Randi Utne Holt

Summary

Affiliation: Norwegian University of Science and Technology
Country: Norway

Publications

  1. doi request reprint Hepatocyte growth factor promotes migration of human myeloma cells
    Randi Utne Holt
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, MTFS, N 7489 Trondheim, Norway
    Haematologica 93:619-22. 2008
  2. ncbi request reprint A selective c-met inhibitor blocks an autocrine hepatocyte growth factor growth loop in ANBL-6 cells and prevents migration and adhesion of myeloma cells
    Håkon Hov
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Clin Cancer Res 10:6686-94. 2004
  3. doi request reprint HGF and IGF-1 synergize with SDF-1α in promoting migration of myeloma cells by cooperative activation of p21-activated kinase
    Torstein Baade Rø
    KG Jebsen Center for Myeloma Research and Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Exp Hematol 41:646-55. 2013
  4. pmc c-Met signaling promotes IL-6-induced myeloma cell proliferation
    Håkon Hov
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Eur J Haematol 82:277-87. 2009
  5. ncbi request reprint Human myeloma cells adhere to fibronectin in response to hepatocyte growth factor
    Randi Utne Holt
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, MTFS, N 7489 Trondheim, Norway
    Haematologica 90:479-88. 2005
  6. ncbi request reprint Bone morphogenetic protein-5, -6 and -7 inhibit growth and induce apoptosis in human myeloma cells
    Torstein Baade Ro
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim N 7489, Norway
    Oncogene 23:3024-32. 2004
  7. ncbi request reprint Tyrosine kinase inhibitors alter adhesivity of prostatic cancer cells to extracellular matrix components
    Haakon Skogseth
    Department of Laboratory Medicine, Children s and Women s Health, Faculty of Medicine, Norwegian Universit of Science and Technology, Trondheim, Norway
    APMIS 114:225-33. 2006

Detail Information

Publications7

  1. doi request reprint Hepatocyte growth factor promotes migration of human myeloma cells
    Randi Utne Holt
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, MTFS, N 7489 Trondheim, Norway
    Haematologica 93:619-22. 2008
    ..Hepatocyte growth factor-mediated migration was dependent on phosphatidylinositol-3-kinase, involved the MAPK/Erk signaling cascade and VLA-4 integrins, but did not involve Akt, mTOR or G proteins...
  2. ncbi request reprint A selective c-met inhibitor blocks an autocrine hepatocyte growth factor growth loop in ANBL-6 cells and prevents migration and adhesion of myeloma cells
    Håkon Hov
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Clin Cancer Res 10:6686-94. 2004
    ..We wanted to examine the role of the hepatocyte growth factor (HGF) receptor c-Met in multiple myeloma by applying a novel selective small molecule tyrosine kinase inhibitor, PHA-665752, directed against the receptor...
  3. doi request reprint HGF and IGF-1 synergize with SDF-1α in promoting migration of myeloma cells by cooperative activation of p21-activated kinase
    Torstein Baade Rø
    KG Jebsen Center for Myeloma Research and Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Exp Hematol 41:646-55. 2013
    ..These findings are likely to be of clinical relevance because multiple myeloma cells are located in an environment containing HGF and IGF-1 and are exposed to an SDF-1α gradient between the bone marrow and peripheral blood. ..
  4. pmc c-Met signaling promotes IL-6-induced myeloma cell proliferation
    Håkon Hov
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Eur J Haematol 82:277-87. 2009
    ..We therefore wanted to investigate if HGF could influence the effects of interleukin (IL)-6...
  5. ncbi request reprint Human myeloma cells adhere to fibronectin in response to hepatocyte growth factor
    Randi Utne Holt
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, MTFS, N 7489 Trondheim, Norway
    Haematologica 90:479-88. 2005
    ..In this work we examined the effect of hepatocyte growth factor (HGF) on the adhesion of myeloma cells and the signaling pathways involved...
  6. ncbi request reprint Bone morphogenetic protein-5, -6 and -7 inhibit growth and induce apoptosis in human myeloma cells
    Torstein Baade Ro
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim N 7489, Norway
    Oncogene 23:3024-32. 2004
    ..Importantly, myeloma cells not responsive to BMP-2 and -4 may still be sensitive to BMP-6 or -7. It is possible that therapeutic use of BMP or BMP analogues could have an impact on both myeloma bone disease and myeloma cell growth...
  7. ncbi request reprint Tyrosine kinase inhibitors alter adhesivity of prostatic cancer cells to extracellular matrix components
    Haakon Skogseth
    Department of Laboratory Medicine, Children s and Women s Health, Faculty of Medicine, Norwegian Universit of Science and Technology, Trondheim, Norway
    APMIS 114:225-33. 2006
    ..Our results point to a possible role of TKIs as suppressors of prostate carcinoma cell adhesion to extracellular matrix components, by acting as inhibitors of integrin expression...