- Evaluation of the long-term reconstituting subset of hematopoietic stem cells with CD150
Institute of Stem Cell Biology and Regenerative Medicine and Department of Pathology, Stanford University School of Medicine, Stanford, California, USA
Stem Cells 27:2498-508. 2009
..This is important for the clarification of lineage relationships and the identification of bona fide regulators of stem cell self-renewal and differentiation both in normal and neoplastic tissues...
- Self-renewal of the long-term reconstituting subset of hematopoietic stem cells is regulated by Ikaros
Institute of Stem Cell Biology and Regenerative Medicine, and Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, California 94305, USA
Stem Cells 27:3082-92. 2009
- Transparency in drug regulation: public assessment reports in Europe and Australia
Therapeutic Goods Administration, Regulatory Services Group, Department of Health, 136 Narrabundah Lane, Symonston, ACT 2609, Australia Electronic address
Drug Discov Today 21:1806-1813. 2016
..Here, we describe the experiences of two established medicines regulators in publishing public assessment reports, and reflect on their future role in communicating medicines information...
- A recessive screen for genes regulating hematopoietic stem cells
Australian Phenomics Facility, John Curtin School of Medical Research, Australian National University, Acton, ACT, Australia
Blood 116:5849-58. 2010
..Such phenotype-driven approaches will provide new knowledge of the genes, protein interactions, and regulatory networks that underpin stem cell biology...
- Epigenetic characterization of hematopoietic stem cell differentiation using miniChIP and bisulfite sequencing analysis
Joanne L Attema
Institute of Stem Cell Biology and Regenerative Medicine, Departments of Pathology and Developmental Biology, Stanford University School of Medicine, Stanford, CA 94305, USA
Proc Natl Acad Sci U S A 104:12371-6. 2007
..Together, these data support a model in which epigenetic modifications serve as an important mechanism to control HSC multipotency...
- Cooperation between somatic Ikaros and Notch1 mutations at the inception of T-ALL
Immunology Department, John Curtin School of Medical Research, Australian National University, Canberra, ACT, Australia
Leuk Res 35:1512-9. 2011
..These findings illuminate the early stages of leukemogenesis by demonstrating progressive exaggeration of Notch1 responsiveness at the DP thymocyte stage brought about by multiple mutations acting in concert upon the Notch1 pathway...
- Widespread failure of hematolymphoid differentiation caused by a recessive niche-filling allele of the Ikaros transcription factor
Australian Cancer Research Foundation Genetics Laboratory and Medical Genome Centre, John Curtin School of Medical Research, Australian National University, ACT 2601, Canberra, Australia
Immunity 19:131-44. 2003
- Connecting mammalian genome with phenome by ENU mouse mutagenesis: gene combinations specifying the immune system
Australian Cancer Research Foundation Genetics Laboratory and Australian Phenomics Facility, John Curtin School of Medical Research, Australian National University, Canberra, ACT 2601 Australia
Annu Rev Genet 39:241-62. 2005
..Second, ENU alleles match those arising by natural variation. By changing individual protein domains or splice products, these alleles reveal separate gene functions specified through protein combinations...
- Expression of TCR-Vβ peptides by murine bone marrow cells does not identify T-cell progenitors
Janice L Abbey
Research School of Biology, Australian National University, Canberra, ACT, Australia
J Cell Mol Med 19:1956-64. 2015
..This pattern of restricted in vivo reconstitution disputes Lin(-) Vβ8.2(+) Cβ(-) BM cells as committed T-cell progenitors, but raises the possibility of progenitors with potential for B-cell development...