Affiliation: Novartis Institutes for BioMedical Research
- Establishment and maintenance of DNA methylation patterns in mammalsT Chen
Epigenetics Program, Novartis Institutes for BioMedical Research, Cambridge, MA 02139, USA
Curr Top Microbiol Immunol 301:179-201. 2006..This review focuses on recent advances in defining the functional domains of DNA methyltransferases and identifying interacting proteins that may contribute to the functional specializations of these enzymes...
- OctreoTher: ongoing early clinical development of a somatostatin-receptor-targeted radionuclide antineoplastic therapyM C Smith
Novartis Pharmaceuticals Corporation, East Hanover, NJ 07936 1080, USA
Digestion 62:69-72. 2000..A fixed-dose regimen of 120 mCi/cycle x 3 cycles administered with concomitant amino acid infusion has been chosen for the study. Phase I data and published literature support that this fixed dose regimen will be safely tolerated...
- Effect of small-sized liposomal Adriamycin administered by various routes on a metastatic breast cancer modelJ H Chen
Department of Vascular and Endocrine Surgery, First Affiliated Hospital of the Fourth Military Medical University, Xi an, Shaanxi Province, China
Endocr Relat Cancer 12:93-100. 2005..c. route to that by the conventional i.v. route can be recommended as a promising procedure to enhance chemotherapeutic effects in patients with metastatic breast cancer...