John S Parks

Summary

Publications

  1. ncbi request reprint Compound heterozygous deletion of the PROP-1 gene in children with combined pituitary hormone deficiency
    O Fofanova
    Endocrinology Research Center, Moscow, Russia
    J Clin Endocrinol Metab 83:2601-4. 1998
  2. pmc Hepatic ABC transporters and triglyceride metabolism
    John S Parks
    Department of Pathology Section on Lipid Sciences, Wake Forest School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Curr Opin Lipidol 23:196-200. 2012
  3. pmc Targeted deletion of hepatocyte ABCA1 leads to very low density lipoprotein triglyceride overproduction and low density lipoprotein hypercatabolism
    Soonkyu Chung
    Department of Pathology Section on Lipid Sciences, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    J Biol Chem 285:12197-209. 2010
  4. pmc Combined therapy of dietary fish oil and stearoyl-CoA desaturase 1 inhibition prevents the metabolic syndrome and atherosclerosis
    J Mark Brown
    Wake Forest University School of Medicine, Department of Pathology, Section on Lipid Sciences, Medical Center Blvd, Winston Salem, NC 27157 1040, USA
    Arterioscler Thromb Vasc Biol 30:24-30. 2010
  5. ncbi request reprint HDLs in apoA-I transgenic Abca1 knockout mice are remodeled normally in plasma but are hypercatabolized by the kidney
    Ji Young Lee
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Lipid Res 46:2233-45. 2005
  6. pmc A novel role for ABCA1-generated large pre-beta migrating nascent HDL in the regulation of hepatic VLDL triglyceride secretion
    Soonkyu Chung
    Department of Pathology Section on Lipid Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Lipid Res 51:729-42. 2010
  7. ncbi request reprint ACAT2 contributes cholesteryl esters to newly secreted VLDL, whereas LCAT adds cholesteryl ester to LDL in mice
    Richard G Lee
    Arteriosclerosis Research Program, Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    J Lipid Res 46:1205-12. 2005
  8. pmc Echium oil reduces plasma triglycerides by increasing intravascular lipolysis in apoB100-only low density lipoprotein (LDL) receptor knockout mice
    Lolita M Forrest
    Department of Pathology Section on Lipid Sciences, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    Nutrients 5:2629-45. 2013
  9. pmc Liver ABCA1 deletion in LDLrKO mice does not impair macrophage reverse cholesterol transport or exacerbate atherogenesis
    Xin Bi
    From the Section on Lipid Sciences, Department of Pathology X B, X Z, M D, E Y B, M D W, A K G, J S P, and Department of Biochemistry J S P, Wake Forest School of Medicine, Winston Salem, NC
    Arterioscler Thromb Vasc Biol 33:2288-96. 2013
  10. pmc Omega-3 fatty acids ameliorate atherosclerosis by favorably altering monocyte subsets and limiting monocyte recruitment to aortic lesions
    Amanda L Brown
    Department of Pathology, Section on Lipid Sciences, Wake Forest School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1040, USA
    Arterioscler Thromb Vasc Biol 32:2122-30. 2012

Detail Information

Publications49

  1. ncbi request reprint Compound heterozygous deletion of the PROP-1 gene in children with combined pituitary hormone deficiency
    O Fofanova
    Endocrinology Research Center, Moscow, Russia
    J Clin Endocrinol Metab 83:2601-4. 1998
    ..This provides the first evidence of heterozygosity for two common deletions as a cause of CPHD in Russian children...
  2. pmc Hepatic ABC transporters and triglyceride metabolism
    John S Parks
    Department of Pathology Section on Lipid Sciences, Wake Forest School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Curr Opin Lipidol 23:196-200. 2012
    ..However, recent studies also suggest that hepatic signaling and lipid mobilization and secretion may explain how HDL affects plasma triglyceride concentrations...
  3. pmc Targeted deletion of hepatocyte ABCA1 leads to very low density lipoprotein triglyceride overproduction and low density lipoprotein hypercatabolism
    Soonkyu Chung
    Department of Pathology Section on Lipid Sciences, Wake Forest University Health Sciences, Winston Salem, North Carolina 27157, USA
    J Biol Chem 285:12197-209. 2010
    ....
  4. pmc Combined therapy of dietary fish oil and stearoyl-CoA desaturase 1 inhibition prevents the metabolic syndrome and atherosclerosis
    J Mark Brown
    Wake Forest University School of Medicine, Department of Pathology, Section on Lipid Sciences, Medical Center Blvd, Winston Salem, NC 27157 1040, USA
    Arterioscler Thromb Vasc Biol 30:24-30. 2010
    ..In this study we tested whether dietary fish oil supplementation could prevent the accelerated atherosclerosis caused by SCD1 inhibition...
  5. ncbi request reprint HDLs in apoA-I transgenic Abca1 knockout mice are remodeled normally in plasma but are hypercatabolized by the kidney
    Ji Young Lee
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Lipid Res 46:2233-45. 2005
    ....
  6. pmc A novel role for ABCA1-generated large pre-beta migrating nascent HDL in the regulation of hepatic VLDL triglyceride secretion
    Soonkyu Chung
    Department of Pathology Section on Lipid Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Lipid Res 51:729-42. 2010
    ....
  7. ncbi request reprint ACAT2 contributes cholesteryl esters to newly secreted VLDL, whereas LCAT adds cholesteryl ester to LDL in mice
    Richard G Lee
    Arteriosclerosis Research Program, Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC, USA
    J Lipid Res 46:1205-12. 2005
    ..0 +/- 0.8% in controls to 0 +/- 0.7% in ACAT2-deficient mice. In conclusion, our data establish that ACAT2 provides core CE of newly secreted VLDL, whereas LCAT adds CE during LDL particle formation...
  8. pmc Echium oil reduces plasma triglycerides by increasing intravascular lipolysis in apoB100-only low density lipoprotein (LDL) receptor knockout mice
    Lolita M Forrest
    Department of Pathology Section on Lipid Sciences, Wake Forest School of Medicine, Winston Salem, NC 27157, USA
    Nutrients 5:2629-45. 2013
    ..Finally, EO may substitute for FO to reduce plasma TG concentrations, but not hepatic steatosis in this mouse model. ..
  9. pmc Liver ABCA1 deletion in LDLrKO mice does not impair macrophage reverse cholesterol transport or exacerbate atherogenesis
    Xin Bi
    From the Section on Lipid Sciences, Department of Pathology X B, X Z, M D, E Y B, M D W, A K G, J S P, and Department of Biochemistry J S P, Wake Forest School of Medicine, Winston Salem, NC
    Arterioscler Thromb Vasc Biol 33:2288-96. 2013
    ..We investigated atherosclerosis development and reverse cholesterol transport in hepatocyte-specific ABCA1 knockout (HSKO) mice in the low-density lipoprotein (LDL) receptor KO (LDLrKO) C57BL/6 background...
  10. pmc Omega-3 fatty acids ameliorate atherosclerosis by favorably altering monocyte subsets and limiting monocyte recruitment to aortic lesions
    Amanda L Brown
    Department of Pathology, Section on Lipid Sciences, Wake Forest School of Medicine, Medical Center Blvd, Winston Salem, NC 27157 1040, USA
    Arterioscler Thromb Vasc Biol 32:2122-30. 2012
    ..Fish oil, containing omega-3 fatty acids, attenuates atherosclerosis. We hypothesized that omega-3 fatty acid-enriched oils are atheroprotective through alteration of monocyte subsets and their trafficking into atherosclerotic lesions...
  11. pmc Myeloid cell-specific ABCA1 deletion protects mice from bacterial infection
    Xuewei Zhu
    Department of Pathology, Section on Lipid Sciences, Wake Forest School of Medicine, Medical Center Blvd, Winston Salem, NC 27157, USA
    Circ Res 111:1398-409. 2012
    ..However, whether ABCA1 expression has a role in regulating macrophage function in vivo is unknown...
  12. ncbi request reprint Functional LCAT deficiency in human apolipoprotein A-I transgenic, SR-BI knockout mice
    Ji Young Lee
    Department of Pathology Section on Lipid Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Lipid Res 48:1052-61. 2007
    ..We conclude that the decreased EC/TC ratio in the plasma of hA-ITg SR-BI-/- mice is attributed to a reduction in LCAT reactivity with SM-enriched HDL particles...
  13. pmc Initial interaction of apoA-I with ABCA1 impacts in vivo metabolic fate of nascent HDL
    Anny Mulya
    Department of Pathology, Wake Forest University Health Sciences, Winston Salem, NC, USA
    J Lipid Res 49:2390-401. 2008
    ....
  14. pmc Myeloid cell-specific ATP-binding cassette transporter A1 deletion has minimal impact on atherogenesis in atherogenic diet-fed low-density lipoprotein receptor knockout mice
    Xin Bi
    From the Department of Pathology Section on Lipid Sciences X B, X Z, C G, S S, Q C, M L, E B, A K G, M D W, A L B, J S P and Department of Biochemistry, Wake Forest School of Medicine, Winston Salem, NC J S P
    Arterioscler Thromb Vasc Biol 34:1888-99. 2014
    ..Myeloid-specific ATP-binding cassette transporter A1 knockout mice in the low-density lipoprotein (LDL) receptor knockout C57BL/6 background were developed to address this question...
  15. pmc An ACACB variant implicated in diabetic nephropathy associates with body mass index and gene expression in obese subjects
    Lijun Ma
    Wake Forest School of Medicine, Winston Salem, North Carolina, United States of America
    PLoS ONE 8:e56193. 2013
    ..The T allele also associated with higher hepatic triglyceride levels. These data support a role for ACACB in obesity and potential roles for altered lipid metabolism in susceptibility to DN...
  16. pmc Increased cellular free cholesterol in macrophage-specific Abca1 knock-out mice enhances pro-inflammatory response of macrophages
    Xuewei Zhu
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Biol Chem 283:22930-41. 2008
    ....
  17. pmc Macrophage ABCA1 reduces MyD88-dependent Toll-like receptor trafficking to lipid rafts by reduction of lipid raft cholesterol
    Xuewei Zhu
    Departments of Pathology Lipid Sciences, Wake Forest University School of Medicine, Winston Salem, NC, USA
    J Lipid Res 51:3196-206. 2010
    ..Collectively, our data suggest that macrophage ABCA1 dampens inflammation by reducing MyD88-dependent TLRs trafficking to lipid rafts by selective reduction of FC content in lipid rafts...
  18. pmc Inhibition of stearoyl-coenzyme A desaturase 1 dissociates insulin resistance and obesity from atherosclerosis
    J Mark Brown
    Department of Pathology, Wake Forest University School of Medicine, Section on Lipid Sciences, Winston Salem, NC 27157 1040, USA
    Circulation 118:1467-75. 2008
    ..Stearoyl-coenzyme A desaturase 1 (SCD1) is a well-known enhancer of the metabolic syndrome. The purpose of the present study was to investigate the role of SCD1 in lipoprotein metabolism and atherosclerosis progression...
  19. ncbi request reprint Minimal lipidation of pre-beta HDL by ABCA1 results in reduced ability to interact with ABCA1
    Anny Mulya
    Department of Pathology Section on Lipid Sciences, Wake Forest University Health Sciences, Medical Center Blvd, Winston Salem, NC 27157 1040, USA
    Arterioscler Thromb Vasc Biol 27:1828-36. 2007
    ..The aim of this study was to determine the role of ATP binding cassette transporter A1 (ABCA1) on generation of different-sized nascent HDLs...
  20. pmc Macrophage 12/15 lipoxygenase expression increases plasma and hepatic lipid levels and exacerbates atherosclerosis
    Shunxing Rong
    Department of Pathology Section on Lipid Sciences, Wake Forest School of Medicine, Winston Salem, NC, USA
    J Lipid Res 53:686-95. 2012
    ..Our results suggest that, in the context of dietary PUFA enrichment, macrophage 12/15LO expression adversely affects plasma and hepatic lipid metabolism, resulting in exacerbated atherosclerosis...
  21. pmc Echium oil reduces atherosclerosis in apoB100-only LDLrKO mice
    Lolita M Forrest
    Department of Pathology Section on Lipid Sciences, Wake Forest School of Medicine, Winston Salem, NC 27157, United States
    Atherosclerosis 220:118-21. 2012
    ..Echium oil contains stearidonic acid (SDA; 18:4, n-3), which is metabolized to EPA in humans and mice, resulting in decreased plasma triglycerides...
  22. pmc Targeted inactivation of hepatic Abca1 causes profound hypoalphalipoproteinemia and kidney hypercatabolism of apoA-I
    Jenelle M Timmins
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Clin Invest 115:1333-42. 2005
    ....
  23. pmc Apolipoprotein M expression increases the size of nascent pre beta HDL formed by ATP binding cassette transporter A1
    Anny Mulya
    Department of Pathology Section on Lipid Sciences, Wake Forest University Health Sciences, Winston Salem, NC 27157, USA
    J Lipid Res 51:514-24. 2010
    ..We propose that apoM may function catalytically at an intracellular site to transfer lipid onto pre beta HDL during or after their formation by ABCA1...
  24. ncbi request reprint Plasma cholesteryl esters provided by lecithin:cholesterol acyltransferase and acyl-coenzyme a:cholesterol acyltransferase 2 have opposite atherosclerotic potential
    Richard G Lee
    Arteriosclerosis Research Program, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Circ Res 95:998-1004. 2004
    ..Overall, the data suggest that ACAT2-derived CE is the predominant atherogenic lipid in blood, and that an important goal for prevention of atherosclerosis is to limit ACAT2-derived CE accumulation in lipoproteins...
  25. pmc Nascent high density lipoproteins formed by ABCA1 resemble lipid rafts and are structurally organized by three apoA-I monomers
    Mary G Sorci-Thomas
    Department of Pathology, Section on Lipid Sciences, Wake Forest Baptist Medical Center, Winston Salem, NC 27157, USA
    J Lipid Res 53:1890-909. 2012
    ..Overall, these new data offer fresh insights into the biogenesis and structural constraints involved in forming nascent HDL from ABCA1...
  26. pmc Adipose tissue ATP binding cassette transporter A1 contributes to high-density lipoprotein biogenesis in vivo
    Soonkyu Chung
    Department of Pathology Section on Lipid Sciences, Wake Forest School of Medicine, Winston Salem, NC, USA
    Circulation 124:1663-72. 2011
    ..However, the extent to which AT ABCA1 expression contributes to HDL biogenesis in vivo is unknown...
  27. pmc Hepatic ABCA1 and VLDL triglyceride production
    Mingxia Liu
    Department of Pathology Section on Lipid Sciences, Wake Forest School of Medicine, Winston Salem, NC, USA
    Biochim Biophys Acta 1821:770-7. 2012
    ..This article is part of a Special Issue entitled: Triglyceride Metabolism and Disease...
  28. pmc Echium oil reduces plasma lipids and hepatic lipogenic gene expression in apoB100-only LDL receptor knockout mice
    Ping Zhang
    Section on Lipid Sciences, Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Nutr Biochem 19:655-63. 2008
    ..In conclusion, EO may provide a botanical alternative to FO for reduction of plasma TG concentrations...
  29. pmc Characterization of circulating APOL1 protein complexes in African Americans
    Allison Weckerle
    Department of Internal Medicine, Sections on Molecular Medicine Wake Forest School of Medicine, Winston Salem, NC 27157
    J Lipid Res 57:120-30. 2016
    ..Serum HPR was less abundant on complex B in individuals with G1 and G2 renal-risk variant genotypes, relative to G0 (P = 0.0002-0.037). These circulating complexes may play roles in HDL metabolism and susceptibility to CVD. ..
  30. pmc Alternative splicing attenuates transgenic expression directed by the apolipoprotein E promoter-enhancer based expression vector pLIV11
    Dongmei Cheng
    Department of Pathology Section on Lipid Sciences, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Lipid Res 51:849-55. 2010
    ....
  31. pmc Apolipoprotein L1 nephropathy risk variants associate with HDL subfraction concentration in African Americans
    Barry I Freedman
    Department of Internal Medicine, Section on Nephrology, Wake Forest School of Medicine, Winston Salem, NC, USA
    Nephrol Dial Transplant 26:3805-10. 2011
    ..Plasma HDL particle subclass concentrations were compared in 73 African Americans based on APOL1 genotypes to detect differences potentially contributing to renal disease...
  32. ncbi request reprint Amino acids 149 and 294 of human lecithin:cholesterol acyltransferase affect fatty acyl specificity
    Yue Zhao
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Lipid Res 45:2310-6. 2004
    ....
  33. pmc Inhibiting DNA Methylation by 5-Aza-2'-deoxycytidine ameliorates atherosclerosis through suppressing macrophage inflammation
    Qiang Cao
    Department of Biology and Center for Obesity Reversal Q C, H S, B X, Georgia State University, Atlanta, Georgia Departments of Internal Medicine Q C, X W, A K M, A D, G A H, S K D, H S, B X and Pathology J S P, Wake Forest School of Medicine, Winston Salem, North Carolina Department of Internal Medicine L J, University of Texas, Southwestern Medical Center, Dallas, Texas Department of Animal and Avian Sciences L Y, University of Maryland, College Park, Maryland and Department of Biochemistry and Molecular Biology H S, Georgia Regents University, Augusta, Georgia
    Endocrinology 155:4925-38. 2014
    ..Our findings provide strong evidence that DNA methylation may play a significant role in cardiovascular diseases and serve as a therapeutic target for prevention and treatment of atherosclerosis. ..
  34. ncbi request reprint Apolipoprotein E is the major physiological activator of lecithin-cholesterol acyltransferase (LCAT) on apolipoprotein B lipoproteins
    Yue Zhao
    Department of Pathology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    Biochemistry 44:1013-25. 2005
    ..We conclude that apoE is a more significant activator of LCAT than apoA-I on mouse apoB lipoproteins...
  35. ncbi request reprint Mechanisms by which botanical lipids affect inflammatory disorders
    Floyd H Chilton
    Center for Botanical Lipids, Wake Forest University, Winston Salem, NC, USA
    Am J Clin Nutr 87:498S-503S. 2008
    ..Echium oil and other oils containing stearidonic acid as well as botanical oil combinations (such as echium and borage oils) hold great promise for modulating inflammatory diseases...
  36. pmc The effect of ACACB cis-variants on gene expression and metabolic traits
    Lijun Ma
    Wake Forest School of Medicine, Winston Salem, North Carolina, United States of America
    PLoS ONE 6:e23860. 2011
    ..We sought to determine whether ACACB transcribed variants were associated with ACACB gene expression and insulin sensitivity in non-diabetic African American (AA) and European American (EA) adults...
  37. pmc CGI-58/ABHD5-derived signaling lipids regulate systemic inflammation and insulin action
    Caleb C Lord
    Department of Pathology, Section on Lipid Sciences, Wake Forest University School of Medicine, Winston Salem, North Carolina, USA
    Diabetes 61:355-63. 2012
    ..Collectively, these findings establish that CGI-58 provides a novel source of signaling lipids. These findings contribute insight into the basic mechanisms linking TH1 cytokine signaling to nutrient metabolism...
  38. ncbi request reprint Negative charge at amino acid 149 is the molecular determinant for substrate specificity of lecithin: cholesterol acyltransferase for phosphatidylcholine containing 20-carbon sn-2 fatty acyl chains
    Yue Zhao
    Department of Pathology, Wake Forest University School of Medicine, Medical Center Boulevard, Winston Salem, North Carolina 27157, USA
    Biochemistry 42:13941-9. 2003
    ..We conclude that the negative charge at amino acid 149 of LCAT is a critical determinant for the specificity of the enzyme for PC containing 18- vs 20-carbon sn-2 fatty acyl chains...
  39. ncbi request reprint ATP-binding cassette transporter AI and its role in HDL formation
    Ji Young Lee
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    Curr Opin Lipidol 16:19-25. 2005
    ..This review focuses on recent progress in ABCA1-mediated HDL formation and regulation of ABCA1 expression...
  40. pmc Botanical oils enriched in n-6 and n-3 FADS2 products are equally effective in preventing atherosclerosis and fatty liver
    Swapnil V Shewale
    Departments of Internal Medicine Section on Molecular Medicine, Wake Forest School of Medicine, Winston Salem, NC 27157 Physiology Pharmacology, Wake Forest School of Medicine, Winston Salem, NC 27157
    J Lipid Res 56:1191-205. 2015
    ....
  41. pmc Histone deacetylase 9 represses cholesterol efflux and alternatively activated macrophages in atherosclerosis development
    Qiang Cao
    From the Departments of Internal Medicine Rheumatology and Immunology Q C, N M, Pathology Lipid Sciences S R, R S C, J S P, and Biochemistry J S P, Wake Forest School of Medicine, Winston Salem, NC and Departments of Internal Medicine and Physiology, The University of Texas Southwestern Medical Center, Dallas J J R
    Arterioscler Thromb Vasc Biol 34:1871-9. 2014
    ..HDAC9 expression was upregulated in human atherosclerotic plaques in different arteries. The molecular mechanisms how HDAC9 might increase atherosclerosis is not clear...
  42. ncbi request reprint Prebeta high density lipoprotein has two metabolic fates in human apolipoprotein A-I transgenic mice
    Ji Young Lee
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, NC 27157, USA
    J Lipid Res 45:716-28. 2004
    ....
  43. ncbi request reprint Compared with Acyl-CoA:cholesterol O-acyltransferase (ACAT) 1 and lecithin:cholesterol acyltransferase, ACAT2 displays the greatest capacity to differentiate cholesterol from sitosterol
    Ryan E Temel
    Department of Pathology, Section on Comparative Medicine, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    J Biol Chem 278:47594-601. 2003
    ..In contrast, ACAT2 demonstrated a strong preference for cholesterol rather than sitosterol. This sterol selectivity by ACAT2 may reflect a role in the sorting of dietary sterols during their absorption by the intestine in vivo...
  44. pmc New roles of HDL in inflammation and hematopoiesis
    Xuewei Zhu
    Department of Pathology Section on Lipid Sciences, Wake Forest School of Medicine, Winston Salem, North Carolina 27157, USA
    Annu Rev Nutr 32:161-82. 2012
    ....
  45. pmc Dietary cholesterol promotes adipocyte hypertrophy and adipose tissue inflammation in visceral, but not in subcutaneous, fat in monkeys
    Soonkyu Chung
    From the Department of Pathology, Sections on Lipid Sciences S C, H C, S M M, A L M, R E T, J S P and Comparative Medicine K K, and Department of Biochemistry J S P, Wake Forest School of Medicine, Winston Salem, NC Department of Nutrition and Health Sciences, University of Nebraska, Lincoln S C Department of Food Science and Human Nutrition, University of Florida, Gainesville S C, J H H and Department of Pathology and Laboratory Medicine, Howard Hughes Medical Institute, University of California, Los Angeles C H, P T
    Arterioscler Thromb Vasc Biol 34:1880-7. 2014
    ..The aim of this study was to determine whether increasing dietary cholesterol intake alters adipose tissue cholesterol content, adipocyte size, and endocrine function in nonhuman primates...
  46. pmc Dietary cholesterol effects on adipose tissue inflammation
    Soonkyu Chung
    aDepartment of Nutrition and Health Sciences, University of Nebraska, Lincoln, Nebraska, USA bDepartments of Internal Medicine Molecular Medicine cBiochemistry, Wake Forest School of Medicine, Winston Salem, North Carolina, USA
    Curr Opin Lipidol 27:19-25. 2016
    ..This review summarizes recent advances in knowledge of adipocyte cholesterol balance and highlights the emerging role of dietary cholesterol in adipose tissue cholesterol balance, inflammation, and systemic energy metabolism...
  47. ncbi request reprint Identification of the lipoprotein initiating domain of apolipoprotein B
    Gregory S Shelness
    Department of Pathology, Wake Forest University School of Medicine, Winston Salem, North Carolina 27157 1040, USA
    J Biol Chem 278:44702-7. 2003
    ..The composition of lipids recruited into lipoproteins by this initiating domain is consistent with formation of small emulsion particles, perhaps by simultaneous desorption of both polar and neutral lipids from a saturated bilayer...
  48. pmc Rosuvastatin induces delayed preconditioning against oxygen-glucose deprivation in cultured cortical neurons
    Ferenc Domoki
    Department of Physiology and Pharmacology, Wake Forest University Health Sciences, Winston Salem, North Carolina, USA
    Am J Physiol Cell Physiol 296:C97-105. 2009
    ..Reduced neuronal ATP levels and ROS production after OGD may be directly involved in the mechanism of neuroprotection...
  49. doi request reprint Lipotoxicity in diabetic nephropathy: the potential role of fatty acid oxidation
    Mariana Murea
    Department of Internal Medicine Nephrology Section, Wake Forest University Baptist Medical Center, Winston Salem, North Carolina 27157 1053, USA
    Clin J Am Soc Nephrol 5:2373-9. 2010
    ..This novel glucolipotoxicity hypothesis in T2DN warrants further investigation...