Srdjan M Vlajkovic

Summary

Affiliation: University of Auckland
Country: New Zealand

Publications

  1. ncbi request reprint Distribution of ectonucleoside triphosphate diphosphohydrolases 1 and 2 in rat cochlea
    Srdjan M Vlajkovic
    Division of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Hear Res 170:127-38. 2002
  2. ncbi request reprint Differential distribution of adenosine receptors in rat cochlea
    Srdjan M Vlajkovic
    Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Cell Tissue Res 328:461-71. 2007
  3. doi request reprint Adenosine receptors regulate susceptibility to noise-induced neural injury in the mouse cochlea and hearing loss
    Srdjan M Vlajkovic
    Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag, 92019, Auckland, New Zealand Centre for Brain Research, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag, 92019, Auckland, New Zealand Electronic address
    Hear Res . 2016
  4. pmc Adenosine and the auditory system
    Srdjan M Vlajkovic
    Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, New Zealand
    Curr Neuropharmacol 7:246-56. 2009
  5. doi request reprint Noise-induced changes in expression levels of NADPH oxidases in the cochlea
    Srdjan M Vlajkovic
    Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand Electronic address
    Hear Res 304:145-52. 2013
  6. pmc Role of adenosine kinase in cochlear development and response to noise
    Srdjan M Vlajkovic
    Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Aukland, New Zealand
    J Neurosci Res 88:2598-609. 2010
  7. pmc Adenosine kinase inhibition in the cochlea delays the onset of age-related hearing loss
    Srdjan M Vlajkovic
    Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, New Zealand
    Exp Gerontol 46:905-14. 2011
  8. doi request reprint Preservation of cochlear function in Cd39 deficient mice
    Srdjan M Vlajkovic
    Department of Physiology, The University of Auckland, 85 Park Road, Grafton, Private Bag 92019, Auckland 1142, New Zealand
    Hear Res 253:77-82. 2009
  9. ncbi request reprint NTPDase1 and NTPDase2 immunolocalization in mouse cochlea: implications for regulation of p2 receptor signaling
    Srdjan M Vlajkovic
    Discipline of Audiology and Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    J Histochem Cytochem 50:1435-42. 2002
  10. ncbi request reprint Activation-dependent trafficking of NTPDase2 in Chinese hamster ovary cells
    Srdjan M Vlajkovic
    Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    Int J Biochem Cell Biol 39:810-7. 2007

Collaborators

Detail Information

Publications24

  1. ncbi request reprint Distribution of ectonucleoside triphosphate diphosphohydrolases 1 and 2 in rat cochlea
    Srdjan M Vlajkovic
    Division of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Hear Res 170:127-38. 2002
    ....
  2. ncbi request reprint Differential distribution of adenosine receptors in rat cochlea
    Srdjan M Vlajkovic
    Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Private Bag 92019, Auckland, New Zealand
    Cell Tissue Res 328:461-71. 2007
    ..Our study provides a framework for further investigation of adenosine signalling in the inner ear, including putative roles in oxidative stress responses...
  3. doi request reprint Adenosine receptors regulate susceptibility to noise-induced neural injury in the mouse cochlea and hearing loss
    Srdjan M Vlajkovic
    Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag, 92019, Auckland, New Zealand Centre for Brain Research, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag, 92019, Auckland, New Zealand Electronic address
    Hear Res . 2016
    ..The findings suggest that the loss of A1AR expression results in an increased susceptibility to cochlear neural injury and hearing loss, whilst absence of A2AAR increases cochlear resistance to acoustic trauma...
  4. pmc Adenosine and the auditory system
    Srdjan M Vlajkovic
    Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, New Zealand
    Curr Neuropharmacol 7:246-56. 2009
    ..Manipulations of the adenosine signalling system thus hold significant promise in the therapeutic management of oxidative stress in the cochlea...
  5. doi request reprint Noise-induced changes in expression levels of NADPH oxidases in the cochlea
    Srdjan M Vlajkovic
    Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand Electronic address
    Hear Res 304:145-52. 2013
    ..Post-exposure inhibition of NADPH oxidases by Diphenyleneiodonium (DPI), a broadly selective NADPH oxidase inhibitor, mitigated noise-induced hearing loss...
  6. pmc Role of adenosine kinase in cochlear development and response to noise
    Srdjan M Vlajkovic
    Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Aukland, New Zealand
    J Neurosci Res 88:2598-609. 2010
    ....
  7. pmc Adenosine kinase inhibition in the cochlea delays the onset of age-related hearing loss
    Srdjan M Vlajkovic
    Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, New Zealand
    Exp Gerontol 46:905-14. 2011
    ..This study provides the first evidence that ARHL can be mitigated by enhancing adenosine signalling in the cochlea...
  8. doi request reprint Preservation of cochlear function in Cd39 deficient mice
    Srdjan M Vlajkovic
    Department of Physiology, The University of Auckland, 85 Park Road, Grafton, Private Bag 92019, Auckland 1142, New Zealand
    Hear Res 253:77-82. 2009
    ..These findings suggest that Cd39 deletion alone does not adversely affect cochlear function, possibly as compensatory up-regulation of other surface located NTPDases may offset predicted alterations in cochlear homeostasis...
  9. ncbi request reprint NTPDase1 and NTPDase2 immunolocalization in mouse cochlea: implications for regulation of p2 receptor signaling
    Srdjan M Vlajkovic
    Discipline of Audiology and Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    J Histochem Cytochem 50:1435-42. 2002
    ..This differential expression of NTPDase1 and 2 in the cochlea suggests spatial regulation of P2 receptor signaling, potentially involving different nucleotide species and hydrolysis kinetics...
  10. ncbi request reprint Activation-dependent trafficking of NTPDase2 in Chinese hamster ovary cells
    Srdjan M Vlajkovic
    Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    Int J Biochem Cell Biol 39:810-7. 2007
    ..The increase in surface-located NTPDase2 may reflect a regulatory mechanism counteracting excessive stimulation and desensitisation of P2 receptors...
  11. ncbi request reprint Noise-induced up-regulation of NTPDase3 expression in the rat cochlea: Implications for auditory transmission and cochlear protection
    Srdjan M Vlajkovic
    Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Brain Res 1104:55-63. 2006
    ..The results suggest a role for NTPDase3 in regulating ATP signaling associated primarily with auditory neurotransmission, and the potential neuroprotective nature of noise-induced up-regulation of this ectonucleotidase in the cochlea...
  12. pmc C-terminal splicing of NTPDase2 provides distinctive catalytic properties, cellular distribution and enzyme regulation
    Carol J H Wang
    Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Park Road, Grafton, Private Bag 92019, Auckland, New Zealand
    Biochem J 385:729-36. 2005
    ..These findings advance the molecular physiology of this enzyme system by characterizing the contribution of the C-terminal domain to many of the enzyme's signature properties...
  13. doi request reprint Developmentally regulated expression of ectonucleotidases NTPDase5 and NTPDase6 and UDP-responsive P2Y receptors in the rat cochlea
    Mary G O'Keeffe
    Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand
    Histochem Cell Biol 133:425-36. 2010
    ..Spatiotemporal topographic expression of NTPDase5 and NTPDase6 and P2Y receptors in adult and developing cochlear tissues provide strong support for the role of pyrimidinergic signalling in cochlear development...
  14. doi request reprint Post exposure administration of A(1) adenosine receptor agonists attenuates noise-induced hearing loss
    Ann Chi Yan Wong
    Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, New Zealand
    Hear Res 260:81-8. 2010
    ..This study pinpoints A(1) adenosine receptors as attractive targets for pharmacological interventions to reduce noise-induced cochlear injury after exposure...
  15. doi request reprint Putative role of border cells in generating spontaneous morphological activity within Kölliker's organ
    M W Nishani Dayaratne
    Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand Centre for Brain Research, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, New Zealand Electronic address
    Hear Res 330:90-7. 2015
    ..Together, these results underline the role of purinergic signalling in initiating morphological events within Kölliker's organ, and suggest a key involvement of border cells surrounding IHCs in regulating this spontaneous activity...
  16. ncbi request reprint Nucleoside transporter expression and adenosine uptake in the rat cochlea
    Abdul F Khan
    Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand
    Neuroreport 18:235-9. 2007
    ..The study suggests that the bi-directional nucleoside transport supports the uptake and recycling of purines and regulates the activation of adenosine receptors by altering adenosine concentrations in cochlear fluid spaces...
  17. doi request reprint Hair cell specific NTPDase6 immunolocalisation in vestibular end organs: potential role of purinergic signaling in vestibular sensory transduction
    Mary G O'Keeffe
    Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Auckland, New Zealand
    J Vestib Res 22:213-9. 2012
    ..NTPDase6 immunolocalisation in the vestibular end organ could be linked to the regulation of P2 receptor signalling and sensory transduction, including maintenance of vestibular hair bundles...
  18. pmc Adenosine amine congener as a cochlear rescue agent
    Srdjan M Vlajkovic
    Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand Centre for Brain Research, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
    Biomed Res Int 2014:841489. 2014
    ..Here we demonstrate the dose-dependent rescue effects of ADAC on noise-induced cochlear injury in a rat model and establish the time window for treatment...
  19. doi request reprint Differential spread of anoxic depolarization contributes to the pattern of neuronal injury after oxygen and glucose deprivation (OGD) in the Substantia Nigra in rat brain slices
    Rashika N Karunasinghe
    Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, 85 Park Road, Auckland 1023, New Zealand
    Neuroscience 340:359-372. 2017
    ..This differential response may affect the pattern of early neuronal injury that develops in the brainstem after acute ischemic insults...
  20. pmc Properties of ATP-gated ion channels assembled from P2X2 subunits in mouse cochlear Reissner's membrane epithelial cells
    Rachel T Morton-Jones
    Department of Physiology, University of Auckland, Auckland, New Zealand
    Purinergic Signal 11:551-60. 2015
    ....
  21. doi request reprint Characterisation of cochlear inflammation in mice following acute and chronic noise exposure
    Winston J T Tan
    Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland, 1142, New Zealand
    Histochem Cell Biol 146:219-30. 2016
    ..This study thus provides further insight into the dynamics of the cochlear inflammatory response induced by exposure to acute and chronic noise. ..
  22. pmc Kölliker's organ and the development of spontaneous activity in the auditory system: implications for hearing dysfunction
    M W Nishani Dayaratne
    Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand Centre for Brain Research, Faculty of Medical and Health Sciences, The University of Auckland, Private Bag 92019, Auckland 1142, New Zealand
    Biomed Res Int 2014:367939. 2014
    ....
  23. pmc Markers of cochlear inflammation using MRI
    Johann Le Floc'h
    Department of Physiology, Faculty of Medical and Health Sciences, The University of Auckland, New Zealand
    J Magn Reson Imaging 39:150-61. 2014
    ..To quantify spatial and temporal inflammation-induced changes in vascular permeability and macrophage infiltration in guinea-pig (GP) cochlea using MRI...
  24. doi request reprint Differential membrane redistribution of P2X receptor isoforms in response to osmotic and hyperglycemic stress in the rat lens
    Haruna Suzuki-Kerr
    Department of Physiology, Faculty of Medical and Health Sciences, University of Auckland, Auckland, New Zealand
    Histochem Cell Biol 131:667-80. 2009
    ..Furthermore they suggest the involvement of specific P2X isoforms in the regulation of fiber cell volume and the initiation of diabetic cataract...