Rigmor Austgulen

Summary

Affiliation: Norwegian University of Science and Technology
Country: Norway

Publications

  1. ncbi request reprint [Recent knowledge on mechanisms underlying development of pre-eclampsia]
    Rigmor Austgulen
    Institutt for kreftforskning og molekylaer medisin, Norges Teknisk Naturvitenskapelige Universitet, 7489 Trondheim
    Tidsskr Nor Laegeforen 124:21-4. 2004
  2. ncbi request reprint Pre-eclampsia: associated with increased syncytial apoptosis when the infant is small-for-gestational-age
    Rigmor Austgulen
    Faculty of Medicine, Institute of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, 7489 Trondheim, Norway
    J Reprod Immunol 61:39-50. 2004
  3. ncbi request reprint Trophoblast apoptosis in human placenta at term as detected by expression of a cytokeratin 18 degradation product of caspase
    Rigmor Austgulen
    Institutes of Cancer Research and Molecular Biology, Norwegian University of Science and Technology, Trondheim, Norway
    Arch Pathol Lab Med 126:1480-6. 2002
  4. doi request reprint Whole-genome microarray and targeted analysis of angiogenesis-regulating gene expression (ENG, FLT1, VEGF, PlGF) in placentas from pre-eclamptic and small-for-gestational-age pregnancies
    Johanne Holm Toft
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    J Matern Fetal Neonatal Med 21:267-73. 2008
  5. pmc A transcriptional profile of the decidua in preeclampsia
    Mari Løset
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Am J Obstet Gynecol 204:84.e1-27. 2011
  6. doi request reprint Decidual expression and maternal serum levels of heme oxygenase 1 are increased in pre-eclampsia
    Irina P Eide
    Department of Cancer Research and Molecular Medicine, Children s and Women s Health, Trondheim, Norway
    Acta Obstet Gynecol Scand 87:272-9. 2008
  7. doi request reprint Distinct First Trimester Cytokine Profiles for Gestational Hypertension and Preeclampsia
    Line H Tangerås
    From the Centre of Molecular Inflammation Research, and Department of Cancer Research and Molecular Medicine L H T, R A, A C I, Department of Circulation and Medical Imaging M A, T F B, and Department of Laboratory Medicine Children s and Women s Health R B S, K A S, Faculty of Medicine, Norwegian University of Science and Technology NTNU, Trondheim, Norway St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway L H T, M A and National Center for Fetal Medicine, Department of Obstetrics and Gynecology, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway R B S, K A S
    Arterioscler Thromb Vasc Biol 35:2478-85. 2015
  8. pmc Identification of ACOX2 as a shared genetic risk factor for preeclampsia and cardiovascular disease
    Asa Johansson
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Eur J Hum Genet 19:796-800. 2011
  9. ncbi request reprint Umbilical cord plasma leptin is increased in preeclampsia
    Rønnaug A Odegård
    Institute of Cancer Research and Molecular Biology, Trondheim, Norway
    Am J Obstet Gynecol 186:427-32. 2002
  10. doi request reprint The HLA-G 14bp gene polymorphism and decidual HLA-G 14bp gene expression in pre-eclamptic and normal pregnancies
    Ann Charlotte Iversen
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Women and Children s Centre, Okav Kyrres gt 11, Trondheim, Norway
    J Reprod Immunol 78:158-65. 2008

Collaborators

Detail Information

Publications23

  1. ncbi request reprint [Recent knowledge on mechanisms underlying development of pre-eclampsia]
    Rigmor Austgulen
    Institutt for kreftforskning og molekylaer medisin, Norges Teknisk Naturvitenskapelige Universitet, 7489 Trondheim
    Tidsskr Nor Laegeforen 124:21-4. 2004
    ..The present paper gives an overview of recent research on mechanisms underlying pre-eclampsia. Special attention is paid to immune reactions at the feto-maternal site and genetics linked to maternal susceptibility...
  2. ncbi request reprint Pre-eclampsia: associated with increased syncytial apoptosis when the infant is small-for-gestational-age
    Rigmor Austgulen
    Faculty of Medicine, Institute of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, 7489 Trondheim, Norway
    J Reprod Immunol 61:39-50. 2004
    ....
  3. ncbi request reprint Trophoblast apoptosis in human placenta at term as detected by expression of a cytokeratin 18 degradation product of caspase
    Rigmor Austgulen
    Institutes of Cancer Research and Molecular Biology, Norwegian University of Science and Technology, Trondheim, Norway
    Arch Pathol Lab Med 126:1480-6. 2002
    ..The monoclonal antibody M30 is directed against a novel epitope of cytokeratin 18 (CK18) that is formed by caspase cleavage early in the apoptotic cascade, and this antibody may therefore be useful for evaluating trophoblast apoptosis...
  4. doi request reprint Whole-genome microarray and targeted analysis of angiogenesis-regulating gene expression (ENG, FLT1, VEGF, PlGF) in placentas from pre-eclamptic and small-for-gestational-age pregnancies
    Johanne Holm Toft
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    J Matern Fetal Neonatal Med 21:267-73. 2008
    ..In addition, a targeted analysis of angiogenesis-regulating gene expression was performed...
  5. pmc A transcriptional profile of the decidua in preeclampsia
    Mari Løset
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Am J Obstet Gynecol 204:84.e1-27. 2011
    ..We sought to obtain insight into possible mechanisms underlying preeclampsia using genomewide transcriptional profiling in decidua basalis...
  6. doi request reprint Decidual expression and maternal serum levels of heme oxygenase 1 are increased in pre-eclampsia
    Irina P Eide
    Department of Cancer Research and Molecular Medicine, Children s and Women s Health, Trondheim, Norway
    Acta Obstet Gynecol Scand 87:272-9. 2008
    ..Heme oxygenase 1 (HMOX1) is an important stress response enzyme and a mediator of cytoprotection against a wide variety of tissue injuries...
  7. doi request reprint Distinct First Trimester Cytokine Profiles for Gestational Hypertension and Preeclampsia
    Line H Tangerås
    From the Centre of Molecular Inflammation Research, and Department of Cancer Research and Molecular Medicine L H T, R A, A C I, Department of Circulation and Medical Imaging M A, T F B, and Department of Laboratory Medicine Children s and Women s Health R B S, K A S, Faculty of Medicine, Norwegian University of Science and Technology NTNU, Trondheim, Norway St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway L H T, M A and National Center for Fetal Medicine, Department of Obstetrics and Gynecology, St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway R B S, K A S
    Arterioscler Thromb Vasc Biol 35:2478-85. 2015
    ....
  8. pmc Identification of ACOX2 as a shared genetic risk factor for preeclampsia and cardiovascular disease
    Asa Johansson
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Trondheim, Norway
    Eur J Hum Genet 19:796-800. 2011
    ..Oxidative stress and increased triglyceride levels are known risk factors for CVD and both have also been associated with PE. Our results suggest that downregulation of ACOX2 is a shared risk factor for PE and CVD...
  9. ncbi request reprint Umbilical cord plasma leptin is increased in preeclampsia
    Rønnaug A Odegård
    Institute of Cancer Research and Molecular Biology, Trondheim, Norway
    Am J Obstet Gynecol 186:427-32. 2002
    ....
  10. doi request reprint The HLA-G 14bp gene polymorphism and decidual HLA-G 14bp gene expression in pre-eclamptic and normal pregnancies
    Ann Charlotte Iversen
    Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology, Women and Children s Centre, Okav Kyrres gt 11, Trondheim, Norway
    J Reprod Immunol 78:158-65. 2008
    ..In conclusion, the fetal HLA-G 14bp genotype is reflected in the decidual HLA-G mRNA splice form profile, but does not appear to be associated with increased risk for development of PE...
  11. ncbi request reprint Relationship of insulin-like growth factor-I and insulin-like growth factor binding proteins in umbilical cord plasma to preeclampsia and infant birth weight
    Lars J Vatten
    Department of Community Medicine and General Practice, Norwegian University of Science and Technology, Trondheim, Norway
    Obstet Gynecol 99:85-90. 2002
    ....
  12. ncbi request reprint Fetal growth restriction is associated with reduced FasL expression by decidual cells
    Irina P Eide
    Department of Cancer Research and Molecular Medicine, DMF, Norwegian University of Science and Technology NTNU, Medisinsk teknisk forskningssenter, Olav Kyrres gt 3, N 7489 Trondheim, Norway
    J Reprod Immunol 74:7-14. 2007
    ..9 and 1.1+/-1.3%, respectively). These findings indicate a reduction of immune privilege in decidua of PE/FGR pregnancies by reduced FasL expression and that DeCs may have a central role in the Fas-FasL-based feto-maternal immune balance...
  13. ncbi request reprint Insulin-like growth factor I and leptin in umbilical cord plasma and infant birth size at term
    Lars J Vatten
    Department of Community Medicine and General Practice, Norwegian University of Science and Technology, Trondheim, Norway
    Pediatrics 109:1131-5. 2002
    ..To determine the independent contributions to infant birth size of insulin-like growth factor I (IGF-I) and leptin measured in umbilical cord plasma...
  14. pmc Mediators of the association between pre-eclampsia and cerebral palsy: population based cohort study
    Kristin Melheim Strand
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, NTNU, PO Box 8905, MTFS, N 7491 Trondheim, Norway
    BMJ 347:f4089. 2013
    ..To test the hypothesis that pre-eclampsia is a risk factor for cerebral palsy mediated through preterm birth and being born small for gestational age...
  15. pmc First Trimester Urine and Serum Metabolomics for Prediction of Preeclampsia and Gestational Hypertension: A Prospective Screening Study
    Marie Austdal
    Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology, 7491 Trondheim, Norway
    Int J Mol Sci 16:21520-38. 2015
    ..The study indicates a potential future role of clinical importance for metabolomic analysis of urine in prediction of preeclampsia. ..
  16. ncbi request reprint Serious foetal growth restriction is associated with reduced proportions of natural killer cells in decidua basalis
    Irina P Eide
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology, Medisinsk teknisk forskningssenter, Olav Kyrres gt 3, Trondheim, Norway
    Virchows Arch 448:269-76. 2006
    ..Our in vivo observations support the hypothesized association between NK cells, impaired placental development and pathogenesis of PE/FGR...
  17. pmc Refined phenotyping identifies links between preeclampsia and related diseases in a Norwegian preeclampsia family cohort
    Liv Cecilie V Thomsen
    aDepartment of Gynecology and Obstetrics, Haukeland University Hospital bDepartment of Clinical Science, University of Bergen, Bergen, Norway cCentre for Genetic Origins of Health and Disease, University of Western Australia, Perth, Australia dCentre of Molecular Inflammation Research, Norwegian University of Science and Technology, Trondheim eDepartment of Obstetrics and Gynecology, Stavanger University Hospital, Stavanger fDepartment of Cancer Research and Molecular Medicine gDepartment of Laboratory Medicine, Children s and Women s Health, Norwegian University of Science and Technology, Trondheim hDepartment of Heart Disease, Haukeland University Hospital, Bergen, Norway
    J Hypertens 33:2294-302. 2015
    ..Preeclamptic women have increased risk for atherothrombotic cardiovascular disease. We aimed to identify heritabilities and phenotypic correlations of preeclampsia and related conditions in the Norwegian Preeclampsia Family Biobank...
  18. pmc The Norwegian preeclampsia family cohort study: a new resource for investigating genetic aspects and heritability of preeclampsia and related phenotypes
    Linda Tømmerdal Roten
    Department of Laboratory Medicine, Children s and Women s Health, The Norwegian University of Science and Technology NTNU, 7491, Trondheim, Norway
    BMC Pregnancy Childbirth 15:319. 2015
    ..A Norwegian Preeclampsia Family Cohort was established to provide a new resource for genetic and molecular studies aiming to improve the understanding of the complex pathophysiology of preeclampsia...
  19. pmc Metabolomic biomarkers in serum and urine in women with preeclampsia
    Marie Austdal
    Department of Circulation and Medical Imaging, Faculty of Medicine, Norwegian University of Science and Technology NTNU, Trondheim, Norway Liaison Committee between the Central Norway Regional Health Authority RHA and Norwegian University of Science and Technology NTNU, Trondheim, Norway St Olavs Hospital, Trondheim University Hospital, Trondheim, Norway
    PLoS ONE 9:e91923. 2014
    ..To explore the potential of magnetic resonance (MR) metabolomics for study of preeclampsia, for improved phenotyping and elucidating potential clues to etiology and pathogenesis...
  20. ncbi request reprint Histologic chorioamnionitis and umbilical serum levels of pro-inflammatory cytokines and cytokine inhibitors
    Henrik Døllner
    Institute of Cancer Research and Molecular Biology, Norwegian University of Science and Technology, Trondheim
    BJOG 109:534-9. 2002
    ..whether leucocyte infiltration in the presence of neonatal disease is associated with additional increase in mediator levels...
  21. pmc Association between the candidate susceptibility gene ACVR2A on chromosome 2q22 and pre-eclampsia in a large Norwegian population-based study (the HUNT study)
    Linda T Roten
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology NTNU, Trondheim, Norway
    Eur J Hum Genet 17:250-7. 2009
    ....
  22. ncbi request reprint Genetic association of preeclampsia to the inflammatory response gene SEPS1
    Eric K Moses
    Department of Genetics, Southwest Foundation for Biomedical Research, San Antonio, TX 78245 0549, USA
    Am J Obstet Gynecol 198:336.e1-5. 2008
    ..The objective of the study was to test for a genetic association between the G-105A promoter polymorphism of the inflammatory mediator Selenoprotein S (SEPS1) and preeclampsia...
  23. ncbi request reprint A comparative study of immunomagnetic methods used for separation of human natural killer cells from peripheral blood
    Anita Øren
    Department of Cancer Research and Molecular Medicine, Norwegian University of Science and Technology NTNU, Medisinsk Teknisk Senter, N 7489 Trondheim, Norway
    J Immunol Methods 303:1-10. 2005
    ..However, when pure NK cells and phenotypic subtypes are to be studied, negative sorting seems most appropriate...