Affiliation: University of Bergen
- Selective transduction of malignant glioma by lentiviral vectors pseudotyped with lymphocytic choriomeningitis virus glycoproteinsHrvoje Miletic
Abteilung für Neuropathologie, Universitat zu Koln, D 50931 Cologne, Germany
Hum Gene Ther 15:1091-100. 2004..In conclusion, lentiviral vectors pseudotyped with LCMV glycoproteins represent an attractive option for gene therapy of malignant glioma...
- Bystander killing of malignant glioma by bone marrow-derived tumor-infiltrating progenitor cells expressing a suicide geneHrvoje Miletic
Abteilung für Neuropathologie, Universitat zu Koln, Koln, Germany
Mol Ther 15:1373-81. 2007..In conclusion, BM-TICs expressing a suicide gene were highly effective in the treatment of malignant glioma in a rat model and therefore hold great potential for the therapy of malignant brain tumors in humans...
- A retroviral packaging cell line for pseudotype vectors based on glioma-infiltrating progenitor cellsYvonne Heidemarie Fischer
University of Lund, Stem Cell Center, BMC B10, 22184 Lund, Sweden
J Gene Med 9:335-44. 2007....
- Normal brain cells contribute to the bystander effect in suicide gene therapy of malignant gliomaHrvoje Miletic
Department of Biomedicine, University of Bergen, Jonas Liesvei 91, Bergen, Norway
Clin Cancer Res 13:6761-8. 2007..Here, we evaluated the therapeutic efficacy of LCMV-GP and vesicular stomatitis virus glycoprotein (VSV-G) pseudotyped vectors...
- Multimodal imaging of neural progenitor cell fate in rodentsYannic Waerzeggers
Laboratory for Gene Therapy and Molecular Imagin, Max Planck Institute for Neurological Research, Cologne, Germany
Mol Imaging 7:77-91. 2008..In conclusion, multimodal imaging can be used for longitudinal noninvasive monitoring of grafted NPCs in rodents...
- Low expression levels of ATM may substitute for CHEK2 /TP53 mutations predicting resistance towards anthracycline and mitomycin chemotherapy in breast cancerStian Knappskog
Section of Oncology, Institute of Medicine, University of Bergen, Jonas Lies vei 65, Bergen, 5020, Norway
Breast Cancer Res 14:R47. 2012..ATM (Ataxia Telangiectasia Mutated protein) is the key activator of p53 and Chk2 in response to genotoxic stress. Here, we sought to evaluate ATM's potential role in resistance to chemotherapy...
- Anti-VEGF therapies for malignant glioma: treatment effects and escape mechanismsHrvoje Miletic
Department of Biomedicine, University of Bergen, NorLux Neuro Oncology, Bergen, Norway
Expert Opin Ther Targets 13:455-68. 2009..GBM appears to be an optimal target for anti-angiogenic therapy as the tumour shows a high degree of endothelial cell proliferation and pro-angiogenic growth factor expression...
- Remission of invasive, cancer stem-like glioblastoma xenografts using lentiviral vector-mediated suicide gene therapyPeter C Huszthy
Department of Biomedicine, University of Bergen, Bergen, Norway
PLoS ONE 4:e6314. 2009..Lentiviral gene therapy is an attractive therapeutic option for human glioblastoma, which we validated in a clinically relevant animal model...
- A reproducible brain tumour model established from human glioblastoma biopsiesJian Wang
Department of Biomedicine, University of Bergen, N 5009 Bergen, Norway
BMC Cancer 9:465. 2009..However, implementing tumour models based on primary tissue requires that these models can be sufficiently standardised with consistently high take rates...
- EGFR wild-type amplification and activation promote invasion and development of glioblastoma independent of angiogenesisKrishna M Talasila
Department of Biomedicine, University of Bergen, Jonas Lies vei 91, 5009, Bergen, Norway
Acta Neuropathol 125:683-98. 2013..In conclusion, our results indicate that activation of wild-type EGFR promotes invasion and glioblastoma development independent of angiogenesis, whereas loss of its activity results in angiogenic tumor growth...
- In vivo animal models for studying brain metastasis: value and limitationsInderjit Daphu
Norlux Neuro Oncology Laboratory, Department of Biomedicine, University of Bergen, Jonas Lies vei 91, 5019, Bergen, Norway
Clin Exp Metastasis 30:695-710. 2013..By combining the knowledge obtained from animal models, new important information on the molecular mechanisms behind metastasis will be obtained, leading to the future development of new therapeutic strategies...
- In vivo models of primary brain tumors: pitfalls and perspectivesPeter C Huszthy
NorLux, Neuro Oncology Laboratory, Department of Biomedicine, University of Bergen, Bergen, Norway
Neuro Oncol 14:979-93. 2012....
- NUMB does not impair growth and differentiation status of experimental gliomasPhilipp Euskirchen
Department of Biomedicine, University of Bergen, Norway
Exp Cell Res 317:2864-73. 2011..We thus show that in experimental gliomas, NUMB overexpression most likely does not exert a tumor suppressor function such as seen in epithelial cancers...
- Targeting the NG2/CSPG4 proteoglycan retards tumour growth and angiogenesis in preclinical models of GBM and melanomaJian Wang
Translational Cancer Research Group, Department of Biomedicine, University of Bergen, Bergen, Norway
PLoS ONE 6:e23062. 2011..Vascular normalisation resulted in increased tumour invasion and decreased apoptosis and necrosis. We conclude that NG2 promotes tumour progression by multiple mechanisms and represents an amenable target for cancer molecular therapy...
- Cancer stem cells and angiogenesisRolf Bjerkvig
NorLux Neuro Oncology, Department of Biomedicine, University of Bergen, N 5009, Bergen, Norway
Semin Cancer Biol 19:279-84. 2009....
- Tumor versus stromal cells in culture--survival of the fittest?Krishna M Talasila
Department of Biomedicine, University of Bergen, Bergen, Norway
PLoS ONE 8:e81183. 2013..This result has an important impact on the establishment of new tumor cell cultures from brain tumors and raises the question of the proper conditions for the growth of the tumor cell populations of interest. ..
- Engraftment of Human Glioblastoma Cells in Immunocompetent Rats through Acquired ImmunosuppressionPeter C Huszthy
K G Jebsen Brain Tumour Research Centre, Department of Biomedicine, University of Bergen, Bergen, Norway Centre for Immune Regulation, Department of Immunology, University of Oslo the National Hospital, Oslo, Norway
PLoS ONE 10:e0136089. 2015..Such adapted GBM cells are in turn able to engraft in immunocompetent rats without signs of an inflammatory response...
- Oncolytic herpes simplex virus type-1 therapy in a highly infiltrative animal model of human glioblastomaPeter C Huszthy
Department of Biomedicine, The Gade Institute, University of Bergen, Bergen, Norway
Clin Cancer Res 14:1571-80. 2008....
- Visualization of CD44 and CD133 in normal pancreas and pancreatic ductal adenocarcinomas: non-overlapping membrane expression in cell populations positive for both markersHeike Immervoll
Section for Pathology, Gade Institute, University of Bergen, Bergen, Norway
J Histochem Cytochem 59:441-55. 2011..The preferentially centroacinar localization of the doubly positive cells in the normal parenchyma suggests that this population could be of particular interest in attempts to identify tumor-initiating cells in PDAC...
- Glioma proliferation as assessed by 3'-fluoro-3'-deoxy-L-thymidine positron emission tomography in patients with newly diagnosed high-grade gliomaRoland Ullrich
Max Planck Institute for Neurological Research with Klaus Joachim Zülch Laboratories, Cologne, Germany
Clin Cancer Res 14:2049-55. 2008....
- A 30-year-old patient with tuberous sclerosisWerner Stenzel
Department of Neuropathology, University of Cologne, Cologne, Germany
Brain Pathol 17:333-4. 2007
- Delineation of brain tumor extent with [11C]L-methionine positron emission tomography: local comparison with stereotactic histopathologyLutz W Kracht
Max Planck Institute for Neurological Research, Cologne, Germany
Clin Cancer Res 10:7163-70. 2004..It remains unclear whether the increased [11C]MET uptake is limited to solid tumor tissue or even detects infiltrating tumor parts...