Hanne F Harbo

Summary

Affiliation: University of Oslo
Country: Norway

Publications

  1. doi From genes to characteristics of multiple sclerosis
    H F Harbo
    Department of Neurology, Oslo University Hospital, Oslo, Norway
    Acta Neurol Scand Suppl . 2012
  2. ncbi Coding region polymorphisms in T cell signal transduction genes. Prevalence and association to development of multiple sclerosis
    Hanne F Harbo
    Institute of Immunology, University of Oslo, Oslo, Norway
    J Neuroimmunol 177:40-5. 2006
  3. doi [New gene map for multiple sclerosis]
    Hanne F Harbo
    Nevrologisk avdeling, Oslo universitetssykehus, Ulleval, Norway
    Tidsskr Nor Laegeforen 131:2126-30. 2011
  4. ncbi Low frequency of the disease-associated DRB1*15-DQB1*06 haplotype may contribute to the low prevalence of multiple sclerosis in Sami
    H F Harbo
    Institute of Immunology, Faculty Division Rikshospitalet, University of Oslo, Oslo, Norway
    Tissue Antigens 69:299-304. 2007
  5. ncbi Genetics in multiple sclerosis: past and future perspectives
    H F Harbo
    Department of Neurology, Ulleval University Hospital, Oslo, Norway
    Acta Neurol Scand Suppl 187:34-8. 2007
  6. doi Norwegian Sami differs significantly from other Norwegians according to their HLA profile
    H F Harbo
    Department of Neurology, Oslo University Hospital, Ulleval, Oslo, Norway
    Tissue Antigens 75:207-17. 2010
  7. doi EFNS guidelines on the molecular diagnosis of neurogenetic disorders: general issues, Huntington's disease, Parkinson's disease and dystonias
    H F Harbo
    Department of Neurology, Ulleval, Oslo University Hospital, University of Oslo, Oslo, Norway
    Eur J Neurol 16:777-85. 2009
  8. ncbi Lack of association with the CD28/CTLA4/ICOS gene region among Norwegian multiple sclerosis patients
    Aslaug R Lorentzen
    Institute of Immunology, University of Oslo and Rikshospitalet University Hospital, 00207 Oslo, Norway
    J Neuroimmunol 166:197-201. 2005
  9. doi Oligoclonal band phenotypes in MS differ in their HLA class II association, while specific KIR ligands at HLA class I show association to MS in general
    Marte W Gustavsen
    Department of Neurology, Oslo University Hospital, Ulleval, Oslo, Norway Institute of Clinical Medicine, University of Oslo, Oslo, Norway Electronic address
    J Neuroimmunol 274:174-9. 2014
  10. doi Association to the Glypican-5 gene in multiple sclerosis
    Aslaug R Lorentzen
    Department of Neurology, Oslo University Hospital, Ulleval, University of Oslo, Oslo, Norway
    J Neuroimmunol 226:194-7. 2010

Detail Information

Publications38

  1. doi From genes to characteristics of multiple sclerosis
    H F Harbo
    Department of Neurology, Oslo University Hospital, Oslo, Norway
    Acta Neurol Scand Suppl . 2012
    ....
  2. ncbi Coding region polymorphisms in T cell signal transduction genes. Prevalence and association to development of multiple sclerosis
    Hanne F Harbo
    Institute of Immunology, University of Oslo, Oslo, Norway
    J Neuroimmunol 177:40-5. 2006
    ....
  3. doi [New gene map for multiple sclerosis]
    Hanne F Harbo
    Nevrologisk avdeling, Oslo universitetssykehus, Ulleval, Norway
    Tidsskr Nor Laegeforen 131:2126-30. 2011
    ..The etiology of the disease is unknown, but both environmental and genetic factors contribute to the risk of developing MS...
  4. ncbi Low frequency of the disease-associated DRB1*15-DQB1*06 haplotype may contribute to the low prevalence of multiple sclerosis in Sami
    H F Harbo
    Institute of Immunology, Faculty Division Rikshospitalet, University of Oslo, Oslo, Norway
    Tissue Antigens 69:299-304. 2007
    ..015). The low frequency of the disease-associated DRB1*15-DQB1*06 haplotype in the Sami population may contribute to the low prevalence of MS in Sami, in addition to other yet unidentified genetic and environmental factors...
  5. ncbi Genetics in multiple sclerosis: past and future perspectives
    H F Harbo
    Department of Neurology, Ulleval University Hospital, Oslo, Norway
    Acta Neurol Scand Suppl 187:34-8. 2007
    ..The ultimate goal of the search for susceptibility genes in MS is to develop diagnostic tools and better treatments that can prevent or reduce the development of symptoms of this often devastating disease...
  6. doi Norwegian Sami differs significantly from other Norwegians according to their HLA profile
    H F Harbo
    Department of Neurology, Oslo University Hospital, Ulleval, Oslo, Norway
    Tissue Antigens 75:207-17. 2010
    ..Our results can be explained by the fact that the two populations have different origins and that the Sami population has remained smaller and more isolated than its neighbors...
  7. doi EFNS guidelines on the molecular diagnosis of neurogenetic disorders: general issues, Huntington's disease, Parkinson's disease and dystonias
    H F Harbo
    Department of Neurology, Ulleval, Oslo University Hospital, University of Oslo, Oslo, Norway
    Eur J Neurol 16:777-85. 2009
    ..Since the publication of the first two EFNS-guideline papers on the molecular diagnosis of neurological diseases in 2001, rapid progress has been made in this field, necessitating an updated series of guidelines...
  8. ncbi Lack of association with the CD28/CTLA4/ICOS gene region among Norwegian multiple sclerosis patients
    Aslaug R Lorentzen
    Institute of Immunology, University of Oslo and Rikshospitalet University Hospital, 00207 Oslo, Norway
    J Neuroimmunol 166:197-201. 2005
    ..In conclusion, this study could not confirm association with the CD28/CTLA4/ICOS gene region...
  9. doi Oligoclonal band phenotypes in MS differ in their HLA class II association, while specific KIR ligands at HLA class I show association to MS in general
    Marte W Gustavsen
    Department of Neurology, Oslo University Hospital, Ulleval, Oslo, Norway Institute of Clinical Medicine, University of Oslo, Oslo, Norway Electronic address
    J Neuroimmunol 274:174-9. 2014
    ..HLA class I alleles and KIR ligands did not differ between OCB phenotypes, but HLA class II associations were convincingly replicated. ..
  10. doi Association to the Glypican-5 gene in multiple sclerosis
    Aslaug R Lorentzen
    Department of Neurology, Oslo University Hospital, Ulleval, University of Oslo, Oslo, Norway
    J Neuroimmunol 226:194-7. 2010
    ..006). Thus, this study supports that MS susceptibility at 13q31-32 may localize to the Glypican-5 gene, which should lead to further fine-mapping, replication and functional studies of this gene...
  11. doi The SH2D2A gene and susceptibility to multiple sclerosis
    Aslaug R Lorentzen
    Department of Neurology, University of Oslo, Oslo, Norway Institute of Immunology, Rikshospitalet University Hospital, Oslo, Norway
    J Neuroimmunol 197:152-8. 2008
    ..In the independent Norwegian, Danish and Swedish sample sets the GA(16) allele showed a combined OR of 1.13, P=0.05. Thus, the present study shows that the SH2D2A gene may contribute to susceptibility to MS...
  12. pmc Allelic imbalance of multiple sclerosis susceptibility genes IKZF3 and IQGAP1 in human peripheral blood
    Pankaj K Keshari
    Department of Neurology, Oslo University Hospital, Oslo, Norway
    BMC Genet 17:59. 2016
    ..Recent genome-wide studies have revealed more than 110 single nucleotide polymorphisms as associated with susceptibility to multiple sclerosis, but their functional contribution to disease development is mostly unknown...
  13. pmc A rare variant of the TYK2 gene is confirmed to be associated with multiple sclerosis
    Inger Lise Mero
    Department of Neurology, Oslo University Hospital, Ulleval, N 0407 Oslo, Norway
    Eur J Hum Genet 18:502-4. 2010
    ..78), and by mega-analysis of 10 642 MS patients, 10 620 controls and 2110 MS trios, the association at genome-wide significance level (P=5.08 x 10(-9), OR 0.77) was shown...
  14. doi Polymorphisms of the BDNF gene show neither association with multiple sclerosis susceptibility nor clinical course
    Inger Lise Mero
    Department of Neurology, Oslo University Hospital, Ulleval, N 0407 Oslo, Norway
    J Neuroimmunol 244:107-10. 2012
    ..No association was found for any of the SNPs to disease susceptibility or any clinical or demographic parameters including sex, age at onset, disease course, disease severity and cognitive impairment...
  15. pmc Multiple Sclerosis Risk Allele in CLEC16A Acts as an Expression Quantitative Trait Locus for CLEC16A and SOCS1 in CD4+ T Cells
    Ingvild S Leikfoss
    Department of Neurology, Oslo University Hospital, Oslo, Norway Institute of Clinical Medicine, University of Oslo, Oslo, Norway
    PLoS ONE 10:e0132957. 2015
    ..Our data imply a possible regulatory role for the multiple sclerosis-associated rs12927355 in CLEC16A. ..
  16. pmc Oligoclonal band status in Scandinavian multiple sclerosis patients is associated with specific genetic risk alleles
    Inger Lise Mero
    Department of Neurology, Oslo University Hospital, Ulleval, and Department of Medical Genetics, University of Oslo, Oslo, Norway
    PLoS ONE 8:e58352. 2013
    ..This suggests differences in disease mechanisms between OCB negative and OCB positive MS with implications for patient management, which need to be further studied...
  17. ncbi Two genome-wide linkage disequilibrium screens in Scandinavian multiple sclerosis patients
    Hanne F Harbo
    Institute of Immunology, Rikshospitalet University Hospital, 0027 Oslo, Norway
    J Neuroimmunol 143:101-6. 2003
    ..Usable data were achieved from the same 3331 markers in both screens. Nine markers from eight genomic regions (1p33, 3q13, 6p21, 6q14, 7p22, 9p21, 9q21 and Xq22) were identified as potentially associated with MS in both screens...
  18. doi Killer immunoglobulin-like receptor ligand HLA-Bw4 protects against multiple sclerosis
    Aslaug R Lorentzen
    Department of Neurology, Faculty Division Ulleval, Oslo University Hospital, University of Oslo, Oslo, Norway
    Ann Neurol 65:658-66. 2009
    ..We investigated the HLA class I alleles defined by their KIR binding motifs and the KIR genes to evaluate whether these genes could influence MS susceptibility or severity, alone or in combination...
  19. pmc Late onset myasthenia gravis is associated with HLA DRB1*15:01 in the Norwegian population
    Angelina H Maniaol
    Department of Neurology, Oslo University Hospital, Ulleval, Oslo, Norway
    PLoS ONE 7:e36603. 2012
    ..Well-powered and comprehensive HLA analyses of subgroups in MG are warranted, especially in late onset MG...
  20. pmc A one year follow-up study of natural killer and dendritic cells activities in multiple sclerosis patients receiving glatiramer acetate (GA)
    Rune A Høglund
    Department of Physiology, Institute of Medical Basal Sciences, University of Oslo, Oslo, Norway
    PLoS ONE 8:e62237. 2013
    ..More recently, cells of the innate immune system such as dendritic cells (DCs) and natural killer (NK) cells have been in focus. Glatiramer acetate (GA) is an approved drug for treating MS patients...
  21. doi Eye and hand motor interactions with the Symbol Digit Modalities Test in early multiple sclerosis
    Gro O Nygaard
    Department of Neurology, Oslo University Hospital, Postal Box 4950 Nydalen, 0424 Oslo, Norway Department of Clinical Medicine, University of Oslo, Postal Box 1171 Blindern, 0318 Oslo, Norway Electronic address
    Mult Scler Relat Disord 4:585-9. 2015
    ..We aimed to test for differences in saccadic initiation time (SI time) between RRMS patients and healthy controls, and whether SI time and hand motor speed interacted with the written version of the Symbol Digit Modalities Test (wSDMT)...
  22. pmc Oligoclonal bands and age at onset correlate with genetic risk score in multiple sclerosis
    Hanne F Harbo
    Department of Neurology, Oslo University Hospital, Norway
    Mult Scler 20:660-8. 2014
    ..Many genetic risk variants are now well established in multiple sclerosis (MS), but the impact on clinical phenotypes is unclear...
  23. doi Reduced perfusion in white matter lesions in multiple sclerosis
    Piotr Sowa
    Department of Radiology and Nuclear Medicine, Oslo University Hospital, Oslo, Norway Institute of Clinical Medicine, University of Oslo, Oslo, Norway Electronic address
    Eur J Radiol 84:2605-12. 2015
    ..To investigate dynamic susceptibility contrast (DSC) perfusion weighted imaging (PWI) in white matter lesions (WML) in patients with multiple sclerosis (MS), using automatically generated binary masks of brain tissue...
  24. doi Prevalence of multiple sclerosis among immigrants in Norway
    Pål Berg-Hansen
    Department of Neurology, Oslo University Hospital, Norway Institute of Clinical Medicine, University of Oslo, Norway
    Mult Scler 21:695-702. 2015
    ..The aim of this study was to investigate MS prevalence in different immigrant populations in Norway and evaluate the effect of migrating from low- to high-risk regions of MS...
  25. pmc Genome-wide DNA methylation profiles indicate CD8+ T cell hypermethylation in multiple sclerosis
    Steffan D Bos
    Department of Neurology, Oslo University Hospital, Oslo, Norway Institute of Clinical Medicine, University of Oslo, Oslo, Norway
    PLoS ONE 10:e0117403. 2015
    ..Determine whether MS-specific DNA methylation profiles can be identified in whole blood or purified immune cells from untreated MS patients...
  26. pmc Genetic overlap between multiple sclerosis and several cardiovascular disease risk factors
    Yunpeng Wang
    NORMENT, K G Jebsen Psychosis Research Centre, Institute of Clinical Medicine, Oslo University Hospital and University of Oslo, Oslo, Norway Division of Mental Health and Addiction, Oslo University Hospital, Oslo, Norway Multimodal Imaging Laboratory, University of California, San Diego, La Jolla, CA, USA Department of Neurosciences, University of California, San Diego, La Jolla, CA, USA
    Mult Scler 22:1783-1793. 2016
    ..Epidemiological findings suggest a relationship between multiple sclerosis (MS) and cardiovascular disease (CVD) risk factors, although the nature of this relationship is not well understood...
  27. pmc A Longitudinal Study of Disability, Cognition and Gray Matter Atrophy in Early Multiple Sclerosis Patients According to Evidence of Disease Activity
    Gro O Nygaard
    Department of Neurology, Oslo University Hospital and Institute of Clinical Medicine, University of Oslo, Oslo, Norway
    PLoS ONE 10:e0135974. 2015
    ..001). These results support the relevance of NEDA as outcome in RRMS and indicate that pathological neurodegeneration in RRMS mainly occur in patients with evidence of disease activity. ..
  28. doi Retinoic acid enhances the levels of IL-10 in TLR-stimulated B cells from patients with relapsing-remitting multiple sclerosis
    Agnete Bratsberg Eriksen
    Department of Biochemistry, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    J Neuroimmunol 278:11-8. 2015
    ..RA revealed the same ability to induce IL-10 as did interferon-β-1b (IFN-β-1b), and B-cells from patients treated with glatiramer acetate or IFN-β-1b still displayed the beneficial effects of RA on the IL-10/TNF-α ratio. ..
  29. pmc Assessing the Power of Exome Chips
    Christian Magnus Page
    Institute of Clinical Medicine, University of Oslo, 0316, Oslo, Norway Department of Neurology, Oslo University Hospital, 0424, Oslo, Norway
    PLoS ONE 10:e0139642. 2015
    ..In addition, when using rare variant chips on cohorts or diseases they were not originally designed for, the identification of associated variants or genes will be even more challenging. ..
  30. pmc From Identification to Characterization of the Multiple Sclerosis Susceptibility Gene CLEC16A
    Tone Berge
    Department of Neurology, Oslo University Hospital, Ulleval, Oslo 0407, Norway
    Int J Mol Sci 14:4476-97. 2013
    ..This may serve as an example of the importance for further molecular investigation of the loci identified in genetic studies, with the aim to translate this knowledge into the clinic...
  31. pmc Identification of human NK17/NK1 cells
    Abhilash D Pandya
    Department of Physiology, Faculty of Medicine, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    PLoS ONE 6:e26780. 2011
    ..We recently described that these cells release the inflammatory cytokines IL-17 and IFN-γ. However, the precise identity of the NK cell subset(s) that secrete these cytokines is not known...
  32. ncbi Variation in interleukin 7 receptor alpha chain (IL7R) influences risk of multiple sclerosis
    Frida Lundmark
    Division of Neurology, Department of Clinical Neuroscience, Karolinska Institutet at Karolinska University Hospital Huddinge, SE 141 86 Stockholm, Sweden
    Nat Genet 39:1108-13. 2007
    ..In addition, we report altered expression of the genes encoding IL7Ralpha and its ligand, IL7, in the cerebrospinal fluid compartment of individuals with multiple sclerosis...
  33. pmc Ethnic variation of Fc gamma receptor polymorphism in Sami and Norwegian populations
    Oivind Torkildsen
    The Multiple Sclerosis National Competence Centre, Haukeland University Hospital, University of Bergen, N 5021 Bergen, Norway
    Immunology 115:416-21. 2005
    ..The Fc gammaR genotypes were non-randomly distributed in both populations. These findings may be important for the prevalence of autoimmune and infectious diseases in the two populations...
  34. ncbi Association analysis of the LAG3 and CD4 genes in multiple sclerosis in two independent populations
    Frida Lundmark
    Division of Neurology, Department of Clinical Neuroscience, Karolinska Institutet at Karolinska University Hospital, Huddinge, Stockholm, Sweden
    J Neuroimmunol 180:193-8. 2006
    ..The result, including a total of 2640 MS patients and 2194 controls shows no significant association with CD4 and LAG3 and MS. We conclude that these genes are of minor importance in regard of genetic predisposition to the MS...
  35. pmc A high-density screen for linkage in multiple sclerosis
    Stephen Sawcer
    University of Cambridge, Department of Clinical Neuroscience, Addenbrooke s Hospital, Hills Road, Cambridge, CB2 2QQ, United Kingdom
    Am J Hum Genet 77:454-67. 2005
    ....
  36. ncbi Linkage disequilibrium screening for multiple sclerosis implicates JAG1 and POU2AF1 as susceptibility genes in Europeans
    Maria Ban
    University of Cambridge, Department of Clinical Neurosciences, Addenbrooke s Hospital, Hills Road, Cambridge, UK
    J Neuroimmunol 179:108-16. 2006
    ..Association mapping across the candidate genes implicated by these markers in 937 UK trio families revealed modestly associated haplotypes in JAG1 (p=0.019) on chromosome 20p12.2 and POU2AF1 (p=0.003) on chromosome 11q23.1...
  37. ncbi [Multiple sclerosis biobank established]
    Hanne F Harbo
    Nevrologisk avdeling, Ulleval universitetssykehus, 0407 Oslo
    Tidsskr Nor Laegeforen 127:2276. 2007