Genomes and Genes
S O Kolset
Affiliation: University of Oslo
- Proteases in Plasma and Kidney of db/db Mice as Markers of Diabetes-Induced NephropathyE Hadler-Olsen
Department of Medical Biology, University of Tromsø, 9037 Tromsø, Norway
ISRN Endocrinol 2011:832642. 2011..These results indicate that higher levels of serine proteinases in plasma may serve as potential markers for kidney changes in db/db mice, whereas a decrease in MMP-9 in the kidney may be related to the glomerular changes...
- Diabetic nephropathy and extracellular matrixS O Kolset
Department of Nutrition, Institute for Basic Medical Sciences, University of Oslo, Oslo, Norway
J Histochem Cytochem 60:976-86. 2012..Whether ECM components can be used as markers for early kidney changes is an important research topic, whereas at present, the clinical use remains to be established...
- Serglycin--structure and biologyS O Kolset
Department of Nutrition, Institute of Basic Medical Sciences, Faculty of Medicine, University of Oslo, Blindern, Oslo, Norway
Cell Mol Life Sci 65:1073-85. 2008..Serglycin is a proteoglycan with important roles in inflammatory reactions...
- Serglycin and secretion in human monocytesSvein Olav Kolset
Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Box 1046, Blindern, 0316, Oslo, Norway
Glycoconj J 25:305-11. 2008....
- Serglycin: a structural and functional chameleon with wide impact on immune cellsSvein O Kolset
Department of Nutrition, University of Oslo, 0316 Oslo, Norway
J Immunol 187:4927-33. 2011..Based on these findings, serglycin is emerging as a structural and functional chameleon, with radically different properties depending on its exact cellular and immunological context...
- The AGE product N epsilon-(carboxymethyl)lysine serum albumin is a modulator of proteoglycan expression in polarized cultured kidney epithelial cellsJ Borrebaek
Institute for Nutrition Research, University of Oslo, Box 1046 Blindern, 0316 Oslo, Norway
Diabetologia 44:488-94. 2001..Advanced glycation end products could, accordingly, promote pathological changes in kidneys of diabetics...
- Serglycin-binding proteins in activated macrophages and plateletsS O Kolset
Institute for Nutrition Research, University of Oslo, Norway
J Leukoc Biol 59:545-54. 1996..Both PF4, MIP-1 alpha, and lysozyme play important role in different types of inflammatory reactions. The interaction with serglycin may indicate that this proteoglycan is involved in the regulation of the inflammatory response...
- Cell surface heparan sulfate proteoglycans and lipoprotein metabolismS O Kolset
Institute for Nutrition Research, University of Oslo, Norway
Cell Mol Life Sci 56:857-70. 1999..In this review we discuss the various roles of heparan sulfate proteoglycans in vascular biology, with emphasis on interactions of heparan sulfate with lipoproteins and lipases and the molecular basis of such interactions...
- Apical secretion of chondroitin sulphate in polarized Madin-Darby canine kidney (MDCK) cellsS O Kolset
Institute for Nutrition Research, University of Oslo, Box 1046 Blindern, Norway
J Cell Sci 112:1797-801. 1999....
- Serglycin expression in CD2+ and CD14+ cells from patients with various rheumatic diseasesL A Omtvedt
Centre for Rheumatic Diseases, The National Hospital, University of Oslo, Norway
Scand J Rheumatol 30:164-6. 2001..Our results demonstrate higher Levels of expression in CD14+ cetts taken from patients with chronic inflammatory diseases than in control subjects. This suggests that serglycin may play a role during the inflammatory process...
- Binding of perlecan to transthyretin in vitroS Smeland
Institute for Nutrition Research, University of Oslo, P O Box 1046, 0316 Oslo, Norway
Biochem J 326:829-36. 1997..Because perlecan is released from transthyretin in water, the binding might be due to hydrophobic interactions...
- Proteoglycans in polarized epithelial Madin-Darby canine kidney cellsK Svennevig
Department of Biochemistry, University of Oslo, Norway
Biochem J 311:881-8. 1995..Versican was also found in both MDCK I and II cells. Compared with perlecan, a larger percentage of versican (43-53%) was found in the cell fractions...
- 8-isoprostane increases scavenger receptor A and matrix metalloproteinase activity in THP-1 macrophages, resulting in long-lived foam cellsH Scholz
Rikshospitalet University Hospital, University of Oslo, Norway
Eur J Clin Invest 34:451-8. 2004....
- Decreasing the metastatic potential in cancers--targeting the heparan sulfate proteoglycansK Fjeldstad
Institute of Basic Medical Sciences, Department of Nutrition, P O Box 1046 Blindern, 0316 Oslo, Norway
Curr Drug Targets 6:665-82. 2005..Several different treatment strategies that target PGs have been developed. They have the potential to be effective in reducing tumor growth and inhibit the formation of metastases. PGs are also valuable tumor markers in several cancers...
- Biocompatibility and pathways of initial complement pathway activation with Phisio- and PMEA-coated cardiopulmonary bypass circuits during open-heart surgeryA S Thiara
Department of Thoracic and Cardiovascular Surgery, Oslo University Hospital, Oslo, Norway
Perfusion 26:107-14. 2011..In conclusion, PMEA- and Phisio-coated circuits displayed similar biocompatibility with respect to inflammatory and haemostatic responses during and after open-heart surgery...
- Proteoglycan synthesis is increased in cells with impaired clathrin-dependent endocytosisA Llorente
Department of Biochemistry, The Norwegian Radium Hospital, Montebello, Norway
J Cell Sci 114:335-43. 2001..Thus, the activation of protein kinase C observed upon inhibition of clathrin-dependent endocytosis may be responsible for the increased synthesis of proteoglycans...
- Uncoupling of stem cell inhibition from monocyte chemoattraction in MIP-1alpha by mutagenesis of the proteoglycan binding siteG J Graham
The Beatson Institute for Cancer Research, CRC Beatson Laboratories, Glasgow, UK
EMBO J 15:6506-15. 1996..The site for interaction with the stem cell receptor must therefore be distinct, suggesting that MIP-1alpha utilizes different receptors for these two different biological processes...