Orish Ebere Orisakwe

Summary

Publications

  1. ncbi Testicular toxicity of rinbacin in rats
    Orish Ebere Orisakwe
    Department of Pharmacology, College of Health Sciences, Nnamdi Azikiwe University, Nnewi, Anambra State, Nigeria
    Biol Pharm Bull 25:206-8. 2002
  2. ncbi Investigation into the nephrotoxicity of Nigerian bonny light crude oil in albino rats
    O E Orisakwe
    Toxiocology Unit, Department of Pharmacology, College of Health Sciences, Nnamdi Azikiwe University, Anambra State, Nigeria
    Int J Environ Res Public Health 1:106-10. 2004
  3. ncbi Heavy metal hazards of sachet water in Nigeria
    Orish Ebere Orisakwe
    Toxicology Unit in the Department of Pharmacology, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria
    Arch Environ Occup Health 61:209-13. 2006
  4. pmc Arsenic and chromium in canned and non-canned beverages in Nigeria: a potential public health concern
    J M U Maduabuchi
    ZETA 12, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, P M B 5001, Nnewi, Anambra State, Nigeria
    Int J Environ Res Public Health 4:28-33. 2007
  5. pmc Heavy metals health risk assessment for population via consumption of food crops and fruits in Owerri, South Eastern, Nigeria
    Orish Ebere Orisakwe
    Toxicology Unit, Clinical Pharmacy Faculty of Pharmacy University of PortHacourt Rivers State Nigeria, PortHacourt, Nigeria
    Chem Cent J 6:77. 2012
  6. doi Lead and cadmium levels of commonly administered pediatric syrups in Nigeria: a public health concern?
    Orish Ebere Orisakwe
    Toxicology Unit, Department of Pharmacology, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Nnewi, Anambra State, Nigeria
    Sci Total Environ 407:5993-6. 2009
  7. ncbi Spermatoxic effects of operation sweep herbal supplement in male albino rats
    O E Orisakwe
    Toxicology Unit, Department of Clinical Pharmacy and Management, Faculty of Pharmaceutical Sciences, University of Port Harcourt, Rivers State, Nigeria
    J Basic Clin Physiol Pharmacol 21:147-56. 2010
  8. ncbi Environmental pollution and blood lead levels in Nigeria: who is unexposed?
    Orish Ebere Orisakwe
    Pharmacology Department, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria
    Int J Occup Environ Health 15:315-7. 2009
  9. ncbi Liver and kidney function tests amongst paint factory workers in Nkpor, Nigeria
    O E Orisakwe
    College of Health Sciences, Nnamdi Azikiwe University, P M B 5001, Nnewi, Anambra State, Nigeria
    Toxicol Ind Health 23:161-5. 2007
  10. ncbi Some plasma and saliva pharmacokinetics parameters of rifampicin in the presence of pefloxacin
    Orish E Orisakwe
    Biokinetics Research Group, Toxicology Unit, Department of Pharmacology, College of Health Sciences, Nnamdi Azikiwe University, Nnewi, Anambra State, Nigeria
    Am J Ther 11:283-7. 2004

Collaborators

  • John Kanayochukwu Nduka
  • Niladri Basu
  • Ejeatuluchukwu Obi
  • Onyenmechi Johnson Afonne
  • Rose Ngozi Asomugha
  • Francis Ifediata
  • Charles Okafor
  • Anthony Igwebe
  • Joy Ebenebe
  • Stanley Catherine Nonyelum
  • J M U Maduabuchi
  • Innocent O Igwilo
  • Chiaku Chinwe Chukwuogor
  • Nnaemeka Arinze Udowelle
  • Chinonso Judith Njoku
  • Ifeoma Victoria Ofoma
  • Samuel James Offor
  • Jerome O Nriagu
  • Onyenmechi J Afonne
  • Basu Nils
  • Jerome Nriagu
  • Chijoke Nwauche Ifeyinwa
  • Nwachukwu Nkem
  • E O Adigba
  • I P Okonkwo
  • C I Oragwu
  • C N Nzegwu
  • Ugwuona John Moses Maduabuchi
  • Tobias Ezejiofor
  • Chudi E Dioka
  • Ukoha Ukoha
  • Lasbery Asomugha
  • Chudi Emma Dioka
  • Gideon I Ndubuka

Detail Information

Publications31

  1. ncbi Testicular toxicity of rinbacin in rats
    Orish Ebere Orisakwe
    Department of Pharmacology, College of Health Sciences, Nnamdi Azikiwe University, Nnewi, Anambra State, Nigeria
    Biol Pharm Bull 25:206-8. 2002
    ..Rinbacin decreases the ESN and causes degenerative lesions, especially at the high dose, in prepubertal rats...
  2. ncbi Investigation into the nephrotoxicity of Nigerian bonny light crude oil in albino rats
    O E Orisakwe
    Toxiocology Unit, Department of Pharmacology, College of Health Sciences, Nnamdi Azikiwe University, Anambra State, Nigeria
    Int J Environ Res Public Health 1:106-10. 2004
    ..05) in creatinine in the high dose group (800mg/kg), and a significant decrease (p ? 0.05) in urea concentration. Histological examination indicates that crude oil induced severe pathologic changes in the forms of necrosis and oedema...
  3. ncbi Heavy metal hazards of sachet water in Nigeria
    Orish Ebere Orisakwe
    Toxicology Unit in the Department of Pharmacology, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria
    Arch Environ Occup Health 61:209-13. 2006
    ..003 to 0.050 mg/l. The biological oxygen demand of the samples ranged from 3.20 to 36.80 mg/L. Other parameters were normal. The authors found that some of the sachet waters contain heavy metals, and consumers may be exposed to hazards...
  4. pmc Arsenic and chromium in canned and non-canned beverages in Nigeria: a potential public health concern
    J M U Maduabuchi
    ZETA 12, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, P M B 5001, Nnewi, Anambra State, Nigeria
    Int J Environ Res Public Health 4:28-33. 2007
    ..This preliminary study highlights the need to study the toxicological implications of chronic low-level exposure to heavy metals from African markets...
  5. pmc Heavy metals health risk assessment for population via consumption of food crops and fruits in Owerri, South Eastern, Nigeria
    Orish Ebere Orisakwe
    Toxicology Unit, Clinical Pharmacy Faculty of Pharmacy University of PortHacourt Rivers State Nigeria, PortHacourt, Nigeria
    Chem Cent J 6:77. 2012
    ..Samples were washed, oven-dried at 70-80°C for 24 h and powdered. Samples were digested with perchloric acid and nitric acid. Metals were analysed with Unicam Atomic Absorption Spectrophotometer...
  6. doi Lead and cadmium levels of commonly administered pediatric syrups in Nigeria: a public health concern?
    Orish Ebere Orisakwe
    Toxicology Unit, Department of Pharmacology, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Nnewi, Anambra State, Nigeria
    Sci Total Environ 407:5993-6. 2009
    ....
  7. ncbi Spermatoxic effects of operation sweep herbal supplement in male albino rats
    O E Orisakwe
    Toxicology Unit, Department of Clinical Pharmacy and Management, Faculty of Pharmaceutical Sciences, University of Port Harcourt, Rivers State, Nigeria
    J Basic Clin Physiol Pharmacol 21:147-56. 2010
    ..5 and 2.25 g/kg. This study suggests that the aqueous extract of the OPS powder may cause epididymal toxicity as shown in the adverse effect on sperm quality...
  8. ncbi Environmental pollution and blood lead levels in Nigeria: who is unexposed?
    Orish Ebere Orisakwe
    Pharmacology Department, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Anambra State, Nigeria
    Int J Occup Environ Health 15:315-7. 2009
    ..Continued high BLLs in Nigeria cast doubt on researchers' ability to find real "unexposed control subjects" in future studies, and point to the importance of controlling environmental lead exposures...
  9. ncbi Liver and kidney function tests amongst paint factory workers in Nkpor, Nigeria
    O E Orisakwe
    College of Health Sciences, Nnamdi Azikiwe University, P M B 5001, Nnewi, Anambra State, Nigeria
    Toxicol Ind Health 23:161-5. 2007
    ..In conclusion, it should be noted that occupational exposure to cadmium or lead among PFW, may compromise the liver and renal functions in man...
  10. ncbi Some plasma and saliva pharmacokinetics parameters of rifampicin in the presence of pefloxacin
    Orish E Orisakwe
    Biokinetics Research Group, Toxicology Unit, Department of Pharmacology, College of Health Sciences, Nnamdi Azikiwe University, Nnewi, Anambra State, Nigeria
    Am J Ther 11:283-7. 2004
    ....
  11. ncbi Urinary excretion of rifampicin in the presence of ciprofloxacin
    Orish E Orisakwe
    Department of Pharmacology, College of Health Sciences, Nnamdi Azikiwe University, Nnewi, Anambra State, Nigeria
    Am J Ther 11:171-4. 2004
    ..The study indicates that rifampicin may be coadministered with ciprofloxacin to check the development of drug resistance to single-drug therapy by susceptible organisms...
  12. ncbi Testicular toxicity of Nigerian bonny light crude oil in male albino rats
    Orish Ebere Orisakwe
    Department of Pharmacology, College of Health Sciences, Nnamdi Azikiwe University, PMB 5001, Nnewi, Anambra State, Nigeria
    Reprod Toxicol 18:439-42. 2004
    ..This study suggests that the Nigerian bonny light crude oil is a testicular toxicant and its use as a folklore medicine may cause infertility...
  13. ncbi Testicular effects of sub-chronic administration of Hibiscus sabdariffa calyx aqueous extract in rats
    Orish Ebere Orisakwe
    Toxicology Unit, Department of Pharmacology, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Nnewi, Anambra State, Nigeria
    Reprod Toxicol 18:295-8. 2004
    ..The 4.6 g/kg dose group, on the other hand, showed disintegration of sperm cells. The results indicate that aqueous HS calyx extract induces testicular toxicity in rats...
  14. ncbi Effect of pefloxacin on the urinary excretion of rifampicin
    Orish E Orisakwe
    Department of Pharmacology, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, PMB 5001, Anambra State, Nigeria
    Am J Ther 11:13-6. 2004
    ..Pefloxacin increases the absorption and urinary excretion of rifampicin by decreasing the gastrointestinal motility through chelation mechanisms...
  15. doi Heavy metal contamination of foods by refuse dump sites in Awka, southeastern Nigeria
    John K C Nduka
    Pure and Industrial Chemistry Department, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria
    ScientificWorldJournal 8:941-8. 2008
    ..Taken together, we may conclude that the consumption of leafy vegetables and crops produced on contaminated soils may pose a health risk to those that reside around the refuse dumps...
  16. ncbi Toxicological study of the Anam River in Otuocha, Anambra State, Nigeria
    Innocent O Igwilo
    Department of Applied Biochemistry, Nnamdi Azikiwe University, Awka, Nigeria
    Arch Environ Occup Health 61:205-8. 2006
    ..00 +/- 1.73 mg/L, 14.44 +/- 3.13 mg/L, 19.33 +/- 0.67 ps cm-L, and 7.09 +/- 0.05, respectively. The World Health Organization guidelines for the parameters in soil were exceeded...
  17. ncbi Impact of effluents from a car battery manufacturing plant in Nigeria on water, soil, and food qualities
    Orish Ebere Orisakwe
    Department of Pharmacology, College of Health Sciences, Nnamdi Azikiwe University, Nnewi Campus, Nigeria
    Arch Environ Health 59:31-6. 2004
    ....
  18. ncbi Nitrate and nitrite levels of potable water supply in Warri, Nigeria: a public health concern
    John Kanayochukwu Nduka
    Nnamdi Azikwe University, Department of Pharmacology, College of Health Sciences, Anambra State, Nigeria
    J Environ Health 72:28-31. 2010
    ..This study suggests that indiscriminate disposal of waste and poor sanitation may be additional contributing factors in the nitrate pollution of the water supply in the Niger Delta area of Nigeria...
  19. doi Elevated prenatal methylmercury exposure in Nigeria: evidence from maternal and cord blood
    Ejeatuluchukwu Obi
    Faculty of Medicine, College of Health Sciences, Nnamdi Azikiwe University, Nnewi, Nigeria
    Chemosphere 119:485-9. 2015
    ..S. EPA) reference dose for mercury. The study shows that pregnant women and their newborns are exposed to methylmercury and that their exposures are higher compared to general populations sampled from other regions of the world...
  20. ncbi Effects of rinbacin extract on rat kidney
    Onyenmechi Johnson Afonne
    Department of Pharmacology, College of Health Sciences, Nnamdi Azikiwe University Nnewi, Anambra State, Nigeria
    Biol Pharm Bull 25:1022-5. 2002
    ..The effects were less marked in the low dose than the high dose group. Chronic administration of rinbacin extract induces nephrotoxicity in young rats...
  21. pmc Assessment of environmental distribution of lead in some municipalities of South-Eastern Nigeria
    John Kanayochukwu Nduka
    Environmental Chemistry and Toxicology Research Unit, Pure and Industrial Chemistry Department, Nnamdi Azikiwe University, Awka Anambra State, Nigeria
    Int J Environ Res Public Health 7:2501-13. 2010
    ..13-0.49 mg/kg and 0.15-0.47 mg/kg for 2007 and 2008, respectively. Rain samples had the least Pb concentration, ranging from 0.103 +/- 0.000 to 0.163 +/- 0.046 mg/L. We may conclude that Nigerians are exposed to environmental Pb...
  22. doi Water-quality issues in the Niger Delta of Nigeria: a look at heavy metal levels and some physicochemical properties
    John Kanayochukwu Nduka
    Environmental Chemistry and Toxicology Research Unit, Pure and Industrial Chemistry Department, Nnamdi Azikiwe University, P M B 5025, Nnewi, Awka Anambra State, Nigeria
    Environ Sci Pollut Res Int 18:237-46. 2011
    ..The present work is an improved attempt at a scientific discourse of water-quality issues in the Niger Delta of Nigeria with respect to heavy metal levels in surface water in view of the hitherto dearth of scientific data...
  23. doi Precipitation chemistry and occurrence of acid rain over the oil-producing Niger Delta region of Nigeria
    John K C Nduka
    Pure and Industrial Chemistry Department, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria
    ScientificWorldJournal 10:528-34. 2010
    ..Crude oil exploration and gas flaring in the Niger Delta, and multiplicity of cottage industries in Awka, impacted on the inorganic ion pollution of the rainwater. This may have public health implications in the region...
  24. pmc Metal concentrations in cosmetics commonly used in Nigeria
    Orish Ebere Orisakwe
    Toxicology Unit, Faculty of Pharmacy, University of Port Harcourt, Rivers State, Nigeria
    ScientificWorldJournal 2013:959637. 2013
    ..Regulatory Agencies in developing nations should take appropriate action for cosmetics that contain lead and cadmium beyond the reference limits...
  25. pmc Heavy metal hazards of pediatric syrup administration in Nigeria: a look at chromium, nickel and manganese
    John Kanayochukwu Nduka
    Environmental Chemistry and Toxicology Research Unit, Pure and Industrial Chemistry Department, Nnamdi Azikiwe University, P M B 5025, Awka Anambra State, Nigeria
    Int J Environ Res Public Health 6:1972-9. 2009
    ..The public health hazards from ingestion of these syrups should be identified and disclosed by in-depth risk assessment studies...
  26. ncbi Human health risk assessment of lead, manganese and copper from scrapped car paint dust from automobile workshops in Nigeria
    John Kanayochukwu Nduka
    Environmental Chemistry and Toxicology Research Unit, Pure and Industrial Chemistry Department, Nnamdi Azikiwe University, Awka, Anambra State, Nigeria
    Environ Sci Pollut Res Int 23:20341-20349. 2016
    ..39E-05 and 8.67E-10 for ingestion, inhalation and dermal exposures respectively. Chronic exposure to scrap car paint dusts may be of significant public health importance in Nigeria as this may add to the body burden of some heavy metals...
  27. ncbi Towards prenatal biomonitoring in eastern Nigeria: assessing lead levels and anthropometric parameters of newborns
    Ejeatuluchukwu Obi
    Faculty of Medicine, College of Health Sciences, Nnamdi Azikiwe University, Nigeria
    J UOEH 36:159-70. 2014
    ..With the exception of cord BLL and crown rump length positive correlation (R=0.204, P=0.026), neither the maternal nor the cord BLL showed any significant association with any of the children's anthropometric parameters. ..
  28. ncbi Heavy metals hazards from Nigerian spices
    Rose Ngozi Asomugha
    Department of Chemistry, Faculty of Science, Nnamdi Azikiwe University Awka, Anambra State, Nigeria
    Rocz Panstw Zakl Hig 67:309-14. 2016
    ..Natural spices are commonly used by the people in Nigeria. They may be easily contaminated with heavy metals when they are dried and then pose a health risk for the consumers...
  29. ncbi Potential hazards of toxic metals found in toothpastes commonly used in Nigeria
    Orish Ebere Orisakwe
    Toxicology Unit, Faculty of Pharmacy, University of Port Harcourt, Port Harcourt, Rivers State, Nigeria
    Rocz Panstw Zakl Hig 67:197-204. 2016
    ..They can however constitute a pos- sible source, amongst others, of toxic metal exposure in public health. Indeed, the public health impact of personal hygiene and consumer products is largely unknown...
  30. ncbi Safety warnings and first aid instructions on consumer and pharmaceutical products in Nigeria: has there been an improvement?
    Stanley Catherine Nonyelum
    Faculty of Pharmaceutical Sciences, University of Port Harcourt, Choba Port Harcourt, Rivers State Nigeria
    J Pak Med Assoc 60:801-4. 2010
    ..To investigate the adequacy of safety warnings and first aid instructions on the labels of pharmaceutical and consumer products in Nigeria...
  31. ncbi Nephrotoxic actions of low-dose mercury in mice: protection by zinc
    Onyenmechi J Afonne
    Department of Pharmacology, College of Health Sciences, Nnamdi Azikiwe University, Nwewi Campus, Nigeria
    Arch Environ Health 57:98-102. 2002
    ..The results indicate that low-dose mercury exposure in mice kidney induces some degenerative effects, which are prevented by zinc...