Zulfiqar A Bhutta

Summary

Affiliation: The Aga Khan University
Country: Pakistan

Publications

  1. doi request reprint Alma-Ata: Rebirth and Revision 6 Interventions to address maternal, newborn, and child survival: what difference can integrated primary health care strategies make?
    Zulfiqar A Bhutta
    Department of Paediatrics and Child Health, The Aga Khan University, Karachi, Pakistan
    Lancet 372:972-89. 2008
  2. doi request reprint Improvement of perinatal and newborn care in rural Pakistan through community-based strategies: a cluster-randomised effectiveness trial
    Zulfiqar A Bhutta
    Division of Women and Child Health, Aga Khan University, Karachi, Pakistan zulfi
    Lancet 377:403-12. 2011
  3. ncbi request reprint Community-based newborn care: are we there yet?
    Zulfiqar A Bhutta
    Department of Paediatrics and Child Health, Aga Khan University, Karachi 74800, Pakistan zulfi
    Lancet 372:1124-6. 2008
  4. doi request reprint Evidence-based interventions for improvement of maternal and child nutrition: what can be done and at what cost?
    Zulfiqar A Bhutta
    Aga Khan University, Karachi, Pakistan
    Lancet 382:452-77. 2013
  5. doi request reprint Reproductive, maternal, newborn, and child health in Pakistan: challenges and opportunities
    Zulfiqar A Bhutta
    Department of Paediatrics and Child Health, Division of Women and Child Health, Aga Khan University, Karachi, Pakistan
    Lancet 381:2207-18. 2013
  6. doi request reprint Effect of provision of daily zinc and iron with several micronutrients on growth and morbidity among young children in Pakistan: a cluster-randomised trial
    Sajid Soofi
    Department of Paediatrics and Child Health, Division of Women and Child Health, The Aga Khan University, Karachi, Pakistan
    Lancet 382:29-40. 2013
  7. doi request reprint Folic acid supplementation during pregnancy for maternal health and pregnancy outcomes
    Zohra S Lassi
    Division of Women and Child Health, Aga Khan University Hospital, Karachi, Pakistan
    Cochrane Database Syst Rev 3:CD006896. 2013
  8. doi request reprint Interventions to address deaths from childhood pneumonia and diarrhoea equitably: what works and at what cost?
    Zulfiqar A Bhutta
    Division of Woman and Child Health, Aga Khan University, Karachi, Pakistan
    Lancet 381:1417-29. 2013
  9. doi request reprint Topical application of chlorhexidine to neonatal umbilical cords for prevention of omphalitis and neonatal mortality in a rural district of Pakistan: a community-based, cluster-randomised trial
    Sajid Soofi
    Division of Women and Child Health, Aga Khan University, Karachi, Pakistan
    Lancet 379:1029-36. 2012
  10. pmc Preventive zinc supplementation in developing countries: impact on mortality and morbidity due to diarrhea, pneumonia and malaria
    Mohammad Yawar Yakoob
    Division of Women and Child Health, The Aga Khan University, Karachi, Pakistan
    BMC Public Health 11:S23. 2011

Detail Information

Publications133 found, 100 shown here

  1. doi request reprint Alma-Ata: Rebirth and Revision 6 Interventions to address maternal, newborn, and child survival: what difference can integrated primary health care strategies make?
    Zulfiqar A Bhutta
    Department of Paediatrics and Child Health, The Aga Khan University, Karachi, Pakistan
    Lancet 372:972-89. 2008
    ..Strengthening MNCH at the primary health-care level should be a priority for countries to reach their Millennium Development Goal targets for reducing maternal and child mortality...
  2. doi request reprint Improvement of perinatal and newborn care in rural Pakistan through community-based strategies: a cluster-randomised effectiveness trial
    Zulfiqar A Bhutta
    Division of Women and Child Health, Aga Khan University, Karachi, Pakistan zulfi
    Lancet 377:403-12. 2011
    ....
  3. ncbi request reprint Community-based newborn care: are we there yet?
    Zulfiqar A Bhutta
    Department of Paediatrics and Child Health, Aga Khan University, Karachi 74800, Pakistan zulfi
    Lancet 372:1124-6. 2008
  4. doi request reprint Evidence-based interventions for improvement of maternal and child nutrition: what can be done and at what cost?
    Zulfiqar A Bhutta
    Aga Khan University, Karachi, Pakistan
    Lancet 382:452-77. 2013
    ....
  5. doi request reprint Reproductive, maternal, newborn, and child health in Pakistan: challenges and opportunities
    Zulfiqar A Bhutta
    Department of Paediatrics and Child Health, Division of Women and Child Health, Aga Khan University, Karachi, Pakistan
    Lancet 381:2207-18. 2013
    ....
  6. doi request reprint Effect of provision of daily zinc and iron with several micronutrients on growth and morbidity among young children in Pakistan: a cluster-randomised trial
    Sajid Soofi
    Department of Paediatrics and Child Health, Division of Women and Child Health, The Aga Khan University, Karachi, Pakistan
    Lancet 382:29-40. 2013
    ..We assessed the effects of provision of two micronutrient powder formulations, with or without zinc, to children in Pakistan...
  7. doi request reprint Folic acid supplementation during pregnancy for maternal health and pregnancy outcomes
    Zohra S Lassi
    Division of Women and Child Health, Aga Khan University Hospital, Karachi, Pakistan
    Cochrane Database Syst Rev 3:CD006896. 2013
    ..to a decrease in serum folate concentration, resulting in a decrease in erythrocyte folate concentration, a rise in homocysteine concentration, and megaloblastic changes in the bone marrow and other tissues with rapidly dividing cells..
  8. doi request reprint Interventions to address deaths from childhood pneumonia and diarrhoea equitably: what works and at what cost?
    Zulfiqar A Bhutta
    Division of Woman and Child Health, Aga Khan University, Karachi, Pakistan
    Lancet 381:1417-29. 2013
    ..Furthermore, several of these interventions could reduce morbidity and overall burden of disease, with possible benefits for developmental outcomes...
  9. doi request reprint Topical application of chlorhexidine to neonatal umbilical cords for prevention of omphalitis and neonatal mortality in a rural district of Pakistan: a community-based, cluster-randomised trial
    Sajid Soofi
    Division of Women and Child Health, Aga Khan University, Karachi, Pakistan
    Lancet 379:1029-36. 2012
    ..We aimed to assess the effect of umbilical-cord cleansing with 4% chlorhexidine (CHX) solution, with or without handwashing with antiseptic soap, on the incidence of omphalitis and neonatal mortality...
  10. pmc Preventive zinc supplementation in developing countries: impact on mortality and morbidity due to diarrhea, pneumonia and malaria
    Mohammad Yawar Yakoob
    Division of Women and Child Health, The Aga Khan University, Karachi, Pakistan
    BMC Public Health 11:S23. 2011
    ....
  11. pmc Improved accessibility of emergency obstetrics and newborn care (EmONC) services for maternal and newborn health: a community based project
    Ali Turab
    Department of Paediatrics and Child Health, Division of Women and Child Health, Aga Khan University, Karachi, Pakistan
    BMC Pregnancy Childbirth 13:136. 2013
    ..Maternal and neonatal mortality remain to be unacceptably high in Pakistan especially in rural areas where more than half of births occur...
  12. doi request reprint Systematic review of zinc fortification trials
    Jai K Das
    Division of Women and Child Health, Aga Khan University, Karachi, Pakistan
    Ann Nutr Metab 62:44-56. 2013
    ..Large-scale fortification programs with robust impact assessment should be initiated to cover larger populations in all age groups. Mass fortification of zinc may be a cost-effective strategy to overcome zinc deficiency...
  13. doi request reprint Nutritional management of the low birth weight/preterm infant in community settings: a perspective from the developing world
    Aamer Imdad
    Division of Women and Child Health, The Aga Khan University, Karachi, Pakistan
    J Pediatr 162:S107-14. 2013
    ..Future research should focus on improving triage of preterm and IUGR infants. Exclusive breastfeeding should be promoted, and appropriate alternative food supplements should be provided when breastfeeding is not possible...
  14. doi request reprint Stillbirths: what difference can we make and at what cost?
    Zulfiqar A Bhutta
    Division of Women and Child Health, Aga Khan University, Karachi, Pakistan
    Lancet 377:1523-38. 2011
    ..The overall costs for these interventions are within the general estimates of cost-effective interventions for maternal care, especially in view of the effects on outcomes across maternal, fetal, and neonatal health...
  15. pmc Implementing community-based perinatal care: results from a pilot study in rural Pakistan
    Zulfiqar A Bhutta
    Department of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan
    Bull World Health Organ 86:452-9. 2008
    ..This pilot study investigated the feasibility of delivering a package of community-based interventions for improving perinatal care using lady health workers (LHWs) and traditional birth attendants (Dais) in rural Pakistan...
  16. pmc Impact of vitamin A supplementation on infant and childhood mortality
    Aamer Imdad
    Division of Women and Child Health, The Aga Khan University, Karachi, Pakistan
    BMC Public Health 11:S20. 2011
    ..The purpose of this paper was to get a point estimate of efficacy of vitamin A supplementation in reducing cause specific mortality by using Child Health Epidemiology Reference Group (CHERG) guidelines...
  17. doi request reprint Can available interventions end preventable deaths in mothers, newborn babies, and stillbirths, and at what cost?
    Zulfiqar A Bhutta
    Center for Global Child Health, Hospital for Sick Children, Toronto, Canada Center of Excellence in Women and Child Health, Aga Khan University, Karachi, Pakistan Electronic address
    Lancet 384:347-70. 2014
    ..Our analysis also indicates that available interventions can reduce the three most common cause of neonatal mortality--preterm, intrapartum, and infection-related deaths--by 58%, 79%, and 84%, respectively...
  18. doi request reprint Absorbed zinc and exchangeable zinc pool size are greater in Pakistani infants receiving traditional complementary foods with zinc-fortified micronutrient powder
    Shabina Ariff
    Aga Khan University, Karachi, Pakistan
    J Nutr 144:20-6. 2014
    ..Additional field studies may be necessary to ascertain the adequacy of this dose for infants at high risk of deficiency. This trial was registered at ClinicalTrials.gov as NCT00705445...
  19. doi request reprint The interconnections between maternal and newborn health--evidence and implications for policy
    Zohra S Lassi
    Division of Women and Child Health, The Aga Khan University, Karachi, Pakistan
    J Matern Fetal Neonatal Med 26:3-53. 2013
    ..These interventions are then grouped into packages of care for delivery at the community, health center or hospital levels...
  20. pmc Evaluation of health workforce competence in maternal and neonatal issues in public health sector of Pakistan: an Assessment of their training needs
    Shabina Ariff
    Department of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan
    BMC Health Serv Res 10:319. 2010
    ..The high mortality rates are partially attributable to scarcity of trained skilled birth attendants and paucity of resources. Empowerment of health care providers with adequate knowledge and skills can serve as instrument of change...
  21. pmc The effect of folic acid, protein energy and multiple micronutrient supplements in pregnancy on stillbirths
    Aamer Imdad
    Division of Women and Child Health, The Aga Khan University, Stadium Road, PO Box 3500, Karachi 74800, Pakistan
    BMC Public Health 11:S4. 2011
    ..This paper is a part of a series to estimate the effect of interventions on stillbirths for input to Live Saved Tool (LiST) model...
  22. ncbi request reprint Community-based intervention packages for reducing maternal and neonatal morbidity and mortality and improving neonatal outcomes
    Zohra S Lassi
    Division of Women and Child Health, Aga Khan University Hospital, Stadium Road, PO Box 3500, Karachi, Pakistan, 74800
    Cochrane Database Syst Rev 11:CD007754. 2010
    ....
  23. doi request reprint Management of newborn infections in primary care settings: a review of the evidence and implications for policy?
    Zulfiqar A Bhutta
    Department of Paediatrics and Child Health, The Aga Khan University, Karachi, Pakistan
    Pediatr Infect Dis J 28:S22-30. 2009
    ..There is an urgent need to define the role of community-based management for neonates with serious bacterial infections--both at home and at first-level facilities...
  24. doi request reprint Maternal nutrition and birth outcomes: effect of balanced protein-energy supplementation
    Aamer Imdad
    Division of Women and Child Health, Aga Khan University, Karachi, Pakistan
    Paediatr Perinat Epidemiol 26:178-90. 2012
    ..62 [95% CI 0.40, 0.98]]. In conclusion, balanced protein-energy supplementation is an effective intervention to reduce the prevalence of LBW and small-for-gestational-age births, especially in undernourished women...
  25. pmc Validation of verbal autopsy tool for ascertaining the causes of stillbirth
    Sidrah Nausheen
    Division of Women and Child Health, Aga Khan University, Karachi, Pakistan
    PLoS ONE 8:e76933. 2013
    ..To assess performance of the WHO revised verbal autopsy tool for ascertaining the causes of still birth in comparison with reference standard cause of death ascertained by standardized clinical and supportive data...
  26. doi request reprint Meeting the challenges of micronutrient malnutrition in the developing world
    Zulfiqar A Bhutta
    Aga Khan University, Karachi, Pakistan
    Br Med Bull 106:7-17. 2013
    ..Major risk factors for undernutrition such as suboptimal breastfeeding and micronutrient deficiencies (vitamin A and zinc) are responsible for more than one-third of all under five child deaths and 11% of the global total disease burden...
  27. doi request reprint Annual Research Review: Improved nutrition--pathway to resilience
    Aisha K Yousafzai
    Department of Paediatrics and Child Health, Division of Women and Child Health, Aga Khan University, Karachi, Pakistan
    J Child Psychol Psychiatry 54:367-77. 2013
    ..A greater understanding is needed about factors which moderate the effects of nutrition-related risks and foster resilience to protect against or ameliorate poor development outcomes...
  28. doi request reprint Routine iron/folate supplementation during pregnancy: effect on maternal anaemia and birth outcomes
    Aamer Imdad
    Division of Women and Child Health, The Aga Khan University, Karachi, Pakistan
    Paediatr Perinat Epidemiol 26:168-77. 2012
    ..80 [95% CI 0.71, 0.90]). Preventive iron supplementation during pregnancy has a significant benefit in reducing incidence of anaemia in mothers and low birthweight in neonates...
  29. doi request reprint Is it time to replace iron folate supplements in pregnancy with multiple micronutrients?
    Zulfiqar A Bhutta
    Division of Women and Child Health, The Aga Khan University, Karachi, Pakistan
    Paediatr Perinat Epidemiol 26:27-35. 2012
    ....
  30. doi request reprint Evidence-based prevention of childhood malnutrition
    Aamer Imdad
    Division of Women and Child Health, Aga Khan University, Karachi, Pakistan
    Curr Opin Clin Nutr Metab Care 14:276-85. 2011
    ..There have been advances in prevention of childhood malnutrition and the purpose of this article was to review the current evidence in the field...
  31. pmc Effect of breastfeeding promotion interventions on breastfeeding rates, with special focus on developing countries
    Aamer Imdad
    Division of Women and Child Health, The Aga Khan University, Karachi, Pakistan
    BMC Public Health 11:S24. 2011
    ..There is much interest in the effectiveness of breastfeeding promotion interventions on breastfeeding rates in early infancy...
  32. doi request reprint Countdown to 2015 decade report (2000-10): taking stock of maternal, newborn, and child survival
    Zulfiqar A Bhutta
    Aga Khan University, Karachi, Pakistan
    Lancet 375:2032-44. 2010
    ..However, much more can and should be done to address maternal and newborn health and improve coverage of interventions related to family planning, care around childbirth, and case management of childhood illnesses...
  33. doi request reprint A comparison of disease caused by Shigella and Campylobacter species: 24 months community based surveillance in 4 slums of Karachi, Pakistan
    Sajid Bashir Soofi
    Department of Paediatrics and Child Health, Aga Khan University, Pakistan
    J Infect Public Health 4:12-21. 2011
    ..In the face of these facts it is empirically important to develop a low cost effective vaccine that can protect these populations for a longer duration...
  34. pmc Effect of case management on neonatal mortality due to sepsis and pneumonia
    Anita K M Zaidi
    Department of Paediatrics and Child Health, The Aga Khan University, Karachi, Pakistan
    BMC Public Health 11:S13. 2011
    ..We have estimated the effect of providing oral, or injectable antibiotics at home or in first-level facilities, and of in-patient hospital care on neonatal mortality from pneumonia and sepsis for use in the Lives Saved Tool (LiST)...
  35. pmc Enhanced disease surveillance through private health care sector cooperation in Karachi, Pakistan: experience from a vaccine trial
    Mohammad Imran Khan
    Department of Paediatrics, Aga Khan University, Karachi, Pakistan
    Bull World Health Organ 84:72-7. 2006
    ..This, however, poses enormous challenges in practice. The process and outcome of recruiting private practice clinics for surveillance in a vaccine trial are described...
  36. doi request reprint Immunogenicity and safety of the Vi-CRM197 conjugate vaccine against typhoid fever in adults, children, and infants in south and southeast Asia: results from two randomised, observer-blind, age de-escalation, phase 2 trials
    Zulfiqar A Bhutta
    Department of Pediatrics and Child Health, Division of Women and Child Health, Aga Khan University, Karachi, Pakistan
    Lancet Infect Dis 14:119-29. 2014
    ..We aimed to assess the immunogenicity and safety of Vi-CRM197 in participants of various ages in endemic countries in south and southeast Asia...
  37. doi request reprint Epidemiology, clinical presentation, and patterns of drug resistance of Salmonella Typhi in Karachi, Pakistan
    M Imran Khan
    Department of Paediatrics, Aga Khan University, Karachi, Pakistan
    J Infect Dev Ctries 6:704-14. 2012
    ..Planning appropriate preventive measures such as immunization requires a clear understanding of disease burden. We conducted a community-based surveillance for Salmonella Typhi infection in children in Karachi, Pakistan...
  38. doi request reprint Global nutrition epidemiology and trends
    Zulfiqar A Bhutta
    Division of Women and Child Health, Aga Khan University, Karachi, Pakistan
    Ann Nutr Metab 61:19-27. 2012
    ..This suggests that interventions requiring strong health systems or behavior change appear to be stalled and need to be re-examined to find more effective ways of delivery...
  39. doi request reprint Prevalence of early childhood disability in a rural district of Sind, Pakistan
    Shahnaz H Ibrahim
    Department of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan
    Dev Med Child Neurol 55:357-63. 2013
    ..Our aim was to determine the prevalence of early childhood (0-5 year) disability in Sind, a rural area of Pakistan...
  40. pmc The effect of providing skilled birth attendance and emergency obstetric care in preventing stillbirths
    Mohammad Yawar Yakoob
    Division of Women and Child Health, The Aga Khan University, Stadium Road, PO Box 3500, Karachi 74800, Pakistan
    BMC Public Health 11:S7. 2011
    ..This review discusses the impact of skilled birth attendance (SBA) and the provision of Emergency Obstetric Care (EOC) on stillbirths and perinatal mortality...
  41. doi request reprint Effectiveness of community case management of severe pneumonia with oral amoxicillin in children aged 2-59 months in Matiari district, rural Pakistan: a cluster-randomised controlled trial
    Sajid Soofi
    Division of Women and Child Health, Aga Khan University, Karachi, Pakistan
    Lancet 379:729-37. 2012
    ..We aimed to establish whether community case identification and management of severe pneumonia by oral antibiotics delivered through community health workers has the potential to reduce the number of infants dying at home...
  42. doi request reprint Community-based treatment of serious bacterial infections in newborns and young infants: a randomized controlled trial assessing three antibiotic regimens
    Anita K M Zaidi
    Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan
    Pediatr Infect Dis J 31:667-72. 2012
    ....
  43. ncbi request reprint Maternal health and survival in Pakistan: issues and options
    Yasir P Khan
    Division of Women and Child Health, The Aga Khan University, Karachi, Pakistan
    J Obstet Gynaecol Can 31:920-9. 2009
    ..Notwithstanding these observations, there are evidence-based interventions available that, if implemented at scale, could make important contributions towards reducing the burden of maternal mortality in Pakistan...
  44. ncbi request reprint Community-based interventions for improving perinatal and neonatal health outcomes in developing countries: a review of the evidence
    Zulfiqar A Bhutta
    Department of Pediatrics and Child Health, Aga Khan University, Stadium Road, Karachi 74800, Pakistan
    Pediatrics 115:519-617. 2005
    ..A comprehensive review of the evidence base for impact of interventions on neonatal health and survival in developing-country communities has not been reported...
  45. doi request reprint Linkages among reproductive health, maternal health, and perinatal outcomes
    Zulfiqar A Bhutta
    Division of Women and Child Health, The Aga Khan University, Karachi, Pakistan
    Semin Perinatol 34:434-45. 2010
    ..This would also allow for greater efficiency in training, monitoring, and supervision of health care workers and would also help families and communities to access and use services easily...
  46. doi request reprint Nutritional deficiencies in the developing world: current status and opportunities for intervention
    Yasir Khan
    Division of Women and Child Health, Aga Khan University, Stadium Road, PO Box 3500, Karachi 74800, Pakistan
    Pediatr Clin North Am 57:1409-41. 2010
    ..Three groups of underlying factors contribute to inadequate dietary intake and infectious disease: inadequate maternal and child care, household food insecurity, and poor health services in an unhealthy environment...
  47. pmc Effect of multiple micronutrient supplementation during pregnancy on maternal and birth outcomes
    Batool Azra Haider
    Division of Women and Child Health, The Aga Khan University, Karachi, Pakistan
    BMC Public Health 11:S19. 2011
    ....
  48. pmc Effect of routine iron supplementation with or without folic acid on anemia during pregnancy
    Mohammad Yawar Yakoob
    Division of Women and Child Health, The Aga Khan University, Karachi, Pakistan
    BMC Public Health 11:S21. 2011
    ..This article aims to address the impact of iron with and without folate supplementation on maternal anemia and provides outcome specific quality according to the Child Health Epidemiology Reference Group (CHERG) guidelines...
  49. pmc Impact of maternal education about complementary feeding and provision of complementary foods on child growth in developing countries
    Aamer Imdad
    Division of Women and Child Health, The Aga Khan University, Karachi, Pakistan
    BMC Public Health 11:S25. 2011
    ..Recommendations have been made for input to the Lives Saved Tool (LiST) model by following standardized guidelines developed by Child Health Epidemiology Reference Group (CHERG)...
  50. doi request reprint Parenting Skills and Emotional Availability: An RCT
    Aisha K Yousafzai
    Division of Women and Child Health, Department of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan
    Pediatrics 135:e1247-57. 2015
    ....
  51. doi request reprint Zinc supplementation fails to increase the immunogenicity of oral poliovirus vaccine: a randomized controlled trial
    M A Habib
    Aga Khan University, Karachi, Pakistan
    Vaccine 33:819-25. 2015
    ..Undernutrition and micronutrient deficiencies, especially zinc deficiency, are major public health problems in Pakistan and could potentially affect the response to enteric vaccines, including oral poliovirus vaccine (OPV)...
  52. doi request reprint Antibiotic therapy versus no antibiotic therapy for children aged two to 59 months with WHO-defined non-severe pneumonia and wheeze
    Zohra S Lassi
    Division of Women and Child Health, Aga Khan University Hospital, Stadium Road, PO Box 3500, Karachi, Pakistan, 74800
    Cochrane Database Syst Rev 5:CD009576. 2014
    ..Therefore, it is essential to explore the role of antibiotics in children with WHO-defined non-severe pneumonia and wheeze and to develop effective guidelines for initial antibiotic treatment...
  53. doi request reprint A study evaluating poliovirus antibodies and risk factors associated with polio seropositivity in low socioeconomic areas of Pakistan
    Ma Habib
    Aga Khan University, Karachi, Pakistan
    Vaccine 31:1987-93. 2013
    ..This paper describes the first population-based seroprevalence survey in Pakistan...
  54. pmc A study to evaluate the acceptability, feasibility and impact of packaged interventions ("Diarrhea Pack") for prevention and treatment of childhood diarrhea in rural Pakistan
    Muhammad Atif Habib
    Department of Paediatrics and Child Health, Women and Child Health Division, Aga Khan University, Karachi, Pakistan
    BMC Public Health 13:922. 2013
    ..This study sought to evaluate the acceptability, feasibility and impact of diarrhea Pack on diarrhea burden...
  55. doi request reprint Effects of calcium supplementation during pregnancy on maternal, fetal and birth outcomes
    Aamer Imdad
    Division of Women and Child Health, Aga Khan University, Karachi, Pakistan
    Paediatr Perinat Epidemiol 26:138-52. 2012
    ..67]). In conclusion, calcium supplementation during pregnancy is associated with a reduction in risk of gestational hypertensive disorders and pre-term birth and an increase in birthweight. There is no increased risk of kidney stones...
  56. pmc Child health and survival in the Eastern Mediterranean region
    Zulfiqar A Bhutta
    Department of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan
    BMJ 333:839-42. 2006
  57. doi request reprint Incidence and pattern of unintentional injuries and resulting disability among children under 5 years of age: results of the National Health Survey of Pakistan
    Zafar Fatmi
    Department of Community Health Sciences, Aga Khan University, Karachi, Pakistan
    Paediatr Perinat Epidemiol 23:229-38. 2009
    ..These results are useful for planning further research and for prioritising prevention programmes nationally and in other developing countries with similar situation...
  58. pmc Effect of preventive zinc supplementation on linear growth in children under 5 years of age in developing countries: a meta-analysis of studies for input to the lives saved tool
    Aamer Imdad
    Division of Women and Child Health, Aga Khan University, Karachi, Pakistan
    BMC Public Health 11:S22. 2011
    ..We have updated and evaluated the available evidence according to Grading of Recommendations, Assessment, Development and Evaluation (GRADE) criteria and tried to explain the difference in results of the previous reviews...
  59. pmc Effectiveness of interventions to screen and manage infections during pregnancy on reducing stillbirths: a review
    Sidra Ishaque
    Division of Women and Child Health, The Aga Khan University, Stadium Road, PO Box 3500, Karachi 74800, Pakistan
    BMC Public Health 11:S3. 2011
    ..This review presents the impact of interventions targeting various important infections during pregnancy on stillbirth or perinatal mortality...
  60. pmc Effect of balanced protein energy supplementation during pregnancy on birth outcomes
    Aamer Imdad
    Division of Women and Child Health, The Aga Khan University, Karachi, Pakistan
    BMC Public Health 11:S17. 2011
    ..This paper is a part of a series of reviews undertaken for getting estimates of effectiveness of an intervention for input to Lives Saved Tool (LiST) model...
  61. doi request reprint What works? Interventions for maternal and child undernutrition and survival
    Zulfiqar A Bhutta
    Aga Khan University, Karachi, Pakistan
    Lancet 371:417-40. 2008
    ..To eliminate stunting in the longer term, these interventions should be supplemented by improvements in the underlying determinants of undernutrition, such as poverty, poor education, disease burden, and lack of women's empowerment...
  62. doi request reprint Maternal micronutrient deficiencies in developing countries
    Zulfiqar A Bhutta
    Department of Paediatrics and Child Health, Aga Khan University, Karachi 74800, Pakistan
    Lancet 371:186-7. 2008
  63. pmc Prenatal exposure to wood fuel smoke and low birth weight
    AMNA R SIDDIQUI
    Department of Public Health Sciences, University of California, Davis, California, USA
    Environ Health Perspect 116:543-9. 2008
    ..Maternal exposure to wood fuel smoke may lead to impaired fetal growth due to hypoxia and or oxidative stress from smoke constituents such as carbon monoxide and particulate matter...
  64. ncbi request reprint A comparative evaluation of multiple micronutrient and iron-folic acid supplementation during pregnancy in Pakistan: impact on pregnancy outcomes
    Zulfiqar A Bhutta
    The Aga Khan University, Karachi, Pakistan
    Food Nutr Bull 30:S496-505. 2009
    ..Intervention strategies largely consist of administration of iron-folic acid supplements during pregnancy...
  65. pmc Delivering interventions to reduce the global burden of stillbirths: improving service supply and community demand
    Zulfiqar A Bhutta
    Division of Maternal and Child Health, The Aga Khan University, Karachi, Pakistan
    BMC Pregnancy Childbirth 9:S7. 2009
    ....
  66. doi request reprint Frequency of isolation of various subtypes and antimicrobial resistance of Shigella from urban slums of Karachi, Pakistan
    Afia Zafar
    Department of Pathology and Microbiology, Aga Khan University Hospitals, Stadium Road, PO Box 3500, Karachi 74800, Pakistan
    Int J Infect Dis 13:668-72. 2009
    ..Therefore we conducted a prospective study to determine the frequency of isolation of Shigella serotypes and antimicrobial resistance...
  67. pmc Current concepts in the diagnosis and treatment of typhoid fever
    Zulfiqar A Bhutta
    Department of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan
    BMJ 333:78-82. 2006
  68. ncbi request reprint Persistent and chronic diarrhea and malabsorption: Working Group report of the second World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition
    Zulfiqar A Bhutta
    J Pediatr Gastroenterol Nutr 39:S711-6. 2004
  69. doi request reprint Micronutrient needs of malnourished children
    Zulfiqar A Bhutta
    The Aga Khan University, Karachi, Pakistan
    Curr Opin Clin Nutr Metab Care 11:309-14. 2008
    ..This review focuses on recent advances in our understanding of undernutrition and micronutrient deficiencies during childhood from a review of the literature over the last 18 months (August 2006-January 2008)...
  70. doi request reprint Effect of administration of antihelminthics for soil-transmitted helminths during pregnancy
    Rehana A Salam
    Division of Women and Child Health, Aga Khan University Hospital, Stadium Road, PO Box 3500, Karachi, Sind, Pakistan, 74800
    Cochrane Database Syst Rev 6:CD005547. 2015
    ..Antihelminthics are highly efficacious in treating hook worm but evidence of their beneficial effect and safety, when given during pregnancy, has not been established...
  71. pmc Micronutrient fortification of food and its impact on woman and child health: a systematic review
    Jai K Das
    Centre of Excellence in Women and Child Health, Aga Khan University, Karachi 74800, Pakistan
    Syst Rev 2:67. 2013
    ..Food fortification is one of the strategies that has been used safely and effectively to prevent vitamin and mineral deficiencies...
  72. ncbi request reprint The effect of therapeutic zinc supplementation among young children with selected infections: a review of the evidence
    Batool A Haider
    Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan
    Food Nutr Bull 30:S41-59. 2009
    ..Zinc deficiency is now widely recognized as a leading risk factor for morbidity and mortality and is estimated to be responsible for approximately 800,000 excess deaths annually among children under 5 years of age...
  73. pmc Role of calcium supplementation during pregnancy in reducing risk of developing gestational hypertensive disorders: a meta-analysis of studies from developing countries
    Aamer Imdad
    Division of Women and Child Health, The Aga Khan University, Karachi, Pakistan
    BMC Public Health 11:S18. 2011
    ..The purpose of this review was to evaluate preventive effect of calcium supplementation during pregnancy on gestational hypertensive disorders and related maternal and neonatal mortality in developing countries...
  74. ncbi request reprint What does absorption capacity not measure?
    Zulfiqar A Bhutta
    Department of Paediatrics and Child Health, Aga Khan University, Karachi 74800, Pakistan
    Lancet 368:428-30. 2006
  75. ncbi request reprint Consecutive outbreaks of Vibrio cholerae O139 and V. cholerae O1 cholera in a fishing village near Karachi, Pakistan
    Fahad J Siddiqui
    Department of Paediatrics, Aga Khan University, P O Box 3500, Stadium Road, Karachi 74800, Pakistan
    Trans R Soc Trop Med Hyg 100:476-82. 2006
    ..Geographically, cases were clustered during the first outbreak but not during the second. Person-to-person contact and water reservoirs appear to be the main transmission routes for cholera in this setting...
  76. pmc Impact of interventions to prevent and manage preeclampsia and eclampsia on stillbirths
    Mehnaz Jabeen
    Division of Women and Child Health, The Aga Khan University, Stadium Road, PO Box 3500, Karachi 74800, Pakistan
    BMC Public Health 11:S6. 2011
    ..We sought to review the effect of aspirin, calcium supplementation, antihypertensive agents and magnesium sulphate on risk stillbirths...
  77. ncbi request reprint Tracking inequity: assessments of poverty-related outcomes
    Zulfiqar A Bhutta
    Department of Paediatrics and Child Health, Aga Khan University, Karachi 74800, Pakistan
    Lancet 369:804-6. 2007
  78. pmc A comparison of fluoroquinolones versus other antibiotics for treating enteric fever: meta-analysis
    Durrane Thaver
    Department of Paediatrics and Child Health, The Aga Khan University, PO Box 3500, Karachi 74800, Pakistan
    BMJ 338:b1865. 2009
    ..To review evidence supporting use of fluoroquinolones as first line agents over other antibiotics for treating typhoid and paratyphoid fever (enteric fever)...
  79. pmc Reducing length of stay in hospital for very low birthweight infants by involving mothers in a stepdown unit: an experience from Karachi (Pakistan)
    Zulfiqar A Bhutta
    Aga Khan University, Karachi 74800, Pakistan
    BMJ 329:1151-5. 2004
    ..The Aga Khan University Medical Center in Karachi, Pakistan, established a neonatal intensive care unit in 1987. By 1993-4, very low birthweight infants remained in hospital for 18-21 days...
  80. pmc Solar water disinfection in household settings: hype or hope?
    Zulfiqar A Bhutta
    Division of Women and Child Health, The Aga Khan University, Karachi, Pakistan
    PLoS Med 6:e1000127. 2009
  81. pmc Effect of screening and management of diabetes during pregnancy on stillbirths
    Madiha Syed
    Division of Women and Child Health, The Aga Khan University, Stadium Road, PO Box 3500, Karachi, Pakistan
    BMC Public Health 11:S2. 2011
    ..We reviewed the potential impact of early detection and control of diabetes mellitus during pregnancy on stillbirths for possible inclusion in the Lives Saved Tool (LiST)...
  82. ncbi request reprint Hospital-acquired neonatal infections in developing countries
    Anita K M Zaidi
    Department of Paediatrics and Child Health, Aga Khan University, Stadium Road, PO Box 3500, Karachi 74800, Pakistan
    Lancet 365:1175-88. 2005
    ..Low-cost, "bundled" interventions using systems quality improvement approaches for improved infection control are possible, but should be supported by evidence in developing country settings...
  83. pmc Elective induction for pregnancies at or beyond 41 weeks of gestation and its impact on stillbirths: a systematic review with meta-analysis
    Arwa Abbas Hussain
    Division of Women and Child Health, The Aga Khan University, Stadium Road, PO Box 3500, Karachi, Pakistan
    BMC Public Health 11:S5. 2011
    ..The purpose of this review was to study the possible impact of induction of labour (IOL) for post-term pregnancies compared to expectant management on stillbirths...
  84. pmc Maternal and child health: is South Asia ready for change?
    Zulfiqar A Bhutta
    Aga Khan University, Karachi 74800, Pakistan
    BMJ 328:816-9. 2004
  85. pmc Drug Resistant Infections in Poor Countries: A major burden on children
    Zulfiqar A Bhutta
    Department of Paediatrics and Child Health, The Aga Khan University, Karachi, Pakistan
    BMJ 336:948-9. 2008
  86. pmc Clinical utility of folate-containing oral contraceptives
    Zohra S Lassi
    Division of Women and Child Health, The Aga Khan University, Karachi, Pakistan
    Int J Womens Health 4:185-90. 2012
    ..It will also describe different modes of supplementing folate and the newer evidence of the effectiveness of adding folate in oral contraceptives for raising serum and red blood cell folate levels...
  87. pmc Schools as potential vaccination venue for vaccines outside regular EPI schedule: results from a school census in Pakistan
    Sajid Bashir Soofi
    Department of Pediatrics and Child Health, Aga Khan University, Karachi, Pakistan
    BMC Res Notes 5:6. 2012
    ..abstract:..
  88. ncbi request reprint Birth asphyxia in developing countries: current status and public health implications
    Batool Azra Haider
    Department of Paediatrics and Child Health, The Aga Khan University, Karachi, Pakistan
    Curr Probl Pediatr Adolesc Health Care 36:178-88. 2006
  89. pmc The Million Death Study in India: cam it help in monitoring the millennium development goals?
    Zulfiqar A Bhutta
    Department of Paediatrics and Child Health, Aga Khan University, Karachi, Pakistan
    PLoS Med 3:e103. 2006
  90. pmc Beyond informed consent
    Zulfiqar A Bhutta
    Aga Khan University, Karachi 74800, Pakistan
    Bull World Health Organ 82:771-7. 2004
    ..Further research is needed to examine the validity and user friendliness of innovations in information sharing procedures for obtaining consent in different cultural settings...
  91. pmc Dealing with childhood pneumonia in developing countries: how can we make a difference?
    Zulfiqar A Bhutta
    Department of Paediatrics and Child Health, The Aga Khan University, Karachi, Pakistan
    Arch Dis Child 92:286-8. 2007
  92. ncbi request reprint Zinc supplementation for the prevention of pneumonia in children aged 2 months to 59 months
    Zohra S Lassi
    Division of Women and Child Health, Aga Khan University Hospital, Stadium Road, PO Box 3500, Karachi, Pakistan, 74800
    Cochrane Database Syst Rev 12:CD005978. 2010
    ..Most deaths occur during infancy and in low-income countries. Daily regimens of zinc have been reported to prevent acute lower respiratory tract infection and reduce child mortality...
  93. doi request reprint Stillbirths: epidemiology, evidence, and priorities for action
    Mohammad Yawar Yakoob
    Division of Women and Child Health, The Aga Khan University, Karachi, Pakistan
    Semin Perinatol 34:387-94. 2010
    ..Other potential social and behavioral interventions include birth spacing, smoking cessation and indoor air pollution control, although the evidence for these is weak...
  94. ncbi request reprint Malnutrition and diarrhea: Working Group Report of the First World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition
    John N Udall Jr
    North American Society of Gastroenterology, Hepatology, and Nutrition, USA
    J Pediatr Gastroenterol Nutr 35:S173-9. 2002
  95. ncbi request reprint Neonatal survival: a call for action
    Jose Martines
    Department of Child and Adolescent Health and Development, WHO, Geneva, Switzerland
    Lancet 365:1189-97. 2005
    ..International donors and leaders of developing countries should be held accountable for meeting their commitments and increasing resources...
  96. ncbi request reprint Antimicrobial resistance in developing countries. Part I: recent trends and current status
    Iruka N Okeke
    Department of Biology, Haverford College, Haverford, PA, USA
    Lancet Infect Dis 5:481-93. 2005
    ..In part II, to be published next month, we will review potential containment strategies that could address this burgeoning problem...
  97. ncbi request reprint Antimicrobial resistance in developing countries. Part II: strategies for containment
    Iruka N Okeke
    Department of Biology, Haverford College, Haverford, PA, USA
    Lancet Infect Dis 5:568-80. 2005
    ....
  98. ncbi request reprint Can the world afford to save the lives of 6 million children each year?
    Jennifer Bryce
    Johns Hopkins University, Bloomberg School of Public Health, 615 North Wolfe Street, Baltimore, MD 21205, USA
    Lancet 365:2193-200. 2005
    ..Here we assess the cost of delivering these interventions, and discuss whether the achievement of the Millennium Development Goal (MDG) for child survival falls within the financial capacities of donors and developing countries...
  99. pmc Bridging the equity gap in maternal and child health
    Zulfiqar A Bhutta
    BMJ 331:585-6. 2005
  100. pmc Cost effectiveness analysis of strategies for maternal and neonatal health in developing countries
    Taghreed Adam
    Health Systems Financing, Evidence and Information for Policy, World Health Organization, Switzerland
    BMJ 331:1107. 2005
    ..To determine the costs and benefits of interventions for maternal and newborn health to assess the appropriateness of current strategies and guide future plans to attain the millennium development goals...
  101. pmc Salmonella paratyphi A rates, Asia
    R Leon Ochiai
    International Vaccine Institute, Kwanak PO Box 14, Seoul, South Korea 151 600
    Emerg Infect Dis 11:1764-6. 2005
    ..Paratyphi A. We compared their incidences by using standardized methods from population-based studies in China, Indonesia, India, and Pakistan...