Helle K Knutsen

Summary

Affiliation: Norwegian Institute of Public Health
Country: Norway

Publications

  1. doi request reprint Sex, BMI and age in addition to dietary intakes influence blood concentrations and congener profiles of dioxins and PCBs
    Helle K Knutsen
    Norwegian Institute of Public Health, Oslo, Norway
    Mol Nutr Food Res 55:772-82. 2011
  2. doi request reprint Dietary exposure to brominated flame retardants correlates with male blood levels in a selected group of Norwegians with a wide range of seafood consumption
    Helle K Knutsen
    Norwegian Institute of Public Health, Oslo, Norway
    Mol Nutr Food Res 52:217-27. 2008
  3. doi request reprint Maternal dietary intake of dioxins and polychlorinated biphenyls and birth size in the Norwegian Mother and Child Cohort Study (MoBa)
    Eleni Papadopoulou
    Centre for Research in Environmental Epidemiology CREAL, Barcelona, Spain Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway Pompeu Fabra University, Barcelona, Spain Electronic address
    Environ Int 60:209-16. 2013
  4. doi request reprint Consumption of fish from a contaminated lake strongly affects the concentrations of polybrominated diphenyl ethers and hexabromocyclododecane in serum
    Cathrine Thomsen
    Norwegian Institute of Public Health, Oslo, Norway
    Mol Nutr Food Res 52:228-37. 2008
  5. doi request reprint Dietary exposure to dioxins and PCBs in a large cohort of pregnant women: results from the Norwegian Mother and Child Cohort Study (MoBa)
    Ida H Caspersen
    Norwegian Institute of Public Health, Oslo, Norway
    Environ Int 59:398-407. 2013
  6. doi request reprint Development and validation of prediction models for blood concentrations of dioxins and PCBs using dietary intakes
    Helen Engelstad Kvalem
    Norwegian Institute of Public Health, Oslo, Norway
    Environ Int 50:15-21. 2012
  7. doi request reprint Fish liver and seagull eggs, vitamin D-rich foods with a shadow: results from the Norwegian Fish and Game Study
    Bryndis E Birgisdottir
    Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway
    Mol Nutr Food Res 56:388-98. 2012
  8. doi request reprint Diet and particularly seafood are major sources of perfluorinated compounds in humans
    Line S Haug
    Division of Environmental Medicine, Norwegian Institute of Public Health, P O Box 4404 Nydalen, NO 0403 Oslo, Norway
    Environ Int 36:772-8. 2010
  9. doi request reprint Role of dietary patterns for dioxin and PCB exposure
    Helen E Kvalem
    Norwegian Institute of Public Health, Oslo, Norway
    Mol Nutr Food Res 53:1438-51. 2009
  10. doi request reprint The impact of commercial rodent diets on the induction of tumours and flat aberrant crypt foci in the intestine of multiple intestinal neoplasia mice
    Camilla Svendsen
    Norwegian Institute of Public Health, Division of Environmental Medicine, Department of Food Safety and Nutrition, PO Box 4404, Nydalen, NO 0403 Oslo, Norway
    Lab Anim 46:207-14. 2012

Collaborators

Detail Information

Publications19

  1. doi request reprint Sex, BMI and age in addition to dietary intakes influence blood concentrations and congener profiles of dioxins and PCBs
    Helle K Knutsen
    Norwegian Institute of Public Health, Oslo, Norway
    Mol Nutr Food Res 55:772-82. 2011
    ....
  2. doi request reprint Dietary exposure to brominated flame retardants correlates with male blood levels in a selected group of Norwegians with a wide range of seafood consumption
    Helle K Knutsen
    Norwegian Institute of Public Health, Oslo, Norway
    Mol Nutr Food Res 52:217-27. 2008
    ..Further, significant but weak correlations were found between dietary exposure and serum levels for Sum PBDEs, BDE-47, and BDE-28 in males. This indicates that other sources in addition to diet need to be addressed...
  3. doi request reprint Maternal dietary intake of dioxins and polychlorinated biphenyls and birth size in the Norwegian Mother and Child Cohort Study (MoBa)
    Eleni Papadopoulou
    Centre for Research in Environmental Epidemiology CREAL, Barcelona, Spain Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway Pompeu Fabra University, Barcelona, Spain Electronic address
    Environ Int 60:209-16. 2013
    ..In conclusion, dietary intakes of dioxins and PCBs during pregnancy were negatively associated with fetal growth, even at intakes below the TWI. ..
  4. doi request reprint Consumption of fish from a contaminated lake strongly affects the concentrations of polybrominated diphenyl ethers and hexabromocyclododecane in serum
    Cathrine Thomsen
    Norwegian Institute of Public Health, Oslo, Norway
    Mol Nutr Food Res 52:228-37. 2008
    ..The median serum HBCD concentration was 4.1 and 2.6 ng/g lipids for men and women, respectively, and was also found to be associated with consumption of fish from Lake Mjøsa...
  5. doi request reprint Dietary exposure to dioxins and PCBs in a large cohort of pregnant women: results from the Norwegian Mother and Child Cohort Study (MoBa)
    Ida H Caspersen
    Norwegian Institute of Public Health, Oslo, Norway
    Environ Int 59:398-407. 2013
    ..Women who according to Norwegian recommendations avoid these food items generally do not have dietary exposure above the tolerable intake of dioxins and dl-PCBs. ..
  6. doi request reprint Development and validation of prediction models for blood concentrations of dioxins and PCBs using dietary intakes
    Helen Engelstad Kvalem
    Norwegian Institute of Public Health, Oslo, Norway
    Environ Int 50:15-21. 2012
    ..In large epidemiologic studies, exposure estimates of these compounds based on analyses of biological material might not be available or affordable...
  7. doi request reprint Fish liver and seagull eggs, vitamin D-rich foods with a shadow: results from the Norwegian Fish and Game Study
    Bryndis E Birgisdottir
    Division of Environmental Medicine, Norwegian Institute of Public Health, Oslo, Norway
    Mol Nutr Food Res 56:388-98. 2012
    ..We investigated whether serum 25-hydroxyvitamin D (25(OH)D) might be compromised by concomitant intake of dl-compounds...
  8. doi request reprint Diet and particularly seafood are major sources of perfluorinated compounds in humans
    Line S Haug
    Division of Environmental Medicine, Norwegian Institute of Public Health, P O Box 4404 Nydalen, NO 0403 Oslo, Norway
    Environ Int 36:772-8. 2010
    ..Further, significant relationships between estimated dietary intakes and serum concentrations have been demonstrated for the first time...
  9. doi request reprint Role of dietary patterns for dioxin and PCB exposure
    Helen E Kvalem
    Norwegian Institute of Public Health, Oslo, Norway
    Mol Nutr Food Res 53:1438-51. 2009
    ..Two were related to high intakes, one dominated by oily fish ((Omega-3)), the other by fish liver and seagull eggs ("northern coastal"). Only the latter was closely associated with high blood concentrations of dioxins and PCBs...
  10. doi request reprint The impact of commercial rodent diets on the induction of tumours and flat aberrant crypt foci in the intestine of multiple intestinal neoplasia mice
    Camilla Svendsen
    Norwegian Institute of Public Health, Division of Environmental Medicine, Department of Food Safety and Nutrition, PO Box 4404, Nydalen, NO 0403 Oslo, Norway
    Lab Anim 46:207-14. 2012
    ..These findings show the importance of defining the type of diet used in experimental intestinal carcinogenesis studies, and that the diet should be taken into consideration when comparing results from different studies with Min mice...
  11. doi request reprint Intestinal carcinogenesis of two food processing contaminants, 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine and 5-hydroxymethylfurfural, in transgenic FVB min mice expressing human sulfotransferases
    Camilla Svendsen
    Norwegian Institute of Public Health, Division of Environmental Medicine, Department of Food Safety and Nutrition, Nydalen, Oslo, Norway
    Mol Carcinog 51:984-92. 2012
    ..4-1.3 per animal). Thus, intestinal expression of human SULT1A1 and 1A2 might increase the susceptibility to compounds bioactivated via this pathway implying that humans might be more susceptible than conventional rodent models...
  12. doi request reprint Prenatal mercury exposure and infant birth weight in the Norwegian Mother and Child Cohort Study
    Kristine Vejrup
    1Division of Epidemiology, Norwegian Institute of Public Health, Post Box 4404 Nydalen, NO 0403 Oslo, Norway
    Public Health Nutr 17:2071-80. 2014
    ..To examine the association between calculated maternal dietary exposure to Hg in pregnancy and infant birth weight in the Norwegian Mother and Child Cohort Study (MoBa)...
  13. ncbi request reprint Intestinal adenomas of Min-mice lack enterochromaffin cells, and have increased lysozyme production in non-Paneth cells
    Trine Husøy
    Department of Food Toxicology, Norwegian Institute of Public Health, P O Box 4404, Nydalen, NO 0403 Oslo, Norway
    Anticancer Res 26:1797-802. 2006
    ..Paneth and enterochromaffin cells were studied in the intestine and intestinal adenomas from Min-mice with heterozygote and homozygote mutations in Apc, respectively...
  14. ncbi request reprint Increased levels of PPARbeta/delta and cyclin D1 in flat dysplastic ACF and adenomas in Apc(Min/+) mice
    Helle K Knutsen
    Department of Food Toxicology, Norwegian Institute of Public Health, Oslo, Norway
    Anticancer Res 25:3781-9. 2005
    ..ACF(Min), with a flat appearance, severe dysplasia and increased beta-catenin expression, are related to adenoma development, whereas classic ACF, with elevated structure, hyperplasia and normal beta-catenin level, are probably not...
  15. ncbi request reprint Connexin43 is overexpressed in Apc(Min/+)-mice adenomas and colocalises with COX-2 in myofibroblasts
    Trine Husøy
    Department of Food Toxicology, Norwegian Institute of Public Health, Oslo, Norway
    Int J Cancer 116:351-8. 2005
    ..We hypothesise that gap junctions may be of importance in the transfer of signals between epithelium and stroma...
  16. ncbi request reprint Truncated mouse adenomatous polyposis coli reduces connexin32 content and increases matrilysin secretion from Paneth cells
    Trine Husøy
    Department of Food Toxicology, Norwegian Institute of Public Health, P O Box 4404 Nydalen, NO 0403 Oslo, Norway
    Eur J Cancer 40:1599-603. 2004
    ..Absence of matrilysin in Min mice reduces adenoma development. Reduced Cx32 and increased matrilysin secretion from Paneth cells could be important to neoplastic development in the intestine...
  17. ncbi request reprint Cells heterozygous for the ApcMin mutation have decreased gap junctional intercellular communication and connexin43 level, and reduced microtubule polymerization
    Trine Husøy
    Department of Food Toxicology, Norwegian Institute of Public Health, PO Box 4404 Nydalen, NO 0403 Oslo, Norway
    Carcinogenesis 24:643-50. 2003
    ..Reduction in GJIC and Cx43 level in IMCE cells may be caused by reduced Cx43 transport as a result of alterations in microtubule function...
  18. ncbi request reprint The min mouse on FVB background: susceptibility to spontaneous and carcinogen-induced intestinal tumourigenesis
    Camilla Svendsen
    Norwegian Institute of Public Health, Division of Environmental Medicine, Department of Food Safety and Nutrition, P O Box 4404, Nydalen, NO 0403 Oslo, Norway
    Anticancer Res 31:785-8. 2011
    ..Treatment with PhIP significantly increased both the number and incidence of tumours in the small intestine, and gave a non-significant increase of tumours and flat ACF in the colon...
  19. ncbi request reprint The colon mitosis inhibitor pyroglutamyl-histidyl-glycine inhibits growth of non-tumorigenic colonic epithelial cells
    Wenche H Reichelt
    Institute of Pediatric Research, University of Oslo, The National Hospital, NO 0027 Oslo, Norway
    Anticancer Res 24:587-91. 2004
    ..However, the effect on non-tumorigenic colonic cells has not been investigated...