Genomes and Genes
Affiliation: Icahn School of Medicine at Mount Sinai
- Infection of lung epithelial cells with pandemic 2009 A(H1N1) influenza viruses reveals isolate-specific differences in infectivity and host cellular responsesJenish R Patel
Immunology and Pathogenesis Branch, Influenza Division, National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia 30333, USA
Viral Immunol 24:89-99. 2011....
- Increased MDSC accumulation and Th2 biased response to influenza A virus infection in the absence of TLR7 in miceVictoria Jeisy-Scott
Influenza Division, National Center for Immunization and Respiratory, Centers for Disease Control and Prevention, Atlanta, Georgia, United States of America
PLoS ONE 6:e25242. 2011..Our findings indicate that TLR7 modulates the accumulation of MDSCs during an IAV infection in mice, and that lack of TLR7 signaling leads to a Th2-biased response...
- Cationic liposome-DNA complexes (CLDC) adjuvant enhances the immunogenicity and cross-protective efficacy of a pre-pandemic influenza A H5N1 vaccine in miceLibo Dong
Centers for Disease Control and Prevention, Atlanta, GA, USA
Vaccine 30:254-64. 2012..Thus, JVRS-100 adjuvanted H5N1 vaccine elicited enhanced humoral and T-cell responses, dose-sparing, and cross-clade protection in mice. CLDC holds promise as an adjuvant for human pre-pandemic inactivated H5N1 vaccines...
- Influenza A virus neuraminidase protein enhances cell survival through interaction with carcinoembryonic antigen-related cell adhesion molecule 6 (CEACAM6) proteinPratibha Gaur
Virology Group, International Centre for Genetic Engineering and Biotechnology, Aruna Asaf Ali Road, New Delhi 110067, India
J Biol Chem 287:15109-17. 2012..These findings indicate that influenza NA not only aids in the release of progeny virions, but also cell survival during viral replication...
- DENV inhibits type I IFN production in infected cells by cleaving human STINGSebastian Aguirre
Department of Microbiology and the Global Health and Emerging Pathogens Institute, Mount Sinai School of Medicine, New York City, New York, United States of America
PLoS Pathog 8:e1002934. 2012....
- Structure and dynamics of the second CARD of human RIG-I provide mechanistic insights into regulation of RIG-I activationFabien Ferrage
Ecole Normale Superieure, Departement de Chimie, UMR 7203 CNRS UPMC ENS, 24, rue Lhomond, 75005 Paris, France
Structure 20:2048-61. 2012..Collectively, our data suggests a close interplay between phosphorylation, ubiquitination, and activation of human RIG-I, all mediated by CARD2...
- Influenza A virus nucleoprotein induces apoptosis in human airway epithelial cells: implications of a novel interaction between nucleoprotein and host protein ClusterinS Tripathi
Virology Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India
Cell Death Dis 4:e562. 2013..Collectively, these findings indicate a new function for IAV NP in inducing host cell death and suggest a role for the host antiapoptotic protein CLU in this process...
- ATPase-driven oligomerization of RIG-I on RNA allows optimal activation of type-I interferonJenish R Patel
1 Department of Microbiology, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA 2 Graduate School of Biomedical Sciences, Icahn School of Medicine at Mount Sinai, New York, New York 10029, USA
EMBO Rep 14:780-7. 2013..These results establish a clear role for the ligand-induced ATPase activity of RIG-I in the stimulation of the IFN response. ..