Leiv Ose

Summary

Affiliation: University of Oslo
Country: Norway

Publications

  1. ncbi request reprint Diagnostic, clinical, and therapeutic aspects of familial hypercholesterolemia in children
    Leiv Ose
    Lipid Clinic, Department of Medicine, Rikshospitalet, Oslo, Norway
    Semin Vasc Med 4:51-7. 2004
  2. ncbi request reprint Familial hypercholesterolemia from children to adults
    Leiv Ose
    Lipid Clinic, Department of Medicine, Rikshospitalet, Oslo, Norway
    Cardiovasc Drugs Ther 16:289-93. 2002
  3. ncbi request reprint Consistency of lipid-altering effects of ezetimibe/simvastatin across gender, race, age, baseline low density lipoprotein cholesterol levels, and coronary heart disease status: results of a pooled retrospective analysis
    Leiv Ose
    Lipid Clinic, Medical Department, Rikshospitalet, Oslo, Norway
    Curr Med Res Opin 22:823-35. 2006
  4. pmc Subjects with low plasma HDL cholesterol levels are characterized by an inflammatory and oxidative phenotype
    Kirsten B Holven
    Department of Nutrition, Institute for Basic Medical Sciences, University of Oslo, Oslo, Norway Faculty of Medicine, University of Oslo, Oslo, Norway
    PLoS ONE 8:e78241. 2013
  5. doi request reprint Cholesterol efflux mediators in homozygous familial hypercholesterolemia patients on low-density lipoprotein apheresis
    Marit S Nenseter
    Lipid Clinic, Oslo University Hospital Rikshospitalet, Oslo, Norway
    J Clin Lipidol 7:109-16. 2013
  6. doi request reprint Subjects with familial hypercholesterolemia are characterized by an inflammatory phenotype despite long-term intensive cholesterol lowering treatment
    Kirsten B Holven
    Department of Nutrition, Institute for Basic Medical Sciences, University of Oslo, Oslo, Norway Faculty of Medicine, University of Oslo, Oslo, Norway Electronic address
    Atherosclerosis 233:561-7. 2014
  7. ncbi request reprint Effects of ezetimibe/simvastatin on lipoprotein subfractions in patients with primary hypercholesterolemia: an exploratory analysis of archived samples using two commercially available techniques
    Leiv Ose
    Lipid Clinic, Medical Department, Rikshospitalet, Oslo, Norway
    Clin Ther 29:2419-32. 2007
  8. doi request reprint Cystatin C levels in plasma and peripheral blood mononuclear cells among hyperhomocysteinaemic subjects: effect of treatment with B-vitamins
    Kari Anne R Tobin
    Lipid Clinic, Oslo University Hospital, Rikshospitalet, Oslo, Norway
    Br J Nutr 102:1783-9. 2009
  9. doi request reprint Lipoprotein(a) levels in coronary heart disease-susceptible and -resistant patients with familial hypercholesterolemia
    Marit S Nenseter
    Lipid Clinic, Oslo University Hospital, Rikshospitalet, 0424 Oslo, Norway
    Atherosclerosis 216:426-32. 2011
  10. doi request reprint HypoCol (red yeast rice) lowers plasma cholesterol - a randomized placebo controlled study
    Martin Prøven Bogsrud
    Lipid Clinic, Rikshospitalet, Oslo University Hospital, Oslo, Norway
    Scand Cardiovasc J 44:197-200. 2010

Collaborators

Detail Information

Publications39

  1. ncbi request reprint Diagnostic, clinical, and therapeutic aspects of familial hypercholesterolemia in children
    Leiv Ose
    Lipid Clinic, Department of Medicine, Rikshospitalet, Oslo, Norway
    Semin Vasc Med 4:51-7. 2004
    ..Pravastatin, simvastatin, and atorvastatin decrease LDL-C 30 to 40% without serious adverse events and have a high degree of compliance...
  2. ncbi request reprint Familial hypercholesterolemia from children to adults
    Leiv Ose
    Lipid Clinic, Department of Medicine, Rikshospitalet, Oslo, Norway
    Cardiovasc Drugs Ther 16:289-93. 2002
    ..An update on several aspects on familial hypercholesterolemia (FH) such as molecular basis, DNA diagnosis, clinical criteria for the diagnosis, treatment of adults and children and psychosocial aspects of FH is presented...
  3. ncbi request reprint Consistency of lipid-altering effects of ezetimibe/simvastatin across gender, race, age, baseline low density lipoprotein cholesterol levels, and coronary heart disease status: results of a pooled retrospective analysis
    Leiv Ose
    Lipid Clinic, Medical Department, Rikshospitalet, Oslo, Norway
    Curr Med Res Opin 22:823-35. 2006
    ..The purpose of this pooled analysis was to evaluate the consistency of efficacy (i.e., between-treatment difference) of EZE/SIMVA versus SIMVA within several selected subgroups of patients with primary hypercholesterolemia...
  4. pmc Subjects with low plasma HDL cholesterol levels are characterized by an inflammatory and oxidative phenotype
    Kirsten B Holven
    Department of Nutrition, Institute for Basic Medical Sciences, University of Oslo, Oslo, Norway Faculty of Medicine, University of Oslo, Oslo, Norway
    PLoS ONE 8:e78241. 2013
    ....
  5. doi request reprint Cholesterol efflux mediators in homozygous familial hypercholesterolemia patients on low-density lipoprotein apheresis
    Marit S Nenseter
    Lipid Clinic, Oslo University Hospital Rikshospitalet, Oslo, Norway
    J Clin Lipidol 7:109-16. 2013
    ..Early initiation of aggressive cholesterol-lowering therapy is essential to prevent premature coronary heart disease. Selective removal of low-density lipoprotein (LDL) by LDL apheresis is a reliable method of treatment...
  6. doi request reprint Subjects with familial hypercholesterolemia are characterized by an inflammatory phenotype despite long-term intensive cholesterol lowering treatment
    Kirsten B Holven
    Department of Nutrition, Institute for Basic Medical Sciences, University of Oslo, Oslo, Norway Faculty of Medicine, University of Oslo, Oslo, Norway Electronic address
    Atherosclerosis 233:561-7. 2014
    ..Statin treatment may normalize LDL-cholesterol levels, but it is not known if the inflammatory responses are normalized in statin-treated FH patients...
  7. ncbi request reprint Effects of ezetimibe/simvastatin on lipoprotein subfractions in patients with primary hypercholesterolemia: an exploratory analysis of archived samples using two commercially available techniques
    Leiv Ose
    Lipid Clinic, Medical Department, Rikshospitalet, Oslo, Norway
    Clin Ther 29:2419-32. 2007
    ..Ezetimibe/simvastatin (E/S) is an efficacious lipid-lowering treatment that inhibits both the intestinal absorption and biosynthesis of cholesterol...
  8. doi request reprint Cystatin C levels in plasma and peripheral blood mononuclear cells among hyperhomocysteinaemic subjects: effect of treatment with B-vitamins
    Kari Anne R Tobin
    Lipid Clinic, Oslo University Hospital, Rikshospitalet, Oslo, Norway
    Br J Nutr 102:1783-9. 2009
    ....
  9. doi request reprint Lipoprotein(a) levels in coronary heart disease-susceptible and -resistant patients with familial hypercholesterolemia
    Marit S Nenseter
    Lipid Clinic, Oslo University Hospital, Rikshospitalet, 0424 Oslo, Norway
    Atherosclerosis 216:426-32. 2011
    ..The aim of the present study was to search for risk markers among FH patients...
  10. doi request reprint HypoCol (red yeast rice) lowers plasma cholesterol - a randomized placebo controlled study
    Martin Prøven Bogsrud
    Lipid Clinic, Rikshospitalet, Oslo University Hospital, Oslo, Norway
    Scand Cardiovasc J 44:197-200. 2010
    ..The primary endpoint in our study was to investigate the effect of a red yeast rice (RYR) product on plasma lipids...
  11. doi request reprint Dietary counseling is associated with an improved lipid profile in children with familial hypercholesterolemia
    Kristin Torvik
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway The Lipid Clinic, Oslo University Hospital, Oslo, Norway
    Atherosclerosis 252:21-7. 2016
    ..The aim of the study was to describe the diet of FH children with respect to fat quality, and to investigate if dietary counseling improved lipid profile...
  12. doi request reprint Elevated serum MMP-9/TIMP-1 ratio in patients with homozygous familial hypercholesterolemia: effects of LDL-apheresis
    Marit S Nenseter
    Lipid Clinic, Oslo University Hospital Rikshospitalet, and Department of Nutrition, Institute for Basic Medical Sciences, University of Oslo, Oslo, Norway
    Cytokine 61:194-8. 2013
    ....
  13. doi request reprint Long-term treatment with pitavastatin is effective and well tolerated by patients with primary hypercholesterolemia or combined dyslipidemia
    Leiv Ose
    Lipid Clinic, Rikshospitalet, Oslo University Hospital, Oslo N 0027, Norway
    Atherosclerosis 210:202-8. 2010
    ..The secondary objectives were to assess the effect on lipid and lipoprotein fractions and ratios, and LDL-C target attainment...
  14. doi request reprint Evidence for impaired physiological decrease in the uteroplacental vascular resistance in pregnant women with familial hypercholesterolemia
    Janette Khoury
    Department of Obstetrics and Gynecology, Rikshospitalet University Hospital, Oslo, Norway
    Acta Obstet Gynecol Scand 88:222-6. 2009
    ..We conclude that pregnancy in FH might be associated with attenuated physiological decrease in mean PI of uterine arteries, possibly reflecting increased uteroplacental vascular resistance unrelated to plasma LDL-cholesterol levels...
  15. ncbi request reprint The dual peroxisome proliferator-activated receptor alpha/gamma agonist tesaglitazar further improves the lipid profile in dyslipidemic subjects treated with atorvastatin
    Serena Tonstad
    Department of Preventive Cardiology, Ulleval University Hospital, N 0407, Oslo, Norway
    Metabolism 56:1285-92. 2007
    ..In conclusion, the addition of tesaglitazar to a background of atorvastatin therapy further improved the dyslipidemia associated with insulin resistance...
  16. doi request reprint Maternal inheritance does not predict cholesterol levels in children with familial hypercholesterolemia
    Ingunn Narverud
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, P O Box 1046 Blindern, 0317, Oslo, Norway Lipid Clinic, Oslo University Hospital Rikshospitalet, P O Box 4950 Nydalen, 0424, Oslo, Norway
    Atherosclerosis 243:155-60. 2015
    ..We investigated the impact of maternal familial hypercholesterolemia (FH) on pre-treatment plasma lipids and C-reactive protein (CRP) levels in non-statin treated FH children...
  17. doi request reprint Maternal familial hypercholesterolaemia (FH) confers altered haemostatic profile in offspring with and without FH
    Ingunn Narverud
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    Thromb Res 131:178-82. 2013
    ....
  18. ncbi request reprint Altered hemostatic balance and endothelial activation in pregnant women with familial hypercholesterolemia
    Agot L Amundsen
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    Thromb Res 120:21-7. 2007
    ..However, whether hemostatic and endothelial activation markers are increased in pregnant FH women compared with non-FH pregnancies, is unknown...
  19. ncbi request reprint Impaired inhibitory effect of interleukin-10 on the balance between matrix metalloproteinase-9 and its inhibitor in mononuclear cells from hyperhomocysteinemic subjects
    Kirsten B Holven
    Lipid Clinic, Rikshospitalet University Hospital, Oslo, Norway
    Stroke 37:1731-6. 2006
    ....
  20. doi request reprint Long-term follow-up of young adults with familial hypercholesterolemia after participation in clinical trials during childhood
    Gisle Langslet
    Lipid Clinic, Division of Medicine, Oslo University Hospital, Oslo, Norway Electronic address
    J Clin Lipidol 9:778-85. 2015
    ..There are little long-term data on patients with familial hypercholesterolemia (FH) who initiated lipid-lowering therapy during childhood...
  21. ncbi request reprint Lipid management and cholesterol goal attainment in Norway
    Leiv Ose
    Lipid Clinic, Department of Medicine, Rikshospitalet, Oslo, Norway
    Am J Cardiovasc Drugs 6:121-8. 2006
    ..To document prescribing patterns of lipid-modifying therapies in hypercholesterolemic patients, cholesterol goal attainment, and factors associated with cholesterol goal attainment in Norway...
  22. doi request reprint Comparison of pitavastatin with simvastatin in primary hypercholesterolaemia or combined dyslipidaemia
    Leiv Ose
    Medical Department, Lipid Clinic, Rikshospitalet, Oslo University Hospital, Oslo, Norway
    Curr Med Res Opin 25:2755-64. 2009
    ....
  23. doi request reprint Diagnosis of familial hypercholesterolemia in general practice using clinical diagnostic criteria or genetic testing as part of cascade genetic screening
    Trond P Leren
    Medical Genetics Laboratory, Department of Medical Genetics, Rikshospitalet Radiumhospitalet Medical Center, Oslo, Norway
    Community Genet 11:26-35. 2008
    ..Too few familial hypercholesterolemia (FH) patients are diagnosed. The most cost-effective strategy to diagnose FH is to examine first-degree relatives of already diagnosed patients. This is referred to as cascade genetic screening...
  24. doi request reprint Screening methods in the diagnosis and assessment of children and adolescents with familial hypercholesterolemia
    Gisle Langslet
    Lipid Clinic, Medical Department, Oslo University Hospital, Oslo, Norway
    Expert Rev Cardiovasc Ther 11:1061-6. 2013
    ..Family cascade screening has been estimated to be the most cost-effective screening method. No general pediatric screening program has been tested on a larger scale, validated or subjected to cost-benefit analyses. ..
  25. ncbi request reprint Exposure of atorvastatin is unchanged but lactone and acid metabolites are increased several-fold in patients with atorvastatin-induced myopathy
    Monica Hermann
    Department of Pharmaceutical Biosciences, School of Pharmacy, University of Oslo, and Lipid Clinic, Rikshospitalet, Norway
    Clin Pharmacol Ther 79:532-9. 2006
    ..This is the first study to investigate whether the pharmacokinetics of either atorvastatin or its metabolites, or both, is altered in patients with atorvastatin-related myopathy compared with healthy controls...
  26. ncbi request reprint Missense mutations in the PCSK9 gene are associated with hypocholesterolemia and possibly increased response to statin therapy
    Knut Erik Berge
    Department of Medical Genetics, Rikshospitalet University Hospital, Oslo, Norway
    Arterioscler Thromb Vasc Biol 26:1094-100. 2006
    ..Also, the cholesterol-lowering effect of statins could be increased in subjects carrying mutations in the PCSK9 gene...
  27. ncbi request reprint Triglyceride-rich HDL3 from patients with familial hypercholesterolemia are less able to inhibit cytokine release or to promote cholesterol efflux
    Inger O Ottestad
    Lipid Clinic, Rikshospitalet University Hospital, Norway
    J Nutr 136:877-81. 2006
    ..These triglyceride rich-HDL3 might be partly responsible for the phenotypic variation among FH-patients with identical LDL-receptor mutations...
  28. ncbi request reprint Hyperhomocysteinemic subjects have enhanced expression of lectin-like oxidized LDL receptor-1 in mononuclear cells
    Kirsten B Holven
    The Lipid Clinic, Medical Department, Rikshospitalet University Hospital, Oslo, Norway
    J Nutr 133:3588-91. 2003
    ....
  29. ncbi request reprint Patients with familial hypercholesterolaemia show enhanced spontaneous chemokine release from peripheral blood mononuclear cells ex vivo. Dependency of xanthomas/xanthelasms, smoking and gender
    Kirsten B Holven
    Lipid Clinic, Rikshospitalet University Hospital, Oslo, Norway
    Eur Heart J 24:1756-62. 2003
    ..However, onset of clinically manifested CAD varies widely among patients with heterozygous FH, and we hypothesized that inflammatory mediators such as chemokines could contribute to atherogenesis in these patients...
  30. ncbi request reprint A multicenter, randomized, double-blind, placebo-controlled, factorial design study to evaluate the lipid-altering efficacy and safety profile of the ezetimibe/simvastatin tablet compared with ezetimibe and simvastatin monotherapy in patients with primary
    Harold E Bays
    Louisville Metabolic and Atherosclerosis Research Center, 3288 Illinois Avenue, Louisville, KY 40213, USA
    Clin Ther 26:1758-73. 2004
    ....
  31. ncbi request reprint [Guidelines for pharmacological primary prevention of cardiovascular diseases--who should be treated?]
    Atle Fretheim
    Brannstasjonen legesenter Arendalsvei 26a 4898 Grimstad
    Tidsskr Nor Laegeforen 122:2277-81. 2002
    ..We have used systematic and explicit methods in the development of a new set of recommendations. This is the first of three articles describing these guidelines...
  32. ncbi request reprint [Which antihypertensive drugs should be used in the primary prevention of cardiovascular disease?]
    Atle Fretheim
    Brannstasjonen legesenter Arendalsvei 26a 4898 Grimstad
    Tidsskr Nor Laegeforen 122:2283-6. 2002
    ..We have used systematic and explicit methods in the development of a new set of recommendations. This is the second of three articles describing these guidelines...
  33. ncbi request reprint [Which cholesterol-lowering drugs should be used in the primary prevention of cardiovascular disease?]
    Atle Fretheim
    Brannstasjonen legesenter Arendalsvei 26a 4898 Grimstad
    Tidsskr Nor Laegeforen 122:2287-8. 2002
    ..We have used systematic and explicit methods in developing a new set of recommendations. This is the last of three articles describing these guidelines...
  34. ncbi request reprint Effects of rosuvastatin and atorvastatin compared over 52 weeks of treatment in patients with hypercholesterolemia
    Anders G Olsson
    Department of Medicine and Care, University Hospital, Linkoping, Sweden
    Am Heart J 144:1044-51. 2002
    ..We compared the effects of rosuvastatin and atorvastatin in reducing LDL-C and achieving LDL-C goals in patients with primary hypercholesterolemia...
  35. ncbi request reprint Efficacy and safety of atorvastatin in children and adolescents with familial hypercholesterolemia or severe hyperlipidemia: a multicenter, randomized, placebo-controlled trial
    Brian W McCrindle
    Division of Pediatric Cardiology, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada
    J Pediatr 143:74-80. 2003
    ..To determine the safety and efficacy of atorvastatin (10 to 20 mg) in children and adolescents with familial hypercholesterolemia or severe hypercholesterolemia...
  36. ncbi request reprint Differential effects of simvastatin and atorvastatin on high-density lipoprotein cholesterol and apolipoprotein A-I are consistent across hypercholesterolemic patient subgroups
    Michael H Davidson
    Chicago Center for Clinical Research, Chicago, Illinois 60610, USA
    Clin Cardiol 26:509-14. 2003
    ..In addition to lowering plasma levels of low-density lipoprotein cholesterol (LDL-C), statins also raise high-density lipoprotein cholesterol (HDL-C)...
  37. ncbi request reprint [A family-based strategy for diagnosing familial hypercholesterolemia]
    Trond P Leren
    Avdeling for medisinsk genetikk, Medisinsk genetisk laboratorium, Rikshopitalet, Oslo
    Tidsskr Nor Laegeforen 124:1228-9. 2004
    ..The most cost-effective way of diagnosing patients with familial hypercholesterolaemia is to perform genetic testing of close relatives of already diagnosed patients...
  38. ncbi request reprint [Lipid profile in children and adolescents with familial hypercholesterolemia]
    Trond P Leren
    Medisinsk genetisk laboratorium, Avdeling for medisinsk genetikk, Rikshospitalet Radiumhospitalet, 0027 Oslo
    Tidsskr Nor Laegeforen 127:2363-6. 2007
    ..Reasons are that the diagnosis may have been uncertain and that the reported lipid levels have been mainly from patients treated at tertiary referral centres...
  39. ncbi request reprint Efficacy and safety of statin therapy in children with familial hypercholesterolemia: a randomized, double-blind, placebo-controlled trial with simvastatin
    Saskia de Jongh
    Department of Vascular Medicine, Emma Children s Hospital, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands
    Circulation 106:2231-7. 2002
    ....