Guro Valen

Summary

Affiliation: University of Oslo
Country: Norway

Publications

  1. pmc Innate immunity and remodelling
    Guro Valen
    Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Postbox 1103 Blindern, 0317, Oslo, Norway
    Heart Fail Rev 16:71-8. 2011
  2. ncbi request reprint Preoperative unstable angina causes venous adaptation to surgical graft injury
    Guro Valen
    Institute of Basic Medical Science, Dept of Physiology University of Oslo, 1103 Blindern, 0317, Oslo, Norway
    Basic Res Cardiol 102:265-73. 2007
  3. doi request reprint Cardioprotection by hypoxia-inducible factor 1 alpha transfection in skeletal muscle is dependent on haem oxygenase activity in mice
    Gabor Czibik
    Department of Physiology, IMB, Institute of Basic Medical Sciences, University of Oslo, PO Box 1103, Blindern, NO 0317 Oslo, Norway
    Cardiovasc Res 82:107-14. 2009
  4. doi request reprint Aquaporin-1 in cardiac endothelial cells is downregulated in ischemia, hypoxia and cardioplegia
    Arkady Rutkovskiy
    Department of Emergency and Intensive Care at the Institute of Clinical Medicine, University of Oslo, Postbox 1171 Blindern, 0318 Oslo, Norway
    J Mol Cell Cardiol 56:22-33. 2013
  5. doi request reprint Gene therapy with hypoxia-inducible factor 1 alpha in skeletal muscle is cardioprotective in vivo
    Gabor Czibik
    Dept of Physiology, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    Life Sci 88:543-50. 2011
  6. doi request reprint Expression of bone morphogenetic protein 4 and its receptors in the remodeling heart
    Xueping Wu
    Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Norway
    Life Sci 97:145-54. 2014
  7. doi request reprint Preconditioning effects of steroids and hyperoxia on cardiac ischemia-reperfusion injury and vascular reactivity
    Mari Liis Kaljusto
    Department of Cardiothoracic Surgery, Faculty Division Ulleval University Hospital, Oslo, Norway
    Eur J Cardiothorac Surg 33:355-63. 2008
  8. doi request reprint Connective tissue growth factor/CCN2 attenuates β-adrenergic receptor responsiveness and cardiotoxicity by induction of G protein-coupled receptor kinase-5 in cardiomyocytes
    Jørgen Gravning
    Institute for Surgical Research, Oslo University Hospital and University of Oslo, Oslo, Norway
    Mol Pharmacol 84:372-83. 2013
  9. doi request reprint In vivo remote delivery of DNA encoding for hypoxia-inducible factor 1 alpha reduces myocardial infarct size
    Gabor Czibik
    Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    Clin Transl Sci 2:33-40. 2009
  10. ncbi request reprint Myocardial protection evoked by hyperoxic exposure involves signaling through nitric oxide and mitogen activated protein kinases
    Arno Ruusalepp
    Institute of Basic Medical Science, Dept of Physiology University of Oslo, Oslo, Norway
    Basic Res Cardiol 102:318-26. 2007

Collaborators

Detail Information

Publications50

  1. pmc Innate immunity and remodelling
    Guro Valen
    Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Postbox 1103 Blindern, 0317, Oslo, Norway
    Heart Fail Rev 16:71-8. 2011
    ....
  2. ncbi request reprint Preoperative unstable angina causes venous adaptation to surgical graft injury
    Guro Valen
    Institute of Basic Medical Science, Dept of Physiology University of Oslo, 1103 Blindern, 0317, Oslo, Norway
    Basic Res Cardiol 102:265-73. 2007
    ..This response was reduced in grafts from patients with unstable angina, indicating a possible systemic preconditioning-like effect of acute coronary syndromes...
  3. doi request reprint Cardioprotection by hypoxia-inducible factor 1 alpha transfection in skeletal muscle is dependent on haem oxygenase activity in mice
    Gabor Czibik
    Department of Physiology, IMB, Institute of Basic Medical Sciences, University of Oslo, PO Box 1103, Blindern, NO 0317 Oslo, Norway
    Cardiovasc Res 82:107-14. 2009
    ..The present study investigates whether the cardioprotection achieved by gene delivery of hypoxia-inducible factor-1 alpha (HIF-1 alpha) depends on the downstream factor haem oxygenase (HMOX)-1...
  4. doi request reprint Aquaporin-1 in cardiac endothelial cells is downregulated in ischemia, hypoxia and cardioplegia
    Arkady Rutkovskiy
    Department of Emergency and Intensive Care at the Institute of Clinical Medicine, University of Oslo, Postbox 1171 Blindern, 0318 Oslo, Norway
    J Mol Cell Cardiol 56:22-33. 2013
    ..AQP1 in mouse hearts is localized to endothelial cell membranes and caveolae. Cardioplegia, ischemia and hypoxia decrease AQP1 mRNA as well as total protein expression and glycosylation, possibly regulated by miR-214...
  5. doi request reprint Gene therapy with hypoxia-inducible factor 1 alpha in skeletal muscle is cardioprotective in vivo
    Gabor Czibik
    Dept of Physiology, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    Life Sci 88:543-50. 2011
    ..We investigated if remote delivery of DNA encoding for HIF-1α is protective against myocardial ischemia-reperfusion injury in vivo...
  6. doi request reprint Expression of bone morphogenetic protein 4 and its receptors in the remodeling heart
    Xueping Wu
    Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Norway
    Life Sci 97:145-54. 2014
    ..We investigated if the expression of BMP4 and its receptors BMPR1a and BMPR2 were activated in post-infarction remodeling and heart failure...
  7. doi request reprint Preconditioning effects of steroids and hyperoxia on cardiac ischemia-reperfusion injury and vascular reactivity
    Mari Liis Kaljusto
    Department of Cardiothoracic Surgery, Faculty Division Ulleval University Hospital, Oslo, Norway
    Eur J Cardiothorac Surg 33:355-63. 2008
    ....
  8. doi request reprint Connective tissue growth factor/CCN2 attenuates β-adrenergic receptor responsiveness and cardiotoxicity by induction of G protein-coupled receptor kinase-5 in cardiomyocytes
    Jørgen Gravning
    Institute for Surgical Research, Oslo University Hospital and University of Oslo, Oslo, Norway
    Mol Pharmacol 84:372-83. 2013
    ..In conclusion, this study uncovers a novel mechanism controlling β-AR responsiveness in cardiomyocytes involving CTGF-mediated regulation of GRK5...
  9. doi request reprint In vivo remote delivery of DNA encoding for hypoxia-inducible factor 1 alpha reduces myocardial infarct size
    Gabor Czibik
    Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    Clin Transl Sci 2:33-40. 2009
    ..In conclusion, remote delivery of DNA for HIF-1 alpha was cardioprotective, represented by consistent infarct size reduction, which may be due to release of paracrine factors from the transfected muscle...
  10. ncbi request reprint Myocardial protection evoked by hyperoxic exposure involves signaling through nitric oxide and mitogen activated protein kinases
    Arno Ruusalepp
    Institute of Basic Medical Science, Dept of Physiology University of Oslo, Oslo, Norway
    Basic Res Cardiol 102:318-26. 2007
    ..We studied a possible role of nitric oxide (NO) and mitogen activated protein kinases (MAPK) in hyperoxic protection...
  11. doi request reprint Expression of retinoic acid target genes in coronary artery disease
    Dusan Bilbija
    Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    Int J Mol Med 33:677-86. 2014
    ..ATRA accumulated in the failing human heart. All investigated cell types present in the heart had induced expression of RA target genes when stimulated with ATRA, which also influenced cell proliferation. ..
  12. doi request reprint Human adaptation to ischemia by preconditioning or unstable angina: involvement of nuclear factor kappa B, but not hypoxia-inducible factor 1 alpha in the heart
    Gabor Czibik
    Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    Eur J Cardiothorac Surg 34:976-84. 2008
    ..We hypothesized that preceding unstable angina and/or ischemic preconditioning activated genes regulated by nuclear factor kappa B (NFkappaB) or hypoxia-inducible factor 1 alpha in parallel to improved cardiac function...
  13. doi request reprint Extracellular mtDNA activates NF-κB via toll-like receptor 9 and induces cell death in cardiomyocytes
    Marte Bliksøen
    Department of Molecular Medicine, Faculty of Medicine, Institute of Basic Medical Sciences, University of Oslo UiO, Oslo, Norway
    Basic Res Cardiol 111:42. 2016
    ..In cardiomyocytes, mtDNA causes mitochondrial dysfunction and death. Endogenous mtDNA in the extracellular space is a danger signal with direct detrimental effects on cardiomyocytes. ..
  14. doi request reprint Cardiac aquaporins
    Arkady Rutkovskiy
    Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Postbox 1103, Blindern, 0371, Oslo, Norway
    Basic Res Cardiol 108:393. 2013
    ..However, they might still prove to be attractive targets for therapy directed to reduce myocardial edema and injury caused by ischemia and reperfusion. ..
  15. doi request reprint Transient hyperosmolality modulates expression of cardiac aquaporins
    Arkady Rutkovskiy
    Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Postboks 1103 Blindern, 0317 Oslo, Norway
    Biochem Biophys Res Commun 425:70-5. 2012
    ..The aim of our study was to investigate if plasma hyperosmolality may regulate cardiac expression of AQP1 and -4, and if so, at which magnitude and time frame such regulation takes place...
  16. doi request reprint Aquaporin-4 in the heart: expression, regulation and functional role in ischemia
    Arkady Rutkovskiy
    Institute of Experimental Medical Research, Institute for Clinical Medicine, University of Oslo, Oslo, Norway
    Basic Res Cardiol 107:280. 2012
    ..AQP4 mRNA expression is downregulated by hypoxia and ischemia. Deletion of AQP4 is protective in acute myocardial ischemia-reperfusion, and this molecule might be a future target in the treatment of acute myocardial infarction...
  17. doi request reprint Mechanisms of novel cardioprotective functions of CCN2/CTGF in myocardial ischemia-reperfusion injury
    M Shakil Ahmed
    Institute for Surgical Research, Department of Cardiology, Center for Heart Failure Research, Oslo University Hospital Rikshospitalet, University of Oslo, Norway
    Am J Physiol Heart Circ Physiol 300:H1291-302. 2011
    ..This report provides novel evidence that CTGF confers cardioprotection by salvage phosphokinase signaling leading to inhibition of GSK-3β activities, activation of phospho-SMAD2, and reprogramming of gene expression...
  18. doi request reprint Higher TNFα responses in young males compared to females are associated with attenuation of monocyte adenylyl cyclase expression
    Petter K Risøe
    Institute for Surgical Research, Oslo University Hospital Rikshospitalet, Oslo, Norway Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Norway
    Hum Immunol 76:427-30. 2015
    ..01 for both isoforms). These data indicate that the stronger TNFα-responses in young males may be partly associated with male-specific down-regulation of adenylyl cyclases...
  19. doi request reprint The p66ShcA adaptor protein regulates healing after myocardial infarction
    Anton Baysa
    Division of Physiology, Department of Molecular Medicine, Institute of Basic Medical Science, University of Oslo, Postbox 1103, Blindern, 0317, Oslo, Norway
    Basic Res Cardiol 110:13. 2015
    ..Upon myocardial infarction p66ShcA regulates MMP-2 activation. The role of p66ShcA in human cardiac disease deserves further study as a potential target for reducing adverse cardiac remodeling post-infarction. ..
  20. doi request reprint Innate immunity and myocardial adaptation to ischemia
    Hanne Støre Valeur
    Institute of Basic Medical Sciences, Department of Physiology, University of Oslo, Blindern, Oslo, Norway
    Basic Res Cardiol 104:22-32. 2009
    ..The possibility that the underlying protective response may involve adaptive immunity through danger signaling is briefly reviewed...
  21. pmc Interleukin-17 (IL-17) expression is reduced during acute myocardial infarction: role on chemokine receptor expression in monocytes and their in vitro chemotaxis towards chemokines
    Maria Troitskaya
    Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Oslo N 0317, Norway
    Toxins (Basel) 4:1427-39. 2012
    ..e., MCP-1/CCL2, and the ligand for CXCR4, i.e., SDF-1α/CXCL12. Our results support the possibility that IL-17 may be beneficial in MI, and this could be due to its ability to inhibit the migration of monocytes...
  22. pmc Retinoic acid signalling is activated in the postischemic heart and may influence remodelling
    Dusan Bilbija
    Department of Physiology, University of Oslo, Oslo, Norway
    PLoS ONE 7:e44740. 2012
    ..We hypothesized that the retinoic acid (RA) signalling pathway is activated in myocardial ischemia and postischemic remodelling...
  23. doi request reprint Cecal ligation and puncture sepsis is associated with attenuated expression of adenylyl cyclase 9 and increased miR142-3p
    Petter K Risøe
    Institute for Surgical Research, Oslo University Hospital Rikshospitalet, University of Oslo, Oslo, Norway
    Shock 36:390-5. 2011
    ..These results indicate that CLP leads to miR142-3p-mediated AC9 reduction in liver macrophages, which may further limit cyclic 3'5'-adenosine monophosphate signaling and the ability of macrophages to resolve the proinflammatory response...
  24. doi request reprint Extracardiac approaches to protecting the heart
    Guro Valen
    Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, Postbox 1103 Blindern, 0317 Oslo, Norway
    Eur J Cardiothorac Surg 35:651-7. 2009
    ..Other approaches to myocardial protection, using cell transfer, gene therapy, and microRNA, are briefly commented on...
  25. doi request reprint Remote transplantation of mesenchymal stem cells protects the heart against ischemia-reperfusion injury
    Mihai Bogdan Preda
    Institute of Cellular Biology and Pathology Nicolae Simionescu of the Romanian Academy, Bucharest, Romania Department of Biochemistry, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway Department of Physiology, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Oslo, Norway
    Stem Cells 32:2123-34. 2014
    ..Remote transplantation of MSC can be considered as an alternative procedure to induce cardioprotection...
  26. doi request reprint A novel glutamate transporter blocker, LL-TBOA, attenuates ischaemic injury in the isolated, perfused rat heart despite low transporter levels
    Vladimir Martinov
    Department of Physiology, Institute of Basic Medical Science, University of Oslo, Oslo, Norway
    Eur J Cardiothorac Surg 45:710-6. 2014
    ..Our objective was to study whether EAATs were expressed in the rat heart and to study whether blocking of transporter operation during cardiac ischaemia could be beneficial...
  27. ncbi request reprint Postconditioning in rats and mice
    Mari Liis Kaljusto
    Department of Cardiothoracic Surgery, Ulleval University Hospital, Oslo, Norway
    Scand Cardiovasc J 40:334-41. 2006
    ..For subsequent studies on the molecular mechanisms of postconditioning, we aimed to identify a robust postconditioning protocol in rat and mouse heart...
  28. ncbi request reprint Gene deletion of NF-kappaB p105 enhances neointima formation in a mouse model of carotid artery injury
    Arno Ruusalepp
    Institute of Basic Medical Sciences, Department of Physiology, University of Oslo, Norway
    Cardiovasc Drugs Ther 20:103-11. 2006
    ..These data indicate that the p105 subunit of NF-kappaB plays an essential role in vascular healing, and defects in NF-kappaB p105 promote neointima hyperplasia...
  29. doi request reprint Increased expression of monocarboxylate transporter 1 after acute ischemia of isolated, perfused mouse hearts
    Vladimir Martinov
    Department of Physiology, Institute of Basic Medical Sciences, University of Oslo, 0317 Oslo, Norway
    Life Sci 85:379-85. 2009
    ..This study investigated the expression and functional role of MCT1 in mouse hearts during acute myocardial ischemia...
  30. ncbi request reprint Pre- and postconditioning during cardiac surgery
    Guro Valen
    Institute of Basic Medical Science, Department of Physiology University of Oslo, 1103 Blindern, 0317 Oslo, Norway
    Basic Res Cardiol 100:179-86. 2005
    ..Possible common signaling pathways of the two phenomena are discussed, and suggested directions for clinical studies are outlined...
  31. ncbi request reprint Nitric oxide mediates protective effect of endothelin receptor antagonism during myocardial ischemia and reperfusion
    Adrian T Gonon
    Department of Cardiology, Karolinska Hospital, 171 76 Stockholm, Sweden
    Am J Physiol Heart Circ Physiol 286:H1767-74. 2004
    ..In conclusion, the dual ETA/ETB receptor antagonist bosentan preserved endothelial and cardiac contractile function during ischemia and reperfusion via a mechanism dependent on endothelial NO production...
  32. ncbi request reprint Small skin burn injury reduces cardiac tolerance to ischemia via a tumor necrosis factor alpha-dependent pathway
    Fausto Labruto
    Crafoord Laboratory for Experimental Surgery, Karolinska University Hospital, Stockholm, Sweden
    Burns 33:606-12. 2007
    ..We hypothesized that small burns affect cardiac tolerance to ischemia, and that tumor necrosis factor alpha (TNFalpha) signaling through endothelin-1 (ET) and nuclear factor kappa B (NF kappaB) are associated...
  33. ncbi request reprint Spontaneous ischemic events in the brain and heart adapt the hearts of severely atherosclerotic mice to ischemia
    Shinichi Tokuno
    Crafoord Laboratory Department of Thoracic Surgery, Karolinska Hospital, Stockholm, Sweden
    Arterioscler Thromb Vasc Biol 22:995-1001. 2002
    ..These findings suggest that spontaneous ischemic events in the brain and heart adapt the heart to ischemia. This can be mimicked by induced brain ischemia, with iNOS as a key factor of protection...
  34. ncbi request reprint Intraperitoneal injection induces a delayed preconditioning-like effect in mice
    Fausto Labruto
    Crafoord Laboratory for Experimental Surgery, Karolinska Institute, Stockholm, Sweden
    Lab Anim 39:298-307. 2005
    ..The mechanism of protection remains to be determined...
  35. ncbi request reprint Myocardial protection by remote preconditioning: the role of nuclear factor kappa-B p105 and inducible nitric oxide synthase
    Guohu Li
    Crafoord Laboratory for Experimental Surgery L6 00, Karolinska Hospital, S 17176 Stockholm, Sweden
    Eur J Cardiothorac Surg 26:968-73. 2004
    ..The present study investigates a possible role for NFkappaB and inducible nitric oxide synthase (iNOS) in adaption to ischemia by remote, delayed protection...
  36. ncbi request reprint Role of tumor necrosis factor alpha and its receptor I in preconditioning by hyperoxia
    Fausto Labruto
    Crafoord Laboratory, L6 00, Karolinska Hospital, 17176 Stockholm, Sweden
    Basic Res Cardiol 100:198-207. 2005
    ..The contractile response to TNFalpha on aortic rings was attenuated by hyperoxic pretreatment and by TNFRI -/-. Thus we conclude that TNFalpha, acting through TNFRI, appears important for the protective effects of hyperoxia...
  37. ncbi request reprint Ischemic postconditioning: brief ischemia during reperfusion converts persistent ventricular fibrillation into regular rhythm
    Michael Galagudza
    Department of Pathophysiology and Laboratory of Circulation, St Petersburg I P Pavlov Federal Medical University, Russian Federation
    Eur J Cardiothorac Surg 25:1006-10. 2004
    ..This phenomenon has been termed ischemic postconditioning. In the present study, we studied the possible effect of postconditioning on persistent reperfusion-induced ventricular fibrillation (VF) in the isolated rat heart model...
  38. ncbi request reprint Vein graft harvesting induces inflammation and impairs vessel reactivity
    Kazuhiro Hinokiyama
    Crafoord Laboratory, Karolinska Hospital, Stockholm, Sweden
    Ann Thorac Surg 82:1458-64. 2006
    ..The surgical procedure may contribute to graft injury. Our aim was to study the impact of surgical handling of saphenous veins on graft inflammation and vascular function...
  39. ncbi request reprint Isoflurane and other commonly used anaesthetics do not protect the isolated buffer perfused mouse heart from ischemia-reperfusion injury
    Michael Galagudza
    Department of Pathophysiology, St Petersburg IP Pavlov Federal Medical University, St Petersburg, Russian Federation
    Clin Exp Pharmacol Physiol 33:315-9. 2006
    ..In mice, isoflurane as well as pentobarbital, opioids and benzodiazepines may be safely used for anaesthesia without a risk of protective side-effects in isolated mouse heart studies...
  40. ncbi request reprint Effects of spontaneous or induced brain ischemia on vessel reactivity: the role of inducible nitric oxide synthase
    Shinichi Tokuno
    Crafoord Laboratory of Experimental Surgery L6 00, Karolinska Hospital, 17176, Stockholm, Sweden
    Life Sci 71:679-92. 2002
    ..These findings suggest that induced brain ischemia as a model of delayed, remote preconditioning protects vessel reactivity, and this protection is mediated by iNOS...
  41. ncbi request reprint The basic biology of apoptosis and its implications for cardiac function and viability
    Guro Valen
    Crafoord Laboratory of Experimental Surgery, Karolinska Hospital, Stockholm, Sweden
    Ann Thorac Surg 75:S656-60. 2003
    ..Apoptosis appears to be induced by myocardial ischemia-reperfusion injury and this is reduced by ischemic preconditioning. Antiapoptotic interventions may be a future target for myocardial protection...
  42. ncbi request reprint Preconditioning and cardiac surgery
    Jarle Vaage
    Department of Thoracic Surgery, Karolinska Hospital, Stockholm, Sweden
    Ann Thorac Surg 75:S709-14. 2003
    ..If the "preconditioning response" is to be exploited in cardiac surgery, targeting the underlying molecular mechanisms must provide easily applicable techniques or drugs, which are shown in large scale clinical studies to be beneficial...
  43. ncbi request reprint Hyperoxia elicits myocardial protection through a nuclear factor kappaB-dependent mechanism in the rat heart
    Peeter Tähepõld
    Crafoord Laboratory of Experimental Surgery, Karolinska Hospital, Stockholm, Sweden
    J Thorac Cardiovasc Surg 125:650-60. 2003
    ..In the present study we investigated whether the cardioprotective effects of hyperoxia were dependent on the redox-sensitive transcription factor nuclear factor kappaB...
  44. ncbi request reprint Deficiency of nitric oxide synthase 2 results in increased neointima formation in a mouse model of vascular injury
    Allan Sirsjo
    Crafoord Laboratory of Experimental Surgery Department of Thoracic Surgery, Karolinska Hospital, Stockholm, Sweden
    J Cardiovasc Pharmacol 41:897-902. 2003
    ..14 and P < 0.01, respectively). Inhibition of NOS2 by two different approaches increased neointima formation in a mouse model of mechanical vessel injury, indicating that the NOS2 expressed in the injured vessel wall is beneficial...
  45. ncbi request reprint Signal transduction through nuclear factor kappa B in ischemia-reperfusion and heart failure
    Guro Valen
    Center for Physiological Gene Function, Karolinska Institute, Von Eulersväg 8, 17177, Stockholm, Sweden
    Basic Res Cardiol 99:1-7. 2004
    ..The present paper reviews the basic regulation of NFkappaB, and the possible role of NFkappaB activation in ischemia-reperfusion injury, in adaptation to ischemia-reperfusion injury, and in chronic heart failure...
  46. ncbi request reprint ADAMTS-4 and -8 are inflammatory regulated enzymes expressed in macrophage-rich areas of human atherosclerotic plaques
    Dick Wågsäter
    Atherosclerosis Research Unit, King Gustav V Research Institute, Department of Medicine, Karolinska Institute, Stockholm, Sweden
    Atherosclerosis 196:514-22. 2008
    ..ADAMTS expression was also examined during atherosclerosis development in mice and in human atherosclerotic plaques...
  47. ncbi request reprint Expression of matrix metalloproteinase 9 and its regulators in the unstable coronary atherosclerotic plaque
    Fei Chen
    Crafoord Laboratory, South Hospital, Stockholm, Sweden
    Int J Mol Med 15:57-65. 2005
    ..Plasma MMP9 antigen was elevated in unstable patients. MMP9 is expressed in the unstable coronary atherosclerotic plaque, as are its transcriptional and posttranscriptional regulators...
  48. ncbi request reprint Cellular signalling mechanisms in adaptation to ischemia-induced myocardial damage
    Guro Valen
    Center for Physiological Gene Function, Institution of Physiology and Pharmacology, Karolinska Institute, Stockholm, Sweden
    Ann Med 35:300-7. 2003
    ..Understanding the underlying mechanisms of action is crucial to making therapeutic use of this powerful mode of myocardial protection...
  49. ncbi request reprint Caught in the act: in vivo molecular imaging of the transcription factor NF-kappaB after myocardial infarction
    Jochen Tillmanns
    Medizinische Klinik der Universität Würzburg, Germany
    Biochem Biophys Res Commun 342:773-4. 2006
    ..Thus, in vivo measurement of the activation of NF-kappaB is feasible. NF-kappaB activity might play an important role for the remodeling process...
  50. ncbi request reprint Apoptosis and angiogenesis are induced in the unstable coronary atherosclerotic plaque
    Fei Chen
    Crafoord Laboratory of Experimental Surgery, Karolinska Institute, South Hospital, Stockholm, Sweden
    Coron Artery Dis 16:191-7. 2005
    ..In this study, we investigated if apoptosis and angiogenesis were induced in the unstable human coronary atherosclerotic plaque compared to stable atherosclerotic plaque...