Knut Falk

Summary

Affiliation: National Veterinary Institute
Country: Norway

Publications

  1. pmc Genomic characterization of the virus causing infectious salmon anemia in Atlantic salmon (Salmo salar L.): an orthomyxo-like virus in a teleost
    S Mjaaland
    National Veterinary Institute and Department of Pharmacology, Microbiology and Food Hygiene, Norwegian College of Veterinary Medicine, Oslo, Norway
    J Virol 71:7681-6. 1997
  2. pmc Pathological pigmentation in cardiac tissues of Atlantic salmon (Salmo salar L.) with cardiomyopathy syndrome
    Hilde A S Fagerland
    Section of Anatomy and Pathology, Department of Basic Science and Aquatic Medicine, Norwegian School of Veterinary Science, 0033 Oslo, Norway
    Vet Res 44:107. 2013
  3. pmc Low virulent infectious salmon anaemia virus (ISAV) replicates and initiates the immune response earlier than a highly virulent virus in Atlantic salmon gills
    Alastair J A McBeath
    Marine Scotland Science, Marine Laboratory, Aberdeen, Scotland, UK
    Vet Res 45:83. 2014
  4. pmc Infectious salmon anaemia virus infection of Atlantic salmon gill epithelial cells
    Simon Chioma Weli
    Norwegian Veterinary Institute, Ullevålsveien 68, PO Box 750 Sentrum, Oslo N 0106, Norway
    Virol J 10:5. 2013
  5. pmc Immunohistochemical detection of piscine reovirus (PRV) in hearts of Atlantic salmon coincide with the course of heart and skeletal muscle inflammation (HSMI)
    Oystein Wessel Finstad
    Department of Food Safety and Infection Biology, Norwegian School of Veterinary Science, Postboks 8146 Dep, N 0033 OSLO Norwegian, Norway
    Vet Res 43:27. 2012
  6. pmc Identification and characterization of viral structural proteins of infectious salmon anemia virus
    Knut Falk
    Section for Fish Health, National Veterinary Institute, Oslo, Austria
    J Virol 78:3063-71. 2004
  7. doi request reprint Molecular characterisation of Atlantic salmon paramyxovirus (ASPV): a novel paramyxovirus associated with proliferative gill inflammation
    K Falk
    National Veterinary Institute, Section for Fish Health, P O Box 8156 Dep, N 0033 Oslo, Norway
    Virus Res 133:218-27. 2008
  8. ncbi request reprint Characterization and applications of a monoclonal antibody against infectious salmon anaemia virus
    K Falk
    National Veterinary Institute, Oslo, Norway
    Dis Aquat Organ 34:77-85. 1998
  9. ncbi request reprint Time course tissue distribution of infectious salmon anaemia virus in experimentally infected Atlantic salmon Salmo salar
    E Rimstad
    Department of Pharmacology, Microbiology and Food Hygiene, Norwegian College of Veterinary Medicine, Oslo, Norway
    Dis Aquat Organ 36:107-12. 1999
  10. pmc Characterisation of a monoclonal antibody detecting Atlantic salmon endothelial and red blood cells, and its association with the infectious salmon anaemia virus cell receptor
    Maria Aamelfot
    Norwegian Veterinary Institute, Oslo, Norway
    J Anat 222:547-57. 2013

Collaborators

Detail Information

Publications28

  1. pmc Genomic characterization of the virus causing infectious salmon anemia in Atlantic salmon (Salmo salar L.): an orthomyxo-like virus in a teleost
    S Mjaaland
    National Veterinary Institute and Department of Pharmacology, Microbiology and Food Hygiene, Norwegian College of Veterinary Medicine, Oslo, Norway
    J Virol 71:7681-6. 1997
    ..This is the first thoroughly characterized orthomyxo-like virus isolated from a teleost...
  2. pmc Pathological pigmentation in cardiac tissues of Atlantic salmon (Salmo salar L.) with cardiomyopathy syndrome
    Hilde A S Fagerland
    Section of Anatomy and Pathology, Department of Basic Science and Aquatic Medicine, Norwegian School of Veterinary Science, 0033 Oslo, Norway
    Vet Res 44:107. 2013
    ..No general systemic activation of the extracutaneous pigmentary system in response to viral infections with affinity to the heart was observed. ..
  3. pmc Low virulent infectious salmon anaemia virus (ISAV) replicates and initiates the immune response earlier than a highly virulent virus in Atlantic salmon gills
    Alastair J A McBeath
    Marine Scotland Science, Marine Laboratory, Aberdeen, Scotland, UK
    Vet Res 45:83. 2014
    ..Contrary to this, HVI initially progressed more slowly in the gills resulting in a slower generalised infection. However HVI ultimately reached a higher viral load and induced a greater mortality. ..
  4. pmc Infectious salmon anaemia virus infection of Atlantic salmon gill epithelial cells
    Simon Chioma Weli
    Norwegian Veterinary Institute, Ullevålsveien 68, PO Box 750 Sentrum, Oslo N 0106, Norway
    Virol J 10:5. 2013
    ..To the best of our knowledge, this is the first demonstration of ISAV infection in Atlantic salmon primary gill epithelial cells. This study thus broadens our understanding of cell tropism and transmission of ISAV in Atlantic salmon...
  5. pmc Immunohistochemical detection of piscine reovirus (PRV) in hearts of Atlantic salmon coincide with the course of heart and skeletal muscle inflammation (HSMI)
    Oystein Wessel Finstad
    Department of Food Safety and Infection Biology, Norwegian School of Veterinary Science, Postboks 8146 Dep, N 0033 OSLO Norwegian, Norway
    Vet Res 43:27. 2012
    ..Immunohistochemical detection of PRV antigens will be beneficial for the understanding of the pathogenesis of HSMI as well as for diagnostic purposes...
  6. pmc Identification and characterization of viral structural proteins of infectious salmon anemia virus
    Knut Falk
    Section for Fish Health, National Veterinary Institute, Oslo, Austria
    J Virol 78:3063-71. 2004
    ..It is proposed that the ISAV vp66 protein be termed nucleoprotein, the gp42 protein be termed HE protein, and the vp22 protein be termed matrix protein...
  7. doi request reprint Molecular characterisation of Atlantic salmon paramyxovirus (ASPV): a novel paramyxovirus associated with proliferative gill inflammation
    K Falk
    National Veterinary Institute, Section for Fish Health, P O Box 8156 Dep, N 0033 Oslo, Norway
    Virus Res 133:218-27. 2008
    ....
  8. ncbi request reprint Characterization and applications of a monoclonal antibody against infectious salmon anaemia virus
    K Falk
    National Veterinary Institute, Oslo, Norway
    Dis Aquat Organ 34:77-85. 1998
    ..A method for detection of viral antigen in cryosections from ISA diseased fish is also reported that may prove useful for the diagnosis and control of ISA...
  9. ncbi request reprint Time course tissue distribution of infectious salmon anaemia virus in experimentally infected Atlantic salmon Salmo salar
    E Rimstad
    Department of Pharmacology, Microbiology and Food Hygiene, Norwegian College of Veterinary Medicine, Oslo, Norway
    Dis Aquat Organ 36:107-12. 1999
    ..Fish giving positive samples after Day 13 p.i. were RT-PCR positive in most organs. These results indicated that between Days 8 to 13 p.i. considerable replication of the virus occurred, combined with wide tissue dissemination...
  10. pmc Characterisation of a monoclonal antibody detecting Atlantic salmon endothelial and red blood cells, and its association with the infectious salmon anaemia virus cell receptor
    Maria Aamelfot
    Norwegian Veterinary Institute, Oslo, Norway
    J Anat 222:547-57. 2013
    ..Finally, the detection of an epitope shared by ECs and RBCs agrees with recent findings that these cells share a common origin, thus the MAb can potentially be used to study the ontogeny of these cells in Atlantic salmon...
  11. pmc Expression of the infectious salmon anemia virus receptor on atlantic salmon endothelial cells correlates with the cell tropism of the virus
    Maria Aamelfot
    Norwegian Veterinary Institute, Oslo, Norway
    J Virol 86:10571-8. 2012
    ..The pattern of virus attachment mirrored closely the distribution of infection, showing that the virus receptor is important for cell tropism, as well as for adsorption to RBCs...
  12. pmc Localised Infection of Atlantic Salmon Epithelial Cells by HPR0 Infectious Salmon Anaemia Virus
    Maria Aamelfot
    Norwegian Veterinary Institute, Oslo, Norway
    PLoS ONE 11:e0151723. 2016
    ..All fish revealed a variable, but increased expression of the immunological markers in comparison to normal healthy fish. Taken together, we conclude that HPR0 causes a localized epithelial infection of Atlantic salmon. ..
  13. doi request reprint The in situ distribution of glycoprotein-bound 4-O-Acetylated sialic acids in vertebrates
    Maria Aamelfot
    Norwegian Veterinary Institute, PO Box 750 Sentrum, 0106, Oslo, Norway
    Glycoconj J 31:327-35. 2014
    ..The seemingly conserved local position through the evolution of the vertebrates, suggests an evolutionary advantage of this sialic acid modification...
  14. doi request reprint Immune responses in Atlantic salmon (Salmo salar) following protective vaccination against infectious salmon anemia (ISA) and subsequent ISA virus infection
    Astrid Lauscher
    Department of Food Safety and Infection Biology, The Norwegian School of Veterinary Science, P O 8146 Dep, N 0033 Oslo, Norway
    Vaccine 29:6392-401. 2011
    ..This study furthers the knowledge about vaccine efficacy and vaccine-induced immunity to ISAV challenge in Atlantic salmon...
  15. ncbi request reprint Atlantic salmon paramyxovirus (ASPV) infection contributes to proliferative gill inflammation (PGI) in seawater-reared Salmo salar
    Agnar Kvellestad
    Department of Basal Medicine and Aquatic Sciences, Norwegian School of Veterinary Science, PO Box 8146 Dep, 0033 Oslo, Norway
    Dis Aquat Organ 67:47-54. 2005
    ..It is concluded that ASPV is at least a contributing cause of PGI. As far as we know, this is the first demonstration of fish disease related to infection with a paramyxovirus...
  16. doi request reprint Microbial and pathological findings in farmed Atlantic salmon Salmo salar with proliferative gill inflammation
    T Steinum
    Section for Fish Health, National Veterinary Institute, Oslo, Norway
    Dis Aquat Organ 91:201-11. 2010
    ..No evidence for the involvement of Atlantic salmon paramyxovirus in PGI development was identified in the present study. High water temperatures and ectoparasites probably exacerbated mortality...
  17. doi request reprint Nodavirus provokes subclinical encephalitis and retinochoroiditis in adult farmed Atlantic cod, Gadus morhua L
    M C Gjessing
    Section for Fish Health, National Veterinary Institute, Oslo, Norway
    J Fish Dis 32:421-31. 2009
    ..Our observations suggest that severe infection and pathological changes may go undetected if investigations are restricted to clinical examination and macroscopic evaluation at necropsy...
  18. ncbi request reprint Longitudinal study of a natural outbreak of heart and skeletal muscle inflammation in Atlantic salmon, Salmo salar L
    R T Kongtorp
    Section for Fish Health, National Veterinary Institute, Oslo, Norway
    J Fish Dis 29:233-44. 2006
    ..Late samples also showed increased fibrosis of cardiac tissue. In conclusion, HSMI appears to be a severe disease with elevated mortality, morbidity close to 100% and prolonged duration...
  19. ncbi request reprint Heart and skeletal muscle inflammation in Atlantic salmon, Salmo salar L: a new infectious disease
    R T Kongtorp
    National Veterinary Institute, Oslo, Norway
    J Fish Dis 27:351-8. 2004
    ..Further investigations are required in order to make conclusions regarding the cause and pathogenesis of HSMI...
  20. doi request reprint Immunohistochemical and Taqman real-time PCR detection of mycobacterial infections in fish
    M A Zerihun
    National Veterinary Institute, Oslo, Norway
    J Fish Dis 34:235-46. 2011
    ..This should in turn allow rapid application of more specific studies, i.e. culture based, to identify the specific Mycobacterium sp. involved...
  21. doi request reprint Intestinal morphology of the wild Atlantic salmon (Salmo salar)
    Guro Løkka
    Department of Basic Sciences and Aquatic Medicine, Norwegian School of Veterinary Science, Oslo, Norway
    J Morphol 274:859-76. 2013
    ..Additionally, immunohistochemistry showing cells positive for cytokeratins, α-actin and proliferating cell nuclear antigen, in addition to alkaline phosphatase reactivity in the segments is presented...
  22. doi request reprint Depletion of CD8 alpha cells from tissues of Atlantic salmon during the early stages of infection with high or low virulent strains of infectious salmon anaemia virus (ISAV)
    Dyveke Lem Hetland
    Department of Basic Sciences and Aquatic Medicine, Norwegian School of Veterinary Science, Oslo, Norway
    Dev Comp Immunol 35:817-26. 2011
    ..These findings suggest a protective role for the CD8 alpha cell population in immune defences against ISAV...
  23. ncbi request reprint Isolation and partial characterization of a novel paramyxovirus from the gills of diseased seawater-reared Atlantic salmon (Salmo salar L)
    Agnar Kvellestad
    Department of Morphology, Genetics and Aquatic Biology, Norwegian School of Veterinary Science, Oslo, Norway
    J Gen Virol 84:2179-89. 2003
    ..Furthermore, replication occurred at 6-21 degrees C, suggesting a host range confined to cold-blooded animals...
  24. pmc Infectious salmon anemia virus specifically binds to and hydrolyzes 4-O-acetylated sialic acids
    Audny Hellebø
    Fish Health Section, National Veterinary Institute, N 0033 Oslo, Norway
    J Virol 78:3055-62. 2004
    ....
  25. pmc Characterization of infectious salmon anemia virus, an orthomyxo-like virus isolated from Atlantic salmon (Salmo salar L.)
    K Falk
    National Veterinary Institute, Oslo, Norway
    J Virol 71:9016-23. 1997
    ....
  26. pmc Infectious salmon anaemia virus (ISAV) mucosal infection in Atlantic salmon
    Maria Aamelfot
    Norwegian Veterinary Institute, Oslo, Norway
    Vet Res 46:120. 2015
    ..Viruses of low and high virulence used in the challenge revealed possible variation in virus progression during infection at the mucosal surfaces. ..
  27. ncbi request reprint Segment 8 encodes a structural protein of infectious salmon anaemia virus (ISAV); the co-linear transcript from Segment 7 probably encodes a non-structural or minor structural protein
    Eirik Bierin
    Intervet Norbio, Bergen, Norway
    Dis Aquat Organ 49:117-22. 2002
    ..studies using this antiserum and a serum against purified virus, show that Segment 8 encodes one of the major structural proteins of the virus whereas the co-linear ORF of Segment 7 probably encodes a non- or minor structural protein..
  28. ncbi request reprint Infectious salmon anemia virus (ISAV) genomic segment 3 encodes the viral nucleoprotein (NP), an RNA-binding protein with two monopartite nuclear localization signals (NLS)
    Vidar Aspehaug
    Department of Biology, University of Bergen, Bergen, Norway
    Virus Res 106:51-60. 2004
    ....