8. 2012
    ..The molecular assays doubled the number of infections identified; picornaviruses were the most frequent in patients of all ages, followed by respiratory syncytial virus and influenza viruses...
  6. pmc Direct and indirect effectiveness of influenza vaccination delivered to children at school preceding an epidemic caused by 3 new influenza virus variants
    W Paul Glezen
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    J Infect Dis 202:1626-33. 2010
    ..This field trial examines the effectiveness of school-based clinics for vaccine delivery before an epidemic caused by 3 new influenza virus variants not contained in the vaccine...
  7. pmc LDH concentration in nasal-wash fluid as a biochemical predictor of bronchiolitis severity
    Federico R Laham
    Baylor College of Medicine, Department of Pediatrics, One Baylor Plaza, Room 248E MS280, Houston, TX 77030, USA
    Pediatrics 125:e225-33. 2010
    ....
  8. ncbi request reprint Comparison of the inhibition of human metapneumovirus and respiratory syncytial virus by NMSO3 in tissue culture assays
    Philip R Wyde
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Antiviral Res 63:51-9. 2004
    ..Interestingly, NMSO3, but not heparin, was able to limit secondary infection and spread of both viruses...
  9. doi request reprint The search for adenovirus 14 in children in Houston, Texas
    Federico R Laham
    Department of Pediatrics, Section of Infectious Diseases, Baylor College of Medicine, Houston, TX, USA
    Pediatr Infect Dis J 27:653-4. 2008
    ..None were Ad14; Ad1, Ad2, and Ad3 were the most common identified serotypes...
  10. pmc Bordetella pertussis is an uncommon pathogen in children hospitalized with bronchiolitis during the winter season
    Pedro A Piedra
    From the Departments of Molecular Virology and Microbiology and Pediatrics, Baylor College of Medicine, Houston, TX Department of Medicine, Boston Children s Hospital, Harvard Medical School, Boston, MA Department of Paediatrics, University of Auckland, Auckland, New Zealand and Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA
    Pediatr Infect Dis J 34:566-70. 2015
    ..S. infants. The objective was to determine the prevalence of B. pertussis infection in children hospitalized with bronchiolitis and to describe its clinical course...
  11. ncbi request reprint Trivalent live attenuated intranasal influenza vaccine administered during the 2003-2004 influenza type A (H3N2) outbreak provided immediate, direct, and indirect protection in children
    Pedro A Piedra
    Baylor College of Medicine, Department of Molecular Virology and Microbiology, Room 248E, One Baylor Plaza, Houston, TX 77030, USA
    Pediatrics 120:e553-64. 2007
    ..The objective of this study was to determine the effectiveness of influenza vaccines for healthy school-aged children when administered during the influenza outbreak...
  12. doi request reprint Post-bronchiolitis Use of Asthma Medication: A Prospective 1-year Follow-up Study
    Eija Bergroth
    From the Department of Pediatrics, Kuopio University Hospital, Kuopio, Finland Department of Pediatrics, Central Hospital of Central Finland, Jyvaskyla, Finland Department of Pediatrics, Turku University Hospital, Turku, Finland Center for Child Health Research, Tampere University and University Hospital, Tampere, Finland Allergy Centre, Tampere University Hospital, Tampere, Finland Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden Department of Molecular Virology and Microbiology and Department of Pediatrics, Baylor College of Medicine, Houston, Texas and Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts
    Pediatr Infect Dis J 35:363-8. 2016
    ..Our aim was to evaluate the association between viral findings during bronchiolitis and the use of asthma controller medication (primary outcome) and systemic corticosteroids (secondary outcome) during the first post-bronchiolitis year...
  13. ncbi request reprint Comparison of the inhibition of human metapneumovirus and respiratory syncytial virus by ribavirin and immune serum globulin in vitro
    Philip R Wyde
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Antiviral Res 60:51-9. 2003
    ..v.IG utilized were found to have equivalent antiviral activity against hMPV and hRSV. In contrast, except for antisera specifically raised against hMPV, all of the other materials tested had marked activity only against hRSV...
  14. ncbi request reprint Respiratory viral infections in patients with chronic, obstructive pulmonary disease
    J David Beckham
    Department of Medicine, Baylor College of Medicine and Ben Taub General Hospital, One Baylor Plaza, Houston, TX 77030, USA
    J Infect 50:322-30. 2005
    ..The purpose of the present study was to apply reverse transcription-PCR (RT-PCR) assays to clinical specimens collected from patients with acute respiratory illness and chronic obstructive pulmonary disease (COPD)...
  15. doi request reprint Nasal Airway Microbiota Profile and Severe Bronchiolitis in Infants: A Case-Control Study
    Kohei Hasegawa
    1Department of Emergency Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, MA 2Department of Pediatrics, Emory University School of Medicine, Atlanta, GA 3Department of Medicine, Boston Children s Hospital, Boston, MA 4Alkek Center for Metagenomics and Microbiome Research, Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 5Department of Molecular Virology and Microbiology, and Pediatrics, Baylor College of Medicine, Houston, TX 6Department of Pediatrics, University of Louisville, Louisville, KY and 7Alfred I duPont Hospital for Children, Wilmington, DE
    Pediatr Infect Dis J . 2016
    ..Little is known about the relationship of airway microbiota with bronchiolitis in infants. We aimed to identify nasal airway microbiota profiles and to determine their association with the likelihood of bronchiolitis in infants...
  16. ncbi request reprint Correlates of immunity to respiratory syncytial virus (RSV) associated-hospitalization: establishment of minimum protective threshold levels of serum neutralizing antibodies
    Pedro A Piedra
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Rm 248E, One Baylor Plaza, Houston, TX, USA
    Vaccine 21:3479-82. 2003
    ..To determine if respiratory syncytial virus (RSV) specific, serum antibody titers correlate with protection against RSV associated-hospitalization at all ages...
  17. doi request reprint Absence of Bordetella pertussis Among Infants Hospitalized for Bronchiolitis in Finland, 2008-2010
    Matti Korppi
    From the Center for Child Health Research, Tampere University and University Hospital, Tampere, Finland Department of Pediatrics, Turku University Hospital, Turku, Finland Department of Pediatrics, Kuopio University Hospital, Kuopio, Finland Department of Molecular Virology and Microbiology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas and Department of Emergency Medicine, Massachusetts General Hospital, Boston, Massachusetts
    Pediatr Infect Dis J 35:219-21. 2016
    ..Respiratory viruses were detected in 89% (71% with respiratory syncytial virus), but no infant had B. pertussis. The latter finding may reflect a positive effect from the broadening of the Finnish pertussis vaccination program in 2005. ..
  18. pmc Gene sequence variability of the three surface proteins of human respiratory syncytial virus (HRSV) in Texas
    Lorena I Tapia
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America Programa de Virología, Instituto de Ciencias Biomedicas, Facultad de Medicina, Universidad de Chile, Santiago, Chile Departamento de Pediatría y Cirugía Infantil Norte, Facultad de Medicina, Universidad de Chile, Santiago, Chile
    PLoS ONE 9:e90786. 2014
    ..We hypothesize that diverse sequence variation of the surface protein genes provide HRSV strains a survival advantage in a partially immune-protected community. ..
  19. pmc Rapid research response to the 2009 A(H1N1)pdm09 influenza pandemic (Revised)
    Wendy A Keitel
    Department of Molecular Virology and Microbiology, Houston, TX, USA
    BMC Res Notes 6:177. 2013
    ..Sera were tested for the presence and level of HAI and neutralizing antibodies against the A(H1N1)pdm09 virus...
  20. doi request reprint Global gene expression profiling in infants with acute respiratory syncytial virus broncholitis demonstrates systemic activation of interferon signaling networks
    KRISTINE L BUCASAS
    Department of Molecular and Human Genetics, Baylor College of Medicine, Houston, TX 77030, USA
    Pediatr Infect Dis J 32:e68-76. 2013
    ..Variation in host response may influence the pathogenesis and disease severity. We evaluated global gene expression profiles to better understand the systemic host response to acute RSV bronchiolitis in infants and young children...
  21. doi request reprint Effects of oseltamivir on influenza-related complications in children with chronic medical conditions
    Pedro A Piedra
    Departments of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    Pediatrics 124:170-8. 2009
    ..This study investigated the influence of oseltamivir on influenza-related complications and hospitalizations for children and adolescents, 1 to 17 years of age, with chronic medical conditions or neurologic or neuromuscular disease...
  22. doi request reprint Clinical Endpoints for Respiratory Syncytial Virus Prophylaxis Trials in Infants and Children in High-income and Middle-income Countries
    Eric A F Simoes
    From the Department of Pediatrics, Section of Infectious Diseases, University of Colorado School of Medicine, Aurora, Colorado Department of Epidemiology and Center for Global Health, Colorado School of Public Health, Aurora, Colorado Neonatology Service, Hospital Clinic, Institut d Investigacios Biomediques August Pi Suñer IDIBAPS, Barcelona, Spain Division of Pulmonology Medicine, Cincinnati Children s Hospital and Medical Center, Cincinnati, Ohio Department of Medicine, Boston Children s Hospital, Harvard Medical School, Boston, Massachusetts Department of Microbiology and Immunology, Department of Pediatrics, Baylor College of Medicine, Houston, Texas Division of Infectious Diseases, Nationwide Children s Hospital, Ohio State University, Columbus, Ohio and Division of Pediatric Infectious Diseases, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma
    Pediatr Infect Dis J 34:1086-92. 2015
    ..Relevant secondary endpoints included reductions in RSV lower respiratory tract infection, RSV-related intensive care unit rates, subsequent recurrent wheezing or asthma and direct and indirect costs. ..
  23. doi request reprint Variability in inpatient management of children hospitalized with bronchiolitis
    Charles G Macias
    Department of Pediatrics, Section of Emergency Medicine, and Center for Clinical Effectiveness, Texas Children s Hospital, Baylor College of Medicine, Houston, Tex Electronic address
    Acad Pediatr 15:69-76. 2015
    ..To determine the variability between hospitals in diagnostic testing and management interventions for children with bronchiolitis admitted to inpatient wards and identify its association with patient characteristics...
  24. doi request reprint Detection of NH1N1 influenza virus in nonrespiratory sites among children
    Susan H Wootton
    From the Department of Pediatrics, Division of Infectious Diseases Department of Pathology, University of Texas UT Health Science Center Department of Molecular Virology and Microbiology and Department of Pediatrics, Baylor College of Medicine, Houston, TX
    Pediatr Infect Dis J 33:95-6. 2014
    ..Gastrointestinal symptoms were common but were not associated with viral RNA in stool. nH1N1 viremia was detected, for the first time, in an immunocompetent child. ..
  25. pmc Nitric oxide metabolites as biomarkers for influenza-like acute respiratory infections presenting to the emergency room
    Asad I Mian
    Dept of Pediatrics, Section of Emergency Medicine, Texas Children s Hospital, Baylor College of Medicine, Houston TX 77030, USA
    Open Respir Med J 6:127-34. 2012
    ....
  26. pmc Rotavirus antigenemia in children is associated with viremia
    Sarah E Blutt
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, United States of America
    PLoS Med 4:e121. 2007
    ..We aimed to analyze a defined patient population to determine if infectious virus could be detected in sera from children with rotavirus antigenemia...
  27. ncbi request reprint Immunogenicity of a new purified fusion protein vaccine to respiratory syncytial virus: a multi-center trial in children with cystic fibrosis
    Pedro A Piedra
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, TX 77030, USA
    Vaccine 21:2448-60. 2003
    ..After 28 days post-vaccination, Nt Ab and Bd Ab to F protein titers declined slowly at rates of 0.23 and 0.37 log2 per month, respectively. The PFP-3 vaccine-induced a robust immune response that lasted throughout the RSV season...
  28. ncbi request reprint Fiber-modified adenoviruses generate subgroup cross-reactive, adenovirus-specific cytotoxic T lymphocytes for therapeutic applications
    Ann M Leen
    Center for Cell and Gene Therapy, Department of Pediatrics, 6621 Fannin S, MC 3 3320, Houston, TX 77030, USA
    Blood 103:1011-9. 2004
    ..This is the first report of a simple and reproducible method to activate and expand Ad-specific cytotoxic T lymphocytes (CTLs), which should be protective against the range of different Ad subtypes that affect transplant recipients...
  29. pmc Live attenuated influenza vaccine, trivalent, is safe in healthy children 18 months to 4 years, 5 to 9 years, and 10 to 18 years of age in a community-based, nonrandomized, open-label trial
    Pedro A Piedra
    Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas 77030, USA
    Pediatrics 116:e397-407. 2005
    ....
  30. ncbi request reprint Future directions in vaccine prevention of respiratory syncytial virus
    Pedro A Piedra
    Department of Molecular Virology, Baylor College of Medicine, Houston, TX 77030, USA
    Pediatr Infect Dis J 21:482-7. 2002
  31. ncbi request reprint Safety of the trivalent, cold-adapted influenza vaccine (CAIV-T) in children
    Pedro A Piedra
    Department of Molecular Virology and Microbiology, Rm 248E, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Semin Pediatr Infect Dis 13:90-6. 2002
    ..CAIV-T did not cause an increase in healthcare utilization. Thus CAIV-T is safe in healthy children and should complement the use of inactivated influenza vaccine, trivalent (IIV-T) in children with underlying chronic conditions...
  32. ncbi request reprint Immunization against viral respiratory disease: a review
    Harry B Greenberg
    Department of Medicine and Microbiology and Immunology, Stanford University School of Medicine, CA, USA
    Pediatr Infect Dis J 23:S254-61. 2004
    ..The World Health Organization is attempting to develop and distribute effective vaccines to prevent/reduce key viral respiratory diseases...
  33. ncbi request reprint Direct and total effectiveness of the intranasal, live-attenuated, trivalent cold-adapted influenza virus vaccine against the 2000-2001 influenza A(H1N1) and B epidemic in healthy children
    Manjusha J Gaglani
    Section of Pediatric Infectious Diseases, Department of Pediatrics, Scott and White Memorial Hospital and Clinic, The Texas A and M University System Health Science Center College of Medicine, Temple, 76508, USA
    Arch Pediatr Adolesc Med 158:65-73. 2004
    ....
  34. ncbi request reprint Estimating efficacy of trivalent, cold-adapted, influenza virus vaccine (CAIV-T) against influenza A (H1N1) and B using surveillance cultures
    M Elizabeth Halloran
    Department of Biostatistics, Rollins School of Public Health, Emory University, 1518 Clifton Road NE, Atlanta, GA 30322, USA
    Am J Epidemiol 158:305-11. 2003
    ..CAIV-T provides substantial protection against a mixture of influenza A (H1N1) and B. Results demonstrate the powerful potential of using validation sets for outcomes in vaccine field studies...
  35. ncbi request reprint Immunopathogenesis of respiratory syncytial virus bronchiolitis
    Berkeley L Bennett
    Department of Pediatrics, Division of Emergency Medicine, Cincinnati Children s Hospital Medical Center, Cincinnati, Ohio, USA
    J Infect Dis 195:1532-40. 2007
    ..The objective of this study was to elucidate the relation between respiratory syncytial virus (RSV) infection and cytokine/chemokine concentrations, as well as the impact that these factors have on the severity of bronchiolitis...