Stein Kaasa

Summary

Affiliation: Norwegian University of Science and Technology
Country: Norway

Publications

  1. ncbi The Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene may influence morphine requirements in cancer pain patients
    Trude Teoline Rakvåg
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology NTNU, N 7489 Trondheim, Norway
    Pain 116:73-8. 2005
  2. ncbi Methodological and structural challenges in palliative care research: how have we fared in the last decades?
    Stein Kaasa
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Norway
    Palliat Med 20:727-34. 2006
  3. doi Symptom assessment in palliative care: a need for international collaboration
    Stein Kaasa
    Pain and Palliation Research Group, Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Trondheim, Norway
    J Clin Oncol 26:3867-73. 2008
  4. doi Interview: Cancer pain management: the last decade and looking forward
    Stein Kaasa
    European Palliative Care Research Centre, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway and Cancer Clinic, St Olavs Hospital, University Hospital of Trondheim, Trondheim, Norway
    Pain Manag 3:431-4. 2013
  5. pmc Health care providers underestimate symptom intensities of cancer patients: a multicenter European study
    Eivor A Laugsand
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology NTNU, Trondheim, Norway
    Health Qual Life Outcomes 8:104. 2010
  6. pmc Using death certificate data to study place of death in 9 European countries: opportunities and weaknesses
    Joachim Cohen
    End of Life Care Research Group, Vrije Universiteit Brussel, Brussels, Belgium
    BMC Public Health 7:283. 2007
  7. pmc Validation of Doloplus-2 among nonverbal nursing home patients--an evaluation of Doloplus-2 in a clinical setting
    Karin Torvik
    Faculty of Nursing, Oslo University College, Oslo, Norway
    BMC Geriatr 10:9. 2010
  8. ncbi Building up research in palliative care: an historical perspective and a case for the future
    Stein Kaasa
    Department of Cancer Research and Molecular Biology, The Norwegian University of Science and Technology, 5th Floor Kreftbygget, 7006 Trondheim, Norway
    Clin Geriatr Med 21:81-92, viii. 2005
  9. doi Palliative care research--priorities and the way forward
    Stein Kaasa
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Trondheim, Norway
    Eur J Cancer 44:1175-9. 2008
  10. ncbi Patient demographics and centre description in European palliative care units
    Stein Kaasa
    Faculty of Medicine, Norwegian University of Science and Technology, Trondheim and Department of Oncology, St Olavs University Hospital, Trondheim, Norway
    Palliat Med 21:15-22. 2007

Detail Information

Publications117 found, 100 shown here

  1. ncbi The Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene may influence morphine requirements in cancer pain patients
    Trude Teoline Rakvåg
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology NTNU, N 7489 Trondheim, Norway
    Pain 116:73-8. 2005
    ..These results suggest that genetic variation in the COMT gene may contribute to variability in the efficacy of morphine in cancer pain treatment...
  2. ncbi Methodological and structural challenges in palliative care research: how have we fared in the last decades?
    Stein Kaasa
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Norway
    Palliat Med 20:727-34. 2006
    ....
  3. doi Symptom assessment in palliative care: a need for international collaboration
    Stein Kaasa
    Pain and Palliation Research Group, Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Trondheim, Norway
    J Clin Oncol 26:3867-73. 2008
    ..In the future, patients may find that a combination of a face-to-face interview plus a transfer of information of subjective symptoms by electronic means will optimize treatment...
  4. doi Interview: Cancer pain management: the last decade and looking forward
    Stein Kaasa
    European Palliative Care Research Centre, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway and Cancer Clinic, St Olavs Hospital, University Hospital of Trondheim, Trondheim, Norway
    Pain Manag 3:431-4. 2013
    b>Stein Kaasa, MD, speaks to Dominic Chamberlain, Assistant Commissioning Editor: Stein Kaasa specializes in oncology and palliative medicine...
  5. pmc Health care providers underestimate symptom intensities of cancer patients: a multicenter European study
    Eivor A Laugsand
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology NTNU, Trondheim, Norway
    Health Qual Life Outcomes 8:104. 2010
    ..The extent of agreement between patient and provider symptom assessments and the association of agreement with demographic- and disease-related factors was examined...
  6. pmc Using death certificate data to study place of death in 9 European countries: opportunities and weaknesses
    Joachim Cohen
    End of Life Care Research Group, Vrije Universiteit Brussel, Brussels, Belgium
    BMC Public Health 7:283. 2007
    ..This study illustrates opportunities and weaknesses of death certificate data to provide such information on place of death and associated factors in nine European countries (seven entire countries and five regions)...
  7. pmc Validation of Doloplus-2 among nonverbal nursing home patients--an evaluation of Doloplus-2 in a clinical setting
    Karin Torvik
    Faculty of Nursing, Oslo University College, Oslo, Norway
    BMC Geriatr 10:9. 2010
    ..The purposes of this study were to examine the use of Doloplus-2 in a nonverbal nursing home population, and to evaluate its reliability and validity by comparing registered nurses' estimation of pain with Doloplus-2 scores...
  8. ncbi Building up research in palliative care: an historical perspective and a case for the future
    Stein Kaasa
    Department of Cancer Research and Molecular Biology, The Norwegian University of Science and Technology, 5th Floor Kreftbygget, 7006 Trondheim, Norway
    Clin Geriatr Med 21:81-92, viii. 2005
    ....
  9. doi Palliative care research--priorities and the way forward
    Stein Kaasa
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Trondheim, Norway
    Eur J Cancer 44:1175-9. 2008
    ..Since the majority of palliative care patients come from oncology, it is important to establish a close collaboration between these two disciplines...
  10. ncbi Patient demographics and centre description in European palliative care units
    Stein Kaasa
    Faculty of Medicine, Norwegian University of Science and Technology, Trondheim and Department of Oncology, St Olavs University Hospital, Trondheim, Norway
    Palliat Med 21:15-22. 2007
    ..The range of services encountered in the survey highlights the need for the organisational and clinical standards for palliative care, which can be audited...
  11. ncbi [Investigation in suspected pulmonary tumor]
    Stein Kaasa
    Kreftavdelingen, St Olavs Hospital, 7006 Trondheim
    Tidsskr Nor Laegeforen 125:2958. 2005
  12. ncbi Palliative care in Norway: a national public health model
    Stein Kaasa
    Palliative Medicine Unit, Department of Oncology, St Olavs Hospital, Trondheim, Norway
    J Pain Symptom Manage 33:599-604. 2007
    ..There are also challenges related to expertise and training, including establishing a program for palliative nursing and getting palliative medicine recognized as a medical specialty...
  13. doi Which domains should be included in a cancer pain classification system? Analyses of longitudinal data
    Anne Kari Knudsen
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Pain 153:696-703. 2012
    ..Initial pain intensity emerged as the strongest predictor of pain outcome after 2 weeks, and incident pain was confirmed to be a relevant domain. The regression models explained only a minor part of the variability of pain outcomes...
  14. ncbi Second-line chemotherapy in recurrent small cell lung cancer. Results from a crossover schedule after primary treatment with cisplatin and etoposide (EP-regimen) or cyclophosphamide, epirubicin, and vincristin (CEV-regimen)
    Stein Sundstrøm
    Department of Oncology, St Olavs Hospital, University Hospital of Trondheim, N 7006 Trondheim, Norway
    Lung Cancer 48:251-61. 2005
    ..Further, to compare the crossover group with patients not receiving chemotherapy...
  15. ncbi Routine drug monitoring of serum concentrations of morphine, morphine-3-glucuronide and morphine-6-glucuronide do not predict clinical observations in cancer patients
    Pål Klepstad
    Department of Anaesthesia and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
    Palliat Med 17:679-87. 2003
    ..This result suggests that therapeutic drug monitoring as a routine tool during chronic morphine treatment has limited value for clinical decision making...
  16. ncbi Intensity and treatment of symptoms in 3,030 palliative care patients: a cross-sectional survey of the EAPC Research Network
    Eivor Alette Laugsand
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    J Opioid Manag 5:11-21. 2009
    ..This study aimed to describe intensity and treatment of symptoms other than pain in European palliative care units...
  17. doi Influence of comorbidity on survival, toxicity and health-related quality of life in patients with advanced non-small-cell lung cancer receiving platinum-doublet chemotherapy
    Bjørn H Grønberg
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, NO 7491 Trondheim, Norway
    Eur J Cancer 46:2225-34. 2010
    ....
  18. ncbi Prospective randomised multicenter trial on single fraction radiotherapy (8 Gy x 1) versus multiple fractions (3 Gy x 10) in the treatment of painful bone metastases
    Stein Kaasa
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Technology and Science, Trondheim, Norway
    Radiother Oncol 79:278-84. 2006
    ..To investigate whether single-fraction radiotherapy is equal to multiple fractions in the treatment of painful metastases...
  19. ncbi The Norwegian Doloplus-2, a tool for behavioural pain assessment: translation and pilot-validation in nursing home patients with cognitive impairment
    Jacob C Hølen
    Pain and Palliation Research Group, Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, N 7006 Trondheim, Norway
    Palliat Med 19:411-7. 2005
    ..The Doloplus-2 is developed for pain assessment in the CI and rates somatic, psychomotor and psychosocial behaviours as indicators of pain...
  20. doi Serum concentrations of opioids when comparing two switching strategies to methadone for cancer pain
    Kristin Moksnes
    Pain and Palliation Research Group, Faculty of Medicine, Norwegian University of Science and Technology NTNU, Trondheim, Norway
    Eur J Clin Pharmacol 68:1147-56. 2012
    ....
  21. doi Is oxycodone efficacy reflected in serum concentrations? A multicenter, cross-sectional study in 456 adult cancer patients
    Trine Naalsund Andreassen
    Pain and Palliation Research Group, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    J Pain Symptom Manage 43:694-705. 2012
    ..The relationship between oxycodone and metabolite serum concentrations and clinical effects has not previously been investigated in cancer pain patients...
  22. pmc Do CYP2D6 genotypes reflect oxycodone requirements for cancer patients treated for cancer pain? A cross-sectional multicentre study
    Trine Naalsund Andreassen
    Pain and Palliation Research Group, Faculty of Medicine, Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, 7489, Trondheim, Norway
    Eur J Clin Pharmacol 68:55-64. 2012
    ....
  23. pmc Day-to-day variations during clinical drug monitoring of morphine, morphine-3-glucuronide and morphine-6-glucuronide serum concentrations in cancer patients. A prospective observational study
    Pål Klepstad
    Department of Circulation and Imaging, Faculty of Medicine, Norwegian University of Science and Technology, N 7489 Trondheim, Norway
    BMC Clin Pharmacol 4:7. 2004
    ..One important factor relevant to drug monitoring is to what extent morphine, M6G and M3G serum concentrations fluctuate during stable morphine treatment...
  24. doi A first step in the development of an international self-report instrument for physical functioning in palliative cancer care: a systematic literature review and an expert opinion evaluation study
    Jorunn L Helbostad
    Pain and Palliation Research Group, Norwegian University of Science and Technology, Norway
    J Pain Symptom Manage 37:196-205. 2009
    ..Further testing of the instrument in a palliative cancer population is needed to develop the final PF instrument...
  25. doi A double-blind, randomized, crossover comparison between single-dose and double-dose immediate-release oral morphine at bedtime in cancer patients
    Ola Dale
    Pain and Palliation Research Group, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    J Pain Symptom Manage 37:68-76. 2009
    ..50 has little clinical significance, and the two procedures are, therefore, clinically equivalent. It is speculated whether the initial higher exposure to morphine-6-glucuronide may have clinical significance...
  26. ncbi Immediate or delayed radiotherapy in advanced non-small cell lung cancer (NSCLC)? Data from a prospective randomised study
    Stein Sundstrøm
    Department of Oncology, St Olavs Hospital of Trondheim, Norway
    Radiother Oncol 75:141-8. 2005
    ..To compare the course of symptoms and health-related quality-of-life (HRQOL) after immediate thoracic radiotherapy (TRT) between symptomatic (S) and non-symptomatic (NS) patients with advanced NSCLC...
  27. pmc A pan-European survey of research in end-of-life cancer care
    Katrin Ruth Sigurdardottir
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, 7006, Trondheim, Norway
    Support Care Cancer 20:39-48. 2012
    ..This survey aimed to map and describe present EOL cancer care research in Europe and to identify priorities and barriers...
  28. ncbi Palliative thoracic radiotherapy in locally advanced non-small cell lung cancer: can quality-of-life assessments help in selection of patients for short- or long-course radiotherapy?
    Stein Sundstrøm
    Department of Oncology, St Olavs Hospital, University Hospital of Trondheim, Norway
    J Thorac Oncol 1:816-24. 2006
    ....
  29. doi Assessment and classification of cancer breakthrough pain: a systematic literature review
    Dagny Faksvåg Haugen
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology NTNU, Trondheim, Norway
    Pain 149:476-82. 2010
    ....
  30. doi Comparisons of patient and physician assessment of pain-related domains in cancer pain classification: results from a large international multicenter study
    Cinzia Brunelli
    Palliative Care, Pain Therapy and Rehabilitation Unit, Fondazione IRCCS Istituto Nazionale dei Tumori, Milano, Italy European Palliative Care Research Centre PRC, Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology NTNU, Trondheim, Norway Electronic address
    J Pain 15:59-67. 2014
    ..6% (95% CI = 13.0-22.2%) for patient ratings vs 3.4% (95% CI = .9-5.9%) for physician ratings. Patients' self-assessment of subjective symptoms should be integrated in future cancer pain classification systems...
  31. pmc Longitudinal associations between exercise and pain in the general population--the HUNT pain study
    Tormod Landmark
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    PLoS ONE 8:e65279. 2013
    ..The aim of the current study was to investigate the association between exercise and pain longitudinally and to use within subjects analyses to remove between subjects confounding...
  32. doi Computer-based symptom assessment is feasible in patients with advanced cancer: results from an international multicenter study, the EPCRC-CSA
    Marianne Jensen Hjermstad
    European Palliative Care Research Centre, Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    J Pain Symptom Manage 44:639-54. 2012
    ..Symptom assessment by computers is only effective if it provides valid results and is perceived as useful for clinical use by the end users: patients and health care providers...
  33. ncbi Pain assessment tools: is the content appropriate for use in palliative care?
    Jacob Chr Hølen
    Pain and Palliation Research Group, Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    J Pain Symptom Manage 32:567-80. 2006
    ..This might reduce compliance and threaten the validity of the assessment. New tools should reflect the clinical relevance of different dimensions and be user-friendly...
  34. doi Variability in UDP-glucuronosyltransferase genes and morphine metabolism: observations from a cross-sectional multicenter study in advanced cancer patients with pain
    Torill Fladvad
    Department of Cancer Research and Molecular Medicine, European Palliative Care Research Center, Children s and Women s Health, Norwegian University of Science and Technology, Trondheim, Norway
    Pharmacogenet Genomics 23:117-26. 2013
    ....
  35. doi Measurement of physical activity in cancer survivors--a comparison of the HUNT 1 Physical Activity Questionnaire (HUNT 1 PA-Q) with the International Physical Activity Questionnaire (IPAQ) and aerobic capacity
    Gro F Bertheussen
    Department of Circulation and Medical Imaging, Norwegian University of Science and Technology NTNU, Trondheim, Norway
    Support Care Cancer 21:449-58. 2013
    ..In order to achieve better scientific knowledge of the effect of PA in cancer survivors, it is of paramount importance to have validated and feasible assessment tools for PA...
  36. ncbi Interviews with patients with advanced cancer--another step towards an international cancer pain classification system
    Anne Kari Knudsen
    European Palliative Care Research Centre, Department of Cancer Research and Molecular Medicine, Faculty of Medicine, NTNU, Trondheim University Hospital, Trondheim, Norway
    Support Care Cancer 20:2491-500. 2012
    ....
  37. doi Feasibility and changes in symptoms and functioning following inpatient cancer rehabilitation
    Gro F Bertheussen
    Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
    Acta Oncol 51:1070-80. 2012
    ....
  38. pmc Physical exercise for cancer patients with advanced disease: a randomized controlled trial
    Line M Oldervoll
    European Palliative Care Research Centre, Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Oncologist 16:1649-57. 2011
    ..A randomized, controlled trial was launched to test the hypothesis that physical exercise reduces fatigue and improves physical performance in cancer patients with advanced and incurable disease...
  39. pmc Genetic variation in the catechol-O-methyltransferase (COMT) gene and morphine requirements in cancer patients with pain
    Trude T Rakvåg
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology NTNU, Trondheim, Norway
    Mol Pain 4:64. 2008
    ..In this study we wanted to investigate if variability in other regions in the COMT gene also contributes to interindividual variability in morphine efficacy...
  40. ncbi Long term methadone for chronic pain: a pilot study of pharmacokinetic aspects
    Olav Magnus S Fredheim
    Pain and Palliation Research Group, Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Eur J Pain 11:599-604. 2007
    ..Our findings contradict that autoinduction of methadone metabolism takes place during long term treatment and supports that a 3-day opioid switch from morphine to methadone followed by a one week titration seems pharmacologically sound...
  41. doi Development of a computer-administered mobility questionnaire
    Jorunn L Helbostad
    Department of Neuroscience, Norwegian University of Science and Technology, Olav Kyrres g, 7006, Trondheim, Norway
    Support Care Cancer 19:745-55. 2011
    ..The specific aim of the present study is to assess psychometric properties of a mobility item bank, with regards to uni-dimensionality, functional coverage, redundant items and gaps in the scale...
  42. doi From "Breakthrough" to "Episodic" Cancer Pain? A European Association for Palliative Care Research Network Expert Delphi Survey Toward a Common Terminology and Classification of Transient Cancer Pain Exacerbations
    Erik Torbjørn Løhre
    European Palliative Care Research Centre, Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway Department of Oncology, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway Electronic address
    J Pain Symptom Manage 51:1013-9. 2016
    ..Breakthrough cancer pain (BTCP) is the most common term for the transient exacerbations of pain, but the ability of the nomenclature to capture relevant pain variations and give treatment guidance is questionable...
  43. ncbi Randomised trial of in-hospital geriatric intervention: impact on function and morale
    Ingvild Saltvedt
    Division of Internal Medicine, Section of Geriatrics, St Olavs University Hospital, Trondheim, Norway
    Gerontology 52:223-30. 2006
    ....
  44. ncbi [Genetic variation-- important for the clinical effect of opioids?]
    Pål Klepstad
    Avdeling for anestesi og akuttmedisin, St Olavs Hospital, 7006 Trondheim
    Tidsskr Nor Laegeforen 125:2655-8. 2005
    ..Results obtained so far strongly suggest that opioid efficacy is partly related to inborn properties caused by genetic variability...
  45. ncbi Measuring quality of palliative care: psychometric properties of the FAMCARE Scale
    Gerd Inger Ringdal
    Department of Psychology, Faculty of Social Sciences and Technology Management, Norwegian University of Science and Technology NTNU, Trondheim, Norway
    Qual Life Res 12:167-76. 2003
    ..One should also explore the possibilities of measuring satisfaction with care prospectively as an integral part of the palliative care program...
  46. doi The Brief Pain Inventory: pain's interference with functions is different in cancer pain compared with noncancer chronic pain
    Jacob C Hølen
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Norway
    Clin J Pain 24:219-25. 2008
    ....
  47. doi Studies comparing Numerical Rating Scales, Verbal Rating Scales, and Visual Analogue Scales for assessment of pain intensity in adults: a systematic literature review
    Marianne Jensen Hjermstad
    Regional Center for Excellence in Palliative Care, Department of Oncology, Oslo University Hospital Ulleval, Oslo, Norway
    J Pain Symptom Manage 41:1073-93. 2011
    ..A literature review of studies specifically comparing the NRS, VRS, and/or VAS for unidimensional self-report of PI was performed as part of the work of the European Palliative Care Research Collaborative on pain assessment...
  48. doi Clinical and genetic factors associated with nausea and vomiting in cancer patients receiving opioids
    Eivor A Laugsand
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, N 7489 Trondheim, Norway
    Eur J Cancer 47:1682-91. 2011
    ..This study investigates whether demographical, disease-related and genetic factors contribute to inter-individual differences in nausea and vomiting among patients receiving opioids for cancer pain...
  49. doi A cross-sectional study on prevalence of pain and breakthrough pain among an unselected group of outpatients in a tertiary cancer clinic
    Sunil X Raj
    European Palliative Care Research Centre, Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Support Care Cancer 22:1965-71. 2014
    ....
  50. doi Prognostic factors in patients with advanced cancer: a comparison of clinicopathological factors and the development of an inflammation-based prognostic system
    Barry J Laird
    Authors Affiliations European Palliative Care Research Centre Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology Departments of Oncology and Anaesthesiology and Emergency Medicine, St Olavs Hospital, Trondheim University Hospital, Trondheim Department of Oncology, Regional Centre for Excellence in Palliative Care, Oslo University Hospital, Oslo, Norway University of Edinburgh, Edinburgh and University of Glasgow, Glasgow, United Kingdom
    Clin Cancer Res 19:5456-64. 2013
    ..A new method of prognosis in advanced cancer (combining performance status and mGPS) is tested and then validated...
  51. doi Lung cancer patients' perceptions of informed consent documents
    Kari Sand
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, St Olavs Hospital, NO 7006 Trondheim, Norway
    Patient Educ Couns 73:313-7. 2008
    ..To compare patients' perceptions and preferences of two different versions of informed consent documents...
  52. pmc Influences on the pharmacokinetics of oxycodone: a multicentre cross-sectional study in 439 adult cancer patients
    Trine Naalsund Andreassen
    Pain and Palliation Research Group, Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Eur J Clin Pharmacol 67:493-506. 2011
    ..The aim of this study was to explore the relationships between ordinary patient characteristics and serum concentrations of oxycodone and the ratios noroxycodone or oxymorphone/oxycodone in cancer patients...
  53. ncbi Pharmacokinetics of intranasal fentanyl spray in patients with cancer and breakthrough pain
    Stein Kaasa
    Department of Cancer Research and Molecular Medicine, Medical Faculty, Norwegian University of Science and Technology, Trondheim, Norway
    J Opioid Manag 6:17-26. 2010
    ..This study reports the pharmacokinetics, tolerability, and safety of an intranasalfentanyl spray (INFS) in patients with cancer and breakthrough pain (BTP)...
  54. doi Which variables are associated with pain intensity and treatment response in advanced cancer patients?--Implications for a future classification system for cancer pain
    Anne Kari Knudsen
    European Palliative Care Research Centre, Faculty of Medicine, NTNU, NO 7006 Trondheim, Norway
    Eur J Pain 15:320-7. 2011
    ..A confirmative and explorative approach was applied to investigate which of the variables identified in the literature, by experts and patients that are associated with pain...
  55. doi Implementation of computerized technology in a palliative care unit
    Beate André
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Palliat Support Care 7:57-63. 2009
    ..The aim of the present study was to investigate the experience with implementation of CT among personnel in symptom assessment at a palliative care unit...
  56. doi Clinical priorities, barriers and solutions in end-of-life cancer care research across Europe. Report from a workshop
    Katrin Ruth Sigurdardottir
    Dept of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, St Olavs Hospital, N 7006 Trondheim, Norway
    Eur J Cancer 46:1815-22. 2010
    ....
  57. ncbi Opioid switching from oral slow release morphine to oral methadone may improve pain control in chronic non-malignant pain: a nine-month follow-up study
    Olav Magnus S Fredheim
    Pain and Palliation Research Group, Institute of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim
    Palliat Med 20:35-41. 2006
    ..This study brings novel information on the long-term consequences for pain control, health-related quality of life and cognitive functioning with a switch from morphine to methadone in the treatment of chronic non-malignant pain...
  58. doi Depression assessment and classification in palliative cancer patients: a systematic literature review
    Elisabet Wasteson
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology NTNU, N 7006 Trondheim, Norway
    Palliat Med 23:739-53. 2009
    ..Few studies classified depression by referring to a diagnostic system or by using cut-off scores. Evidently, there is a need for a consensus on how to assess and conceptualize depression and related conditions in palliative care...
  59. ncbi Opioid switching from morphine to methadone causes a minor but not clinically significant increase in QTc time: A prospective 9-month follow-up study
    Olav Magnus S Fredheim
    Pain and Palliation Research Group, Institute of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    J Pain Symptom Manage 32:180-5. 2006
    ..We observed no episodes of arrhythmias...
  60. pmc Doloplus-2, a valid tool for behavioural pain assessment?
    Jacob C Hølen
    Pain and Palliation Research Group, Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    BMC Geriatr 7:29. 2007
    ..Our objectives were to test the criterion validity and inter-rater reliability of the Doloplus-2, and to explore a design for validations of behavioural pain assessment tools...
  61. ncbi Acute geriatric intervention increases the number of patients able to live at home. A prospective randomized study
    Ingvild Saltvedt
    Section of Geriatrics, Department of Internal Medicine, University Hospital of Trondheim, Trondheim, Norway
    Aging Clin Exp Res 16:300-6. 2004
    ..The aim of this presentation was to study the impact of treatment in a GEMU on health care utilization...
  62. doi How are palliative care cancer populations characterized in randomized controlled trials? A literature review
    Katrin Ruth Sigurdardottir
    European Palliative Care Research Centre, Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology NTNU, Trondheim, Norway Sunniva Centre for Palliative Care, Haraldsplass Deaconess Hospital, Bergen, Norway Regional Centre of Excellence for Palliative Care, Western Norway, Haukeland University Hospital, Bergen, Norway Electronic address
    J Pain Symptom Manage 47:906-914.e17. 2014
    ..The difficulties in defining a palliative care patient accentuate the need to provide stringent descriptions of the patient population in palliative care research...
  63. doi Late radiation effects to the rectum and anus after treatment for prostate cancer; validity of the LENT/SOMA score
    Jo A Lund
    Cancer Clinic, St Olavs Hospital, University Hospital of Trondheim, Trondheim, Norway
    Acta Oncol 52:727-35. 2013
    ..The aim of the present study was to validate the LENT/SOMA scoring system for recto-anal side effects after treatment for prostate cancer in a randomized trial...
  64. ncbi The Norwegian brief pain inventory questionnaire: translation and validation in cancer pain patients
    Pål Klepstad
    Department of Anesthesiology and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
    J Pain Symptom Manage 24:517-25. 2002
    ....
  65. doi Estimating the prevalence of chronic pain: validation of recall against longitudinal reporting (the HUNT pain study)
    Tormod Landmark
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Pain 153:1368-73. 2012
    ..Thus pain reporting in the general population is stable and cross-sectional measures may give valid prevalence estimates of chronic pain...
  66. doi Associations between recreational exercise and chronic pain in the general population: evidence from the HUNT 3 study
    Tormod Landmark
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Pain 152:2241-7. 2011
    ....
  67. doi European Palliative Care Research Collaborative pain guidelines: opioid switching to improve analgesia or reduce side effects. A systematic review
    Ola Dale
    Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Norway
    Palliat Med 25:494-503. 2011
    ..Due to serious design limitations, the level of evidence was low (D). Randomized trials, with standardization of cohort classification, use of outcomes and analysis are warranted to establish the practice of opioid switching...
  68. doi Starting step III opioids for moderate to severe pain in cancer patients: dose titration: a systematic review
    Pål Klepstad
    Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
    Palliat Med 25:424-30. 2011
    ..Two randomized controlled trials were identified. One study compared starting opioid treatment with intravenous morphine versus IR oral morphine and one study compared IR oral morphine versus sustained release oral morphine...
  69. pmc Inadequate symptom control in advanced cancer patients across Europe
    Eivor A Laugsand
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Medisinsk teknisk forskningssenter, Olav Kyrres gate 9, 7489 Trondheim, Norway
    Support Care Cancer 19:2005-14. 2011
    ..The purpose of this study is to examine the adequacy of treatment for constipation, nausea, depression and poor sleep and the factors associated with inadequate symptom control in cancer patients receiving opioids...
  70. doi Validation of the intestinal part of the prostate cancer questionnaire "QUFW94": psychometric properties, responsiveness, and content validity
    Randi J Reidunsdatter
    Department of Radiography, Faculty of Technology, Sør Trøndelag University College, Trondheim, Norway
    Int J Radiat Oncol Biol Phys 77:793-804. 2010
    ..The aim of this study was to explore the validity and responsiveness of the intestinal part of the prostate cancer-specific questionnaire QUFW94...
  71. doi "The healthy me appears": palliative cancer patients' experiences of participation in a physical group exercise program
    Hanne Paltiel
    Physiotherapy Department, St Olavs University Hospital, Trondheim, Norway
    Palliat Support Care 7:459-67. 2009
    ..The purpose of the present study was to understand the meaning of such an intervention for the individual participant and thereby to provide knowledge for shaping future clinical practice...
  72. ncbi Self-reports are not related to objective assessments of cognitive function and sedation in patients with cancer pain admitted to a palliative care unit
    Pål Klepstad
    Department of Anesthesia and Medical Imaging, Norwegian University of Science and Technology, Trondheim
    Palliat Med 16:513-9. 2002
    ..This finding illustrates the importance of differentiating between observations and patient self-reports. The results also question the validity of patient self-reports for measurements of cognitive failure and sedation...
  73. ncbi Immediate- or sustained-release morphine for dose finding during start of morphine to cancer patients: a randomized, double-blind trial
    P Klepstad
    Department of Anesthesiology, University Hospital of Trondheim, N 7006, Trondheim, Norway
    Pain 101:193-8. 2003
    ..Similar global satisfactions with the morphine treatments were reported. In conclusion, a simplified titration using sustained-release morphine once daily is equally effective as immediate-release morphine given 4-hourly...
  74. ncbi The validity of EORTC QLQ-C30 fatigue scale in advanced cancer patients and cancer survivors
    Heidi Knobel
    Unit for Applied Clinical Research, Department of Cancer Research and Molecular Medicine, The Norwegian University of Science and Technology, N 7006 Trondheim, Norway
    Palliat Med 17:664-72. 2003
    ..The validity of the EORTC QLQ-C30 fatigue scale is to be questioned for use in palliative care patients. In studies with fatigue as a defined end point, a domain-specific instrument should, therefore, be added...
  75. ncbi [Use of opioids against severe cancer pain]
    Petter C Borchgrevink
    Senter for smerte og sammensatte lidelser, Anestesiavdelingen, St Olavs Hospital, 7006 Trondheim
    Tidsskr Nor Laegeforen 124:337-8. 2004
  76. ncbi Pain and pain treatments in European palliative care units. A cross sectional survey from the European Association for Palliative Care Research Network
    Pål Klepstad
    Department of Circulation and Medical Imaging, Norwegian University of Science and Technology, Trondheim, Norway
    Palliat Med 19:477-84. 2005
    ..We observed large variations in the use of opioids across countries. Finally, we observed that only a minority of the patients who used morphine needed very high doses...
  77. ncbi Patterns of drug prescription in a geriatric evaluation and management unit as compared with the general medical wards: a randomised study
    Ingvild Saltvedt
    Section of Geriatrics, Division of Medicine, St Olavs University Hospital, Trondheim, Norway
    Eur J Clin Pharmacol 61:921-8. 2005
    ..This study's objective was to determine whether patients treated in a geriatric evaluation and management unit (GEMU) had a more appropriate drug profile than patients treated in the general medical wards (MW)...
  78. doi Early pharmacokinetics of nasal fentanyl: is there a significant arterio-venous difference?
    Kristin Moksnes
    Department of Circulation and Medical Imaging, Pain and Palliation Research Group, Norwegian University of Science and Technology, St Olav University Hospital, Kreftbygget, 5th Floor, Olav Kyrres gate 17, 7006, Trondheim, Norway
    Eur J Clin Pharmacol 64:497-502. 2008
    ..We have investigated the arterio-venous difference in the pharmacokinetics of 50 microg fentanyl during the first hour following nasal administration and documented its tolerability in opioid-naïve middle-aged to elderly patients...
  79. doi Management of opioid-induced nausea and vomiting in cancer patients: systematic review and evidence-based recommendations
    Eivor A Laugsand
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Norway
    Palliat Med 25:442-53. 2011
    ..The evidence was also too limited to prioritize between symptomatic treatment and adjustment of the opioid treatment...
  80. pmc Physical activity in Hodgkin's lymphoma survivors with and without chronic fatigue compared with the general population - a cross-sectional study
    Line M Oldervoll
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, The Norwegian University of Science and Technology NTNU, Trondheim, Norway
    BMC Cancer 7:210. 2007
    ..The secondary objective was to compare these results with data from age and gender adjusted data from the general population (Gen-Pop)...
  81. doi A systematic review of oxymorphone in the management of chronic pain
    Fadia Mayyas
    Pain and Palliation Research Group, Norwegian University of Science and Technology, 7489Trondheim, Norway
    J Pain Symptom Manage 39:296-308. 2010
    ..No significant differences between oxymorphone and oxycodone at equipotent doses were found. In conclusion, oxymorphone is superior to placebo. There is no evidence that the efficacy of oxymorphone differs from other opioids...
  82. ncbi Validation and comparison of the health-related quality-of-life instruments EORTC QLQ-C30 and SF-36 in assessment of patients with chronic nonmalignant pain
    Olav Magnus S Fredheim
    Pain and Palliation Research Group, Norwegian University of Science and Technology, Trondheim, Norway
    J Pain Symptom Manage 34:657-65. 2007
    ..The EORTC QLQ-C30 is a valid alternative to the SF-36 when a broader assessment of symptoms is desired...
  83. ncbi Quality of life in palliative care: principles and practice
    Stein Kaasa
    Department of Oncology and Radiotherapy, Palliative Medicine Unit, Trondheim University Hospital, Trondheim, Norway
    Palliat Med 17:11-20. 2003
    ....
  84. ncbi Health-related quality of life (HRQOL) in family members of cancer victims: results from a longitudinal intervention study in Norway and Sweden
    Gerd Inger Ringdal
    Department of Psychology, Norwegian University of Science and Technology NTNU, Trondheim, Norway
    Palliat Med 18:108-20. 2004
    ..Before we may reach a definitive conclusion on the effects of palliative care programs for the HRQOL of family members, we need further longitudinal intervention studies with large samples...
  85. doi Phase III study by the Norwegian lung cancer study group: pemetrexed plus carboplatin compared with gemcitabine plus carboplatin as first-line chemotherapy in advanced non-small-cell lung cancer
    Bjørn H Grønberg
    3 etg, Gastro Sør, St Olavs Hospital, NO 7006 Trondheim, Norway
    J Clin Oncol 27:3217-24. 2009
    ..CONCLUSION Pemetrexed/carboplatin provides similar HRQoL and survival when compared with gemcitabine/carboplatin with less hematologic toxicity and less need for supportive care...
  86. ncbi The effect of a physical exercise program in palliative care: A phase II study
    Line M Oldervoll
    The Norwegian Cancer Society, Department of Cancer Research and Molecular Medicine, St Olavs Hospital, Trondheim, Norway
    J Pain Symptom Manage 31:421-30. 2006
    ..05). Physical exercise seems to be a feasible way to improve well-being among patients with incurable cancer. Future randomized trials are needed to confirm the results...
  87. doi Associations between physical activity and physical and mental health--a HUNT 3 study
    Gro F Bertheussen
    Department of Circulation and Medical Imaging, Norwegian University of Science and Technology and Department of Physical Medicine and Rehabilitation, St Olav University Hospital, Trondheim, Norway
    Med Sci Sports Exerc 43:1220-8. 2011
    ..We assessed how frequency, duration, and intensity of PA were related to HRQoL in younger (<65 yr) and older (≥65 yr) females and males...
  88. ncbi Pain in elderly hospitalized cancer patients with bone metastases in Norway
    Karin Torvik
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology NTNU, Trondheim, Norway
    Int J Palliat Nurs 14:238-45. 2008
    ..The study also examined differences in global quality of life (QoL) and pain interference with patient function between middle-aged and elderly patients with bone metastases...
  89. doi Computer-based assessment of symptoms and mobility in palliative care: feasibility and challenges
    Even Hovig Fyllingen
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology NTNU, Trondheim, Norway
    J Pain Symptom Manage 38:827-36. 2009
    ..001) and performance status (P<0.001). Because higher age and worse performance status resulted in more need of assistance, assessment tools should be short and user-friendly to ensure good compliance in frail patients...
  90. ncbi [Palliative medicine-- research and education in a new specialist field]
    Stein Kaasa
    Seksjon lindrende behandling, Kreftavdelingen, St Olavs Hospital og Institutt for kreftforskning og molekylaer medisin, Det medisinske fakultet, Norges Teknisk Naturvitenskapelige Universitet, 7006 Trondheim
    Tidsskr Nor Laegeforen 126:333-6. 2006
    ..However, there is a need to strengthen research in this area. Chairs in palliative medicine will facilitate such a development and are urgently needed in all medical schools...
  91. ncbi [The specialist field of palliative medicine]
    Stein Kaasa
    Seksjon lindrende behandling, Kreftavdelingen, St Olavs Hospital og Institutt for kreftforskning og molekylaer medisin, Det medisinske fakultet, Norges Teknisk Naturvitenskapelige Universitet, 7006 Trondheim
    Tidsskr Nor Laegeforen 126:326-8. 2006
    ..To reach these goals, a multi-professional approach is needed, and the doctor in charge must be highly qualified clinically and academically and willing and able to cooperate with colleagues and other healthcare professionals...
  92. ncbi Assessing physical functioning: a systematic review of quality of life measures developed for use in palliative care
    Marit S Jordhoy
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology NTNU, Trondheim, Norway
    Palliat Med 21:673-82. 2007
    ..Physical functioning (PF) is therefore a crucial domain for quality of life (Qol) assessments. The purpose of this study was to review how PF assessments are performed in Qol instruments developed for palliative care..
  93. ncbi Morphine glucuronide-to-morphine plasma ratios are unaffected by the UGT2B7 H268Y and UGT1A1*28 polymorphisms in cancer patients on chronic morphine therapy
    Monica Holthe
    Institute of Cancer Research and Molecular Biology, Faculty of Medicine, Norwegian University of Science and Technology, 7489 Trondheim, Norway
    Eur J Clin Pharmacol 58:353-6. 2002
    ..Our objective was to investigate whether the UGT2B7 H268Y and UGT1A1*28 polymorphisms contribute to the variability in morphine glucuronide-to-morphine plasma ratios among cancer patients undergoing analgesic therapy with morphine...
  94. ncbi Hypofractionated palliative radiotherapy (17 Gy per two fractions) in advanced non-small-cell lung carcinoma is comparable to standard fractionation for symptom control and survival: a national phase III trial
    Stein Sundstrøm
    Department of Oncology, St Olavs Hospital, University Hospital of Trondheim, N 7006 Trondheim, Norway Stein Sundstrom stolav no
    J Clin Oncol 22:801-10. 2004
    ..To investigate whether the effect of hypofractionated thoracic radiotherapy (TRT) is comparable to more standard fractionated radiotherapy (RT) in advanced non-small-cell lung cancer (NSCLC)...
  95. ncbi Reduced mortality in treating acutely sick, frail older patients in a geriatric evaluation and management unit. A prospective randomized trial
    Ingvild Saltvedt
    Section of Geriatrics, Department of Internal Medicine, University Hospital of Trondheim, Trondheim, Norway
    J Am Geriatr Soc 50:792-8. 2002
    ..The present study evaluated whether treatment in a GEMU would reduce mortality as compared to traditional treatment delivered in the Department of Internal Medicine...
  96. ncbi Family satisfaction with end-of-life care for cancer patients in a cluster randomized trial
    Gerd Inger Ringdal
    Department of Psychology, Norwegian University of Science and Technology, Trondheim, Norway
    J Pain Symptom Manage 24:53-63. 2002
    ..This difference remained unchanged after controlling for a range of other relevant factors: relationship to the deceased, sex and age of the respondent, sex and age of the patient, time since inclusion in the study, and place of death...
  97. ncbi Are palliative cancer patients willing and able to participate in a physical exercise program?
    Line M Oldervoll
    Norwegian Cancer Society, Oslo, Norway
    Palliat Support Care 3:281-7. 2005
    ..The primary aim of the present article was to identify palliative care patient populations who are willing to participate in and able to complete a group exercise/physical training program designed specifically for the individual patient...
  98. doi The importance of key personnel and active management for successful implementation of computer-based technology in palliative care: results from a qualitative study
    Beate André
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Comput Inform Nurs 26:183-9. 2008
    ..There is a need for skilled and motivated key personnel in the unit if implementation is to be successful...
  99. ncbi [Specialised short-term wards in nursing homes--the Trondheim model]
    Helge Garåsen
    Institutt for samfunnsmedisin, Norges Teknisk Naturvitenskapelige Universitet, 7491 Trondheim
    Tidsskr Nor Laegeforen 125:1503-5. 2005
    ..There is a considerable professional gap between community care services and services offered by the general hospitals...
  100. ncbi [The cooperation between Helse Midt-Norge and NTNU supports clinical research]
    Per G Farup
    Enhet for anvendt klinisk forskning, Institutt for kreftforskning og molekylaermedisin, Det medisinske fakultet, Norges teknisk vitenskapelige universitet, 7006 Trondheim
    Tidsskr Nor Laegeforen 125:2382-3. 2005
  101. ncbi Attitudes towards, and wishes for, euthanasia in advanced cancer patients at a palliative medicine unit
    Sissel Johansen
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology NTNU, Trondheim, Norway
    Palliat Med 19:454-60. 2005
    ..The aim of this study is to explore and describe attitudes towards, and wishes for, euthanasia/PAS in cancer patients with short life expectancy...