Jørgen Jensen

Summary

Affiliation: Norwegian School of Sport Sciences
Country: Norway

Publications

  1. pmc The role of skeletal muscle glycogen breakdown for regulation of insulin sensitivity by exercise
    Jørgen Jensen
    Department of Physical Performance, Norwegian School of Sport Sciences Oslo, Norway
    Front Physiol 2:112. 2011
  2. doi request reprint Effects of adrenaline on whole-body glucose metabolism and insulin-mediated regulation of glycogen synthase and PKB phosphorylation in human skeletal muscle
    Jørgen Jensen
    Department of Physiology, National Institute of Occupational Health, P O Box 8149 Dep, N 0033 Oslo, Norway
    Metabolism 60:215-26. 2011
  3. ncbi request reprint GSK-3beta regulation in skeletal muscles by adrenaline and insulin: evidence that PKA and PKB regulate different pools of GSK-3
    Jørgen Jensen
    Department of Physiology, National Institute of Occupational Health, P O Box 8149 Dep, N 0033, Oslo, Norway
    Cell Signal 19:204-10. 2007
  4. doi request reprint Insulin-stimulated glycogen synthesis and glycogen synthase activation after electrical stimulation of epitrochlearis muscles with different initial glycogen contents
    Yu Chiang Lai
    Department of Physical Performance, Norwegian School of Sport Sciences, PO Box 4014 Ullevål Stadion, N 0806 Oslo, Norway
    Arch Physiol Biochem 116:116-27. 2010
  5. doi request reprint Additive effect of contraction and insulin on glucose uptake and glycogen synthase in muscle with different glycogen contents
    Yu Chiang Lai
    Department of Physiology, National Institute of Occupational Health, Oslo, Norway
    J Appl Physiol (1985) 108:1106-15. 2010
  6. ncbi request reprint Contraction activates glucose uptake and glycogen synthase normally in muscles from dexamethasone-treated rats
    Jérôme Ruzzin
    Dept of Physiology, National Institute of Occupational Health, PO Box 8149 Dep, N 0033, Oslo, Norway
    Am J Physiol Endocrinol Metab 289:E241-50. 2005
  7. ncbi request reprint Regulation of muscle glycogen synthase phosphorylation and kinetic properties by insulin, exercise, adrenaline and role in insulin resistance
    Jørgen Jensen
    Department of Physiology, National Institute of Occupational Health, Thiruvallur, Oslo, Norway
    Arch Physiol Biochem 115:13-21. 2009
  8. ncbi request reprint Muscle glycogen inharmoniously regulates glycogen synthase activity, glucose uptake, and proximal insulin signaling
    Jørgen Jensen
    Department of Physiology, National Institute of Occupational Health, Oslo, Norway
    Am J Physiol Endocrinol Metab 290:E154-E162. 2006
  9. pmc Effect of acute exercise on glycogen synthase in muscle from obese and diabetic subjects
    Jørgen Jensen
    Department of Physical Performance, Norwegian School of Sport Sciences, Oslo, Norway
    Am J Physiol Endocrinol Metab 303:E82-9. 2012
  10. pmc Beta-adrenoceptor stimulation potentiates insulin-stimulated PKB phosphorylation in rat cardiomyocytes via cAMP and PKA
    Jorid T Stuenaes
    Department of Physiology, National Institute of Occupational Health, Oslo, Norway
    Br J Pharmacol 160:116-29. 2010

Collaborators

Detail Information

Publications21

  1. pmc The role of skeletal muscle glycogen breakdown for regulation of insulin sensitivity by exercise
    Jørgen Jensen
    Department of Physical Performance, Norwegian School of Sport Sciences Oslo, Norway
    Front Physiol 2:112. 2011
    ..The reduction of skeletal muscle glycogen after exercise allows a healthy storage of carbohydrates after meals and prevents development of type 2 diabetes...
  2. doi request reprint Effects of adrenaline on whole-body glucose metabolism and insulin-mediated regulation of glycogen synthase and PKB phosphorylation in human skeletal muscle
    Jørgen Jensen
    Department of Physiology, National Institute of Occupational Health, P O Box 8149 Dep, N 0033 Oslo, Norway
    Metabolism 60:215-26. 2011
    ..Still, insulin normalized adrenaline-mediated hyperglycemia...
  3. ncbi request reprint GSK-3beta regulation in skeletal muscles by adrenaline and insulin: evidence that PKA and PKB regulate different pools of GSK-3
    Jørgen Jensen
    Department of Physiology, National Institute of Occupational Health, P O Box 8149 Dep, N 0033, Oslo, Norway
    Cell Signal 19:204-10. 2007
    ..Further, we hypothesise that each of these pools is involved in the control of different cellular processes...
  4. doi request reprint Insulin-stimulated glycogen synthesis and glycogen synthase activation after electrical stimulation of epitrochlearis muscles with different initial glycogen contents
    Yu Chiang Lai
    Department of Physical Performance, Norwegian School of Sport Sciences, PO Box 4014 Ullevål Stadion, N 0806 Oslo, Norway
    Arch Physiol Biochem 116:116-27. 2010
    ..In conclusion, after contraction insulin-stimulated glycogen synthesis was increased by rather similar magnitude at all glycogen contents in concert with increased glycogen synthase activation...
  5. doi request reprint Additive effect of contraction and insulin on glucose uptake and glycogen synthase in muscle with different glycogen contents
    Yu Chiang Lai
    Department of Physiology, National Institute of Occupational Health, Oslo, Norway
    J Appl Physiol (1985) 108:1106-15. 2010
    ..Furthermore, contraction, insulin, and glycogen content all regulate GS Ser641 phosphorylation and GS fractional activity in concert...
  6. ncbi request reprint Contraction activates glucose uptake and glycogen synthase normally in muscles from dexamethasone-treated rats
    Jérôme Ruzzin
    Dept of Physiology, National Institute of Occupational Health, PO Box 8149 Dep, N 0033, Oslo, Norway
    Am J Physiol Endocrinol Metab 289:E241-50. 2005
    ..After contraction, insulin's ability to stimulate glycogen synthesis was completely restored in epitrochlearis and improved in soleus from dexamethasone-treated rats...
  7. ncbi request reprint Regulation of muscle glycogen synthase phosphorylation and kinetic properties by insulin, exercise, adrenaline and role in insulin resistance
    Jørgen Jensen
    Department of Physiology, National Institute of Occupational Health, Thiruvallur, Oslo, Norway
    Arch Physiol Biochem 115:13-21. 2009
    ..In this paper we discuss the physiological regulation of glycogen synthase phosphorylation and how the phosphorylation pattern regulates glycogen synthase kinetic properties...
  8. ncbi request reprint Muscle glycogen inharmoniously regulates glycogen synthase activity, glucose uptake, and proximal insulin signaling
    Jørgen Jensen
    Department of Physiology, National Institute of Occupational Health, Oslo, Norway
    Am J Physiol Endocrinol Metab 290:E154-E162. 2006
    ..Insulin resistance" is observed at the level of glycogen synthase, and the reduced glycogen synthesis leads to increased levels of glucose 6-phosphate, glycolytic flux, and accumulation of nonphosphorylated 2-deoxyglucose...
  9. pmc Effect of acute exercise on glycogen synthase in muscle from obese and diabetic subjects
    Jørgen Jensen
    Department of Physical Performance, Norwegian School of Sport Sciences, Oslo, Norway
    Am J Physiol Endocrinol Metab 303:E82-9. 2012
    ..We conclude that the molecular regulatory process by which exercise promotes glycogen synthesis in muscle is preserved in insulin-resistant subjects...
  10. pmc Beta-adrenoceptor stimulation potentiates insulin-stimulated PKB phosphorylation in rat cardiomyocytes via cAMP and PKA
    Jorid T Stuenaes
    Department of Physiology, National Institute of Occupational Health, Oslo, Norway
    Br J Pharmacol 160:116-29. 2010
    ..The purpose of the present study was to investigate the interaction between insulin and beta-adrenergic stimulation in regulation of PKB phosphorylation...
  11. ncbi request reprint Adrenaline potentiates insulin-stimulated PKB activation in the rat fast-twitch epitrochlearis muscle without affecting IRS-1-associated PI 3-kinase activity
    Jørgen Jensen
    Department of Physiology, National Institute of Occupational Health, P O Box 8149 Dep, Oslo, 0033, Norway
    Pflugers Arch 456:969-78. 2008
    ..These results indicate that the combination of adrenaline and insulin may activate novel signalling molecules rather than just summing up their effects on linear pathways...
  12. doi request reprint Effect of insulin and contraction on glycogen synthase phosphorylation and kinetic properties in epitrochlearis muscles from lean and obese Zucker rats
    Fang Chin Lin
    Department of Physical Performance, Norwegian School of Sport Sciences, P O Box 4014 Ullevål Stadion, N 0806 Oslo, Norway
    Am J Physiol Cell Physiol 302:C1539-47. 2012
    ..In conclusion, contraction-mediated activation and dephosphorylation of GS were normal in muscles from obese Zucker rats, whereas insulin-mediated GS activation and dephosphorylation were impaired...
  13. ncbi request reprint Glycogen content and contraction regulate glycogen synthase phosphorylation and affinity for UDP-glucose in rat skeletal muscles
    Yu Chiang Lai
    Dept of Physiology, National Institute of Occupational Health, P O Box 8149, Dep N 0033, Oslo, Norway
    Am J Physiol Endocrinol Metab 293:E1622-9. 2007
    ..Contraction increases GS affinity for UDP-glucose independently of glycogen content and creates a unique phosphorylation pattern...
  14. doi request reprint Sprint interval running increases insulin sensitivity in young healthy subjects
    Marit Sandvei
    Department of Physical Performance, Norwegian School of Sport Science, PO Box 4014 Ullevål Stadion, N 0806 Oslo, Norway
    Arch Physiol Biochem 118:139-47. 2012
    ....
  15. ncbi request reprint Adrenaline potentiates insulin-stimulated PKB activation via cAMP and Epac: implications for cross talk between insulin and adrenaline
    Erlend O Brennesvik
    Department of Physiology, National Institute of Occupational Health, P O Box 8149 Dep, N 0033, Oslo, Norway
    Cell Signal 17:1551-9. 2005
    ..Furthermore, the fact that adrenaline alone did not activate PKB or p70(S6K) suggests that a hormone can be a potent regulator of signalling despite no effects being seen when co-activators are lacking...
  16. ncbi request reprint Attenuated adrenergic responses to exercise in women with fibromyalgia--a controlled study
    Liv Giske
    Department of Work related Musculoskeletal Disorders, National Institute of Occupational Health, Oslo, Norway
    Eur J Pain 12:351-60. 2008
    ..Muscle performance was altered with increased muscle activity during the exercise. Women with FM showed an attenuated Adr response to repetitive isometric exercise...
  17. pmc Tyramine Reveals Failing α2-Adrenoceptor Control of Catecholamine Release and Total Peripheral Vascular Resistance in Hypertensive Rats
    Torill Berg
    Department of Physiology, Institute of Basic Medical Sciences, University of Oslo Oslo, Norway
    Front Neurol 4:19. 2013
    ..Our results indicate that presynaptic α-adrenoceptor regulation of norepinephrine release from nerve vesicles and epinephrine secretion is dysfunctional in SHRs, but can be restored by clonidine...
  18. pmc Plasma Norepinephrine in Hypertensive Rats Reflects α(2)-Adrenoceptor Release Control Only When Re-Uptake is Inhibited
    Torill Berg
    Department of Physiology, Institute of Basic Medical Sciences, University of Oslo Oslo, Norway
    Front Neurol 3:160. 2012
    ..2A)AR inhibited epinephrine secretion, particularly in SHR. α(2A)AR supported α(1)AR-induced vasoconstriction equally in the two strains. α(2)AR malfunctions were therefore not detected in SHR under this basal condition...
  19. pmc Simultaneous parasympathetic and sympathetic activation reveals altered autonomic control of heart rate, vascular tension, and epinephrine release in anesthetized hypertensive rats
    Torill Berg
    Department of Physiology, Institute of Basic Medical Sciences, University of Oslo Oslo, Norway
    Front Neurol 2:71. 2011
    ..A βAR-activated, probably vagal afferent mechanism, hampered epinephrine secretion in SHR. Thus, 4-AP activated the autonomic system and exposed mechanisms relevant to hypertensive disease...
  20. doi request reprint Role of beta1-3-adrenoceptors in blood pressure control at rest and during tyramine-induced norepinephrine release in spontaneously hypertensive rats
    Torill Berg
    Department of Physiology, Institute for Basic Medical Sciences, University of Oslo, 0317 Oslo, Norway
    Hypertension 55:1224-30. 2010
    ..There was also a hypertensive, nerve-activated vasoconstrictory mechanism present in hypertensive rats, involving central beta(1)- and peripheral beta(2)-adrenoceptors combined...
  21. ncbi request reprint Nutritional concerns in the diabetic athlete
    Jørgen Jensen
    Department of Physiology, National Institute of Occupational Health, PO Box 8149 Dep, N 0033, Oslo, Norway
    Curr Sports Med Rep 3:192-7. 2004
    ..For type II diabetics, exercise is normally performed to improve insulin sensitivity and to reduce body weight. Carbohydrates should only be supplied to prevent hypoglycemia...