Inger Sandlie

Summary

Affiliation: University of Oslo
Country: Norway

Publications

  1. pmc Stabilizing mutations increase secretion of functional soluble TCR-Ig fusion proteins
    Elin Lunde
    Department of Molecular Biosciences, Centre for Immune Regulation, University of Oslo, Oslo 0316, Norway
    BMC Biotechnol 10:61. 2010
  2. ncbi request reprint Identification of a polymeric Ig receptor binding phage-displayed peptide that exploits epithelial transcytosis without dimeric IgA competition
    Ranveig Braathen
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, Rikshospitalet University Hospital, N 0027 Oslo, Norway
    J Biol Chem 281:7075-81. 2006
  3. pmc Cross-species binding analyses of mouse and human neonatal Fc receptor show dramatic differences in immunoglobulin G and albumin binding
    Jan Terje Andersen
    Department of Molecular Biosciences and Centre for Immune Regulation, University of Oslo, P O Box 1041, N 0371 Oslo, Norway
    J Biol Chem 285:4826-36. 2010
  4. ncbi request reprint Processing of an antigenic sequence from IgG constant domains for presentation by MHC class II
    Morten Flobakk
    Department of Molecular Biosciences, University of Oslo, Oslo, Norway
    J Immunol 181:7062-72. 2008
  5. doi request reprint Ligand binding and antigenic properties of a human neonatal Fc receptor with mutation of two unpaired cysteine residues
    Jan T Andersen
    Department of Molecular Biosciences and Centre for Immune Regulation, University of Oslo, Norway
    FEBS J 275:4097-110. 2008
  6. ncbi request reprint A strategy for bacterial production of a soluble functional human neonatal Fc receptor
    Jan Terje Andersen
    Department of Molecular Biosciences, University of Oslo, Oslo, Norway
    J Immunol Methods 331:39-49. 2008
  7. ncbi request reprint Induction of central T cell tolerance: recombinant antibodies deliver peptides for deletion of antigen-specific (CD4+)8+ thymocytes
    Karoline Western Schjetne
    Institute of Immunology, University of Oslo, Rikshospitalet University Hospital, Oslo, Norway
    Eur J Immunol 35:3142-52. 2005
  8. doi request reprint FcRn binding properties of an abnormal truncated analbuminemic albumin variant
    Jan Terje Andersen
    Department of Molecular Biosciences and Centre for Immune Regulation, University of Oslo, 0316 Oslo, Norway
    Clin Biochem 43:367-72. 2010
  9. doi request reprint Identification of a high affinity FcgammaRIIA-binding peptide that distinguishes FcgammaRIIA from FcgammaRIIB and exploits FcgammaRIIA-mediated phagocytosis and degradation
    Gøril Berntzen
    Department of Molecular Biosciences, University of Oslo, Oslo, Norway
    J Biol Chem 284:1126-35. 2009
  10. ncbi request reprint MHC class II loading of high or low affinity peptides directed by Ii/peptide fusion constructs: implications for T cell activation
    Tone F Gregers
    Division of Cell and Molecular Biology, Department of Biology, University of Oslo, N 0316 Oslo, Norway
    Int Immunol 15:1291-9. 2003

Collaborators

Detail Information

Publications24

  1. pmc Stabilizing mutations increase secretion of functional soluble TCR-Ig fusion proteins
    Elin Lunde
    Department of Molecular Biosciences, Centre for Immune Regulation, University of Oslo, Oslo 0316, Norway
    BMC Biotechnol 10:61. 2010
    ..They are structurally unrelated with different variable (V), diversity (D) and joining (J) segments, but each share one V gene segment, either Vα or Vβ, with the well characterized murine TCR, 2C...
  2. ncbi request reprint Identification of a polymeric Ig receptor binding phage-displayed peptide that exploits epithelial transcytosis without dimeric IgA competition
    Ranveig Braathen
    Laboratory for Immunohistochemistry and Immunopathology LIIPAT, Institute of Pathology, University of Oslo, Rikshospitalet University Hospital, N 0027 Oslo, Norway
    J Biol Chem 281:7075-81. 2006
    ..This implied that the C9A peptide sequence may be exploited for pIgR-mediated epithelial transport without interfering with secretory immunity...
  3. pmc Cross-species binding analyses of mouse and human neonatal Fc receptor show dramatic differences in immunoglobulin G and albumin binding
    Jan Terje Andersen
    Department of Molecular Biosciences and Centre for Immune Regulation, University of Oslo, P O Box 1041, N 0371 Oslo, Norway
    J Biol Chem 285:4826-36. 2010
    ..Such distinct cross-species FcRn binding differences must be taken into consideration when IgG- and albumin-based therapeutics and diagnostics are evaluated in rodents for their pharmacokinetics...
  4. ncbi request reprint Processing of an antigenic sequence from IgG constant domains for presentation by MHC class II
    Morten Flobakk
    Department of Molecular Biosciences, University of Oslo, Oslo, Norway
    J Immunol 181:7062-72. 2008
    ..Comparing loop 4C(H)2 with loop 6C(H)1 mutants after injection of Ab in BALB/c mice, the former was by far the most efficient and induced specific T cell activation at concentrations at least 100-fold lower than loop 6C(H)1...
  5. doi request reprint Ligand binding and antigenic properties of a human neonatal Fc receptor with mutation of two unpaired cysteine residues
    Jan T Andersen
    Department of Molecular Biosciences and Centre for Immune Regulation, University of Oslo, Norway
    FEBS J 275:4097-110. 2008
    ..This finding will greatly facilitate the selection and characterization of such binders...
  6. ncbi request reprint A strategy for bacterial production of a soluble functional human neonatal Fc receptor
    Jan Terje Andersen
    Department of Molecular Biosciences, University of Oslo, Oslo, Norway
    J Immunol Methods 331:39-49. 2008
    ..This method may be easily adapted for the expression of large amounts of other FcRn species and MHC class I related molecules...
  7. ncbi request reprint Induction of central T cell tolerance: recombinant antibodies deliver peptides for deletion of antigen-specific (CD4+)8+ thymocytes
    Karoline Western Schjetne
    Institute of Immunology, University of Oslo, Rikshospitalet University Hospital, Oslo, Norway
    Eur J Immunol 35:3142-52. 2005
    ..These experiments suggest that Troybodies constructed to target specifically thymic APC could be useful tools for induction and maintenance of central T cell tolerance in autoimmune diseases...
  8. doi request reprint FcRn binding properties of an abnormal truncated analbuminemic albumin variant
    Jan Terje Andersen
    Department of Molecular Biosciences and Centre for Immune Regulation, University of Oslo, 0316 Oslo, Norway
    Clin Biochem 43:367-72. 2010
    ..Such variants may have altered FcRn binding properties that affect their half-life, biodistribution and thereby transport ability...
  9. doi request reprint Identification of a high affinity FcgammaRIIA-binding peptide that distinguishes FcgammaRIIA from FcgammaRIIB and exploits FcgammaRIIA-mediated phagocytosis and degradation
    Gøril Berntzen
    Department of Molecular Biosciences, University of Oslo, Oslo, Norway
    J Biol Chem 284:1126-35. 2009
    ..It is thus overlapping but not identical to that of IgG. Neither activating receptors FcgammaRI and FcgammaRIII, nor FcgammaRIIB, all of which lack Phe(163), bound the peptide...
  10. ncbi request reprint MHC class II loading of high or low affinity peptides directed by Ii/peptide fusion constructs: implications for T cell activation
    Tone F Gregers
    Division of Cell and Molecular Biology, Department of Biology, University of Oslo, N 0316 Oslo, Norway
    Int Immunol 15:1291-9. 2003
    ..This probably reflects the number of class II/peptide complexes at the cell surface and is discussed...
  11. ncbi request reprint DNA vaccines increase immunogenicity of idiotypic tumor antigen by targeting novel fusion proteins to antigen-presenting cells
    Agnete B Fredriksen
    Institute of Immunology, University of Oslo, Rikshospitalet and Rikshospitalet University Hospital, Sognsvannsvn 20, 0027 Oslo, Norway
    Mol Ther 13:776-85. 2006
    ..Targeting to APC was essential for these effects. The results show that immunogenicity of plasmid DNA vaccines can be increased by inducing muscle to secrete proteins that target antigen to APC...
  12. pmc Expanding the versatility of phage display I: efficient display of peptide-tags on protein VII of the filamentous phage
    Geir Åge Løset
    Centre for Immune Regulation, University of Oslo, Oslo, Norway
    PLoS ONE 6:e14702. 2011
    ..Display on other coat proteins such as pVII allows for display of heterologous peptide sequences on the virions in addition to those displayed on pIII and pVIII. In addition, pVII display is an alternative to pIII or pVIII display...
  13. pmc Periplasmic expression of soluble single chain T cell receptors is rescued by the chaperone FkpA
    Kristin S Gunnarsen
    Centre for Immune Regulation, University of Oslo, Oslo, Norway
    BMC Biotechnol 10:8. 2010
    ..Here we present an optimized periplasmic bacterial expression system for soluble single chain (sc) TCRs...
  14. pmc Expanding the versatility of phage display II: improved affinity selection of folded domains on protein VII and IX of the filamentous phage
    Geir Åge Løset
    Centre for Immune Regulation, University of Oslo, Oslo, Norway
    PLoS ONE 6:e17433. 2011
    ..Thus, display on other coat proteins such as pVII or pIX might be more attractive. Neither pVII nor pIX display have gained widespread use or been characterized in detail like pIII and pVIII display...
  15. ncbi request reprint Prolonged and increased expression of soluble Fc receptors, IgG and a TCR-Ig fusion protein by transiently transfected adherent 293E cells
    Gøril Berntzen
    Department of Molecular Biosciences, University of Oslo, P O Box 1041, 0316, Oslo, Norway
    J Immunol Methods 298:93-104. 2005
    ..The approach should be of interest to laboratories that do not have access to a bioreactor but still have a requirement for reasonable amounts of protein to be produced in an easy and cost-effective manner...
  16. ncbi request reprint The cytoplasmic tail of invariant chain modulates antigen processing and presentation
    Tone F Gregers
    Division of Molecular Cell Biology, Department of Biology, University of Oslo, Oslo, Norway
    Eur J Immunol 33:277-86. 2003
    ..Mol. Biol. Cell 2002). Together, the data reveal an additional property of the Iip33 cytoplasmic tail that contributes to the modulation of antigen processing and presentation...
  17. doi request reprint Posttranslational modification of gluten shapes TCR usage in celiac disease
    Shuo Wang Qiao
    Department of Immunology, Centre for Immune Regulation, University of Oslo, 0027 Oslo, Norway
    J Immunol 187:3064-71. 2011
    ..The findings have implications for understanding T cell responses to posttranslationally modified Ags...
  18. ncbi request reprint The versatile MHC class I-related FcRn protects IgG and albumin from degradation: implications for development of new diagnostics and therapeutics
    Jan Terje Andersen
    Department of Molecular Biosciences and Centre for Immune Regulation, University of Oslo, Oslo, Norway
    Drug Metab Pharmacokinet 24:318-32. 2009
    ..This review summarizes our current understanding of FcRn function and discusses its relevance for development of new IgG and albumin based therapeutics and diagnostics...
  19. doi request reprint Reliable titration of filamentous bacteriophages independent of pIII fusion moiety and genome size by using trypsin to restore wild-type pIII phenotype
    Geir Åge Løset
    Department of Molecular Biosciences, University of Oslo, Oslo, Norway
    Biotechniques 44:551-2, 554. 2008
    ..The results show that the trypsin treatment has a very large but heterogeneous effect on the phage infection efficiency, depending on the pIII fusion domain and the valence of display...
  20. ncbi request reprint Differential segmental flexibility and reach dictate the antigen binding mode of chimeric IgD and IgM: implications for the function of the B cell receptor
    Geir A Løset
    Department of Molecular Biosciences, University of Oslo, Oslo, Norway
    J Immunol 172:2925-34. 2004
    ..The dissociation rate, however, was slower for IgM at high epitope density and for IgD at low epitope density. Taken together, the results show that IgM and IgD with identical Ag binding regions have different Ag binding properties...
  21. ncbi request reprint The conserved histidine 166 residue of the human neonatal Fc receptor heavy chain is critical for the pH-dependent binding to albumin
    Jan Terje Andersen
    Department of Molecular Biosciences, University of Oslo, Oslo, Norway
    Eur J Immunol 36:3044-51. 2006
    ..Our results show clear evidence that the conserved H166 is a key player in the FcRn-albumin interaction...
  22. ncbi request reprint Efficient delivery of T cell epitopes to APC by use of MHC class II-specific Troybodies
    Elin Lunde
    Institute of Immunology, University of Oslo, National Hospital, P O Box 1050 Blindern, N 0316 Oslo, Norway
    J Immunol 168:2154-62. 2002
    ..The study shows that class II-specific Troybodies can deliver a variety of T cell epitopes to professional APC for efficient presentation, in vitro as well as in vivo. Thus, Troybodies may be useful as tools in vaccine development...
  23. ncbi request reprint The carboxyl-terminal domains of IgA and IgM direct isotype-specific polymerization and interaction with the polymeric immunoglobulin receptor
    Ranveig Braathen
    Laboratory of Immunohistochemistry and Immunopathology, Institute of Pathology, University of Oslo, Rikshospitalet, N 0027 Oslo, Norway
    J Biol Chem 277:42755-62. 2002
    ..This recombinant molecule formed J chain-containing pentamers that could, like IgA, efficiently form covalent complexes with the human pIgR ectodomain, known as secretory component...
  24. pmc Structure-based mutagenesis reveals the albumin-binding site of the neonatal Fc receptor
    Jan Terje Andersen
    Centre for Immune Regulation and Department of Molecular Biosciences, University of Oslo, Oslo N 0316, Norway
    Nat Commun 3:610. 2012
    ..Molecular details of the FcRn-albumin complex may guide the development of novel albumin variants with altered serum half-life as carriers of drugs...