Peter D Pare

Summary

Publications

  1. pmc Genes related to emphysema are enriched for ubiquitination pathways
    Sergey Stepaniants
    University of British Columbia Centre for Heart and Lung Innovation, St Paul s Hospital, 1081 Burrard St, Vancouver V6Z 1Y6, BC, Canada
    BMC Pulm Med 14:187. 2014
  2. pmc Functional characterization of the matrix metalloproteinase-1 cigarette smoke-responsive region and association with the lung health study
    Alison M Wallace
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Respir Res 13:79. 2012
  3. pmc Airway-parenchymal interdependence
    Peter D Pare
    University of British Columbia, Vancouver, British Columbia, Canada
    Compr Physiol 2:1921-35. 2012
  4. pmc Genetic testing for respiratory disease: are we there yet?
    Peter D Pare
    University of British Columbia, James Hoog Research Centre, St Paul s Hospital, Vancouver, British Columbia
    Can Respir J 19:246-8. 2012
  5. ncbi request reprint Transforming growth factor-beta1 polymorphisms, airway responsiveness and lung function decline in smokers
    Emiko Ogawa
    James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Room 166, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
    Respir Med 101:938-43. 2007
  6. pmc Role of genetic susceptibility to latent adenoviral infection and decreased lung function
    Ikuma Kasuga
    The James Hogg iCAPTURE Centre, University of British Columbia, St Paul s Hospital, Vancouver, Canada
    Respir Med 103:1672-80. 2009
  7. doi request reprint Analyses of associations with asthma in four asthma population samples from Canada and Australia
    Denise Daley
    James Hogg iCAPTURE Center, University of British Columbia UBC, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada
    Hum Genet 125:445-59. 2009
  8. doi request reprint Regulatable stiffness in relaxed airway smooth muscle: a target for asthma treatment?
    Abdul Raqeeb
    James Hogg Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
    J Appl Physiol (1985) 112:337-46. 2012
  9. pmc NFE2L2 pathway polymorphisms and lung function decline in chronic obstructive pulmonary disease
    Andrew J Sandford
    UBC James Hogg Research Centre, Providence Heart Lung Institute, St Paul s Hospital, Vancouver, British Columbia, Canada
    Physiol Genomics 44:754-63. 2012
  10. pmc Contribution of alpha- and beta-defensins to lung function decline and infection in smokers: an association study
    Alison M Wallace
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, Vancouver, Canada
    Respir Res 7:76. 2006

Collaborators

Detail Information

Publications77

  1. pmc Genes related to emphysema are enriched for ubiquitination pathways
    Sergey Stepaniants
    University of British Columbia Centre for Heart and Lung Innovation, St Paul s Hospital, 1081 Burrard St, Vancouver V6Z 1Y6, BC, Canada
    BMC Pulm Med 14:187. 2014
    ..Despite their convergence in altered physiology, different mechanisms contribute to these processes. The relationships between gene expression and these specific phenotypes may be more revealing than comparison with lung function...
  2. pmc Functional characterization of the matrix metalloproteinase-1 cigarette smoke-responsive region and association with the lung health study
    Alison M Wallace
    Department of Medicine, Columbia University College of Physicians and Surgeons, New York, NY, USA
    Respir Res 13:79. 2012
    ..Prior studies have demonstrated that the distal 1.5 kb of the MMP-1 promoter is fundamental in directing the induction of the MMP-1 gene by cigarette smoke...
  3. pmc Airway-parenchymal interdependence
    Peter D Pare
    University of British Columbia, Vancouver, British Columbia, Canada
    Compr Physiol 2:1921-35. 2012
    ..Weakening of the forces of interdependence contributes to airway dysfunction and gas exchange impairment in acute and chronic airway diseases including asthma and emphysema...
  4. pmc Genetic testing for respiratory disease: are we there yet?
    Peter D Pare
    University of British Columbia, James Hoog Research Centre, St Paul s Hospital, Vancouver, British Columbia
    Can Respir J 19:246-8. 2012
    ..The present brief review provides a report card on the progress toward that goal with respect to respiratory disease. Should generalized population screening for genetic risk factors for respiratory disease be instituted? Or not?..
  5. ncbi request reprint Transforming growth factor-beta1 polymorphisms, airway responsiveness and lung function decline in smokers
    Emiko Ogawa
    James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, Room 166, 1081 Burrard Street, Vancouver, BC, Canada V6Z 1Y6
    Respir Med 101:938-43. 2007
    ..04). These data suggest that the T-C polymorphism at position +869 in the TGF-beta1 gene contributes to airway hyperresponsiveness, but not to rapid decline of lung function...
  6. pmc Role of genetic susceptibility to latent adenoviral infection and decreased lung function
    Ikuma Kasuga
    The James Hogg iCAPTURE Centre, University of British Columbia, St Paul s Hospital, Vancouver, Canada
    Respir Med 103:1672-80. 2009
    ..Therefore, we investigated the contribution of HLA, CXADR, and ITGB5 genetic variants to the presence of the E1A gene and to level of lung function...
  7. doi request reprint Analyses of associations with asthma in four asthma population samples from Canada and Australia
    Denise Daley
    James Hogg iCAPTURE Center, University of British Columbia UBC, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada
    Hum Genet 125:445-59. 2009
    ..To aid in future replication studies of asthma genes a comprehensive database was compiled and is available to the scientific community at http://genapha.icapture.ubc.ca/...
  8. doi request reprint Regulatable stiffness in relaxed airway smooth muscle: a target for asthma treatment?
    Abdul Raqeeb
    James Hogg Research Centre, University of British Columbia, Vancouver, British Columbia, Canada
    J Appl Physiol (1985) 112:337-46. 2012
    ..The results suggest that airway stiffness can be readily modulated by targeting the calcium-sensitive component of the passive stiffness within the muscle layer...
  9. pmc NFE2L2 pathway polymorphisms and lung function decline in chronic obstructive pulmonary disease
    Andrew J Sandford
    UBC James Hogg Research Centre, Providence Heart Lung Institute, St Paul s Hospital, Vancouver, British Columbia, Canada
    Physiol Genomics 44:754-63. 2012
    ....
  10. pmc Contribution of alpha- and beta-defensins to lung function decline and infection in smokers: an association study
    Alison M Wallace
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, Vancouver, Canada
    Respir Res 7:76. 2006
    ....
  11. doi request reprint Time course of isotonic shortening and the underlying contraction mechanism in airway smooth muscle
    Harley T Syyong
    James Hogg Research Centre St Paul s Hospital, Univ of British Columbia, 1081 Burrard St, Rm 166, Vancouver, BC, Canada
    J Appl Physiol (1985) 111:642-56. 2011
    ....
  12. doi request reprint Mechanical properties of asthmatic airway smooth muscle
    Leslie Y M Chin
    Dept of Pathology and Laboratory Medicine, St Paul s Hospital, Vancouver, BC, Canada
    Eur Respir J 40:45-54. 2012
    ..These data may relate to reduced bronchodilation induced by a deep inspiration in asthmatic subjects...
  13. ncbi request reprint The role of airway smooth muscle during an attack of asthma simulated in vitro
    Brent E McParland
    Department of Medicine, James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital Providence Health Care, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Respir Cell Mol Biol 33:500-4. 2005
    ..75 +/- 0.2-fold, respectively. Shortening of ASM in response to contractile agonists can lead to adaptation of the muscle to the shortened length that, in turn, can result in further shortening and the potential for airway closure...
  14. ncbi request reprint 'Sarcomeres' of smooth muscle: functional characteristics and ultrastructural evidence
    Ana M Herrera
    Department of Pathology and Laboratory Medicine, St Paul s Hospital Providence Health Care, University of British Columbia, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada
    J Cell Sci 118:2381-92. 2005
    ..The structural malleability necessary for length adaptation precludes formation of a permanent filament lattice and explains the lack of aligned filament arrays in registers, which also explains why smooth muscle is 'smooth'...
  15. pmc Effect of heme oxygenase-1 polymorphisms on lung function and gene expression
    Goh Tanaka
    UBC James Hogg Research Center, Providence Heart Lung Institute, St, Paul s Hospital, Vancouver, B C, Canada
    BMC Med Genet 12:117. 2011
    ..We determined whether HMOX1 polymorphisms were associated with lung function in COPD patients and whether the variants had functional effects...
  16. ncbi request reprint Reconcilable differences: a cross-sectional study of the relationship between socioeconomic status and the magnitude of short-acting beta-agonist use in asthma
    Larry D Lynd
    Faculty of Pharmaceutical Sciences, University of British Columbia, Vancouver, BC, Canada
    Chest 126:1161-8. 2004
    ..To assess the association between socioeconomic status (SES) and short-acting (SA) beta-agonist use, controlling for asthma severity...
  17. ncbi request reprint Quantitative assessment of airway remodeling using high-resolution CT
    Yasutaka Nakano
    University of British Columbia, McDonald Research Laboratories iCAPTURE Center, St Paul s Hospital, Vancouver, BC, Canada
    Chest 122:271S-275S. 2002
    ..With additional advances in technology, it is likely that quantitative assessment of airway wall dimensions will ultimately provide a valuable tool for the study of airway disease...
  18. ncbi request reprint Association of Hck genetic polymorphisms with gene expression and COPD
    Xiaozhu Zhang
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, University of British Columbia, 1081 Burrard Street, Room 166, Vancouver, BC, Canada
    Hum Genet 120:681-90. 2007
    ..These data suggest that the insertion/deletion polymorphism could be a functional polymorphism of the Hck gene, may contribute to COPD pathogenesis and modify COPD-related phenotypes...
  19. doi request reprint Adaptation of airway smooth muscle to basal tone: relevance to airway hyperresponsiveness
    Ynuk Bosse
    the James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research St Paul s Hospital, Room 166 1081, Burrard Street, Vancouver, BC, V6Z 1Y6 Canada
    Am J Respir Cell Mol Biol 40:13-8. 2009
    ..Force adaptation in ASM as a consequence of prolonged exposure to the many spasmogens found in asthmatic airways could be a mechanism contributing to AHR seen in asthma...
  20. doi request reprint Increase in passive stiffness at reduced airway smooth muscle length: potential impact on airway responsiveness
    Ynuk Bosse
    James Hogg iCAPTURE Centre St Paul s Hospital, 1081 Burrard St, Vancouver, BC, Canada
    Am J Physiol Lung Cell Mol Physiol 298:L277-87. 2010
    ..Redevelopment and maintenance of passive stiffness following muscle shortening could contribute to airway hyperresponsiveness by attenuating the airway wall strain induced by tidal breathing and DI...
  21. ncbi request reprint Changes in force-velocity properties of trachealis due to oscillatory strains
    Lu Wang
    Department of Medicine, iCAPTURE Center, St Paul s Hospital, Providence Health Care, University of British Columbia, Vancouver, British Columbia, Canada V6T 1Z3
    J Appl Physiol 92:1865-72. 2002
    ..The results, however, could be explained if the possibility of reorganization of the contractile filaments due to oscillatory strains was considered...
  22. ncbi request reprint Polymorphisms of the GM-CSF genes and the development of atopic diseases in at-risk children
    Jian Qing He
    UBC McDonald Research Laboratories iCAPTURE Center, St Paul s Hospital, Vancouver, BC, Canada
    Chest 123:438S. 2003
  23. pmc Effect of gene environment interactions on lung function and cardiovascular disease in COPD
    Tillie Louise Hackett
    University of British Columbia, James Hogg Research Laboratories, St Paul s Hospital, Division of Respirology, Department of Medicine, Vancouver, BC, Canada
    Int J Chron Obstruct Pulmon Dis 6:277-87. 2011
    ....
  24. doi request reprint Chronic activation in shortened airway smooth muscle: a synergistic combination underlying airway hyperresponsiveness?
    Ynuk Bosse
    The James Hogg iCAPTURE Centre, Providence Health Care St Paul s Hospital, Vancouver, BC, V6Z 1Y6 Canada
    Am J Respir Cell Mol Biol 42:341-8. 2010
    ..In vivo these changes will be translated into excessive airway narrowing in response to naturally occurring and pharmacological bronchoconstricting stimuli...
  25. doi request reprint Alveolar macrophage proteinase/antiproteinase expression in lung function and emphysema
    Takeo Ishii
    Institute for Heart and Lung Health, St Paul s Hospital, Vancouver, BC
    Eur Respir J 43:82-91. 2014
    ..We conclude that increased MMP12 and MMP1 expression may play a role in the pathogenesis of emphysema. Cathepsin L and MMP9 may be involved in the development of airflow limitation. ..
  26. pmc Force maintenance and myosin filament assembly regulated by Rho-kinase in airway smooth muscle
    Bo Lan
    Bioengineering College, Chongqing University, Chongqing, China Institute of Biomedical Engineering and Health Sciences, Changzhou University, Changzhou, China and Centre for Heart Lung Innovation, St Paul s Hospital, University of British Columbia, Vancouver, Canada
    Am J Physiol Lung Cell Mol Physiol 308:L1-10. 2015
    ..The results also suggest that dissolution of myosin filaments may be one of the mechanisms underlying the phenomenon of fluidization. These findings can shed light on the mechanism underlying deep inspiration induced bronchodilation. ..
  27. doi request reprint Decrease of airway smooth muscle contractility induced by simulated breathing maneuvers is not simply proportional to strain
    Chris D Pascoe
    University of British Columbia, James Hogg Research Center, St Paul s Hospital Vancouver, British Columbia, Canada
    J Appl Physiol (1985) 114:335-43. 2013
    ..More surprisingly, the reduction of strain induced by tone was not proportional to its effect on the decline of force induced by simulated breathing maneuvers...
  28. ncbi request reprint Models of contractile units and their assembly in smooth muscle
    Farah Ali
    Department of Experimental Medicine, University of British Columbia, Vancouver, Canada
    Can J Physiol Pharmacol 83:825-31. 2005
    ..The contractile apparatus is assumed malleable in that the number of contractile units in series and in parallel can be altered to accommodate strains on the muscle and to maintain the muscle's optimal mechanical function...
  29. ncbi request reprint Length adaptation of airway smooth muscle
    Ynuk Bosse
    The James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, Providence Health Care St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada, V6Z 1Y6
    Proc Am Thorac Soc 5:62-7. 2008
    ....
  30. ncbi request reprint Tissue elastance influences airway smooth muscle shortening: comparison of mechanical properties among different species
    Anabelle M Opazo Saez
    UBC Pulmonary Research Laboratory, St Paul s Hospital, Vancouver, BC, Canada
    Can J Physiol Pharmacol 80:865-71. 2002
    ....
  31. doi request reprint Associations and interactions of genetic polymorphisms in innate immunity genes with early viral infections and susceptibility to asthma and asthma-related phenotypes
    Denise Daley
    University of British Columbia James Hogg Research Centre, Institute for Heart and Lung Health, Vancouver, British Columbia, Canada
    J Allergy Clin Immunol 130:1284-93. 2012
    ..The innate immune system is essential for host survival because of its ability to recognize invading pathogens and mount defensive responses...
  32. doi request reprint Force oscillations simulating breathing maneuvers do not prevent force adaptation
    Chris Pascoe
    University of British Columbia, James Hogg Research Center, St Paul s Hospital Vancouver, Canada
    Am J Respir Cell Mol Biol 47:44-9. 2012
    ..The lack of effect of simulated breathing maneuvers on force adaptation suggests that this gain in ASM force may occur in vivo and could contribute to the development of airway hyperresponsiveness...
  33. doi request reprint It's not all smooth muscle: non-smooth-muscle elements in control of resistance to airflow
    Ynuk Bosse
    The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, Providence Health Care St Paul s Hospital, Department of Medicine, Respiratory Division, University of British Columbia, Vancouver, BC
    Annu Rev Physiol 72:437-62. 2010
    ..A detailed understanding of the mechanisms and consequences of increased airway resistance is vital to our attempts to alleviate the enormous burden of suffering caused by obstructive lung diseases...
  34. ncbi request reprint Characterization of airway plugging in fatal asthma
    Laura M Kuyper
    University of British Columbia McDonald Research Laboratories, St Paul s Hospital, Vancouver, British Columbia, Canada
    Am J Med 115:6-11. 2003
    ..In this study, we examined the hypothesis that obstruction of the airway lumen by an exudate containing mucus and cells is a key feature of fatal asthma attacks...
  35. pmc DNA methylation profiles of airway epithelial cells and PBMCs from healthy, atopic and asthmatic children
    Dorota Stefanowicz
    Department of Medicine, James Hogg Research Centre at the Heart and Lung Institute, University of British Columbia and St Paul s Hospital, Vancouver, British Columbia, Canada
    PLoS ONE 7:e44213. 2012
    ..Epigenetic modifications, such as DNA methylation, can be influenced by the environment and result in changes to gene expression...
  36. ncbi request reprint Relationship of matrix metalloproteinase mRNA expression and genetic polymorphisms to emphysema
    Raja T Abboud
    Division of Respiratory Medicine, University of British Columbia, 2775 Heather Street, Vancouver, BC, V5Z 3J5 Canada
    Proc Am Thorac Soc 3:475. 2006
  37. ncbi request reprint Gene expression profiling in patients with chronic obstructive pulmonary disease and lung cancer
    I Ming Wang
    McDonald Research Wing, Room 166, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
    Am J Respir Crit Care Med 177:402-11. 2008
    ..Chronic obstructive lung disease (COPD) is a common and disabling lung disease for which there are few therapeutic options...
  38. doi request reprint Dense-body aggregates as plastic structures supporting tension in smooth muscle cells
    Jie Zhang
    James Hogg Centre for Cardiovascular and Pulmonary Research, Providence Heart and Lung Institute, Vancouver, British Columbia, Canada
    Am J Physiol Lung Cell Mol Physiol 299:L631-8. 2010
    ..The finding suggests that the structural plasticity of hollow organs may originate from the dense-body cables within the smooth muscle cells...
  39. pmc Differential expression of tissue repair genes in the pathogenesis of chronic obstructive pulmonary disease
    John V Gosselink
    The iCAPTURE Centre for Cardiovascular and Pulmonary Research and University of British Columbia, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada
    Am J Respir Crit Care Med 181:1329-35. 2010
    ..The airflow limitation that defines severity of chronic obstructive pulmonary disease (COPD) is caused by a combination of small airway obstruction and emphysematous lung destruction...
  40. pmc Nitric oxide synthase polymorphisms, gene expression and lung function in chronic obstructive pulmonary disease
    Farzian Aminuddin
    The University of British Columbia James Hogg Research Centre, Providence Heart Lung Institute, Vancouver, Canada
    BMC Pulm Med 13:64. 2013
    ....
  41. pmc Small-airway obstruction and emphysema in chronic obstructive pulmonary disease
    John E McDonough
    University of British Columbia James Hogg Research Centre, St Paul s Hospital, Vancouver, BC, Canada
    N Engl J Med 365:1567-75. 2011
    ..We wanted to determine whether there was a relationship between small-airway obstruction and emphysematous destruction in COPD...
  42. ncbi request reprint A lung tissue bank for gene expression studies in chronic obstructive pulmonary disease
    Lily Ding
    Department of Pathology, University of British Columbia iCAPTURE Centre McDonald Research Laboratories, Vancouver, British Columbia, Canada
    COPD 1:191-204. 2004
    ..Storage time had no detectable effect on RNA quality. We conclude that both frozen and paraffin-embedded tissues as well as laser-captured cells are suitable for gene expression studies but frozen tissue offered greater sensitivity...
  43. doi request reprint Biphasic force response to iso-velocity stretch in airway smooth muscle
    Brandon A Norris
    Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada Centre for Heart Lung Innovation, St Paul s Hospital, University of British Columbia, Vancouver, British Columbia, Canada
    Am J Physiol Lung Cell Mol Physiol 309:L653-61. 2015
    ..Different responses due to different interventions suggest that cross-bridge and cytoskeletal stiffness is regulated differently by the kinases. ..
  44. doi request reprint Polymorphisms associated with expression of BPIFA1/BPIFB1 and lung disease severity in cystic fibrosis
    Aabida Saferali
    1 Centre for Heart Lung Innovation, UBC and St Paul s Hospital, Vancouver, British Columbia
    Am J Respir Cell Mol Biol 53:607-14. 2015
    ..0314). These findings were confirmed with quantitative PCR and Western blotting. We conclude that the G allele of rs1078761 may be detrimental to lung function in CF owing to decreased levels of BPIFA1 and BPIFB1. ..
  45. ncbi request reprint Role of exercise and nutrition status on bone mineral density in cystic fibrosis
    Despina D Frangolias
    University of British Columbia, Vancouver, BC, Canada
    J Cyst Fibros 2:163-70. 2003
    ..Exercise has been shown to maintain or increase bone mineral density (BMD) in non-CF populations...
  46. pmc Survival after lung volume reduction in chronic obstructive pulmonary disease: insights from small airway pathology
    James C Hogg
    University of British Columbia iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, Vancouver, BC, Canada
    Am J Respir Crit Care Med 176:454-9. 2007
    ..COPD is associated with reduced life expectancy...
  47. doi request reprint Length oscillation mimicking periodic individual deep inspirations during tidal breathing attenuates force recovery and adaptation in airway smooth muscle
    Abdul Raqeeb
    Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    J Appl Physiol (1985) 109:1476-82. 2010
    ....
  48. ncbi request reprint Patterns of inhaled asthma medication use: a 3-year longitudinal analysis of prescription claims data from British Columbia, Canada
    Larry D Lynd
    Department of Health Care and Epidemiology, University of British Columbia, Vancouver, BC, Canada V6Z 1Y6
    Chest 122:1973-81. 2002
    ..To assess trends in asthma management and to identify factors associated with increasing short-acting (SA) beta-agonist utilization in British Columbia using administrative prescription data...
  49. doi request reprint Molecular mechanisms underlying variations in lung function: a systems genetics analysis
    Ma en Obeidat
    University of British Columbia Center for Heart Lung Innovation, St Paul s Hospital, Vancouver, BC, Canada
    Lancet Respir Med 3:782-95. 2015
    ..We used a systems genetics approach to identify single nucleotide polymorphisms (SNPs) associated with lung function that act as eQTLs and change the level of expression of their target genes in lung tissue; termed eSNPs...
  50. pmc Expression of matrix metalloproteinase-1 in alveolar macrophages, type II pneumocytes, and airways in smokers: relationship to lung function and emphysema
    Alison M Wallace
    St Paul s Hospital, University of British Columbia Center for Heart Lung Innovation, 166 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada
    Lung 192:467-72. 2014
    ..Matrix metalloproteinase-1, also known as interstitial collagenase, has been implicated as a potentially important proteinase in the genesis of chronic obstructive pulmonary disease and, more specifically, emphysema...
  51. doi request reprint Development and maintenance of force and stiffness in airway smooth muscle
    Bo Lan
    Bioengineering College, Chongqing University, Chongqing, China, Centre for Heart and Lung Innovation, St Paul s Hospital and University of British Columbia, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada
    Can J Physiol Pharmacol 93:163-9. 2015
    ..Oscillatory strain from tidal breathing and deep inspiration is believed to be the counter balance that prevents hypercontraction and stiffening of ASM in vivo. Dysregulation of this balance could lead to AHR seen in asthma. ..
  52. ncbi request reprint Structural basis for exaggerated airway narrowing
    Peter D Pare
    Department of Medicine and Respiratory Division and The James Hogg iCAPTURE Centre, St Paul s Hospital, University of British Columbia, Vancouver, BC, Canada
    Can J Physiol Pharmacol 85:653-8. 2007
    ..This brief review summarizes the quantitative changes in the dimensions and organization of the airway wall compartments that have been described and explains how structural alterations may lead to the exaggerated airway narrowing...
  53. pmc Airway imaging in disease: gimmick or useful tool?
    Peter D Pare
    University of British Columbia James Hogg Research Centre and Institute for Heart Lung Health, Vancouver, British Columbia, Canada
    J Appl Physiol (1985) 113:636-46. 2012
    ....
  54. ncbi request reprint Single-nucleotide polymorphisms and lung disease: clinical implications
    Scott J Tebbutt
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, University of British Columbia, 1081 Burrard St, Vancouver, BC, Canada
    Chest 131:1216-23. 2007
    ..We conclude with a brief discussion of the future of medicine and how genetic knowledge and application can play an ever-increasing and important role in more effective diagnosis and treatment at a more personalized level...
  55. pmc Recent advances in asthma genetics
    Jian Zhang
    James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St, Paul s Hospital, Vancouver, B, C, V6Z 1Y6
    Respir Res 9:4. 2008
    ..Some important genes such as filaggrin, interleukin-13, interleukin-17 and the cysteinyl leukotriene receptor-1 which not only were replicated by independent association studies but also have functional data are reviewed in this article...
  56. pmc Lack of association of TIM3 polymorphisms and allergic phenotypes
    Jian Zhang
    James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St, Paul s Hospital, Vancouver, BC, Canada
    BMC Med Genet 10:62. 2009
    ..The aims of this study were to examine whether genetic variation in the promoter region of TIM3 influenced transcription of the gene and risk for allergic phenotypes...
  57. ncbi request reprint Airway wall remodeling in asthma: from the epithelial layer to the adventitia
    Ynuk Bosse
    James Hogg iCAPTURE Centre St Paul s Hospital, Room 166, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6, Canada
    Curr Allergy Asthma Rep 8:357-66. 2008
    ..This review describes the tissue remodeling observed in different compartments of the asthmatic airway wall, from the airway lumen to adventitia. The underlying mechanisms driving the remodeling processes are also briefly reviewed...
  58. pmc Quantification of lung surface area using computed tomography
    Ren Yuan
    University of British Columbia James Hogg Research Centre and the Heart and Lung Institute, St Paul s Hospital, Burrard Street, Vancouver, Canada
    Respir Res 11:153. 2010
    ..To incorporate both regional lung density measured by CT and cluster analysis of low attenuation areas for comparison with histological measurement of surface area per unit lung volume...
  59. ncbi request reprint Ultrastructural basis of airway smooth muscle contraction
    Chun Y Seow
    Department of Pathology and Laboratory Medicine and the James Hogg iCAPTURE Centre, St Paul s Hospital, University of British Columbia, Vancouver, BC, Canada
    Can J Physiol Pharmacol 85:659-65. 2007
    ..A list of unanswered questions regarding smooth muscle ultrastructure is also proposed in this review, in the hope that it will provide some guidance for future research...
  60. ncbi request reprint Mechanism of partial adaptation in airway smooth muscle after a step change in length
    Farah Ali
    Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada
    J Appl Physiol 103:569-77. 2007
    ..The partially adapted intermediate state is perhaps more physiologically relevant than the fully adapted state seen under static conditions, and it simulates a more realistic behavior for ASM in vivo...
  61. pmc Myosin filaments in smooth muscle cells do not have a constant length
    Jeffrey C Y Liu
    C Y Seow James Hogg Research Centre, St Paul s Hospital, 1081 Burrard Street, Vancouver, BC, Canada, V6Z 1Y6
    J Physiol 591:5867-78. 2013
    ....
  62. doi request reprint Sex differences in emphysema and airway disease in smokers
    Pat G Camp
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, Vancouver, BC, Canada
    Chest 136:1480-8. 2009
    ..The purpose of this study was to test for sex differences in COPD phenotypes by using high-resolution CT (HRCT) scanning in male and female smokers with and without COPD...
  63. ncbi request reprint Understanding the biological differences in susceptibility to chronic obstructive pulmonary disease between men and women
    Don D Sin
    University of British Columbia, Vancouver, British Columbia, Canada
    Proc Am Thorac Soc 4:671-4. 2007
    ..This article reviews this and other potential mechanisms that may confer increased susceptibility of COPD to female smokers...
  64. pmc Genetics and genomics of chronic obstructive pulmonary disease
    Edwin K Silverman
    UBC James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, St Paul s Hospital, Vancouver, BC V6Z 1Y6, Canada
    Proc Am Thorac Soc 6:539-42. 2009
    ..Although both of these unbiased approaches are in their infancy, they have already provided exciting new avenues for future investigation and potentially now approaches to risk prediction and therapy...
  65. ncbi request reprint The growing burden of chronic obstructive pulmonary disease and lung cancer in women: examining sex differences in cigarette smoke metabolism
    Sigal Ben-Zaken Cohen
    James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, St Paul s Hospital, and the Department of Medicine, The University of British Columbia, 1081 Burrard Street, Vancouver, BC V6Z 1Y6, Canada
    Am J Respir Crit Care Med 176:113-20. 2007
    ..In this article, we explore CYP and other related pathways as potential mechanisms and targets of future research and novel discoveries to curb the growing epidemic of COPD and lung cancer in women...
  66. doi request reprint Localization of DNA and RNA in eosinophil secretory granules
    Ali R Behzad
    The James Hogg iCAPTURE Centre, St Paul s Hospital, Department of Medicine, University of British Columbia, Vancouver, B C, Canada
    Int Arch Allergy Immunol 152:12-27. 2010
    ....
  67. doi request reprint COPD phenotypes in biomass smoke- versus tobacco smoke-exposed Mexican women
    Pat G Camp
    University of British Columbia, St Paul s Hospital, Vancouver, BC
    Eur Respir J 43:725-34. 2014
    ..05). Biomass smoke exposure is associated with less emphysema but more air trapping than tobacco smoke exposure, suggesting an airway-predominant phenotype. ..
  68. ncbi request reprint Physiological changes at altitude in nonasthmatic and asthmatic subjects
    Dianna Louie
    Sir Winston Churchill Secondary School, University of British Columbia, McDonald Research Laboratories iCAPTURE Centre, St Paul s Hospital, Vancouver, Canada
    Can Respir J 11:197-9. 2004
    ..These data suggest that asthmatic subjects develop bronchoconstriction when they go to very high altitudes, possibly via the same mechanism that causes exercise-induced asthma...
  69. ncbi request reprint Acetylcholine-induced asynchronous calcium waves in intact human bronchial muscle bundle
    Jiazhen M Dai
    The James Hogg iCAPTURE Center for Cardiovascular and Pulmonary Research, University of British Columbia, and St Paul s Hospital, Room 166, 1081 Burrard Street, Vancouver, BC, V6Z 1Y6 Canada
    Am J Respir Cell Mol Biol 36:600-8. 2007
    ..These findings for the first time demonstrate the occurrence and the role of ACW in excitation-contraction coupling in adult human ASM...
  70. doi request reprint A 'Good' muscle in a 'Bad' environment: the importance of airway smooth muscle force adaptation to airway hyperresponsiveness
    Ynuk Bosse
    The James Hogg Research Center, Providence Health Care St Paul s Hospital, Vancouver, BC, Canada
    Respir Physiol Neurobiol 179:269-75. 2011
    ..We speculate that the increased basal ASM-tone in asthma, due to the presence of inflammation-derived spasmogens, produces an increase in the force-generating capacity of ASM, predisposing to AHR during subsequent challenge...
  71. doi request reprint Bronchoprotective effect of simulated deep inspirations in tracheal smooth muscle
    Christopher D Pascoe
    Department of Medicine, University of British Columbia, Vancouver, British Columbia, Canada Center for Heart Lung Innovation, St Paul s Hospital, Vancouver, British Columbia, Canada
    J Appl Physiol (1985) 117:1502-13. 2014
    ..These results suggest that DIs confer bronchoprotection because they increase the compliance of ASM, which, consequently, promotes greater strain from subsequent DI and fosters the reopening of closed airways. ..
  72. doi request reprint The importance of complete tissue homogenization for accurate stoichiometric measurement of myosin light chain phosphorylation in airway smooth muscle
    Lu Wang
    a Respiratory Division, Department of Medicine, Vancouver, BC V5Z 1M9, Canada
    Can J Physiol Pharmacol 93:155-62. 2015
    ..This finding suggests that for accurate estimation of the stoichiometry of MLC20 phosphorylation it is necessary to consider the contribution from the pellet portion of the muscle tissue homogenate. ..
  73. doi request reprint Gene expression in asthmatic airway smooth muscle: a mixed bag
    Christopher D Pascoe
    a Department of Medicine, University of British Columbia, Vancouver, BC V5Z 1M9, Canada
    Can J Physiol Pharmacol 93:137-43. 2015
    ..Removal of the ASM from this environment could explain why hypercontractility is rarely seen ex vivo. ..
  74. ncbi request reprint On the terminology for describing the length-force relationship and its changes in airway smooth muscle
    Tony R Bai
    James Hogg iCAPTURE Centre for Cardiovascular and Pulmonary Research, University of British Columbia, Vancouver, Canada
    J Appl Physiol 97:2029-34. 2004
    ..We also discuss frequently used terms that do not have commonly accepted definitions that should be used cautiously...
  75. ncbi request reprint Physical integrity of smooth muscle myosin filaments is enhanced by phosphorylation of the regulatory myosin light chain
    Kelvin Ip
    James Hogg iCAPTURE Centre, St Paul s Hospital, Vancouver, Canada
    Cell Physiol Biochem 20:649-58. 2007
    ..Phosphorylation of the 20-kD regulatory myosin light chain (MLC20) enhances filament formation. It is not known whether the phosphorylated and non-phosphorylated filaments possess the same structural integrity...
  76. ncbi request reprint Airway wall remodeling: friend or foe?
    Brent E McParland
    McDonald Research Laboratory The iCAPTURE Center, St Paul s Hospital, University of British Columbia, Vancouver, Canada V6Z 1Y6
    J Appl Physiol 95:426-34. 2003
    ..This minireview discusses the evidence for airway wall remodeling and its effects, friend and/or foe, on airway narrowing in asthmatic patients...
  77. ncbi request reprint Using administrative healthcare data to recruit study subjects: experience with 'camouflaged sampling'
    Larry D Lynd
    Department of Health Care and Epidemiology, Faculty of Medicine University of British Columbia, Centre for Health Evaluation and Outcomes Sciences, Vancouver, BC, Canada
    Eur J Epidemiol 19:517-25. 2004
    ..To recruit a sample of asthmatics heterogeneous for short-acting (SA) beta-agonist use while protecting their privacy, and to compare participants recruited via 'camouflaged sampling' to those recruited through media advertising...