Robert J Weeks

Summary

Affiliation: University of Otago
Country: New Zealand

Publications

  1. ncbi request reprint Detailed methylation analysis of CpG islands on human chromosome region 9p21
    Robert J Weeks
    Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Genes Chromosomes Cancer 45:357-64. 2006
  2. doi request reprint Global demethylation in loss of imprinting subtype of Wilms tumor
    Jackie L Ludgate
    Department of Pathology, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Genes Chromosomes Cancer 52:174-84. 2013
  3. pmc Genome-wide DNA methylation map of human neutrophils reveals widespread inter-individual epigenetic variation
    Aniruddha Chatterjee
    Department of Pathology, Dunedin School of Medicine, University of Otago, 270 Great King Street, Dunedin 9054, New Zealand
    Sci Rep 5:17328. 2015
  4. doi request reprint A mutation of human cytochrome c enhances the intrinsic apoptotic pathway but causes only thrombocytopenia
    Ian M Morison
    Department of Biochemistry, University of Otago, PO Box 56, Dunedin 9054, New Zealand
    Nat Genet 40:387-9. 2008
  5. pmc TESTIN Induces Rapid Death and Suppresses Proliferation in Childhood B Acute Lymphoblastic Leukaemia Cells
    Robert J Weeks
    Department of Pathology, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    PLoS ONE 11:e0151341. 2016
  6. doi request reprint Hypomethylation of functional retrotransposon-derived genes in the human placenta
    Erin C Macaulay
    Department of Pathology, Dunedin School of Medicine and National Research Centre for Growth and Development, University of Otago, New Zealand
    Mamm Genome 22:722-35. 2011
  7. pmc Technical considerations for reduced representation bisulfite sequencing with multiplexed libraries
    Aniruddha Chatterjee
    Department of Pathology, Dunedin School of Medicine, University of Otago, 270 Great King Street, Dunedin 9054, New Zealand
    J Biomed Biotechnol 2012:741542. 2012
  8. pmc Silencing of TESTIN by dense biallelic promoter methylation is the most common molecular event in childhood acute lymphoblastic leukaemia
    Robert J Weeks
    Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, PO Box 56, Dunedin 9054, New Zealand
    Mol Cancer 9:163. 2010
  9. doi request reprint Epigenetic silencing in non-neoplastic epithelia identifies E-cadherin (CDH1) as a target for chemoprevention of lobular neoplasia
    Donghui Zou
    Cancer Genetics Laboratory, Biochemistry Department, University of Otago, Aotearoa, New Zealand
    J Pathol 218:265-72. 2009

Collaborators

Detail Information

Publications9

  1. ncbi request reprint Detailed methylation analysis of CpG islands on human chromosome region 9p21
    Robert J Weeks
    Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, Dunedin, New Zealand
    Genes Chromosomes Cancer 45:357-64. 2006
    ..Our data, which showed heterogeneous and low-level methylation of CpG islands, have obvious implications for methylation studies...
  2. doi request reprint Global demethylation in loss of imprinting subtype of Wilms tumor
    Jackie L Ludgate
    Department of Pathology, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    Genes Chromosomes Cancer 52:174-84. 2013
    ..This would suggest that the LOI subtype of Wilms tumor, which unlike other subtypes results from an epimutation, has a global deregulation of methylation mechanisms...
  3. pmc Genome-wide DNA methylation map of human neutrophils reveals widespread inter-individual epigenetic variation
    Aniruddha Chatterjee
    Department of Pathology, Dunedin School of Medicine, University of Otago, 270 Great King Street, Dunedin 9054, New Zealand
    Sci Rep 5:17328. 2015
    ..Transcriptome analysis indicates that iVMF methylation at differentially expressed exons has a positive correlation and local effect on the inclusion of that exon in the mRNA transcript. ..
  4. doi request reprint A mutation of human cytochrome c enhances the intrinsic apoptotic pathway but causes only thrombocytopenia
    Ian M Morison
    Department of Biochemistry, University of Otago, PO Box 56, Dunedin 9054, New Zealand
    Nat Genet 40:387-9. 2008
    ..Notably, the family has no other phenotypic indication of abnormal apoptosis, implying that cytochrome c activity is not a critical regulator of most physiological apoptosis...
  5. pmc TESTIN Induces Rapid Death and Suppresses Proliferation in Childhood B Acute Lymphoblastic Leukaemia Cells
    Robert J Weeks
    Department of Pathology, Dunedin School of Medicine, University of Otago, Dunedin, New Zealand
    PLoS ONE 11:e0151341. 2016
    ..The aims of the present study were to demonstrate that TES promoter methylation is aberrant, to determine the effects of TES re-expression in ALL, and to determine if those effects are mediated via TP53 activity...
  6. doi request reprint Hypomethylation of functional retrotransposon-derived genes in the human placenta
    Erin C Macaulay
    Department of Pathology, Dunedin School of Medicine and National Research Centre for Growth and Development, University of Otago, New Zealand
    Mamm Genome 22:722-35. 2011
    ....
  7. pmc Technical considerations for reduced representation bisulfite sequencing with multiplexed libraries
    Aniruddha Chatterjee
    Department of Pathology, Dunedin School of Medicine, University of Otago, 270 Great King Street, Dunedin 9054, New Zealand
    J Biomed Biotechnol 2012:741542. 2012
    ..Here we provide a roadmap of modifications, strategies, and trouble shooting approaches we implemented to optimize sequencing of multiplexed libraries on an a RRBS background...
  8. pmc Silencing of TESTIN by dense biallelic promoter methylation is the most common molecular event in childhood acute lymphoblastic leukaemia
    Robert J Weeks
    Cancer Genetics Laboratory, Department of Biochemistry, University of Otago, PO Box 56, Dunedin 9054, New Zealand
    Mol Cancer 9:163. 2010
    ..By screening candidate genes, we have detected frequent and dense methylation of the TESTIN (TES) promoter...
  9. doi request reprint Epigenetic silencing in non-neoplastic epithelia identifies E-cadherin (CDH1) as a target for chemoprevention of lobular neoplasia
    Donghui Zou
    Cancer Genetics Laboratory, Biochemistry Department, University of Otago, Aotearoa, New Zealand
    J Pathol 218:265-72. 2009
    ..Furthermore, the presence of CDH1 methylation in pre-neoplastic epithelia suggests the existence of mammary regions with increased disease susceptibility, providing an explanation for the often multifocal presentation of LBC...