Terje Espevik

Summary

Affiliation: Norwegian University of Science and Technology
Country: Norway

Publications

  1. ncbi request reprint Development, characterization and use of monoclonal antibodies against sTRAIL: measurement of sTRAIL by ELISA
    Nina Beate Liabakk
    Faculty of Medicine, Institute of Cancer Research and Molecular Biology, Norwegian University of Science and Technology, Medisinsk Teknisk Senter, N 7489 Trondheim, Norway
    J Immunol Methods 259:119-28. 2002
  2. ncbi request reprint Mechanisms of TLR9 activation
    Eicke Latz
    Division of Infectious Diseases, University of Massachusetts Medical School, 364 Plantation Street, LRB 370M, Worcester, MA 01605, USA
    J Endotoxin Res 10:406-12. 2004
  3. ncbi request reprint Cell distributions and functions of Toll-like receptor 4 studied by fluorescent gene constructs
    Terje Espevik
    Norwegian University of Science and Technology, Trondheim, Norway
    Scand J Infect Dis 35:660-4. 2003
  4. doi request reprint The induction of cytokines by polycation containing microspheres by a complement dependent mechanism
    Anne Mari Rokstad
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Biomaterials 34:621-30. 2013
  5. pmc Cellular trafficking of lipoteichoic acid and Toll-like receptor 2 in relation to signaling: role of CD14 and CD36
    Nadra J Nilsen
    Norwegian University of Science and Technology, Institute of Cancer Research and Molecular Medicine, Trondheim, Norway
    J Leukoc Biol 84:280-91. 2008
  6. pmc Cholesterol crystals induce complement-dependent inflammasome activation and cytokine release
    Eivind O Samstad
    Centre of Molecular Inflammation Research, Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim N 7491, Norway
    J Immunol 192:2837-45. 2014
  7. doi request reprint Microencapsulation of small intestinal neuroendocrine neoplasm cells for tumor model studies
    Anne M Rokstad
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Cancer Sci 103:1230-7. 2012
  8. ncbi request reprint IL-10 enhances MD-2 and CD14 expression in monocytes and the proteins are increased and correlated in HIV-infected patients
    Øystein Sandanger
    Norwegian University of Science and Technology, Institute of Cancer Research and Molecular Medicine, Trondheim, Norway
    J Immunol 182:588-95. 2009
  9. doi request reprint The Rab11a GTPase controls Toll-like receptor 4-induced activation of interferon regulatory factor-3 on phagosomes
    Harald Husebye
    Norwegian University of Science and Technology, Department of Cancer Research and Molecular Medicine, N 7489 Trondheim, Norway
    Immunity 33:583-96. 2010
  10. ncbi request reprint Lipopolysaccharide and double-stranded RNA up-regulate toll-like receptor 2 independently of myeloid differentiation factor 88
    Nadra Nilsen
    Norwegian University of Science and Technology, Institute of Cancer Research and Molecular Medicine, Olav Kyrres gt 3, N 7489 Trondheim, Norway
    J Biol Chem 279:39727-35. 2004

Detail Information

Publications62

  1. ncbi request reprint Development, characterization and use of monoclonal antibodies against sTRAIL: measurement of sTRAIL by ELISA
    Nina Beate Liabakk
    Faculty of Medicine, Institute of Cancer Research and Molecular Biology, Norwegian University of Science and Technology, Medisinsk Teknisk Senter, N 7489 Trondheim, Norway
    J Immunol Methods 259:119-28. 2002
    ..It will also permit studies of release mechanisms as well as possible functions of the soluble form of this molecule...
  2. ncbi request reprint Mechanisms of TLR9 activation
    Eicke Latz
    Division of Infectious Diseases, University of Massachusetts Medical School, 364 Plantation Street, LRB 370M, Worcester, MA 01605, USA
    J Endotoxin Res 10:406-12. 2004
    ..In stimulated cells, TLR9 translocated to CpG-DNA or microbial DNA containing structures in the endosome, where TLR9 binds to DNA and initiates signaling...
  3. ncbi request reprint Cell distributions and functions of Toll-like receptor 4 studied by fluorescent gene constructs
    Terje Espevik
    Norwegian University of Science and Technology, Trondheim, Norway
    Scand J Infect Dis 35:660-4. 2003
    ..Furthermore, LPS stimulation recruited the adapter molecule, MyD88, to the inside of the plasma membrane. Thus, LPS signaling commences on the plasma membrane and is independent of trafficking to the Golgi...
  4. doi request reprint The induction of cytokines by polycation containing microspheres by a complement dependent mechanism
    Anne Mari Rokstad
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Biomaterials 34:621-30. 2013
    ....
  5. pmc Cellular trafficking of lipoteichoic acid and Toll-like receptor 2 in relation to signaling: role of CD14 and CD36
    Nadra J Nilsen
    Norwegian University of Science and Technology, Institute of Cancer Research and Molecular Medicine, Trondheim, Norway
    J Leukoc Biol 84:280-91. 2008
    ..Our results suggest that LTA signaling preferentially occurs at the plasma membrane, is independent of internalization, and is facilitated by CD36 and CD14 as coreceptors for TLR2...
  6. pmc Cholesterol crystals induce complement-dependent inflammasome activation and cytokine release
    Eivind O Samstad
    Centre of Molecular Inflammation Research, Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim N 7491, Norway
    J Immunol 192:2837-45. 2014
    ..In light of this, complement inhibition might be an interesting therapeutic approach for treatment of atherosclerosis. ..
  7. doi request reprint Microencapsulation of small intestinal neuroendocrine neoplasm cells for tumor model studies
    Anne M Rokstad
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Cancer Sci 103:1230-7. 2012
    ..Alginate microspheres technology can thus be used to tailor different functional bioreactors for both in vitro and in vivo studies...
  8. ncbi request reprint IL-10 enhances MD-2 and CD14 expression in monocytes and the proteins are increased and correlated in HIV-infected patients
    Øystein Sandanger
    Norwegian University of Science and Technology, Institute of Cancer Research and Molecular Medicine, Trondheim, Norway
    J Immunol 182:588-95. 2009
    ..Of interest, we found that IL-10, CD14, and MD-2 levels were positively correlated, suggesting that IL-10 may be a driving force for increased release of MD-2 and CD14 during systemic inflammation...
  9. doi request reprint The Rab11a GTPase controls Toll-like receptor 4-induced activation of interferon regulatory factor-3 on phagosomes
    Harald Husebye
    Norwegian University of Science and Technology, Department of Cancer Research and Molecular Medicine, N 7489 Trondheim, Norway
    Immunity 33:583-96. 2010
    ..Moreover, Rab11a silencing reduced the amount of TRAM on phagosomes. Thus, Rab11a is an important regulator of TLR4 and TRAM transport to E. coli phagosomes thereby controlling IRF3 activation from this compartment...
  10. ncbi request reprint Lipopolysaccharide and double-stranded RNA up-regulate toll-like receptor 2 independently of myeloid differentiation factor 88
    Nadra Nilsen
    Norwegian University of Science and Technology, Institute of Cancer Research and Molecular Medicine, Olav Kyrres gt 3, N 7489 Trondheim, Norway
    J Biol Chem 279:39727-35. 2004
    ..Up-regulation of TLR2 in the presence of low, yet clinically relevant amounts of microbial products may be an important mechanism by which the immune system boosts its response to a beginning infection...
  11. doi request reprint Reconstituted High-Density Lipoprotein Attenuates Cholesterol Crystal-Induced Inflammatory Responses by Reducing Complement Activation
    Nathalie Niyonzima
    Department of Cancer Research and Molecular Medicine, Centre of Molecular Inflammation Research, Norwegian University of Science and Technology, N 7491 Trondheim, Norway
    J Immunol 195:257-64. 2015
    ..Our results support and extend the notion that CC are potent triggers of inflammation, and that rHDL may have a beneficial role in controlling the CC-induced inflammatory responses by inhibiting complement deposition on the crystals. ..
  12. ncbi request reprint Involvement of toll-like receptor (TLR) 2 and TLR4 in cell activation by mannuronic acid polymers
    Trude H Flo
    Institute of Cancer Research and Molecular Biology and the Institute of Biotechnology, Norwegian University of Science and Technology, 7489 Trondheim, Norway
    J Biol Chem 277:35489-95. 2002
    ..Taken together the results suggest that both TLR2 and TLR4 are involved in cell activation by poly-M and that TLR4 may be required in primary murine macrophages...
  13. doi request reprint Alginate microbeads are complement compatible, in contrast to polycation containing microcapsules, as revealed in a human whole blood model
    Anne Mari Rokstad
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Acta Biomater 7:2566-78. 2011
    ..We propose the whole blood model as an important tool for measuring bioincompatibility of microcapsules and microbeads for future applications as well as determining the mechanisms leading to inflammatory reactions...
  14. pmc Whole genome gene expression meta-analysis of inflammatory bowel disease colon mucosa demonstrates lack of major differences between Crohn's disease and ulcerative colitis
    Atle Van Beelen Granlund
    Centre of Molecular Inflammation Research, Norwegian University of Science and Technology, Trondheim, Norway
    PLoS ONE 8:e56818. 2013
    ..A meta-analysis including all available, comparable data was used to explore important aspects of IBD inflammation, thereby validating consistent gene expression patterns...
  15. doi request reprint Alginates induce differentiation and expression of CXCR7 and CXCL12/SDF-1 in human keratinocytes--the role of calcium
    Jørgen Stenvik
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, St Olavs Hospital, N 7491 Trondheim, Norway
    J Biomed Mater Res A 100:2803-12. 2012
    ..This study defines two biological effects of ultrapure alginates on KCs, both being dependent on the alginate structure, and being either dependent or independent of Ca...
  16. doi request reprint Mucosal toll-like receptor 3-dependent synthesis of complement factor B and systemic complement activation in inflammatory bowel disease
    Ann E Ostvik
    Centre of Molecular Inflammation Research, Norwegian University of Science and Technology, Trondheim, Norway Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway Department of Gastroenterology and Hepatology, St Olav s University Hospital, Trondheim, Norway Department of Laboratory Medicine, Children s and Women s Health, Norwegian University of Science and Technology, Trondheim, Norway Department of Pathology and Medical Genetics, St Olav s University Hospital, Trondheim, Norway Research Laboratory, Department of Laboratory Medicine, Nordland Hospital, Bodø, Norway Department of Immunology, Oslo University Hospital Rikshospitalet, Oslo, Norway K G Jebsen IRC, University of Oslo, Oslo, Norway and Department of Infectious Diseases, St Olav s University Hospital, Trondheim, Norway
    Inflamm Bowel Dis 20:995-1003. 2014
    ....
  17. doi request reprint TLR8 Senses Staphylococcus aureus RNA in Human Primary Monocytes and Macrophages and Induces IFN-β Production via a TAK1-IKKβ-IRF5 Signaling Pathway
    Bjarte Bergstrøm
    Centre of Molecular Inflammation Research, Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim N 7491, Norway
    J Immunol 195:1100-11. 2015
    ..aureus in human primary phagocytes, including the induction of IFN-β and IL-12 production via a TAK1 -: IKKβ -: IRF5 pathway that can be inhibited by TLR2 signaling. ..
  18. ncbi request reprint Cell-compatible covalently reinforced beads obtained from a chemoenzymatically engineered alginate
    Anne Mari Rokstad
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Biomaterials 27:4726-37. 2006
    ..The exceptional stability and the cell compatibility of the new CEPC beads make them interesting as bioreactors for delivering therapeutic proteins in future applications...
  19. ncbi request reprint Visualization of alginate-poly-L-lysine-alginate microcapsules by confocal laser scanning microscopy
    Berit L Strand
    Department of Biotechnology, Norwegian University of Science and Technology, Trondheim, Norway
    Biotechnol Bioeng 82:386-94. 2003
    ..As the labeling procedures are easy to perform, the method can also be used for a variety of other polymers in other microencapsulation systems...
  20. doi request reprint Direct measurement of the interaction force between immunostimulatory CpG-DNA and TLR9 fusion protein
    Dionne C G Klein
    Department of Physics, Norwegian University of Science and Technology, N 7491 Trondheim, Norway
    J Mol Recognit 25:74-81. 2012
    ..14 ± 0.10 s(-1) and a binding interaction length of x(β) = 0.30 ± 0.03 nm, which are consistent with literature values. Various models for the molecular interaction of this innate immune receptor binding to CpG-DNA are discussed...
  21. ncbi request reprint On-pump versus off-pump coronary artery bypass grafting: more heat-shock protein 70 is released after on-pump surgery
    Brit Dybdahl
    Faculty of Medicine, Institute of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Eur J Cardiothorac Surg 25:985-92. 2004
    ..Hypothesizing that use of cardiopulmonary bypass (CPB) leads to more circulating HSP70, we explored the release of it in 10 patients undergoing CABG with the use of CPB, and in 10 patients undergoing off-pump surgery CABG (OPCAB)...
  22. doi request reprint TLR3 mediates release of IL-1β and cell death in keratinocytes in a caspase-4 dependent manner
    Øystein Grimstad
    Centre of Molecular Inflammation Research, Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway Department of Dermatology, St Olavs Hospital HF, Trondheim University Hospital, Trondheim, Norway Electronic address
    J Dermatol Sci 72:45-53. 2013
    ..Caspase-4 is required for maturation of pro-IL-1β through activation of caspase-1 in keratinocytes...
  23. pmc Intracellular Mycobacterium avium intersect transferrin in the Rab11(+) recycling endocytic pathway and avoid lipocalin 2 trafficking to the lysosomal pathway
    Oyvind Halaas
    Department of Cancer Research and Molecular Medicine, Norges Teknisk Naturvitenskapelige Universitet, and St Olavs Hospital, Trondheim, Norway
    J Infect Dis 201:783-92. 2010
    ..Thus, mycobacteria seem to reside in the Rab11(+) endocytic recycling pathway, thereby retaining access to nutrition and avoiding endocytosed immunoproteins like Lcn2...
  24. doi request reprint Alginate microsphere compositions dictate different mechanisms of complement activation with consequences for cytokine release and leukocyte activation
    Pontus Ørning
    Centre of Molecular Inflammation Research, and Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    J Control Release 229:58-69. 2016
    ..MCP-1 is one exception dependent on the fluid phase complement activation mediated through CR3. ..
  25. doi request reprint Enhanced expression of CXCL10 in inflammatory bowel disease: potential role of mucosal Toll-like receptor 3 stimulation
    Ann E Ostvik
    Department of Gastroenterology and Hepatology, St Olav s University Hospital, Trondheim, Norway
    Inflamm Bowel Dis 19:265-74. 2013
    ..The chemokine CXCL10 and its receptor CXCR3 were among the upregulated genes. This study examined the expression of CXCL10 and the mechanisms for its release in patients with UC or CD and in intestinal epithelial cell (IEC) lines...
  26. pmc Endocytic pathways regulate Toll-like receptor 4 signaling and link innate and adaptive immunity
    Harald Husebye
    Institute of Cancer Research and Molecular Medicine, The Norwegian University of Science and Technology, Trondheim, Norway
    EMBO J 25:683-92. 2006
    ..Our results show that endosomal trafficking of the LPS receptor complex is essential for signal termination and LPS-associated antigen presentation, thus controlling both innate and adaptive immunity through TLR4...
  27. doi request reprint Oligodeoxynucleotides inhibit Toll-like receptor 3 mediated cytotoxicity and CXCL8 release in keratinocytes
    Oystein Grimstad
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Exp Dermatol 21:7-12. 2012
    ..With these findings, we see a promising potential for ODNs in inhibiting TLR3-induced responses in inflammatory skin disorders...
  28. doi request reprint Non-healing is associated with persistent stimulation of the innate immune response in chronic venous leg ulcers
    Brita S Pukstad
    Institute of Cancer Research and Molecular Medicine, Norwegian University of Technology and Science, 7089 Trondheim, Norway
    J Dermatol Sci 59:115-22. 2010
    ..Although these wounds are often characterized as being in a state of persistent inflammation, the impact and participation of the innate immune responses in sustaining this inflammation needs further investigation...
  29. ncbi request reprint Microcapsules made by enzymatically tailored alginate
    Berit L Strand
    Department of Biotechnology, Sem Saelandsvei 6 8, 7491 Trondheim, Norway
    J Biomed Mater Res A 64:540-50. 2003
    ..Finally, alginate with an alternating structure interacted more strongly with the alginate-PLL capsule than did alginate with a high content of M blocks or G blocks or than an alginate consisting mainly of M...
  30. doi request reprint Relative chemokine and adhesion molecule expression in Mediterranean spotted fever and African tick bite fever
    Jan K Damås
    Research Institute for Internal Medicine, Rikshospitalet University Hospital, 0027 Oslo, Norway
    J Infect 58:68-75. 2009
    ..We hypothesized that different inflammatory potential in endothelial cells could contribute to the different clinical features in these rickettsioses...
  31. doi request reprint CD14, TLR4 and TRAM Show Different Trafficking Dynamics During LPS Stimulation
    Dionne C G Klein
    Department of Cancer Research and Molecular Medicine, Centre of Molecular Inflammation Research, Norwegian University of Science and Technology, Trondheim, Norway
    Traffic 16:677-90. 2015
    ..Moreover, CD14/LPS but not TRAM was immobilized on RAB11A-positive endosomes, which indicates that TRAM and CD14/LPS can independently be recruited to endosomes. ..
  32. pmc A role for the adaptor proteins TRAM and TRIF in toll-like receptor 2 signaling
    Nadra J Nilsen
    From the Centre of Molecular Inflammation Research, Department of Cancer Research and Molecular Medicine, and the KG Jebsen Center for Myeloma Research, Norwegian University of Science and Technology, N 7489 Trondheim, Norway
    J Biol Chem 290:3209-22. 2015
    ..Our results show a novel function of TRAM and TRIF in TLR2-mediated signal transduction, and the findings broaden our understanding of how Toll/interleukin-1 receptor adaptor proteins may participate in signaling downstream from TLR2. ..
  33. doi request reprint A proviral role for CpG in cytomegalovirus infection
    Ann Charlotte Iversen
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    J Immunol 182:5672-81. 2009
    ..The contrasting and time-dependent effects of CpG on HCMV infectivity reveal a complex interplay between CpG, TLR9, and HCMV infection. Additionally, the data suggest a potentially harmful role for CpG in the promotion of HCMV infection...
  34. pmc Toll-like receptor 3 associates with c-Src tyrosine kinase on endosomes to initiate antiviral signaling
    Ingvild Bjellmo Johnsen
    Department of Laboratory Medicine, Children s and Women s Health, Institute of Laboratory Medicine, Children s and Women s Health, Norwegian University of Science and Technology, Trondheim, Norway
    EMBO J 25:3335-46. 2006
    ..These results provide novel insight into the molecular mechanisms of TLR3-mediated signaling, which may contribute to the understanding of innate immune responses during viral infections...
  35. doi request reprint Cellular sources and inducers of cytokines present in acute wound fluid
    Øystein Grimstad
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Wound Repair Regen 19:337-47. 2011
    ..New interactions between cytokines and growth factors were revealed, which may have important roles in wound healing, including IL-1β-induced IFN-γ and IL-10-induced VEGF...
  36. pmc Cytokine Profiles in Human Metapneumovirus Infected Children: Identification of Genes Involved in the Antiviral Response and Pathogenesis
    Jostein Malmo
    Childhood Airway Infections Research Group, Department of Laboratory Medicine, Children s and Women s Health, Faculty of Medicine, Norwegian University of Science and Technology, 7491 Trondheim, Norway
    PLoS ONE 11:e0155484. 2016
    ..Our study is the first to demonstrate that inflammasome components are associated with increased illness severity in hMPV-infected children. ..
  37. doi request reprint Heparin-like properties of sulfated alginates with defined sequences and sulfation degrees
    Øystein Arlov
    Department of Biotechnology, Norwegian University of Science and Technology, Sem Sælands vei 6 8, 7034 Trondheim, Norway
    Biomacromolecules 15:2744-50. 2014
    ....
  38. ncbi request reprint Microencapsulation of cells producing therapeutic proteins: optimizing cell growth and secretion
    Anne Mari Rokstad
    Institute of Cancer Research and Molecular Biology, Norwegian University of Science and Technology, Trondheim
    Cell Transplant 11:313-24. 2002
    ....
  39. ncbi request reprint Inflammatory response after open heart surgery: release of heat-shock protein 70 and signaling through toll-like receptor-4
    Brit Dybdahl
    Faculty of Medicine, Institute of Cancer Research and Molecular Biology, Norwegian University of Science and Technology, Trondheim, Norway
    Circulation 105:685-90. 2002
    ..The main aims of our study were to explore the release of HSP70 and the regulation of monocyte TLR-2 and TLR-4 expression after CABG...
  40. doi request reprint CpG-oligodeoxynucleotide inhibits Smad-dependent bone morphogenetic protein signaling: effects on myeloma cell apoptosis and in vitro osteoblastogenesis
    Nikolai N Nørgaard
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    J Immunol 185:3131-9. 2010
    ..In conclusion, our results demonstrate that PTO-CpG-ODN inhibits BMP-signaling, and thus might provoke unwanted TLR9-independent side effects in patients...
  41. doi request reprint Higher order structure of short immunostimulatory oligonucleotides studied by atomic force microscopy
    Dionne C G Klein
    Department of Physics, Norwegian University of Science and Technology, Trondheim, Norway
    Ultramicroscopy 110:689-93. 2010
    ..Detailed structural analysis of the atomic force microscopy topographs is presented for two different sample preparation methods...
  42. ncbi request reprint Lipopolysaccharide rapidly traffics to and from the Golgi apparatus with the toll-like receptor 4-MD-2-CD14 complex in a process that is distinct from the initiation of signal transduction
    Eicke Latz
    University of Massachusetts Medical School, Division of Infectious Diseases, Worcester 01605, USA
    J Biol Chem 277:47834-43. 2002
    ..Golgi-associated TLR4 expression was disrupted by brefeldin A, yet LPS signaling was preserved. We conclude that LPS signaling may be initiated by surface aggregation of TLR4 and is not dependent upon LPS trafficking to the Golgi...
  43. pmc Human gingival CD14(+) fibroblasts primed with gamma interferon increase production of interleukin-8 in response to lipopolysaccharide through up-regulation of membrane CD14 and MyD88 mRNA expression
    Riyoko Tamai
    Department of Microbiology and Immunology, Tohoku University School of Dentistry, Sendai 980 8575, Japan
    Infect Immun 70:1272-8. 2002
    ....
  44. ncbi request reprint TLR9 signals after translocating from the ER to CpG DNA in the lysosome
    Eicke Latz
    Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Lazare Research Building 308, 364 Plantation Street, Worcester, MA 01605, USA
    Nat Immunol 5:190-8. 2004
    ..Our data indicate a previously unknown mechanism of cellular activation involving the recruitment of TLR9 from the ER to sites of CpG DNA uptake, where signal transduction is initiated...
  45. pmc Importance of extra- and intracellular domains of TLR1 and TLR2 in NFkappa B signaling
    Frantisek Sandor
    Department of Medicine, University of Massachusetts Medical Center, Worcester, MA 01605 2324, USA
    J Cell Biol 162:1099-110. 2003
    ..The domains from each receptor did not need to be contained within a single contiguous protein. Chimeric TLR analysis further defined the toll/IL-1R domains as the area of crucial intracellular TLR1-TLR2 interaction...
  46. ncbi request reprint Lysines 128 and 132 enable lipopolysaccharide binding to MD-2, leading to Toll-like receptor-4 aggregation and signal transduction
    Alberto Visintin
    Division of Infectious Diseases and Immunology, Department of Medicine, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 278:48313-20. 2003
    ..These findings help clarify the earliest events of TLR4 triggering by LPS and identify MD-2 as an attractive target for pharmacological intervention in endotoxin-mediated diseases...
  47. ncbi request reprint Cutting edge: link between innate and adaptive immunity: Toll-like receptor 2 internalizes antigen for presentation to CD4+ T cells and could be an efficient vaccine target
    Karoline W Schjetne
    Institute of Immunology, University of Oslo, Rikshospitalet, Oslo, Norway
    J Immunol 171:32-6. 2003
    ..This novel function of TLR2 represents a link between innate and adaptive immunity and indicates that TLR2 could be a promising target for vaccines...
  48. ncbi request reprint Toll-like receptor-mediated tumor necrosis factor and interleukin-10 production differ during systemic inflammation
    Minou Adib-Conquy
    UP Cytokines and Inflammation, 28 rue du Dr Roux, 75724 Paris Cedex 15, France
    Am J Respir Crit Care Med 168:158-64. 2003
    ..In conclusion, the immunodysregulation described for patients with trauma is not a generalized phenomenon but depends on the stimulus and the signaling pathway...
  49. ncbi request reprint A novel host-parasite lipid cross-talk. Schistosomal lyso-phosphatidylserine activates toll-like receptor 2 and affects immune polarization
    Desiree van der Kleij
    Department of Parasitology, Leiden University Medical Center, The Netherlands
    J Biol Chem 277:48122-9. 2002
    ..Taken together, these findings provide evidence for a novel host-parasite interaction that may be central to long term survival of the parasite and limited host pathology with implications beyond parasitology...
  50. ncbi request reprint Induction of cytokine production in human T cells and monocytes by highly purified lipoteichoic acid: involvement of Toll-like receptors and CD14
    Espen Ellingsen
    Institute for Surgical Research, Rikshospitalet National Hospital, N 0027 Oslo, Norway
    Med Sci Monit 8:BR149-56. 2002
    ..aureus LTA to stimulate the production of pro-inflammatory cytokines in human leukocytes at both mRNA and protein level, and to study the involvement of Toll-like receptors (TLRs) and CD14 in this response...
  51. ncbi request reprint The proinflammatory CD14+CD16+DR++ monocytes are a major source of TNF
    Kai Uwe Belge
    Institute for Immunology, University of Muenchen, Germany
    J Immunol 168:3536-42. 2002
    ..This indicates that the minor population of CD14(+)CD16(+) monocytes are major producers of TNF in human blood...
  52. ncbi request reprint The LPS receptor generates inflammatory signals from the cell surface
    Eicke Latz
    Division of Infectious Diseases, University of Massachusetts Medical School, 364 Plantation Street, Worcester, MA 01605, USA
    J Endotoxin Res 9:375-80. 2003
    ..Thus, LPS signaling commences after LPS recognition by surface-expressed TLR4 independent of LPS trafficking to the Golgi...
  53. ncbi request reprint Monoclonal antibodies against TRAIL
    Nina Beate Liabakk
    Institute of Cancer Research and Molecular Medicine Norwegian University of Science and Technology, N 7489 Trondheim, Norway
    Vitam Horm 67:65-79. 2004
    ..In addition, the physiological significance of some results obtained by using monoclonal antibodies against TRAIL are discussed...
  54. ncbi request reprint Tolerance induced by the lipopeptide Pam3Cys is due to ablation of IL-1R-associated kinase-1
    Maciej Siedlar
    Institute for Immunology, University of Muenchen, Muenchen, Germany
    J Immunol 173:2736-45. 2004
    ....
  55. ncbi request reprint Soluble toll-like receptor 2 in HIV infection: association with disease progression
    Lars Heggelund
    Section of Clinical Immunology and Infectious Diseases, Medical Department, Rikshospitalet University Hospital, University of Oslo, Oslo, Norway
    AIDS 18:2437-9. 2004
  56. ncbi request reprint Human receptors of innate immunity (CD14, TLR2) are promising targets for novel recombinant immunoglobulin-based vaccine candidates
    Gro Tunheim
    Institute of Immunology, University of Oslo and Rikshospitalet Radiumhospitalet Medical Center, Sognsvannsveien 20, Rikshospitalet, Oslo, Norway
    Vaccine 25:4723-34. 2007
    ..The results show that TLR2 and CD14 are efficient targets for delivery of antigen to APC for stimulation of HLA class II-restricted CD4(+) T cells. Thus, receptors of innate immunity should be further explored as targets for vaccines...
  57. pmc Bacteroides fragilis-derived lipopolysaccharide produces cell activation and lethal toxicity via toll-like receptor 4
    Giuseppe Mancuso
    Department of Pathology and Experimental Microbiology, University of Messina, Messina, Italy
    Infect Immun 73:5620-7. 2005
    ..These data may be useful to devise strategies to prevent the pathophysiologic changes observed during B. fragilis sepsis and to better understand structure-activity relationships of LPS...
  58. ncbi request reprint Binding of lipopeptide to CD14 induces physical proximity of CD14, TLR2 and TLR1
    Maria Manukyan
    Department of Immunology and Cell Biology, Research Center Borstel, Borstel, Germany
    Eur J Immunol 35:911-21. 2005
    ..Thus, LP binding to CD14 is the first step in the LP recognition, inducing physical proximity of CD14 and LP with TLR2/TLR1 and formation of the TLR2 signaling complex...
  59. ncbi request reprint Increased expression of toll-like receptor 2 on monocytes in HIV infection: possible roles in inflammation and viral replication
    Lars Heggelund
    Section of Clinical Immunology and Infectious Diseases, Rikshospitalet University Hospital, N 0027, Oslo, Norway
    Clin Infect Dis 39:264-9. 2004
    ..Toll-like receptors (TLRs) are key pattern-recognition receptors of the innate immune system, but their role in human immunodeficiency virus (HIV) infection is largely unknown...
  60. ncbi request reprint The journey of Toll-like receptors in the cell
    Oyvind Halaas
    Institute of Cancer Research and Molecular Medicine, NTNU, N 7489 Trondheim, Norway
    Adv Exp Med Biol 598:35-48. 2007
  61. pmc Stages of meningococcal sepsis simulated in vitro, with emphasis on complement and Toll-like receptor activation
    Bernt Christian Hellerud
    Department of Pediatrics, Ulleval University Hospital, and University of Oslo, Oslo, Norway
    Infect Immun 76:4183-9. 2008
    ..Therapeutically, CD14 inhibition alone was most efficient at a low bacterial concentration, whereas addition of a complement inhibitor may be beneficial when the bacterial load increases...
  62. ncbi request reprint Ligand-induced conformational changes allosterically activate Toll-like receptor 9
    Eicke Latz
    Department of Medicine, Division of Infectious Diseases and Immunology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    Nat Immunol 8:772-9. 2007
    ..Our results indicate that the formation of TLR9 dimers is not sufficient for its activation but instead that TLR9 activation is regulated by conformational changes induced by DNA containing CpG...