Rune Blomhoff

Summary

Affiliation: University of Oslo
Country: Norway

Publications

  1. ncbi request reprint [Antioxidants and oxidative stress]
    Rune Blomhoff
    Institutt for medisinske basalfag, Universitetet i Oslo, Postboks 1046 Blindern, 0316 Oslo
    Tidsskr Nor Laegeforen 124:1643-5. 2004
  2. ncbi request reprint [Biological effects of vitamin K and concentration of vitamin K in Norwegian food]
    Christian A Drevon
    Avdeling for ernaeringsvitenskap, Institutt for medisinske basalfag, Universitetet i Oslo, Postboks 1046 Blindern, 0316 Oslo
    Tidsskr Nor Laegeforen 124:1650-4. 2004
  3. ncbi request reprint Strong in vivo activation of NF-kappaB in mouse lenses by classic stressors
    George Alexander
    Institute for Nutrition Research, University of Oslo, Oslo, Norway
    Invest Ophthalmol Vis Sci 44:2683-8. 2003
  4. ncbi request reprint Reoxygenation of hypoxic mice with 100% oxygen induces brain nuclear factor-kappa B
    Gaute Døhlen
    Department of Pediatric Research, Rikshospitalet, University of Oslo, 0027 Oslo, Norway
    Pediatr Res 58:941-5. 2005
  5. ncbi request reprint Corneal NF-kappaB activity is necessary for the retention of transparency in the cornea of UV-B-exposed transgenic reporter mice
    George Alexander
    Department of Nutrition, Faculty of Medicine, University of Oslo, P O Box 1046, Blindern, 0316 Oslo, Norway
    Exp Eye Res 82:700-9. 2006
  6. ncbi request reprint Gene deletion of NF-kappaB p105 enhances neointima formation in a mouse model of carotid artery injury
    Arno Ruusalepp
    Institute of Basic Medical Sciences, Department of Physiology, University of Oslo, Norway
    Cardiovasc Drugs Ther 20:103-11. 2006
  7. ncbi request reprint Content of redox-active compounds (ie, antioxidants) in foods consumed in the United States
    Bente L Halvorsen
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    Am J Clin Nutr 84:95-135. 2006
  8. ncbi request reprint Health benefits of nuts: potential role of antioxidants
    Rune Blomhoff
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    Br J Nutr 96:S52-60. 2006
  9. ncbi request reprint Oxidative stress markers and antioxidant status after oral iron supplementation to very low birth weight infants
    Kristin Braekke
    Pediatric Intensive Care Unit, Ulleval University Hospital, Oslo, Norway
    J Pediatr 151:23-8. 2007
  10. ncbi request reprint Antioxidant activity in the newborn brain: a luciferase mouse model
    Gaute Dohlen
    Department of Pediatric Research, Rikshospitalet Medical Center, Oslo, Norway
    Neonatology 93:125-31. 2008

Collaborators

  • Christian A Drevon
  • Lene F Andersen
  • D R Jacobs
  • Leiv Ose
  • Paul C Evans
  • Katherine M Phillips
  • Kristin Braekke
  • Regina Brigelius-Flohe
  • S Frantz
  • Ola Didrik Saugstad
  • Duk Hee Lee
  • Sanjay Gupta
  • Annetine Staff
  • G Valen
  • Gaute Dohlen
  • Harald Carlsen
  • George Alexander
  • Jan Øivind Moskaug
  • Mari C W Myhrstad
  • Bente L Halvorsen
  • Jan Ø Moskaug
  • Liv M I Austenaa
  • Kari Holte
  • Heidi L Wold
  • Sofie Notebaert
  • Eugene V Vykhovanets
  • Sandra J Campbell
  • Anette Karlsen
  • B Rhiannon Noble
  • Dirk Kluth
  • Jason Partridge
  • Ingvild Paur
  • Jochen Tillmanns
  • Arno Ruusalepp
  • Maria Muriach
  • Petter Laake
  • Stefan Hartmann
  • Gaute Døhlen
  • Monica H Carlsen
  • Siv K Bøhn
  • Arne Svilaas
  • Haruki Senoo
  • Kenjiro Wake
  • Anne M Myhre
  • Steinar Dragland
  • Derek A Mann
  • Daniel Janssen
  • Gregory T MacLennan
  • Martin I Resnick
  • Evelyne Meyer
  • Sanjeev Shukla
  • Daniel C Anthony
  • Fiona Oakley
  • Peter Vandenabeele
  • Ahmed M Elsharkawy
  • Randal P Babiuk
  • Riki Kawaguchi
  • Thomas E Gundersen
  • Justin C Mason
  • Robin D Clugston
  • Le Luong
  • Siv Kjølsrud Bøhn
  • T Michael Underhill
  • Dorian O Haskard
  • Hui Sun
  • John J Greer
  • Anne Kinderlerer
  • Antje Banning
  • Lars Retterstøl
  • Mustafa Zakkar
  • Leiv Sandvik
  • Hera Chaudhury
  • Paul G Walfish
  • Mike Johns
  • Karine Enesa
  • Maria Miranda
  • Francisco J Romero
  • Jorge Barcia
  • Johann Bauersachs
  • Inma Almansa
  • Laura Calvillo
  • Francisco Bosch-Morell
  • Zhong qun Yan
  • Georg Ertl
  • Emma Arnal
  • Gabor Czibik
  • Goran K Hansson
  • Jan Øyvind Moskaug
  • Jochen Bausch
  • Dieter Hartmann

Detail Information

Publications36

  1. ncbi request reprint [Antioxidants and oxidative stress]
    Rune Blomhoff
    Institutt for medisinske basalfag, Universitetet i Oslo, Postboks 1046 Blindern, 0316 Oslo
    Tidsskr Nor Laegeforen 124:1643-5. 2004
    ..An improved antioxidant defence may therefore protect against these diseases. Recent studies have demonstrated that dietary plants contain several hundred different antioxidants...
  2. ncbi request reprint [Biological effects of vitamin K and concentration of vitamin K in Norwegian food]
    Christian A Drevon
    Avdeling for ernaeringsvitenskap, Institutt for medisinske basalfag, Universitetet i Oslo, Postboks 1046 Blindern, 0316 Oslo
    Tidsskr Nor Laegeforen 124:1650-4. 2004
    ..Vitamin K has several biological effects and dietary intake seems to be more important than previously believed because of low bioavailability of the vitamins from the colon...
  3. ncbi request reprint Strong in vivo activation of NF-kappaB in mouse lenses by classic stressors
    George Alexander
    Institute for Nutrition Research, University of Oslo, Oslo, Norway
    Invest Ophthalmol Vis Sci 44:2683-8. 2003
    ..To examine the in vivo activation of nuclear factor (NF)-kappaB in mouse lens epithelia by using bacterial lipopolysaccharide (LPS), tumor necrosis factor (TNF)-alpha, and UV-B radiation...
  4. ncbi request reprint Reoxygenation of hypoxic mice with 100% oxygen induces brain nuclear factor-kappa B
    Gaute Døhlen
    Department of Pediatric Research, Rikshospitalet, University of Oslo, 0027 Oslo, Norway
    Pediatr Res 58:941-5. 2005
    ..However, when reoxygenation occurs with 21% O2 (room air), no elevation in NF-kappaB activity is observed. Thus, reoxygenation with room air may induce less brain inflammation than reoxygenation with pure oxygen...
  5. ncbi request reprint Corneal NF-kappaB activity is necessary for the retention of transparency in the cornea of UV-B-exposed transgenic reporter mice
    George Alexander
    Department of Nutrition, Faculty of Medicine, University of Oslo, P O Box 1046, Blindern, 0316 Oslo, Norway
    Exp Eye Res 82:700-9. 2006
    ....
  6. ncbi request reprint Gene deletion of NF-kappaB p105 enhances neointima formation in a mouse model of carotid artery injury
    Arno Ruusalepp
    Institute of Basic Medical Sciences, Department of Physiology, University of Oslo, Norway
    Cardiovasc Drugs Ther 20:103-11. 2006
    ..These data indicate that the p105 subunit of NF-kappaB plays an essential role in vascular healing, and defects in NF-kappaB p105 promote neointima hyperplasia...
  7. ncbi request reprint Content of redox-active compounds (ie, antioxidants) in foods consumed in the United States
    Bente L Halvorsen
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    Am J Clin Nutr 84:95-135. 2006
    ..We suggest that other redox-active phytochemicals may be more effective and that a combination of different redox-active compounds (ie, antioxidants or reductants) may be needed for proper protection against oxidative damage...
  8. ncbi request reprint Health benefits of nuts: potential role of antioxidants
    Rune Blomhoff
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    Br J Nutr 96:S52-60. 2006
    ..Further studies are needed to clarify whether antioxidants contribute to this apparent beneficial health effect of nuts...
  9. ncbi request reprint Oxidative stress markers and antioxidant status after oral iron supplementation to very low birth weight infants
    Kristin Braekke
    Pediatric Intensive Care Unit, Ulleval University Hospital, Oslo, Norway
    J Pediatr 151:23-8. 2007
    ..To evaluate whether our current practice of giving iron 18 mg daily to 6-week-old infants with very low birth weight (VLBW) was associated with increased oxidative stress markers or decreased antioxidant status...
  10. ncbi request reprint Antioxidant activity in the newborn brain: a luciferase mouse model
    Gaute Dohlen
    Department of Pediatric Research, Rikshospitalet Medical Center, Oslo, Norway
    Neonatology 93:125-31. 2008
    ..The aim of this study is to present a model that can monitor genetic activity in vivo during pregnancy and the first 10 days of life...
  11. ncbi request reprint Molecular imaging of NF-kappaB in prostate tissue after systemic administration of IL-1 beta
    Eugene V Vykhovanets
    Department of Urology, Case Western Reserve University, University Hospitals Case Medical Center, Cleveland, Ohio 44106, USA
    Prostate 68:34-41. 2008
    ..A wide range of human cancers and inflammatory disorders express inappropriate regulation of NF-kappaB. The role of NF-kappaB in intraprostatic inflammation has not been elucidated...
  12. doi request reprint In vivo imaging of NF-kappaB activity during Escherichia coli-induced mammary gland infection
    Sofie Notebaert
    Laboratory of Biochemistry, Faculty of Veterinary Medicine, Ghent University, 9820 Merelbeke, Belgium
    Cell Microbiol 10:1249-58. 2008
    ....
  13. ncbi request reprint In vivo imaging of NF-kappa B activity
    Harald Carlsen
    Institute for Nutrition Research, University of Oslo, Blindern, 0316 Oslo, Norway
    J Immunol 168:1441-6. 2002
    ..Thus, we have developed a versatile model for monitoring NF-kappaB activation in vivo...
  14. ncbi request reprint Molecular imaging of the transcription factor NF-kappaB, a primary regulator of stress response
    Harald Carlsen
    Department of Nutrition, Faculty of Medicine, University of Oslo, P O Box 1046 Blindern, N 0316 Oslo, Norway
    Mutat Res 551:199-211. 2004
    ....
  15. ncbi request reprint A systematic screening of total antioxidants in dietary plants
    Bente L Halvorsen
    Institute for Nutrition Research, Faculty of Medicine, University of Oslo, Blindern, 0316 Oslo, Norway
    J Nutr 132:461-71. 2002
    ..Vegetables contributed only 8.9%. The systematic analysis presented here will facilitate research into the nutritional role of the combined effect of antioxidants in dietary plants...
  16. ncbi request reprint Vitamin A status significantly alters nuclear factor-kappaB activity assessed by in vivo imaging
    Liv M I Austenaa
    Department of Nutrition, Faculty of Medicine, University of Oslo, Norway
    FASEB J 18:1255-7. 2004
    ..Our results suggest that vitamin A status, and vitamin A itself, affects NF-kappaB activity in vivo and that the elevated NF-kappaB activity in VAD may be a mechanism underlying some of the features of VAD syndrome...
  17. ncbi request reprint Whole-grain consumption is associated with a reduced risk of noncardiovascular, noncancer death attributed to inflammatory diseases in the Iowa Women's Health Study
    David R Jacobs
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    Am J Clin Nutr 85:1606-14. 2007
    ..It has recently been shown that oxidative stress, infection, and inflammation are predominant pathophysiologic factors for several major diseases...
  18. ncbi request reprint Laminar shear stress acts as a switch to regulate divergent functions of NF-kappaB in endothelial cells
    Jason Partridge
    BHF Cardiovascular Medicine, National Heart and Lung Institute, Imperial College London, Hammersmith Campus, Du Cane Rd, London W12 ONN, UK
    FASEB J 21:3553-61. 2007
    ..Thus modulation of NF-kappaB function may underlie the atheroprotective effects of laminar shear stress...
  19. ncbi request reprint Berry intake increases the activity of the gamma-glutamylcysteine synthetase promoter in transgenic reporter mice
    Harald Carlsen
    Institute for Nutrition Research, University of Oslo, Oslo, Norway
    J Nutr 133:2137-40. 2003
    ..Our results demonstrate for the first time that berry extracts rich in polyphenols and EA can induce GCS(h) in vivo. The induction of protective enzymes may be important for the chemopreventive effects of fruits and vegetables...
  20. ncbi request reprint Anthocyanins inhibit nuclear factor-kappaB activation in monocytes and reduce plasma concentrations of pro-inflammatory mediators in healthy adults
    Anette Karlsen
    Department of Nutrition, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway N 0316
    J Nutr 137:1951-4. 2007
    ....
  21. ncbi request reprint Mechanisms of action of the congenital diaphragmatic hernia-inducing teratogen nitrofen
    B Rhiannon Noble
    Department of Physiology, University of Alberta, Edmonton, Alberta, Canada T6G 2S2
    Am J Physiol Lung Cell Mol Physiol 293:L1079-87. 2007
    ..Retinoid signaling perturbations do not appear to involve oxidative effects of nitrofen. Any substantial roles of nitrofen-induced perturbations of thyroid hormone signaling or receptor function are not supported...
  22. ncbi request reprint Several culinary and medicinal herbs are important sources of dietary antioxidants
    Steinar Dragland
    The Norwegian Crop Research Institute, Apelsvold Research Station Div Kise, N 2350 Nes, Norway
    J Nutr 133:1286-90. 2003
    ..It is tempting to speculate that several of the effects due to these herbs are mediated by their antioxidant activities...
  23. ncbi request reprint Flavonoids increase the intracellular glutathione level by transactivation of the gamma-glutamylcysteine synthetase catalytical subunit promoter
    Mari C W Myhrstad
    Institute for Nutrition Research, University of Oslo, Oslo, Norway
    Free Radic Biol Med 32:386-93. 2002
    ..This effect may be exerted in part through GCS gene regulation, and may also contribute to the disease-preventing effect of fruits and vegetables...
  24. doi request reprint Hepatic nuclear factor kappa B regulates neutrophil recruitment to the injured brain
    Sandra J Campbell
    Experimental Neuropathology, Department of Pharmacology, University of Oxford, Oxford, United Kingdom
    J Neuropathol Exp Neurol 67:223-30. 2008
    ..In conclusion, acute brain injury is associated with rapid and robust activation of hepatic NF-kappa B, which is required for efficient mobilization of circulating leukocytes to the brain...
  25. ncbi request reprint Modulation of pregnane X receptor- and electrophile responsive element-mediated gene expression by dietary polyphenolic compounds
    Dirk Kluth
    German Institute of Human Nutrition, Potsdam Rehbrucke, Arthur Scheunert Allee 114 116, D 14558 Nuthetal, Germany
    Free Radic Biol Med 42:315-25. 2007
    ..It is concluded that individual polyphenols as well as polyphenol-rich plant extracts may affect phase 1 and 2 enzyme expression by distinct mechanisms that must be elucidated, before potential health effects can reliably be predicted...
  26. ncbi request reprint Water-miscible, emulsified, and solid forms of retinol supplements are more toxic than oil-based preparations
    Anne M Myhre
    Sogn Center for Child and Adolescent Psychiatry, University Hospital, University of Oslo, Blindern, 0316 Oslo, Norway
    Am J Clin Nutr 78:1152-9. 2003
    ..It is well established that an excessive intake of retinol (vitamin A) is toxic; however, it has been > 25 y since the last extensive treatise of case reports on this subject...
  27. ncbi request reprint Is serum gamma glutamyltransferase a marker of oxidative stress?
    Duk Hee Lee
    Department of Preventive Medicine and Health Promotion Research Center, School of Medicine, Kyungpook National University, Daegu, South Korea
    Free Radic Res 38:535-9. 2004
    ..Even though studies on serum and/or cellular GGT is at a beginning stage, our epidemiological findings suggest that serum GGT might be useful in studying oxidative stress-related issues in both epidemiological and clinical settings...
  28. ncbi request reprint Polyphenols and glutathione synthesis regulation
    Jan Ø Moskaug
    Institute for Nutrition Research, University of Oslo, Norway
    Am J Clin Nutr 81:277S-283S. 2005
    ....
  29. ncbi request reprint Dietary antioxidants and cardiovascular disease
    Rune Blomhoff
    Department of Nutrition, Institute for Basic Medical Sciences, University of Oslo, PO Box 1046, Blindern, N 0316 Oslo, Norway
    Curr Opin Lipidol 16:47-54. 2005
    ..Intervention with alpha-tocopherol, ascorbic acid and beta-carotene does not appear to reduce pathogenesis. The purpose of this review is to describe alternative antioxidant mechanisms that may be involved...
  30. ncbi request reprint Exposure to retinyl esters, retinol, and retinoic acids in non-pregnant women following increasing single and repeated oral doses of vitamin A
    Stefan Hartmann
    Roche Vitamins Ltd, Basel, Switzerland
    Ann Nutr Metab 49:155-64. 2005
    ..High intakes of vitamin A cause congenital malformations in experimental animals with elevated generation of retinoic acids (RA). Results in humans are conflicting...
  31. ncbi request reprint Molecular imaging of the biological effects of quercetin and quercetin-rich foods
    Jan Øivind Moskaug
    Institute for Nutrition Research, Faculty of Medicine, University of Oslo, P O Box 1046, Blindern, 0316 Oslo, Norway
    Mech Ageing Dev 125:315-24. 2004
    ..We utilize these in vivo models to elucidate the role of various flavonoids, such as quercetin, for modulating gene expression related to oxidative stress and the antioxidant defence system...
  32. ncbi request reprint Caught in the act: in vivo molecular imaging of the transcription factor NF-kappaB after myocardial infarction
    Jochen Tillmanns
    Medizinische Klinik der Universität Würzburg, Germany
    Biochem Biophys Res Commun 342:773-4. 2006
    ..Thus, in vivo measurement of the activation of NF-kappaB is feasible. NF-kappaB activity might play an important role for the remodeling process...
  33. ncbi request reprint Intakes of antioxidants in coffee, wine, and vegetables are correlated with plasma carotenoids in humans
    Arne Svilaas
    Lipid Clinic, Medical Department, Rikshospitalet, University of Oslo, Oslo, Norway
    J Nutr 134:562-7. 2004
    ..These data agree with the hypothesis that dietary antioxidants other than the well-known antioxidants contribute to our antioxidant defense. Surprisingly, the single greatest contributor to the total antioxidant intake was coffee...
  34. ncbi request reprint Vitamin A distribution and content in tissues of the lamprey, Lampetra japonica
    Heidi L Wold
    Institute for Nutrition Research, Faculty of Medicine, University of Oslo, Oslo, Norway
    Anat Rec A Discov Mol Cell Evol Biol 276:134-42. 2004
    ..Stellate cells derived from the splanchnic and intermediate mesoderm have high capacity and fibroblasts derived from the somatic and dorsal mesoderm have low capacity for the storage of vitamin A in the lamprey...
  35. ncbi request reprint Lutein effect on retina and hippocampus of diabetic mice
    Maria Muriach
    Departamento de Fisiologia, Farmacología and Toxicología, Universidad CEU Cardenal Herrera, Valencia, Spain
    Free Radic Biol Med 41:979-84. 2006
    ..Lutein could be an appropriate coadjuvant treatment for the changes observed in this study...
  36. ncbi request reprint Noninvasive in vivo imaging of protein kinase A activity
    Jan Øivind Moskaug
    Department of Biochemistry, Institute of Basic Medical Sciences, University of Oslo, Oslo, Norway
    Mol Imaging 7:35-41. 2008
    ..This study shows that luciferase can be used for in vivo measurements of kinase activity, suggesting that different kinase target sequences in luciferase can monitor kinase activity modulation...