Christopher S Stevenson

Summary

Affiliation: Novartis Institutes for BioMedical Research

Publications

  1. ncbi Characterization of cigarette smoke-induced inflammatory and mucus hypersecretory changes in rat lung and the role of CXCR2 ligands in mediating this effect
    Christopher S Stevenson
    Novartis Institute of Biomedical Research, Respiratory Disease Area, Horsham, West Sussex, UK
    Am J Physiol Lung Cell Mol Physiol 288:L514-22. 2005
  2. ncbi Aerobic capacity, oxidant stress, and chronic obstructive pulmonary disease--a new take on an old hypothesis
    Christopher S Stevenson
    Novartis Institutes for BioMedical Research, Respiratory Disease Area, Wimblehurst Road, Horsham, West Sussex RH12 5AB, UK
    Pharmacol Ther 110:71-82. 2006
  3. pmc Pharmacological characterisation of anti-inflammatory compounds in acute and chronic mouse models of cigarette smoke-induced inflammation
    Wing Yan Heidi Wan
    Respiratory Disease Area, Novartis Institutes for BioMedical Research, Wimblehurst Road, Horsham RH12 5AB, UK
    Respir Res 11:126. 2010
  4. ncbi Comprehensive gene expression profiling of rat lung reveals distinct acute and chronic responses to cigarette smoke inhalation
    Christopher S Stevenson
    Respiratory Disease Area, Novartis Institutes for BioMedical Research, Horsham, West Sussex, United Kingdom
    Am J Physiol Lung Cell Mol Physiol 293:L1183-93. 2007
  5. doi Comparison of cigarette smoke-induced acute inflammation in multiple strains of mice and the effect of a matrix metalloproteinase inhibitor on these responses
    Abigail Morris
    Respiratory Disease Area, Novartis Institutes for BioMedical Research, Horsham, UK
    J Pharmacol Exp Ther 327:851-62. 2008
  6. ncbi Effect of adenosine A2A receptor activation in murine models of respiratory disorders
    Olivier Bonneau
    Respiratory Diseases Area, Novartis Institutes for BioMedical Research, Horsham, England, UK
    Am J Physiol Lung Cell Mol Physiol 290:L1036-43. 2006
  7. ncbi Cigarette smoke disrupts VEGF165-VEGFR-2 receptor signaling complex in rat lungs and patients with COPD: morphological impact of VEGFR-2 inhibition
    John A Marwick
    Department of Environmental Medicine, University of Rochester Medical Center, Box 850, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 290:L897-908. 2006
  8. ncbi Cigarette smoke alters chromatin remodeling and induces proinflammatory genes in rat lungs
    John A Marwick
    MRC Centre for Inflammation Research, Department of Environmental Medicine, University of Edinburgh, UK
    Am J Respir Cell Mol Biol 31:633-42. 2004

Collaborators

Detail Information

Publications8

  1. ncbi Characterization of cigarette smoke-induced inflammatory and mucus hypersecretory changes in rat lung and the role of CXCR2 ligands in mediating this effect
    Christopher S Stevenson
    Novartis Institute of Biomedical Research, Respiratory Disease Area, Horsham, West Sussex, UK
    Am J Physiol Lung Cell Mol Physiol 288:L514-22. 2005
    ..These observations represent a paradigm for the study of acute, repetitive lung insults that contribute to the development of chronic disease...
  2. ncbi Aerobic capacity, oxidant stress, and chronic obstructive pulmonary disease--a new take on an old hypothesis
    Christopher S Stevenson
    Novartis Institutes for BioMedical Research, Respiratory Disease Area, Wimblehurst Road, Horsham, West Sussex RH12 5AB, UK
    Pharmacol Ther 110:71-82. 2006
    ..Thus, those smokers who have the greatest aerobic capacity will be most resistant to the effects of chronic cigarette smoke exposure and be less likely to develop COPD...
  3. pmc Pharmacological characterisation of anti-inflammatory compounds in acute and chronic mouse models of cigarette smoke-induced inflammation
    Wing Yan Heidi Wan
    Respiratory Disease Area, Novartis Institutes for BioMedical Research, Wimblehurst Road, Horsham RH12 5AB, UK
    Respir Res 11:126. 2010
    ..Our aim was to determine whether the prophylactic effects of reference anti-inflammatory compounds in acute mouse smoking models reflected their therapeutic effects in (more clinically relevant) chronic systems...
  4. ncbi Comprehensive gene expression profiling of rat lung reveals distinct acute and chronic responses to cigarette smoke inhalation
    Christopher S Stevenson
    Respiratory Disease Area, Novartis Institutes for BioMedical Research, Horsham, West Sussex, United Kingdom
    Am J Physiol Lung Cell Mol Physiol 293:L1183-93. 2007
    ..As such, it appears that metabolic pathways are central to dealing with the stress of CS exposure; however, over time, inflammation and stress response gene sets become the most significantly affected in the chronic response to CS...
  5. doi Comparison of cigarette smoke-induced acute inflammation in multiple strains of mice and the effect of a matrix metalloproteinase inhibitor on these responses
    Abigail Morris
    Respiratory Disease Area, Novartis Institutes for BioMedical Research, Horsham, UK
    J Pharmacol Exp Ther 327:851-62. 2008
    ..In addition, the ability of broad-spectrum MMP inhibitors to inhibit smoke-induced acute neutrophil inflammation is strain-dependent, whereas its ability to limit macrophage infiltration may be route dependent...
  6. ncbi Effect of adenosine A2A receptor activation in murine models of respiratory disorders
    Olivier Bonneau
    Respiratory Diseases Area, Novartis Institutes for BioMedical Research, Horsham, England, UK
    Am J Physiol Lung Cell Mol Physiol 290:L1036-43. 2006
    ..Together, these results suggest that activation of the A(2A) receptor would have a beneficial effect by inhibiting inflammatory cell influx and downregulating inflammatory cell activation in asthma and COPD, respectively...
  7. ncbi Cigarette smoke disrupts VEGF165-VEGFR-2 receptor signaling complex in rat lungs and patients with COPD: morphological impact of VEGFR-2 inhibition
    John A Marwick
    Department of Environmental Medicine, University of Rochester Medical Center, Box 850, 601 Elmwood Avenue, Rochester, NY 14642, USA
    Am J Physiol Lung Cell Mol Physiol 290:L897-908. 2006
    ..However, targeted therapies to restore VEGF(165)-VEGFR-2 complex may promote endothelial cell survival and help to ameliorate emphysema...
  8. ncbi Cigarette smoke alters chromatin remodeling and induces proinflammatory genes in rat lungs
    John A Marwick
    MRC Centre for Inflammation Research, Department of Environmental Medicine, University of Edinburgh, UK
    Am J Respir Cell Mol Biol 31:633-42. 2004
    ..These findings suggest a possible molecular mechanism by which cigarette smoke drives proinflammatory gene transcription and an inflammatory response in the lungs...